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1. 发明申请

WO2013153362A1 CALIBRATOR FOR A SENSOR 审中-公开
标题翻译：传感器校准器
公开(公告)号：WO2013153362A1
公开(公告)日：2013-10-17
申请号：PCT/GB2013/050860
申请日：2013-04-02
申请人： LIGHTSHIP MEDICAL LIMITED
发明人： CRANE, Barry Colin , PATERSON, William , BARWELL, Nicholas Paul
IPC分类号： A61B5/145 , A61B5/1459 , A61B5/1495 , G01N27/327 , G01N21/64
CPC分类号： A61B5/1495 , A61B5/14503 , A61B5/14532 , A61B5/1459 , A61B2560/0223 , A61B2560/0228 , A61B2562/242 , A61L2/081 , A61L2202/24 , B01J19/00 , G01N21/278 , G01N33/50 , G01N33/66 , G01N2021/6484 , G01N2021/772 , G01N2021/775 , G01N2021/7786
摘要： A calibrator, for calibrating a sensor, has a calibration chamber for containing a calibration liquid. The liquid comprises water or an aqueous solution of an analyte to be sensed. A hydrogen peroxide-quenching material is provided exposed to the interior of the calibration chamber. The hydrogen peroxide-quenching material contacts the calibration liquid. After the calibration chamber containing the calibration liquid is sterilized by irradiation with gamma radiation, the hydrogen peroxide-quenching material decomposes any hydrogen peroxide formed in the calibration liquid to avoid adverse effects on a sensor placed in contact with the calibration liquid.
摘要翻译：用于校准传感器的校准器具有用于容纳校准液体的校准室。液体包含水或待检测分析物的水溶液。设置暴露于校准室内部的过氧化氢骤冷材料。过氧化氢淬火材料接触校准液。在含有校准液的校准室通过γ射线照射消毒后，过氧化氢骤冷材料分解校准液中形成的任何过氧化氢，以避免对与校准液体接触的传感器产生不利影响。

2. 发明申请

WO2015118313A1 GLUCOSE SENSOR CALIBRATION 审中-公开
标题翻译：葡萄糖传感器校准
公开(公告)号：WO2015118313A1
公开(公告)日：2015-08-13
申请号：PCT/GB2015/050283
申请日：2015-02-03
申请人： LIGHTSHIP MEDICAL LIMITED
发明人： CRANE, Barry Colin , BARWELL, Nicholas Paul , PATERSON, William
IPC分类号： A61B5/1495 , A61B5/145 , A61B5/1459
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1459 , A61B2560/0233
摘要： A process for calibrating a glucose sensor under sterile conditions includes providing separate, sterile, glucose-containing calibration fluids, each having a different glucose concentration, and in turn providing these fluids to a sensing zone containing a sensing probe of a glucose sensor. Each solution is typically, in turn, propelled into the sensing zone, thus flushing out used fluid already present in the sensing zone. The process provides rapid calibration of a glucose sensor in a sterile fashion and is therefore appropriate for point-of-use calibration.
摘要翻译：用于在无菌条件下校准葡萄糖传感器的方法包括提供分开的，无菌的含葡萄糖的校准流体，其各自具有不同的葡萄糖浓度，并且进而将这些流体提供到包含葡萄糖传感器的感测探针的感测区域。每个溶液通常又被推进到感测区域中，从而冲洗已经存在于感测区域中的已使用流体。该方法以无菌方式提供葡萄糖传感器的快速校准，因此适用于使用点校准。

