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1. 发明申请

WO2002060275A1 PRODUCTION OF CAPSULES AND PARTICLES FOR IMPROVEMENT OF FOOD PRODUCTS 审中-公开
标题翻译：生产用于改进食品的胶囊和颗粒
公开(公告)号：WO2002060275A1
公开(公告)日：2002-08-08
申请号：PCT/US2002/002787
申请日：2002-01-30
申请人： KRAFT FOODS HOLDINGS, INC. , RIPOLL, Antonio, Barrero , GANAN-CALVO, Alfonso, M. , LOSCERTALES, Ignacio, Gonzalez , BON, Raul, Cortijo , MARQUEZ, Manuel
发明人： RIPOLL, Antonio, Barrero , GANAN-CALVO, Alfonso, M. , LOSCERTALES, Ignacio, Gonzalez , BON, Raul, Cortijo , MARQUEZ, Manuel
IPC分类号： A23L1/00
CPC分类号： B01J13/04 , A23L27/00 , A23L33/10 , A23P10/30
摘要： The present invention is related to the production of capsules or particles of micro and nanometric size, for introduction into food, using stable electrified coaxial jets of two immiscible liquids with diameters in the micro and nanometric range. An aerosol of charged structured droplets forms when the jets dissociate by capillary instabilities. The structured droplets, which are mano-dispersed in size, contain a first liquid (generally the material desired to be added) that is surrounded by a second liquid. Generally the second liquid provides a barrier or protective coating which allows the addition of the first liquid to a food product without adversely affecting the organoleptic or other properties of the food product.
摘要翻译：本发明涉及使用具有微米和纳米范围直径的两种不混溶液体的稳定带电的同轴射流来生产用于引入食品的微米和纳米尺寸的胶囊或颗粒。当喷流通过毛细管不稳定性分解时，形成带电结构的液滴的气溶胶。手工分散尺寸的结构化液滴含有由第二液体包围的第一液体（通常是期望添加的材料）。通常，第二液体提供阻挡或保护涂层，其允许将第一液体添加到食品中，而不会不利地影响食品的感官或其他性质。

2. 发明申请

WO2003013283A1 STABLE AND BIOAVAILABLE IRON FORTIFIED BEVERAGES 审中-公开
标题翻译：稳定和生物可利用的钢铁饮料
公开(公告)号：WO2003013283A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/023872
申请日：2002-07-23
申请人： KRAFT FOODS HOLDINGS, INC. , AKASHE, Ahmad , BALDWIN, Cheryl , LYLE, Barbara , MARQUEZ, Manuel
发明人： AKASHE, Ahmad , BALDWIN, Cheryl , LYLE, Barbara , MARQUEZ, Manuel
IPC分类号： A23L2/02
CPC分类号： A61K31/295 , A23L33/165 , A23V2002/00 , A23V2250/1592 , A23V2250/032 , A23V2250/708 , A23V2250/712 , A23V2250/51082 , A23V2200/044
摘要： Beverages and powdered beverage mixes fortified with ferric EDT A as an iron source are provided. The beverages and beverage mixes fortified with ferric EDTA according to this invention have superior iron bioavailability and excellent storage stability. The present invention also is directed to a method of using such ferric EDT A-fortified beverages to prevent or treat iron- deficiency anemia in individuals by administering the iron fortified beverage of the invention in an effective amount to an individual in need thereof.
摘要翻译：提供用铁源EDT A强化的饮料和粉末饮料混合物作为铁源。根据本发明的用EDTA加强的饮料和饮料混合物具有优异的铁生物利用度和优异的储存稳定性。本发明还涉及一种使用这种三价EDTA强化饮料来预防或治疗个体中的铁缺乏性贫血的方法，该方法是将有效量的本发明的铁强化饮料施用于有需要的个体。

