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1. 发明申请

WO2022096718A1 CONSTANT PRESSURE FUEL ENHANCEMENT SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2022096718A1
公开(公告)日：2022-05-12
申请号：PCT/EP2021/080958
申请日：2021-11-08
申请人： EXEN HOLDINGS, LLC , MCCARTHY, Denis Alexis
发明人： LUND, Morten Andre
IPC分类号： F02D19/08 , F02M37/00
摘要： A fuel enhancement method and system for supplying the engine with a pressurized fuel mixture comprising a mixture of the liquid fuel and the gaseous component including provisions to maintain the ratio of gas to liquid in the mixture at a predetermined value and maintain the pressure of the fuel mixture applied to the engine at a predetermined value. A system using variable speed drive pumps is disclosed.

2. 发明申请

WO2011026529A1 NOVEL ANTIBACTERIAL HYDROXYPHENYL COMPOUND 审中-公开
标题翻译：新型抗菌羟基化合物
公开(公告)号：WO2011026529A1
公开(公告)日：2011-03-10
申请号：PCT/EP2009/064973
申请日：2009-11-11
申请人： FAB PHARMA SAS , GERUSZ, Vincent , FAIVRE, Fabien , OXOBY, Mayalen , DENIS, Alexis , BONVIN, Yannick
发明人： GERUSZ, Vincent , FAIVRE, Fabien , OXOBY, Mayalen , DENIS, Alexis , BONVIN, Yannick
IPC分类号： C07C235/44 , C07C255/54 , A61P31/04 , A61K31/166
CPC分类号： C07C235/46 , C07C255/54
摘要： The invention relates to a novel hydroxyphenyl compound, to the preparation of the compound and intermediates used therein, to the use of the compound as an antibacterial medicament and pharmaceutical compositions containing the compound.
摘要翻译：本发明涉及一种新的羟基苯基化合物，用于制备化合物及其中使用的中间体，该化合物用作抗细菌药物和含有该化合物的药物组合物。

3. 发明申请

WO2009112703A1 2-AMINO-2-PHENYLALKANOL DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译： 2-氨基-2-苯基卡诺醇衍生物及其制备方法和含有该组合物的药物组合物
公开(公告)号：WO2009112703A1
公开(公告)日：2009-09-17
申请号：PCT/FR2009000106
申请日：2009-01-30
申请人： OROXCELL , DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24 , C07C219/22
CPC分类号： C07C271/16 , A61K9/2054 , C07C219/22 , C07C271/22 , C07C271/48 , C07C333/04 , C07D213/80 , C07D213/82 , C07D317/40
摘要： Esters derived from 2-amino-2-phenylalkanol of general formula (I) in which: R1 is H, straight or branched C1 to C4 alkyl, straight or branched C2 to C4 alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, R2 is a -CO-R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or else R2 is a -CO-Y-R4 radical for which Y is -O-, -S-, -NH-, or -Nalk- for which alk is straight or branched (C1 to C4) alkyl, and R4 is alkyl, aryl, aralkyl or heterocyclylalkyl, which may be substituted by one or more halogen atoms or OH radicals, straight or branched (C1 to C4) alkyl radicals, or straight or branched (C1 to C4) alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino radicals, or oxo radicals, or which may be substituted by R5COO- in which R5 is an alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by the residue of an amino acid, or represents a heterocycle, or else R2 is a (C2 to C4) alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5-or 6-membered heterocycle optionally bearing another heteroatom (O or N), or substituted by alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, it being understood that said straight or branched substituted alkyl radical comprises at least C2 between >N-R2 and the substituent; and R3 is a straight or branched (C1 to C4) alkyl unless specifically mentioned, alkyl or acyl are straight or branched (C1 to C7), in their R or S forms or mixtures thereof, and also the pharmaceutically acceptable salts thereof when they exist.
摘要翻译：衍生自通式（I）的2-氨基-2-苯基烷醇的酯，其中：R 1是H，直链或支链C 1 -C 4烷基，被OH取代的直链或支链C 2 -C 4烷基，烷氧基，烷硫基，酰氧基，NH 2，烷基氨基，二烷基氨基，烷基氨基甲酰氧基，烷氧基羰基氨基，脲基或烷基脲基，R 2为其中R为H，烷基，芳基，杂环基，苄基或杂环基甲基或其中R 2为-CO-Y- Y是-O - ， - S - ， - NH-或-Nalk-，其中alk是直链或支链（C1-C4）烷基，R4是烷基，芳基，芳烷基或杂环基烷基，（C 1 -C 4）烷基或直链或支链（C 1 -C 4）烷氧基，烷硫基，酰氨基烷硫基，烷氧羰基或酰氨基，或氧代基，或可被R 5 COO- 其中R5是任选被苄氧羰基氨基，酰氨基或氨基酸残基取代的烷基，或者代表a 杂环，或者R 2是被OH，烷氧基，烷硫基，酰氧基，NH 2，烷基氨基，二烷基氨基取代的（C 2 -C 4）烷基，其任选地与它们所连接的氮原子一起形成5-或6-元杂环带有另一个杂原子（O或N），或被烷基氨基甲酰氧基，烷氧基羰基氨基，脲基或烷基脲基取代，应理解为所述直链或支链取代的烷基包含> N-R2与取代基之间的至少C2; 除非特别提及，R 3是直链或支链（C 1 -C 4）烷基，烷基或酰基是直链或支链（C 1 -C 7），它们的R或S形式或其混合物，以及它们存在时的药学上可接受的盐。