3. 发明申请

WO2013024260A1 BARRIER LAYER FOR GLUCOSE SENSOR 审中-公开
标题翻译：葡萄糖传感器的障碍层
公开(公告)号：WO2013024260A1
公开(公告)日：2013-02-21
申请号：PCT/GB2012/051921
申请日：2012-08-08
申请人： LIGHTSHIP MEDICAL LIMITED , CRANE, Barry , PATERSON, William , BARWELL, Nicholas Paul
发明人： CRANE, Barry , PATERSON, William , BARWELL, Nicholas Paul
IPC分类号： C12Q1/00 , G01N21/77 , G01N27/40 , G01N27/404 , G01N21/64
CPC分类号： G01N33/66 , G01N21/6428 , G01N21/7703 , G01N33/582 , G01N2021/6434 , G01N2021/772 , G01N2021/7786 , Y10T29/49
摘要： An optical glucose sensor for detecting and/or quantifying the amount of glucose in a sample comprising: -a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; -an optical waveguide for directing incident light onto the sensing region; and -a glucose-permeable barrier layer comprising a semi-permeable membrane having pores and a hydrophilic polymerwithin the pores of the semi- permeable membrane, the barrier layer overlying at least a part of the sensing region; wherein the sensor is adapted so that glucose enters the sensing region of the sensor through the glucose-permeable barrier layer, and an ROS-quenching agent is present in the sensing region and/or the glucose-permeable barrier layer.
摘要翻译：一种用于检测和/或定量样品中葡萄糖量的光学葡萄糖传感器，包括： - 包含用于结合葡萄糖的硼酸受体和与所述受体相关的荧光团的感测区域; - 用于将入射光引导到感测区域的光波导; 以及 - 葡萄糖可渗透屏障层，其包含在所述半透膜的孔中具有孔和亲水性聚合物的半透膜，所述阻挡层覆盖所述感测区域的至少一部分; 其中所述传感器适于使得葡萄糖通过所述葡萄糖可渗透阻隔层进入所述传感器的感测区域，并且所述感测区域和/或所述葡萄糖可渗透阻挡层中存在ROS猝灭剂。

4. 发明申请

WO2013190281A1 GLUCOSE SENSOR 审中-公开
标题翻译：葡萄糖传感器
公开(公告)号：WO2013190281A1
公开(公告)日：2013-12-27
申请号：PCT/GB2013/051582
申请日：2013-06-18
申请人： LIGHTSHIP MEDICAL LIMITED
发明人： CRANE, Barry Colin , PATERSON, William , BARWELL, Nicholas Paul , EDGLEY, Peter
IPC分类号： G01N33/487 , G01N33/66
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/1473 , G01N21/6408 , G01N21/6428 , G01N21/7703 , G01N27/3271 , G01N2021/6432 , G01N2021/6434 , G01N2021/6441 , G01N2021/6484 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , G01N2021/7793
摘要： A method of quantifying the amount of glucose in a sample is provided herein that may further comprise an interferent such as mannitol. At least two measurements are obtained using measurement methods that differ in their sensitivity to the amount of interferent in the sample, thus enabling the results to be compared to determine whether any interferent is present in the sample. A glucose sensor for carrying out a method described herein is also provided.
摘要翻译：本文提供了定量样品中葡萄糖量的方法，其可以进一步包含诸如甘露醇之类的干扰物。使用与样品中干扰物量的敏感性不同的测量方法获得至少两次测量，从而使结果能够比较，以确定样品中是否存在任何干扰物。还提供了用于执行本文所述方法的葡萄糖传感器。

5. 发明申请

WO2013136044A3 SENSOR FOR DETECTING THE AMOUNT OF ANALYTE IN A SAMPLE 审中-公开
公开(公告)号：WO2013136044A3
公开(公告)日：2013-09-19
申请号：PCT/GB2013/050407
申请日：2013-02-20
申请人： LIGHTSHIP MEDICAL LIMITED
发明人： PATERSON, William , BARWELL, Nick , CULBERT, Bruce , CRANE, Barry, Colin
IPC分类号： A61B5/145 , G01N33/66 , G01N21/77
摘要： A sensor (1) or detecting and/or quantifying the amount of analyte in a sample, the sensor including: • -a sensing region (3); and • -a barrier layer (BL) including a reactive oxygen species (ROS) -quenching, analyte-permeable membrane having an ROS- quenching agent adsorbed thereto; • wherein the sensor is adapted so that the sample enters the sensing region of the sensor through said barrier layer.

