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    • 9. 发明申请
    • HEMATOPOIETIC STEM CELL GROWTH FACTOR (SCGF)
    • HEMATOPOIETIC STEM CELL GROWTH FACTOR(SCGF)
    • WO1998008869A1
    • 1998-03-05
    • PCT/JP1997002985
    • 1997-08-27
    • KYOWA HAKKO KOGYO CO., LTD.HIRAOKA, AtsunobuSUGIMURA, AtsushiMIO, Hiroyuki
    • KYOWA HAKKO KOGYO CO., LTD.
    • C07K14/52
    • C07K14/475A61K38/00
    • A novel polypeptide exhibiting a growth promoting activity on hematopoietic stem cells; a gene encoding this polypeptide; an antibody reacting specifically with the polypeptide; a process for isolating the above-mentioned gene; and a vector to be used in this process. Thus, the pathologies of various hemopoietic organ diseases caused by abnormalities in hematopoietic cells and bone marrow inhibition can be clarified and, in its turn, these diseases can be diagnosed or treated. Also, it becomes possible to amplify hematopoietic cells in vitro for marrow graft required in treating these diseases or to elevate the gene transfer efficiency into hematopoietic stem cells for gene utilization. Moreover, the above-mentioned process and vector for isolating the SCGF gene are applicable to the clarification of other novel genes and thus contribute to the development of genetic engineering techniques.
    • 一种对造血干细胞具有生长促进活性的新型多肽; 编码该多肽的基因; 特异性与多肽反应的抗体; 分离上述基因的方法; 以及在此过程中使用的向量。 因此,可以明确造血细胞异常引起的各种造血器官疾病和骨髓抑制的病态,从而可以诊断或治疗这些疾病。 此外,可以在体外扩增用于治疗这些疾病所需的骨髓移植物的造血细胞,或者将基因转移效率提高到造血干细胞中用于基因利用。 此外,用于分离SCGF基因的上述方法和载体可用于澄清其他新基因,从而有助于基因工程技术的发展。