4. 发明申请

WO2008117225A3 NEW IMIDAZOLO-HETEROARYL DERIVATIVES WITH ANTIBACTERIAL PROPERTIES 审中-公开
标题翻译：具有抗菌性质的新型咪唑啉衍生物
公开(公告)号：WO2008117225A3
公开(公告)日：2008-11-20
申请号：PCT/IB2008051080
申请日：2008-03-21
申请人： MUTABILIS SA , ESCAICH SONIA , DENIS ALEXIS , GERUSZ VINCENT , MOREAU FRANCOIS , OXOBY MAYALEN
发明人： ESCAICH SONIA , DENIS ALEXIS , GERUSZ VINCENT , MOREAU FRANCOIS , OXOBY MAYALEN
IPC分类号： C07D471/04 , A61K31/437 , A61K31/5025 , A61P31/04 , C07D487/04 , G01N33/15
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to Imidazolo-heteroaryl derivatives of formula (I). The compounds inhibit the activity of the Dlta enzyme of Gram-positive bacteria and are useful to treat Gram-positive bacterial infections. Furthermore the application discloses method for assessing the Dlta inhibitory activity of tested molecules and a method for measuring the efficacy of molecules in inhibiting bacteria proliferation in vitro.
摘要翻译：本发明涉及式（I）的咪唑并 - 杂芳基衍生物。这些化合物抑制革兰氏阳性菌的Dlta酶的活性，可用于治疗革兰氏阳性细菌感染。此外，本申请公开了用于评估测试分子的Dlta抑制活性的方法和用于测量分子在体外抑制细菌增殖的功效的方法。

5. 发明申请

WO2005108384A1 3- OR 4-MONOSUBSTITUTED PHENOL AND THIOPHENOL DERIVATIVES USEFUL AS H3 LIGANDS 审中-公开
标题翻译： 3-或4-单取代苯酚和噻吩酚衍生物有效用作H3配体
公开(公告)号：WO2005108384A1
公开(公告)日：2005-11-17
申请号：PCT/IB2005/001114
申请日：2005-04-19
申请人： WARNER-LAMBERT COMPANY LLC , BERNARDELLI, Patrick , CRONIN, Andrew, Michael , DENIS, Alexis , DENTON, Stephen, Martin , JACOBELLI, Henry , KEMP, Mark, Ian , LORTHIOIS, Edwige , ROUSSEAU, Fiona , SERRADEIL-CIVIT, Delphine , VERGNE, Fabrice
发明人： BERNARDELLI, Patrick , CRONIN, Andrew, Michael , DENIS, Alexis , DENTON, Stephen, Martin , JACOBELLI, Henry , KEMP, Mark, Ian , LORTHIOIS, Edwige , ROUSSEAU, Fiona , SERRADEIL-CIVIT, Delphine , VERGNE, Fabrice
IPC分类号： C07D309/06
CPC分类号： C07D309/06 , C07D207/08 , C07D207/12 , C07D213/82 , C07D295/088 , C07D295/12 , C07D295/135 , C07D295/155 , C07D295/26 , C07D309/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The invention relates to 3- or 4-monosubstituted phenol and thiophenol derivatives of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol and thiophenol derivatives are H 3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及式（1）的3-或4-单取代的苯酚和苯硫酚衍生物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。所述3-或4-单取代的苯酚和苯硫酚衍生物是H3配体，可用于许多疾病，病症和病症，特别是炎性，过敏性和呼吸道疾病，病症和病症。