6. 发明申请

WO2013072699A1 GLUCOSE SENSOR CALIBRATION 审中-公开
标题翻译：葡萄糖传感器校准
公开(公告)号：WO2013072699A1
公开(公告)日：2013-05-23
申请号：PCT/GB2012/052848
申请日：2012-11-16
申请人： LIGHTSHIP MEDICAL LIMITED
发明人： CRANE, Barry Colin , PATERSON, William
IPC分类号： G01N33/66 , A61B5/145 , A61B5/1495 , G01N27/327
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/1459 , A61B5/1495 , G01N33/66
摘要： A method of calibrating a glucose sensor, which method comprises: (a) preparing a first glucose-containing calibration solution by combining water or an aqueous solution with alpha and beta glucose, the alpha and beta glucose being provided in solid form; (b) exposing a glucose sensor to said first glucose-containing calibration solution and determining the sensor output; (c) exposing the glucose sensor to one or more further calibration solutions having different glucose concentrations from each other and from said first glucose-containing calibration solution and determining the sensor output for the or each calibration solution; and (d) determining a calibration curve from the sensor output data collected in steps (b) and (c); wherein the first glucose-containing calibration solution of step (a),and if used the or each glucose-containing calibration solution of step (c), is prepared using 25 to 50 % alpha glucose and 50 to 75 % beta glucose, and wherein the first glucose-containing calibration solution of step (a), and if used the or each glucose-containing calibration solution of step (c), is prepared by combining water or an aqueous solution with freeze-dried glucose.
摘要翻译：一种校准葡萄糖传感器的方法，所述方法包括：（a）通过将水或水溶液与α和β葡萄糖结合来制备第一含葡萄糖的校准溶液，所述α和β葡萄糖以固体形式提供; （b）将葡萄糖传感器暴露于所述第一含葡萄糖校准溶液并确定传感器输出; （c）将所述葡萄糖传感器暴露于具有彼此不同葡萄糖浓度和所述第一含葡萄糖的校准溶液的一种或多种另外的校准溶液，并确定所述或每种校准溶液的传感器输出; 和（d）从步骤（b）和（c）中收集的传感器输出数据确定校准曲线; 其中步骤（a）的第一含葡萄糖的校准溶液和如果使用步骤（c）的或每个含葡萄糖的校准溶液，使用25至50％的α葡萄糖和50至75％的β葡萄糖制备，其中步骤（a）的第一种含葡萄糖的校准溶液，如果使用，则通过将水或水溶液与冷冻干燥的葡萄糖组合来制备步骤（c）的或每种含葡萄糖的校准溶液。

7. 发明申请

WO2012164268A1 OPTICAL GLUCOSE BIOSENSOR CALIBRATION USING DIFFERENT TEMPERATURE CALIBRATION SOLUTIONS 审中-公开
标题翻译：光学葡萄糖生物传感器校准使用不同的温度校准解决方案
公开(公告)号：WO2012164268A1
公开(公告)日：2012-12-06
申请号：PCT/GB2012/051188
申请日：2012-05-25
申请人： LIGHTSHIP MEDICAL LIMITED , BARWELL, Nicholas Paul , EDGLEY, Peter , MACKENZIE, Alasdair Allan , PATERSON, William , CRANE, Barry Colin
发明人： BARWELL, Nicholas Paul , EDGLEY, Peter , MACKENZIE, Alasdair Allan , PATERSON, William , CRANE, Barry Colin
IPC分类号： G01N33/58 , G01N33/66
CPC分类号： G01K15/005 , G01N33/5438 , G01N33/582 , G01N33/66
摘要： A method of calibrating a reversible-binding sensor for detecting an analyte includes: (i) varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor; (ii) determining the sensor output for the first calibration solution as a function of temperature; (iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution; (iv) determining the sensor output for the second calibration solution as a function of temperature; and (v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor.
摘要翻译：校准用于检测分析物的可逆结合传感器的方法包括：（i）将第一校准溶液的温度从第一温度（T1）改变到第二温度（T2），同时第一校准溶液与传感器的感测区域; （ii）确定作为温度的函数的第一校准溶液的传感器输出; （iii）当第二校准溶液与感测区域接触时，将第二校准溶液的温度从第三温度（T3）变化到第四温度（T4），第二校准溶液具有不同的分析物浓度从第一个校准溶液的; （iv）确定作为温度的函数的第二校准溶液的传感器输出; 和（v）使用来自步骤（ii）和（iv）的确定的传感器输出来校准传感器。

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