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1. 发明申请

WO2012174119A3 COMPOSITIONS AND METHODS FOR DETECTION OF CRONOBACTER SPP. AND CRONOBACTER SPECIES AND STRAINS 审中-公开
标题翻译：用于检测CRONOBACTER SPP的组合物和方法。和克隆物种和菌株
公开(公告)号：WO2012174119A3
公开(公告)日：2013-04-11
申请号：PCT/US2012042263
申请日：2012-06-13
申请人： LIFE TECHNOLOGIES CORP , JI YONGMEI , SHIH SHEUNG-MEI RITA , DEGORICIJA LOVORKA , ZHOU ZHAOHUI , CUMMINGS CRAIG , FURTADO MANOHAR , BRZOSKA PIUS , BURRELL ANGELA , LEONG HARRISON , FANG XINGWANG , BOUNPHENG MANGKEY , SHAH ROHAN
发明人： JI YONGMEI , SHIH SHEUNG-MEI RITA , DEGORICIJA LOVORKA , ZHOU ZHAOHUI , CUMMINGS CRAIG , FURTADO MANOHAR , BRZOSKA PIUS , BURRELL ANGELA , LEONG HARRISON , FANG XINGWANG , BOUNPHENG MANGKEY , SHAH ROHAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12R1/01
摘要： Disclosed are genomic sequences for nine strains of Cronobacter spp. (C. sakazakii - 696, 701, 680; C. malonaticus - 507, 681; C. turicensis - 564; C. muytjensii - 530; C. dublinensis - 582; C. genomospl - 581) and compositions, methods, and kits for detecting, identifying and distinguishing Cronobacter spp. strains from each other and from non-Cronobacter spp. strains. Some embodiments describe isolated nucleic acid compositions unique to certain Cronobacter strains as well as compositions that are specific to all Cronobacter spp. Primer and probe compositions and methods of use of primers and probes are also provided. Kits for identification of Cronobacter spp. are also described. Some embodiments relate to computer software methods for setting a control based threshold for analysis of PCR
摘要翻译：公开了九个克罗杆菌属菌株的基因组序列。（C. sakazakii-696,701,680; C. malonaticus-507,681; C. turicensis-564; C. muytjensii-530; C.dublinensis-582; C.基因组蛋白-58）和组合物，方法和试剂盒用于检测，识别和鉴别克罗杆菌属。菌株彼此和非克罗杆菌属。株。一些实施方案描述了某些克罗杆菌菌株特有的分离的核酸组合物以及对所有克罗杆菌属特异性的组合物。还提供引物和探针组合物以及引物和探针的使用方法。克隆杆菌属鉴定试剂盒也被描述。一些实施例涉及用于设置用于PCR分析的基于控制的阈值的计算机软件方法

2. 发明申请

WO2012006565A3 SYSTEMS AND METHODS FOR ASSIGNING ATTRIBUTES TO A PLURALITY OF SAMPLES 审中-公开
标题翻译：将属性分配给多个样本的系统和方法
公开(公告)号：WO2012006565A3
公开(公告)日：2012-04-19
申请号：PCT/US2011043419
申请日：2011-07-08
申请人： LIFE TECHNOLOGIES CORP , LEONG HARRISON , WU RUOYUN , LEE THIAM CHYE
发明人： LEONG HARRISON , WU RUOYUN , LEE THIAM CHYE
IPC分类号： G06F19/10 , G06F3/048 , G06F3/14
CPC分类号： B01L7/52 , B01L3/5085 , B01L3/50851 , B01L99/00 , B01L2300/023 , B01L2300/024 , B01L2300/025 , B01L2300/027 , B01L2300/046 , B01L2300/0654 , B01L2300/0822 , B01L2300/0829 , G01N2035/00891
摘要： Systems and methods for assigning attributes to a plurality of samples are provided. An exemplary system includes an instrument configured to perform an experiment on a plurality of samples in a multi- sample support device and to produce a plurality of measured values. The system further includes a computer system in communication with the instrument. The computer system is configured to receive the plurality of measured values from the instrument, store the plurality of measured values in a memory configured as a grid of cells representing the grid of the multi- sample support device, display the grid of cells in a graphical user interface, receive a selected cell from the graphical user interface, receive two or more attribute values for the selected cell from the graphical user interface, and store the two or more assigned attribute values along with a measured value of the selected cell in the memory configured as a grid of cells.
摘要翻译：提供了将属性分配给多个样本的系统和方法。示例性系统包括被配置为对多样本支持装置中的多个样本执行实验并产生多个测量值的仪器。该系统还包括与仪器通信的计算机系统。计算机系统被配置为从仪器接收多个测量值，将多个测量值存储在被配置为表示多样本支持设备的网格的单元格网格的存储器中，将单元格网格显示在图形中用户界面，从图形用户界面接收所选择的单元，从图形用户界面接收所选单元格的两个或多个属性值，并将所分配的两个或更多个属性值连同选定单元格的测量值一起存储在存储器中配置为单元格网格。

