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1. 发明申请

WO1996007322A1 METHOD OF SENSITIZING TUMOR CELLS WITH ADENOVIRUS E1A 审中-公开
标题翻译：用ADENOVIRUS E1A致敏肿瘤细胞的方法
公开(公告)号：WO1996007322A1
公开(公告)日：1996-03-14
申请号：PCT/US1995011342
申请日：1995-09-05
申请人： LA JOLLA CANCER RESEARCH FOUNDATION
发明人： LA JOLLA CANCER RESEARCH FOUNDATION , FRISCH, Steven, M.
IPC分类号： A01N43/04
CPC分类号： C07K14/005 , A61K38/00 , A61K41/0038 , C12N2710/10322
摘要： The present invention is directed to methods of sensitizing a human tumor cell with adenovirus E1A. The methods involve treating a human tumor cell by, first, introducing into the tumor cell nucleic acid encoding a polypeptide having adenovirus E1A activity, expressing the E1A active polypeptide in the cell, and then either contacting the E1A expressing tumor cell with a chemotherapeutic agent or irradiating the E1A-expressing tumor cell. The invention also provides methods of enhancing a subject's response to chemotherapy or irradiation by introducing into a subject's tumor cells nucleic acid encoding a polypeptide having adenovirus E1A activity, expressing the E1A active polypeptide in the cells and finally, administering either a chemotherapeutic agent or irradiation. The invention also provides a method of treating cancer.
摘要翻译：本发明涉及用腺病毒E1A敏化人肿瘤细胞的方法。所述方法包括通过首先将编码具有腺病毒E1A活性的多肽的肿瘤细胞核酸引入细胞中表达E1A活性多肽，然后将表达E1A的肿瘤细胞与化学治疗剂接触或照射表达E1A的肿瘤细胞。本发明还提供了通过将受试者的肿瘤细胞核酸编码为具有腺病毒E1A活性的多肽，在细胞中表达E1A活性多肽，最后施用化学治疗剂或照射，来提供受试者对化疗或照射的反应的方法。本发明还提供了一种治疗癌症的方法。

2. 发明申请

WO1994009160A1 METHOD OF INHIBITING REPLICATION OF HYPERPROLIFERATIVE CELLS 审中-公开
标题翻译：抑制高增殖细胞再生的方法
公开(公告)号：WO1994009160A1
公开(公告)日：1994-04-28
申请号：PCT/US1993009774
申请日：1993-10-13
申请人： LA JOLLA CANCER RESEARCH FOUNDATION
发明人： LA JOLLA CANCER RESEARCH FOUNDATION , FRISCH, Steven, M.
IPC分类号： C12Q01/68
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C07K14/82 , C12N2710/10322 , C12N2740/13043
摘要： This invention relates to methods for converting a pathologic hyperproliferative human cell to its non-malignant phenotype. The method comprises introducing into the cell a nucleic acid encoding a polypeptide having adenovirus E1A activity and growing the cellunder conditions such that the polypeptide is produced. This invention also relates to a method of converting a population of pathologic hyperproliferative cells in a subject to a non-hyperproliferative state by expressing, in some but not all of the hyperproliferative cells, an isolated nucleic acid sequence encoding a polypeptide having adenovirus E1A activity. In a further aspect, the invention relates to promoting differentiation of pathologically hyperproliferative cells.
摘要翻译：本发明涉及将病理性过度增殖性人类细胞转化为其非恶性表型的方法。该方法包括向细胞中引入编码具有腺病毒E1A活性的多肽的核酸，并在产生多肽的条件下生长细胞。本发明还涉及通过在一些但不是全部的过度增殖细胞中表达编码具有腺病毒E1A活性的多肽的分离的核酸序列，将受试者中的病理性过度增殖细胞群转化为非过度增殖状态的方法。另一方面，本发明涉及促进病理性过度增殖细胞的分化。

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