专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2015128334A9 3H-THIENO[3,4]PYRIMIDIN-4-ONEAND PYRROLOPYRIMID-4-ONE AS GRAM-POSITIVE ANTIBACTERIAL AGENTS 审中-公开
标题翻译： 3H-THIENO [3,4]嘧啶-4-酮和吡咯并吡啶-4-酮作为正性抗菌剂
公开(公告)号：WO2015128334A9
公开(公告)日：2015-09-03
申请号：PCT/EP2015/053858
申请日：2015-02-24
申请人： LABORATOIRE BIODIM
发明人： ATAMANYUK, Dmytro , CHEVREUIL, Francis , FAIVRE, Fabien , GERUSZ, Vincent , GOLD, Johan , MOREAU, François , SIMON, Christophe
IPC分类号： C07D487/04 , C07D495/04 , A61K31/53 , A61K31/519 , A61P31/04
摘要： The invention relates to novel heteroaromatic derivatives of formula (I) and their addition salts thereof with acids and bases; their preparation, their use as drugs and pharmaceutical compositions and associations containing them. wherein A, B, T, V, X and Y represent organic substituents as defined herein, The compounds of formula (I) are able to inhibit the activity of the Gram-positive bacterial DltA enzyme and they are used to prevent and/or treat Gram-positive bacterial infections in humans or animals, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity,
摘要翻译：本发明涉及式（I）的新型杂芳族衍生物及其与酸和碱的加成盐; 它们的制备，它们作为药物和药物组合物的用途以及包含它们的组合。其中A，B，T，V，X和Y表示如本文所定义的有机取代基。式（I）的化合物能够抑制革兰氏阳性细菌DltA酶的活性，并且它们用于预防和/或治疗单独或与抗细菌剂，抗微生物剂或增强宿主先天免疫力的药物相关的人或动物中的革兰氏阳性细菌感染

2. 发明申请

WO2015001128A1 METHOD OF PRODUCING AN INACTIVATED LENTIVIRUS, ESPECIALLY HIV, VACCINE, KIT AND METHOD OF USE 审中-公开
标题翻译：产生灭活性淋巴细胞的方法，特别是HIV，疫苗，药盒和使用方法
公开(公告)号：WO2015001128A1
公开(公告)日：2015-01-08
申请号：PCT/EP2014/064476
申请日：2014-07-07
申请人： LABORATOIRE BIODIM
发明人： BENAROUS, Richard , LE ROUZIC, Erwann , BRUNEAU, Jean-Michel , BONNARD, Damien , MOREAU, François
IPC分类号： A61K39/12
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5252 , C12N7/00 , C12N2740/16034 , C12N2740/16061 , C12N2740/16063
摘要： A novel method for producing an immunogenic composition or vaccine comprising inactivated lentivirus, in particular inactivated HIV, wherein producer cells producing, preferably constituvely producing lentivirus particles are provided, the lentivirus particles are produced by these producer cells in the presence of an antiretroviral (ARV) agent which is an inhibitor of the IN-LEDGF/p75 interaction, the inactivated lentivirus is recovered and formulated in a pharmaceutically acceptable vehicle or carrier. The invention also relates to immunogenic compositions or vaccines and to methods for the therapeutic or prophylactic treatment of a mammal, especially a human, and various therapy combinations involving the administration of said immunogenic compositions or vaccines.
摘要翻译：一种用于产生免疫原性组合物或疫苗的新方法，其包含灭活的慢病毒，特别是灭活的HIV，其中提供产生优选选择性产生的慢病毒颗粒的生产细胞，所述慢病毒颗粒在抗逆转录病毒（ARV）存在下由这些生产细胞产生，作为IN-LEDGF / p75相互作用的抑制剂的药剂，将灭活的慢病毒回收并配制在药学上可接受的载体或载体中。本发明还涉及免疫原性组合物或疫苗以及治疗或预防性治疗哺乳动物，特别是人的方法，以及涉及施用所述免疫原性组合物或疫苗的各种治疗组合。