3. 发明申请

WO2012068276A3 SYSTEMS AND METHODS FOR THE ANALYSIS OF PROXIMITY BINDING ASSAY DATA 审中-公开
标题翻译：用于分析接近结合测定数据的系统和方法
公开(公告)号：WO2012068276A3
公开(公告)日：2012-07-19
申请号：PCT/US2011061034
申请日：2011-11-16
申请人： LIFE TECHNOLOGIES CORP , LEONG HARRISON , MAJUMDAR NIVEDITA , SWARTZMAN ELANA
发明人： LEONG HARRISON , MAJUMDAR NIVEDITA , SWARTZMAN ELANA
IPC分类号： G06F19/24
CPC分类号： G06F19/18 , G06F19/24
摘要： A proximity binding assay (PBA) is performed on at least one test sample, at least one reference sample, a background sample, and one or more calibration samples using a thermal cycler instrument. Ct values are determined for at least one set of test sample data and at least one set of reference sample data. Background corrected Ct values are calculated using a corresponding value in a background sample data set. A linear range is determined for the background corrected Ct values as a function of sample quantity. A linear regression line is calculated for each linear range. One or more parameter values of an exponential model (EM) fold change formula are estimated from the one or more sets of calibration sample data. A target protein quantity and associated confidence interval are calculated using the linear regression lines and the EM fold change formula.
摘要翻译：使用热循环仪器在至少一个测试样品，至少一个参考样品，背景样品和一个或多个校准样品上进行接近结合测定（PBA）。对至少一组测试样本数据和至少一组参考样本数据确定Ct值。背景校正的Ct值是使用背景样本数据集中的对应值计算的。根据样品数量确定背景校正Ct值的线性范围。针对每个线性范围计算线性回归线。根据一组或多组校准样本数据估计指数模型（EM）倍数变化公式的一个或多个参数值。使用线性回归线和EM倍数变化公式计算目标蛋白质量和相关置信区间。

4. 发明申请

WO2008070328A3 SYSTEMS AND METHODS FOR BASELINING AND REAL-TIME PCR DATA ANALYSIS 审中-公开
标题翻译：用于基线和实时PCR数据分析的系统和方法
公开(公告)号：WO2008070328A3
公开(公告)日：2008-11-13
申请号：PCT/US2007082458
申请日：2007-10-24
申请人： APPLERA CORP , LEONG HARRISON
发明人： LEONG HARRISON
IPC分类号： C12P19/34 , G06F19/00
CPC分类号： G06K9/00523
摘要： Systems and methods according to embodiments of the present teachings incorporate a set of possible signal transforms that can be used to examine the baseline region of an amplification profile for noise. In embodiments, a difference time series analysis can be performed to determine deviations of detected fluorescent or other signal intensity in the early cycles of a PCR or other reaction over a median difference time series magnitude. In embodiments, difference time series analysis or other detection techniques can be performed over different hop sizes producing a multi-resolution analysis. In embodiments, the amplification profile can be transmitted to a set of noise detectors whose individual results or decisions are polled or weighted to determine the presence of noise in the baseline or other region. In embodiments, a second derivative analysis on the baseline region can be performed.
摘要翻译：根据本教导的实施例的系统和方法包含一组可能的信号变换，其可用于检查噪声的放大轮廓的基线区域。在实施方式中，可以执行差异时间序列分析以确定在PCR的早期周期或其他反应中的中值差异时间序列幅度上的检测到的荧光或其他信号强度的偏差。在实施例中，可以在产生多分辨率分析的不同跳段大小上执行差异时间序列分析或其他检测技术。在实施例中，可以将放大曲线传送到一组噪声检测器，其中对各个结果或决定进行轮询或加权以确定基线或其他区域中存在噪声。在实施例中，可以执行对基线区域的二阶导数分析。

5. 发明申请

WO2014074735A3 VISUALIZATION TOOLS FOR DIGITAL PCR DATA 审中-公开
标题翻译：用于数字PCR数据的可视化工具
公开(公告)号：WO2014074735A3
公开(公告)日：2014-08-07
申请号：PCT/US2013068984
申请日：2013-11-07
申请人： LIFE TECHNOLOGIES CORP
发明人： LEONG HARRISON , MAJUMDAR NIVEDITA SUMI , MARKS JEFFREY , STRAUB THEODORE , TALBOT RYAN , BODNER KEVIN , HOARD DAVID
IPC分类号： G06F19/26
CPC分类号： G06T11/206 , G06F19/26 , G06T11/203
摘要： A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.
摘要翻译：提供了一种用于生成数据可视化的方法。该方法包括将来自衬底的检测数据的一部分的表示显示给用户。该方法进一步包括产生用于该部分检测数据的数据质量值，并与该部分检测数据的表示一起显示该部分检测数据的数据质量值的指示。该方法进一步包括由用户选择质量值阈值，并显示针对满足质量值阈值的部分检测数据的数据质量值的调整指示。

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