3. 发明申请

WO2007038219A2 SYNTHESIS OF COLUMNAR HYDROGEL COLLOIDAL CRYSTALS IN WATER-ORGANIC SOLVENT MIXTURE 审中-公开
标题翻译：水有机溶剂混合物中柱状氢化钙晶体的合成
公开(公告)号：WO2007038219A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/036879
申请日：2006-09-21
申请人： UNIVERSITY OF NORTH TEXAS , HU, Zhibing , ZHOU, Jun , CAI, Tong , TANG, Shijun , MARQUEZ, Manuel
发明人： HU, Zhibing , ZHOU, Jun , CAI, Tong , TANG, Shijun , MARQUEZ, Manuel
IPC分类号： C30B29/58 , C30B29/60 , C08F220/04 , G02B5/20
CPC分类号： C30B5/00 , C30B29/58
摘要： The compositions of hydrogel colloidal crystals are made from mixing an aqueous suspension of poly-N-isopropylacrylamide ("PNIPAM")-co-allylamine microgels with dichloromethane, forming a PNIPAM-co-allylamine/dichloromethane mixture. The PNIPAM-co-allylamine/dichloromethane mixture is incubated for a period of time at a given temperature, forming the colloidal crystal material. The colloidal crystals can be stabilized by diffusing a glutaric dialdehyde solution into the colloidal crystal material. The concentration of polymer matrix microgels can determine the orientation of random or columnar crystals.
摘要翻译：水凝胶胶体晶体的组成通过将聚-N-异丙基丙烯酰胺（“PNIPAM”） - 共 - 烯丙基胺微凝胶的水悬浮液与二氯甲烷混合，形成PNIPAM-共 - 烯丙基胺/二氯甲烷混合物来制备。将PNIPAM-共 - 烯丙基胺/二氯甲烷混合物在给定温度下温育一段时间，形成胶体晶体材料。可以通过将戊二醛溶液扩散到胶体晶体材料中来稳定胶体晶体。聚合物基质微凝胶的浓度可以确定随机或柱状晶体的取向。

4. 发明申请

WO2005072334A2 PHOTORESPONSIVE HYDROGELS 审中-公开
公开(公告)号：WO2005072334A2
公开(公告)日：2005-08-11
申请号：PCT/US2005/002317
申请日：2005-01-24
申请人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , GARCIA, Antonio, A. , ROSARIO, Rohit , GUST, John, Devens, Jr. , HAYES, Mark, A. , MARQUEZ, Manuel , HU, Zhibing , CAI, Tong
发明人： GARCIA, Antonio, A. , ROSARIO, Rohit , GUST, John, Devens, Jr. , HAYES, Mark, A. , MARQUEZ, Manuel , HU, Zhibing , CAI, Tong
IPC分类号： A61K47/34
CPC分类号： C08F2/50 , A61K47/34
摘要： Disclosed are photoresponsive hydrogels. The compositions disclosed herein can be prepared by polymerizing a hydrogel precursor and a spiropyran. The properties of the disclosed compositions can be changed by exposure to light, pH, and temperature. Methods of using the disclosed compositions to deliver pharmaceutical actives are also disclosed.
摘要翻译：公开了光响应水凝胶。本文公开的组合物可以通过聚合水凝胶前体和螺吡喃来制备。所公开的组合物的性质可以通过暴露于光，pH和温度而改变。还公开了使用所公开的组合物递送药物活性物质的方法。

5. 发明申请

WO2003018548A2 HALOGENATED CALIXPYRROLES, CALIXPYRIDINOPYRROLES AND CALIXPYRIDINES, AND USES THEREOF 审中-公开
标题翻译：羟基喹喔啉，氯丙基吡咯烷酮和卡必普林及其用途
公开(公告)号：WO2003018548A2
公开(公告)日：2003-03-06
申请号：PCT/US2002/027252
申请日：2002-08-26
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SESSLER, Jonathan, L. , MARQUEZ, Manuel , ANZENBACHER, Pavel, Jr. , SHRIVER, James, A.
发明人： SESSLER, Jonathan, L. , MARQUEZ, Manuel , ANZENBACHER, Pavel, Jr. , SHRIVER, James, A.
IPC分类号： C07D
CPC分类号： C07F17/02 , B01J20/22 , B01J20/281 , B01J20/286 , B01J20/288 , B01J45/00 , B01J2220/54 , C07D487/22 , C07D495/22 , C07D498/22 , G01N30/02 , G01N30/482 , G01N30/88 , G01N2030/484 , G21F9/06 , G21F9/12 , B01D15/26
摘要： The present invention provides halogenated calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles having 4-12 pyrrolic rings with greater stability, enhanced anion and neutral molecule binding affinity, and different binding selectivites as compared to their non-halogenated congeners as judged from 1 H NMR, 19 F NMR and fluorescence emission spectroscopic analyses.
摘要翻译：本发明提供具有4-12个吡咯环的卤代杯吡咯，杯吡啶并吡咯大环，其具有更高的稳定性，增强的阴离子和中性分子结合亲和力，以及与其非卤化同系物相比，从1 H NMR ，19 F NMR和荧光发射光谱分析。

