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1. 发明申请

WO1990013321A1 BLOOD PUMP 审中-公开
标题翻译：血液泵
公开(公告)号：WO1990013321A1
公开(公告)日：1990-11-15
申请号：PCT/US1990002478
申请日：1990-05-04
申请人： LEOCOR, INC.
发明人： LEOCOR, INC. , WIJAY, Bandula , ANGELINI, Paolo
IPC分类号： A61M01/00
CPC分类号： A61M25/104 , A61M1/1018 , A61M1/1037 , A61M1/1046 , A61M1/1081 , A61M1/1087 , A61M1/1096 , A61M25/0071 , A61M25/1002 , A61M2025/0006 , A61M2025/1059 , A61M2025/1079 , A61M2025/1093 , Y10S128/12
摘要： The invention is a disposable, positive displacement piston pump (P), having a polycarbonate body (B), a piston (10), an inlet valve (22), and an outlet valve (24). The outlet valve (24) is connected to an exit chamber (28), which is separated from the exit valve (24) by an elastomeric membrane (18). The elastomeric membrane (18) encloses an accumulation chamber (16) which is filled with a fluid such as air under atmospheric pressure. Pulsations in outlet pressure caused by stroking of the piston (10) are dampened by the flexing action of the elastomeric membrane (18), compressing the fluid within the accumulator chamber (16). The throw out of the pump is pressure-dampened and is of sufficient pressure to flow through very low-profile angioplasty catheters (A) having perfusion lumens (42) extending therethrough. The combination of the pump (P) with a very low-profile balloon angioplasty catheter (A) allows access of the catheter to a constricted passage with the ability to pump a sufficient volume of blood through such a low-profile catheter during balloon inflations.
摘要翻译：本发明是具有聚碳酸酯体（B），活塞（10），入口阀（22）和出口阀（24）的一次性容积式活塞泵（P）。出口阀（24）连接到通过弹性膜（18）与出口阀（24）分离的出口室（28）。弹性膜（18）包围积聚室（16），其在大气压下填充有诸如空气的流体。通过弹性膜（18）的弯曲作用，压缩活塞（10）中的流动引起的出口压力的脉冲，压缩蓄能器室（16）内的流体。泵的输出被压力衰减并且具有足够的压力以流过具有从其延伸的灌注腔（42）的非常薄型的血管成形术导管（A）。泵（P）与非常低轮廓的气囊血管成形术导管（A）的组合允许导管进入狭窄的通道，具有在球囊充气期间通过这种低轮廓导管泵送足够体积的血液的能力。

2. 发明申请

WO1989002763A1 CATHETER FOR DILATING STENOTIC LESIONS 审中-公开
标题翻译：用于脱水椎间盘的导管
公开(公告)号：WO1989002763A1
公开(公告)日：1989-04-06
申请号：PCT/US1988003250
申请日：1988-09-20
申请人： LEOCOR, INC.
发明人： LEOCOR, INC. , WIJAY, Bandula , ANGELINI, Paolo
IPC分类号： A61M25/00
CPC分类号： A61M25/104 , A61M25/0068 , A61M25/0069 , A61M25/0071 , A61M25/1002 , A61M2025/0006 , A61M2025/0081 , A61M2025/1059 , A61M2025/1079 , A61M2025/1093
摘要： A catheter for dilating stenotic lesions has an elongated body with at least one lumen extending therethrough. A tip, constructed of materials softer than the elongated body is attached to the distal end of the body. The tip segment has at least one lumen passing therethrough which is in alignment with the lumen in the elongated body. A guide is adapted to pass through the aligned lumens. A balloon is connected to the distal segment of the elongated body over its outer periphery, thereby creating a balloon cavity therebetween. At least one additional lumen is provided in the elongated body in flow communication with the balloon cavity, for selective inflation and deflation thereof, with a contrast fluid.
摘要翻译：用于扩张狭窄病变的导管具有细长体，其具有延伸穿过其中的至少一个腔。由比细长体更柔软的材料构成的尖端附接到身体的远端。尖端段具有通过其中的至少一个腔，其与细长体中的内腔对准。引导件适于穿过对准的内腔。气球在其外周边连接到细长主体的远侧部分，从而在它们之间形成球囊腔。在细长体中提供至少一个另外的腔，其与气囊腔流动连通，用于与对比液一起选择性地充气和放气。