6. 发明申请

WO2003098353A1 MONOCOMPONENT DEVELOPER FOR ELECTROPHOTOGRAPHY 审中-公开
标题翻译：电摄影单声道开发商
公开(公告)号：WO2003098353A1
公开(公告)日：2003-11-27
申请号：PCT/IE2003/000075
申请日：2003-05-14
申请人： AETAS TECHNOLOGY INCORPORATED , McCARTHY, Denis Alexis , SCHEIN, Laurence B.
发明人： SCHEIN, Laurence B.
IPC分类号： G03G9/097
CPC分类号： G03G13/08 , G03G9/097 , G03G9/09708
摘要： A jump monocomponent development arragement includes a dielectric photoreceptor belt having an image-bearing surface for receiving an electrostatic charge image and a development station having a supply of toner particles (46) with a mean diameter in a range from 8 microns to 14 and including large and small additive particles (70) and small additive particles (68) having mean diameters in size ranges of 6 to 12 nm and 20 to 50 nm, respectively, and in amounts sufficient to provide surface coverage of the toner particles (46) in ranges from about 5 percent to about 50 percent and about 50 percent to about 150 percent, respectively.
摘要翻译：跳跃单组分显影装置包括具有用于接收静电荷图像的图像承载表面的介电感光体带和具有平均直径在8微米至14度的调色剂颗粒（46）的供应的显影台，并且包括大的和分别具有6至12nm和20至50nm尺寸范围的平均直径的小添加剂颗粒（70）和小添加剂颗粒（68），并且其量足以提供调色剂颗粒（46）的表面覆盖范围分别为约5％至约50％和约50％至约150％。

7. 发明申请

WO2003024809A1 METHOD AND DEVICE FOR BONDING TWO WEBS 审中-公开
标题翻译：用于绑定两个WEBS的方法和装置
公开(公告)号：WO2003024809A1
公开(公告)日：2003-03-27
申请号：PCT/IE2002/000132
申请日：2002-09-10
申请人： AETAS TECHNOLOGY, INCORPORATED , MCCARTHY, Denis, Alexis , MCKIM, James, E.
发明人： MCKIM, James, E.
IPC分类号： B65C9/18
CPC分类号： B65C9/1819 , B65C1/025 , B65C9/44 , B65H37/002 , B65H39/16 , B65H2701/124
摘要： The present invention is an automated arrangement for applying strip material to a web belt. One purpose of the present invention is to provide a solution to the known problem of securing material to an organic photoconductor ("OPC") belt material in an automated manufacturing environment. Usually, material is applied to an OPC belt by hand. Hand application of strip material is time-consuming, costly, and prone to inaccurate placement on the OPC belt. The extra time taken to apply the strip material by hand increase the OPC belt's exposure to light, which can damage the OPC material. Furthermore, pulling the strip by hand can deform the strip because of excessive force used to pull the strip before application. Thus using an automated, controlled process to apply material minimizes damage to the belt and strip, resulting in higher yield of belts and strips per spool.
摘要翻译：本发明是一种将条带材料施加到幅带上的自动布置。本发明的一个目的是提供在自动化制造环境中将材料固定到有机光电导体（“OPC”）带材料的已知问题的解决方案。通常用手将材料施加到OPC带上。带材的手工施加是耗时，昂贵的，并且易于在OPC带上放置不准确。手工涂抹条带材所需的额外时间增加了OPC带的光照，可能会损坏OPC材料。此外，用手拉动带子可能使带材变形，因为在施加之前用于拉伸带材的过大的力。因此，使用自动控制的方法来施加材料可以最大限度地减少对带和带的损伤，从而导致每个卷轴带和带的产量更高。

8. 发明申请

WO1998003530A1 NOVEL ERYTHROMYCIN DERIVATIVES, METHOD FOR PREPARING SAME AND USE THEREOF AS DRUGS 审中-公开
标题翻译：新型红霉素衍生物，其制备方法和作为药物使用的方法
公开(公告)号：WO1998003530A1
公开(公告)日：1998-01-29
申请号：PCT/FR1997001372
申请日：1997-07-23
申请人： ROUSSEL UCLAF , AGOURIDAS, Constantin , CHANTOT, Jean-François , DENIS, Alexis , PEJAC, Jean-Marie
发明人： ROUSSEL UCLAF
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： Compounds of formula (I), wherein R is hydrogen, alkyl optionally substituted by halogen or a (CH2)mAr radical or a radical (a), where m is an integer from 1 to 8, each of n and p, which are the same or different, is an integer from 0 to 6, each of A and B, which are the same or different, is hydrogen or halogen or alkyl, and Ar is aryl or heteroaryl, and Z is hydrogen or a carboxylic acid residue; a method for preparing same, and the use of said compounds as drugs, are disclosed.
摘要翻译：式（I）的化合物，其中R是氢，任选地被卤素或（CH 2）mAr基团或基团（a）取代的烷基，其中m是1至8的整数，n和p各自是相同或不同，为0至6的整数，A和B各自相同或不同，为氢或卤素或烷基，Ar为芳基或杂芳基，Z为氢或羧酸残基; 公开了其制备方法和所述化合物作为药物的用途。