6. 发明申请

WO2011056390A2 METHOD OF MAKING AN ARTIFICIAL MICRO-GLAND THAT IS ANISOTROPIC 审中-公开
标题翻译：制造人造纤维细胞的方法
公开(公告)号：WO2011056390A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/052986
申请日：2010-10-16
申请人： MARQUEZ, Manuel , MARQUEZ, Samantha
发明人： MARQUEZ, Manuel , MARQUEZ, Samantha
IPC分类号： A61K35/12 , A61K35/16 , A61K35/14 , C12N5/07 , C12N5/09 , A61P5/00
CPC分类号： A61K36/02 , A61K35/74
摘要： A method is disclosed for making an artificial micro-gland having a continuous anisotropic membrane of two or more types of living cells. A first step includes forming a carrier fluid in a microchannel in a laminar flow of two distinct fluid flows. Another step includes introducing a template, which may itself be anisotropic, into the microchannel in a manner such that the template straddles the interface between the first fluid-flow and the second fluid-flow. In some embodiments two types of living cells within the template are separately attracted one of the fluid flows by the presence of an agent of taxis. In other embodiments, cells within one or the other of the fluid flows are attracted to agents within the template. Membranes form on the template and join together to form a complete cellular membrane around a reservoir.
摘要翻译：公开了一种用于制造具有两种或更多种类型活细胞的连续各向异性膜的人造微腺的方法。第一步骤包括在两个不同流体流的层流中在微通道中形成载流体。另一步骤包括将模板本身可以是各向异性的，以使模板跨越第一流体流与第二流体流之间的界面的方式引入微通道。在一些实施方案中，模板内的两种类型的活细胞通过出租车的出现分开地吸引流体流中的一种。在其它实施例中，一个或另一个流体流中的细胞被吸引到模板内的试剂上。在模板上形成膜并连接在一起以在储存器周围形成完整的细胞膜。

7. 发明申请

WO2011056389A2 METHOD OF MAKING AN ARTIFICIAL MICRO-GLAND USING TAXIS 审中-公开
标题翻译：使用TAXIS制造人造微球的方法
公开(公告)号：WO2011056389A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/052985
申请日：2010-10-16
申请人： MARQUEZ, Manuel , MARQUEZ, Samantha
发明人： MARQUEZ, Manuel , MARQUEZ, Samantha
IPC分类号： A61K35/12 , A61K35/16 , A61K35/14 , C12N5/07 , C12N5/09 , A61P5/00
CPC分类号： A61K36/02 , A61K35/74
摘要： A method makes an artificial micro-gland by taxis. A monodisperse multiple emulsion is produced with a first fluid; a second fluid confined within the first fluid; a third fluid within the second fluid. Interfaces between fluids permit living cells dispersed in one fluid to migrate towards an adjacent fluid having a different concentration of an agent affecting the metabolic activity of the living cells. Waiting, usually about 30 minutes, allows the living cells to migrate to the interface, forming the continuous membrane. Once formed, the artificial micro-gland is removed from the remains of the emulsion. The artificial micro-gland may be given a second layer of different cells when the emission of the cells of the artificial micro-gland is used as the agent to attract the different cells. The method may also be used to produce an artificial micro-gland within an artificial micro-gland.
摘要翻译：一种方法是通过出租车制造人造微腺。用第一种流体制备单分散多重乳液; 限制在第一流体内的第二流体; 第二流体内的第三流体。流体之间的界面允许分散在一种流体中的活细胞迁移到具有不同浓度的影响活细胞的代谢活性的试剂的相邻流体。等待，通常约30分钟，允许活细胞迁移到界面，形成连续膜。一旦形成，人造微腺从乳液的残余物中除去。当将人造微腺细胞的发射用作吸引不同细胞的药剂时，人造微腺体可以被给予第二层不同的细胞。该方法还可用于在人造微腺体内产生人造微腺体。

8. 发明申请

WO2010114710A3 An artificial micro-gland 审中-公开
公开(公告)号：WO2010114710A3
公开(公告)日：2010-10-07
申请号：PCT/US2010/027751
申请日：2010-03-18
申请人： MARQUEZ, Manuel , MARQUEZ, Samantha , GARCIA, Antonio
发明人： MARQUEZ, Manuel , MARQUEZ, Samantha , GARCIA, Antonio
IPC分类号： A61K9/16 , A61K9/14 , A61K9/127 , A61K9/06 , A61K47/30
摘要： A micro-scale artificial gland is disclosed in the form of an independent unit for promoting biological activity. The artificial gland includes cells formed in a membrane enclosing a reservoir. The reservoir is a bio-reactor capable of containing a product of activity of the cells. The reservoir comprises a gas, a liquid, and a gel and preferably also contains nanoparticles, a buffer, a surfactant, and, a gel precursor. The reservoir may also contain cells. Nanoparticles may also surround the artificial gland to form a protective coating. A variety of methods are disclosed for making the artificial gland by directed assembly of cells into the artificial micro-gland by gel, liquid or bubble templating. All involve coating the surface of gel, droplet or bubble with the living cells and the stabilizing the cells on the surface of gels, droplets or bubbles.

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