3. 发明申请

WO2014067904A1 NEW ANTIBACTERIAL COMPOUNDS AND BIOLOGICAL APPLICATIONS THEREOF 审中-公开
标题翻译：新抗菌化合物及其生物应用
公开(公告)号：WO2014067904A1
公开(公告)日：2014-05-08
申请号：PCT/EP2013/072526
申请日：2013-10-28
申请人： LABORATOIRE BIODIM
发明人： ATAMANYUK, Dmytro , GERUSZ, Vincent , MOREAU, François , HENRYON, Vivien , MONBRUN, Jérôme , AIRIAU, Etienne
IPC分类号： C07F9/09 , A61K31/661 , A61P31/04
CPC分类号： C07F9/09 , A61K31/661 , A61K45/06 , C07F9/091 , C07F9/38 , Y02A50/473 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： The invention relates to compounds of formulae (Ia), (Ib) or (Ic) wherein, - A 1 and A 2 , identical or different, are H, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) fluoroalkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, (C 1 -C 6 ) alkyl-OR a , (C 1 -C 6 ) alkyl-SR a , (C 1 -C 6 ) alkyl-NR a R b , OR a , SR a , NR a R b , or COR a ; - A 3 is H, OH or form a carbonyl with A 4 ; - A 4 is H, OH or form a carbonyl with A 3 ; - A 5 is H, CR a R b OH, F, OH or forms a double bond with X in the case where X is CH; - A 6 is H or F; - X is CH 2 , CHF, CF 2 , CHOH, O, S, NR a or a simple bond, or X is CH in the case where A 5 forms with X a double bond; - Y is P(O) (OR a ) (OR b ) or P (O) (OR a ) (NR a R b ); - V is O or S; - A 7 is H, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) fluoroalkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl or (C 1 -C 6 ) alkyl-OR a ; - A 8 is OH or H, - R a and R b , identical or different, are H, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) fluoroalkyl, (C 1 -C 6 ) alkyl-OH or (C 1 -C 6 ) alkyl-O- (C 1 - C 6 ) alkyl; and their addition salts thereof with acids and bases, their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity.
摘要翻译：本发明涉及式（Ia），（Ib）或（Ic）化合物，其中-A1和A2相同或不同，为H，（C1-C6）烷基，（C1-C6）氟烷基，（C2-C6 ），（C 1 -C 6）烷基-OR a，（C 1 -C 6）烷基-SRa，（C 1 -C 6）烷基-NR a R b，OR a，SR a，NR a R b或COR 3; - A3是H，OH或与A4形成羰基; - A4是H，OH或与A3形成羰基; 在X为CH的情况下，A5为H，CRaRbOH，F，OH或与X形成双键; - A6是H或F; - X为CH 2，CHF，CF 2，CHOH，O，S，NR a或简单键，或者X为CH时，X为双键; - Y是P（O）（OR a）（OR b）或P（O）（OR a）（NR a R b）; - V是O或S; A7为H，（C1-C6）烷基，（C1-C6）氟代烷基，（C2-C6）烯基，（C2-C6）炔基或（C1-C6）烷基-ORa; - A8是OH或H，-Ra和Rb相同或不同，是H，（C1-C6）烷基，（C1-C6）氟代烷基，（C1-C6）烷基-OH或（C1-C6）烷基-O - （C 1 -C 6）烷基; 以及它们与酸和碱的加成盐，它们的制备及其在抗菌预防和治疗中的用途，其单独使用或与抗菌素，抗毒性药物或增强宿主先天免疫力的药物联合使用。

4. 发明申请

WO2015128334A1 3H-THIENO[3,4]PYRIMIDIN-4-ONEAND PYRROLOPYRIMID-4-ONE AS GRAM-POSITIVE ANTIBACTERIAL AGENTS 审中-公开
公开(公告)号：WO2015128334A1
公开(公告)日：2015-09-03
申请号：PCT/EP2015/053858
申请日：2015-02-24
申请人： LABORATOIRE BIODIM
发明人： ATAMANYUK, Dmytro , CHEVREUIL, Francis , FAIVRE, Fabien , GERUSZ, Vincent , GOLD, Johan , MOREAU, François , SIMON, Christophe
IPC分类号： C07D487/04 , C07D495/04 , A61K31/53 , A61K31/519 , A61P31/04
CPC分类号： C07D495/04 , C07D487/04
摘要： The invention relates to novel heteroaromatic derivatives of formula (I) and their addition salts thereof with acids and bases; their preparation, their use as drugs and pharmaceutical compositions and associations containing them. wherein A, B, T, V, X and Y represent organic substituents as defined herein, The compounds of formula (I) are able to inhibit the activity of the Gram-positive bacterial DltA enzyme and they are used to prevent and/or treat Gram-positive bacterial infections in humans or animals, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity,