3. 发明申请

WO1997025093A1 FLUTED BALLOON CATHETER 审中-公开
标题翻译：流体气球导管
公开(公告)号：WO1997025093A1
公开(公告)日：1997-07-17
申请号：PCT/US1996020302
申请日：1996-12-20
申请人： LEOCOR, INC.
发明人： LEOCOR, INC. , WIJAY, Bandula
IPC分类号： A61M29/00
CPC分类号： A61M25/1038 , A61M25/10 , A61M25/1002 , A61M2025/1004
摘要： The present invention provides a catheter (10) with at least one lumen (22) therethrough, and a balloon (16) sealingly engaged in fluid communication with the lumen (22). The balloon (16) has a predetermined folding pattern with at least three collapsible grooves or depressions (20). Upon deflation, the grooves or depressions (20) automatically collapse inward, resulting in a folded configuration which can be twisted into a very low profile configuration. The catheter body (10) preferably is made of polyether ether ketone ("PEEK"), and the fluted balloon (16) preferably is made of polyvinylidine fluoride ("PVDF") and polyurethane.
摘要翻译：本发明提供了一种具有穿过其中的至少一个内腔（22）的导管（10），以及密封地与腔（22）流体连通的气囊（16）。气球（16）具有至少三个可折叠凹槽或凹陷（20）的预定折叠图案。在收缩时，凹槽或凹陷（20）自动地向内折叠，导致可以扭曲成非常低轮廓构型的折叠构造。导管体（10）优选由聚醚醚酮（“PEEK”）制成，并且槽纹球囊（16）优选由聚偏二氟乙烯（“PVDF”）和聚氨酯制成。

4. 发明申请

WO1992020398A1 PERFUSION CATHETER 审中-公开
标题翻译：灌注导管
公开(公告)号：WO1992020398A1
公开(公告)日：1992-11-26
申请号：PCT/US1991003638
申请日：1991-05-23
申请人： LEOCOR, INC.
发明人： LEOCOR, INC. , WIJAY, Bandula , ANGELINI, Paolo
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61M25/1011 , A61M2025/1052 , A61M2025/1097
摘要： A low-profile angioplasty catheter (14) is disclosed which is insertable through a guiding catheter (13). The angioplasty catheter has two balloons. The distal balloon (17) dilates the stenosis. The proximal balloon (16) is separately inflatable and selectively closes the annular passage (30) between the angioplasty catheter and the guiding catheter. The angioplasty catheter has a central lumen with a series of openings allowing fluid communication from the central lumen into the annular passage proximally of the balloon which seals the annular passage. While the first balloon (17) is inflated to dilate the stenosis, blood can be withdrawn from an arterial source through a lumen (11, 12) (or plurality thereof) in the guiding catheter and pumped into the annular passage (30) between the angioplasty catheter and the guiding catheter. The blood then passes through the openings (15) proximal to the proximal balloon (16) into the central lumen of the PTCA catheter and flows beyond the distal tip (18) of the angioplasty catheter to maintain circulation of the patient's blood at a point distal of the stenosis.
摘要翻译：公开了一种可以通过引导导管（13）插入的低剖面血管成形术导管（14）。血管成形术导管具有两个气囊。远端球囊（17）扩张狭窄。近端气囊（16）可分开充气并选择性地封闭血管成形术导管和引导导管之间的环形通道（30）。血管成形术导管具有中央腔，其具有一系列开口，允许从中心腔流体连通到密封环形通道的球囊的近侧的环形通道。当第一气球（17）被膨胀以扩张狭窄时，血液可以从动脉源通过引导导管中的内腔（11,12）（或多个）被抽出并被泵送到环形通道（30）之间血管成形术导管和引导导管。然后，血液通过靠近近端球囊（16）的开口（15）进入PTCA导管的中心腔，并流过血管成形术导管的远端（18），以保持患者血液在远端的狭窄。

5. 发明申请

WO1998020929A1 BALLOON CATHETER WITH MULTIPLE DISTENSIBILITIES 审中-公开
标题翻译：具有多种不同性质的气球导管
公开(公告)号：WO1998020929A1
公开(公告)日：1998-05-22
申请号：PCT/US1997020629
申请日：1997-11-13
申请人： LEOCOR, INC.
发明人： LEOCOR, INC. , WIJAY, Bandula
IPC分类号： A61M29/02
CPC分类号： A61M25/1029 , A61L29/049 , A61M25/10 , A61M2025/1059 , B29C55/26 , B29L2031/7542 , C08L67/02
摘要： A balloon on a balloon catheter has two different rates of distensibility. It can be used to perform angioplasty by taking advantage of its high strength and relatively low distensibility up to a predetermined range of inflation pressures and still be used to set a stent by operating within a pressure range where there is a higher distensibility. The balloon can be a single material that is biaxially oriented less than fully, or a blend of materials similarly oriented. Strands of a more crystalline material may run longitudinally through a matrix of a less crystalline material, with the resulting balloon, when not fully biaxially oriented, exhibiting high burst strength and two different rates of distension at different applied inflation pressures.
摘要翻译：球囊导管上的气球具有两种不同的扩张率。它可用于通过利用其高强度和相对较低的扩张性到达预定的充气压力范围来进行血管成形术，并且仍然用于通过在具有较高扩张性的压力范围内操作来设置支架。气囊可以是双轴取向小于完全的单一材料，或者材料的混合物类似地定向。更结晶的材料的束可以纵向延伸通过较不结晶的材料的基体，当不完全双轴取向时，所得到的球囊在不同的施加的充气压力下表现出高的爆裂强度和两种不同的膨胀速率。