9. 发明申请

WO2008038136A2 NEW CHEMICAL INHIBITORS OF BACTERIAL HEPTOSE SYNTHESIS, METHODS FOR THEIR PREPARATION AND BIOLOGICAL APPLICATIONS OF SAID INHIBITORS 审中-公开
标题翻译：细菌肝素合成新化学抑制剂，其抑制剂的制备和生物应用方法
公开(公告)号：WO2008038136A2
公开(公告)日：2008-04-03
申请号：PCT/IB2007/003276
申请日：2007-09-25
申请人： MUTABILIS SA , ESCAICH, Sonia , DENIS, Alexis , MOREAU, François , GERUSZ, Vincent , DESROY, Nicolas
发明人： ESCAICH, Sonia , DENIS, Alexis , MOREAU, François , GERUSZ, Vincent , DESROY, Nicolas
CPC分类号： C07D417/14 , C07D401/12 , C07D405/12 , C07D417/12
摘要： The invention relates to new compounds having heptose synthesis inhibitory properties, of formula (I) or a pharmaceutically acceptable salt, or prodrug thereof, wherein A is an aryl or heterocycle, optionally substituted by one or several identical or different R such as H, C1-C10 alkyl, C1-C10 alkyl-OR 1 , C1-C10 alkyl-NR 1 R 1 , alkoxy, hydroxy, thioalkyl, aryl, heterocycle, halogen, nitro, cyano, CO 2 R 1 , NR 1 R 1 , NR 1 C(O)R 1 , C(O)NR 1 R 1 , NR 1 C(S)R 1 , C(S)NR 1 R 1 , SO 2 NR 1 R 1 , SO 2 R 1 , NR 1 SO 2 R 1 , NR 1 C(O)NR 1 R 1 , NR 1 C(O)OR 1 , NR 1 C(S)NR 1 R 1 , NR 1 C(S)OR 1 , R 1 C=NOR 1 , C(O)R 1 , aryloxy, thioaryl, alkenyl, alkynyl R1 identical or different is H or C1-C10 alkyl B 1 , B 2 , B 3 identical or not represent C, N, O, S to form a five-membered aromatic ring wherein from one to three carbon atoms are replaced by a heteroatom selected from S, O, N optionally substituted by one or several identical or different R such as defined above B 4 is C or N Y is H, C1-C10 alkyl, alkoxy, thio-alkyl, optionally substituted by one or several identical or different R such as defined above W is C, O or N, substituted or not by one or several C1-C10 alkyl radicals D is an heterocycle optionally substituted by one or several identical or different R such as defined above.
摘要翻译：本发明涉及具有式（I）的肝素合成抑制性质的新化合物或其药学上可接受的盐或前药，其中A是芳基或杂环，任选被一个或多个相同或不同的R如H，C1 -C 10烷基，C 1 -C 10烷基-OR 1，C 1 -C 10烷基-NR 1 R 1，烷氧基，羟基，硫代烷基，芳基，杂环，卤素，硝基，氰基，CO 2 R 1，NR 1 R 1，NR N， C（O）R 1，C（O）NR 1 R 1，NR 1， C（S）R 1，C（S）NR 1 R 1，SO 2 NR 3， 2个1，1个，1个，1个，2个，1个，1个，1个，1个，1个，3个， NR 1，NR 1，NR 1，NR 1，NR 1， 1个C（O）OR 1，NR 1 C（S）NR 1 R 1，，NR 1 C（S）OR 1，R 1 C = NOR 1，C（O）R 芳氧基，硫代芳基，烯基，炔基R1相同或相同不同的是H或C 1 -C 10烷基B 1，B 2，B 3 3相同或不表示C，N，O，S以形成一个五元芳环，其中一至三个碳原子被选自任选被一个或多个相同或不同的R如上面定义的R 4取代的S，O，N的杂原子取代为C 或NY为H，任选被一个或几个相同或不同的R取代的C 1 -C 10烷基，烷氧基，硫代烷基，W如C，O或N，被一个或多个C 1 -C 10烷基取代或不被 D是任选被一个或多个相同或不同的R取代的杂环，如上所定义。

10. 发明申请

WO2007135562A3 HYDROXYPHENYL DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF 审中-公开
公开(公告)号：WO2007135562A3
公开(公告)日：2007-11-29
申请号：PCT/IB2007/002127
申请日：2007-04-16
申请人： MUTABILIS S.A. , DENIS, Alexis , GERUSZ, Vincent , BONVIN, Yannick
发明人： DENIS, Alexis , GERUSZ, Vincent , BONVIN, Yannick
IPC分类号： C07D213/643 , C07D213/73 , C07D213/74 , C07C69/24 , C07C211/52 , C07D213/75 , C07C43/263 , C07C49/84 , C07C251/38 , C07D401/12 , C07C309/73 , C07C43/295
摘要： The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and /or anti-parasitic agents.

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