5. 发明申请

WO2012172043A1 PURINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS FOR PREVENTION OR TREATMENT OF BACTERIAL INFECTIONS 审中-公开
标题翻译：嘌呤衍生物及其作为预防或治疗细菌感染的药物
公开(公告)号：WO2012172043A1
公开(公告)日：2012-12-20
申请号：PCT/EP2012/061428
申请日：2012-06-15
申请人： LABORATOIRE BIODIM , ATAMANYUK, Dmytro , DENIS, Alexis , GERUSZ, Vincent , LEDOUSSAL, Benoît , BONVIN, Yannick , DESROY, Nicolas , GOLD, Johan , MOREAU, François , OXOBY, Mayalen
发明人： ATAMANYUK, Dmytro , DENIS, Alexis , GERUSZ, Vincent , LEDOUSSAL, Benoît , BONVIN, Yannick , DESROY, Nicolas , GOLD, Johan , MOREAU, François , OXOBY, Mayalen
IPC分类号： C07D473/32 , A61K31/52 , A61P31/04
CPC分类号： C07D473/32
摘要： The invention relates to the compounds of general formula (I) and their addition salts thereof with acids and bases: wherein A is phenyl, naphthyl and 5-10 membered monocyclic or bicyclic unsaturated heterocycle, optionally substituted by a group R1 which is as defined in the application and is itself optionally substitutes by a group R2 which is as defined in the application and is itself optionally substituted by a group R3 which is defined in the application, Y and W, identical or different, are H, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, phenyl or 4-10 monocyclic or bicyclic saturated or unsaturated heterocycle, optionally substituted by R1, or Y and/or W form a 4-10 membered cycle with R1, or Y and W form with N a saturated or unsaturated nitrogenous 4-10 membered mono, bi or tricyclic system, fused, bridged or spiro system, said system being optionally substituted by R1, said system being different from morpholine, with the proviso that when Y and A are phenyl or heterocycle, W is not H, a process and intermediates for their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them.
摘要翻译：本发明涉及通式（I）的化合物及其与酸和碱的加成盐：其中A是苯基，萘基和5-10元单环或双环不饱和杂环，任选地被如下定义的基团R 1所取代：本申请本身可以任选地被如申请中定义的基团R2取代，并且本身任选被在应用中定义的基团R 3取代，Y和W相同或不同，为H，（C 1 -C 6）烷基，（C 2 -C 6）烯基，（C 2 -C 6）炔基，苯基或4-10单环或双环饱和或不饱和杂环，任选被R 1取代，或Y和/或W与R 1形成4-10元环，或Y和W与N形成饱和或不饱和的含氮4-10元单，双或三环系统，稠合，桥连或螺环系统，所述系统任选被R 1取代，所述系统不同于吗啉，条件是当 Y和A是苯基或杂环 W不是H，它们的制备方法和中间体以及它们在抗菌预防和治疗中的用途，其单独使用或与抗菌剂，抗毒素剂或增强宿主先天免疫力的药物联合使用，以及含有它们的药物组合物和组合物。

6. 发明申请

WO2012073214A4 HEPTOSE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS 审中-公开
公开(公告)号：WO2012073214A4
公开(公告)日：2012-06-07
申请号：PCT/IB2011/055404
申请日：2011-12-01
申请人： LABORATOIRE BIODIM , GERUSZ, Vincent , VINCENT, Stéphane , OXOBY, Mayalen , ATAMANYUK, Dmytro , MOREAU, François , ANDALOUSSI, Mounir , TIKAD, Abdellatif
发明人： GERUSZ, Vincent , VINCENT, Stéphane , OXOBY, Mayalen , ATAMANYUK, Dmytro , MOREAU, François , ANDALOUSSI, Mounir , TIKAD, Abdellatif
IPC分类号： C07H3/02 , C07H11/04 , C07H15/04 , C07D309/10 , A61K31/351 , A61K31/7004 , A61K31/7024 , A61K31/7028 , A61P31/04
摘要： Compounds having the general formula (I) pharmaceutical compositions containing them for use in inhibiting bacterial heptose biosynthesis and thereby lowering or suppressing bacterial virulence.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式