6. 发明申请

WO1991008014A1 LOW PROFILE CATHETER 审中-公开
标题翻译：低剖面导管
公开(公告)号：WO1991008014A1
公开(公告)日：1991-06-13
申请号：PCT/US1990006775
申请日：1990-11-19
申请人： LEOCOR, INC.
发明人： LEOCOR, INC. , WIJAY, Bandula , ANGELINI, Paolo
IPC分类号： A61M29/02
CPC分类号： A61M25/104 , A61M25/0054 , A61M2025/0006
摘要： An angioplasty catheter comprising an inner (10) and outer (12) tubular members, each having a proximal and distal segment. The distal segment (20) of the outer body member (12) is softer than the proximal segment (18) of the outer body member (12). Similarly, the distal segment (16) of the inner body member (10) is softer than the proximal segment (14) of the inner body member (10). The proximal segment of the inner body member is harder than the proximal segment of the outer body member. The distal segment (20) of the outer body member (12) is softer than the distal segment (16) of the inner body member (10). A balloon (26) spans the distal segments (16, 20) of the inner and outer body members, effectively closing off an annulus created between the nested inner and outer body members. The combination of hardnesses provides for sufficient body strength to allow pushability, combined with sufficient distal softness to avoid trauma to the arterial walls during insertion.
摘要翻译：一种血管成形术导管，包括内部（10）和外部（12）管状构件，每个管状构件具有近端和远端段。外主体构件（12）的远侧段（20）比外体构件（12）的近端段（18）更软。类似地，内主体构件（10）的远端段（16）比内体构件（10）的近端段（14）更软。内部本体构件的近端段比外部本体构件的近端段更硬。外主体构件（12）的远端段（20）比内体构件（10）的远端段（16）更软。气球（26）跨越内部和外部本体构件的远端段（16,20），有效地封闭在嵌套的内部和外部主体构件之间产生的环。硬度的组合提供足够的身体强度以允许推动性，结合足够的远端柔软度以避免在插入期间对动脉壁的创伤。

7. 发明申请

WO1997029720A1 STENT DELIVERY SYSTEM 审中-公开
标题翻译： STENT交付系统
公开(公告)号：WO1997029720A1
公开(公告)日：1997-08-21
申请号：PCT/US1997002634
申请日：1997-02-20
申请人： LEOCOR, INC.
发明人： LEOCOR, INC. , WIJAY, Bandula
IPC分类号： A61F11/00
CPC分类号： A61F2/95
摘要： A stent delivery apparatus is disclosed comprising a movable inner tube (19) and a fixed outer tube (6) having corrugations or undulations (24) at its distal end. The undulations or corrugations (24) are stretched by movement of the inner tube (19), whereupon the stent (2) is placed over the relatively flattened undulations or corrugations (24). A solid structure or an open structure such as a coil can be used for this purpose. One large proximal undulation (24) is provided for preventing the stent (12) from sliding from the pre-determined location during the setting. Upon relative movement between the inner and outer tubes (19, 6) which can be a single longitudinal or twisting movement or a combination of such movements, the undulations (24) under the stent (2) are outwardly relaxed, forcing the stent (2) to expand toward the vascular wall. The relative movement is then reversed to retract the undulations (24) and the delivery device withdrawn. In an alternative embodiment, the undulations (24) are perforated to allow perfusion under and through the stent (2) from point external to the patient's body to a point distal of the placement of the stent (2) during the procedure of stent (2) expansion.
摘要翻译：公开了一种支架输送装置，其包括在其远端具有波纹或起伏（24）的可移动内管（19）和固定外管（6）。起伏或波纹（24）通过内管（19）的移动被拉伸，于是支架（2）放置在相对扁平的起伏或波纹（24）上。为了这个目的，可以使用固体结构或诸如线圈的开放结构。提供一个大的近端起伏（24），用于防止支架（12）在设定期间从预定位置滑动。在内管和外管（19,6）之间的相对运动可以是单个纵向或扭转运动或这种运动的组合，支架（2）下面的起伏（24）向外松弛，迫使支架（2 ）向血管壁扩张。然后反转相对运动以收缩起伏（24）并将递送装置取出。在替代实施例中，波纹（24）是穿孔的，以允许在支架（2）的过程内从支架外部的位置到穿过支架（2）的位置并穿过支架（2），在支架（2））扩张。

8. 发明申请

WO1989008471A1 LOW-PROFILE ANGIOPLASTY BALLOON CATHETER WITH GUIDEWIRE 审中-公开
标题翻译：带轮廓的低剖面阴茎血管导管
公开(公告)号：WO1989008471A1
公开(公告)日：1989-09-21
申请号：PCT/US1989000725
申请日：1989-02-28
申请人： LEOCOR, INC. , WIJAY, Bandula , ANGELINI, Paolo
发明人： LEOCOR, INC.
IPC分类号： A61M25/00
CPC分类号： A61M25/104 , A61L29/06 , A61M2025/0004 , C08L79/08
摘要： A very low-profile balloon catheter (12) is disclosed that allows for an independently movable, steerable and removable guidewire (26). After removal of the guidewire, the balloon catheter retains adequately angiographic and hemodynamic characteristics. Such catheter construction allows for exchange of guidewires. A tracking mechanical device is included and provides excellent and easy advancement of the balloon catheter through severe obstructions.

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