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1. 发明申请

WO0160833A3 MOTILIDE COMPOUNDS 审中-公开
标题翻译：胶体化合物
公开(公告)号：WO0160833A3
公开(公告)日：2002-01-24
申请号：PCT/US0105218
申请日：2001-02-15
申请人： KOSAN BIOSCIENCES INC , ASHLEY GARY , BURLINGAME MARK , CARRERAS CHRISTOPHER , SANTI DANIEL
发明人： ASHLEY GARY , BURLINGAME MARK , CARRERAS CHRISTOPHER , SANTI DANIEL
IPC分类号： A61K31/7048 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/14 , A61P1/16 , A61P17/00 , C07H17/08 , A61K31/70
CPC分类号： C07H17/08
摘要： The present invention provides novel macrolide compounds of the formulas (I, II, III or IV) wherein: R is hydroxyl or methoxy; R is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR , (a, b, c, and d) where R is C1-C10 alkenyl, C2-C10 alkynyl, aryl or heteroaryl and R and R are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl; R and R are each independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, alkylaryl, alkenylaryl, alkynylaryl or R and R together form a cycloalkyl or a cycloaryl moiety; R is hydrogen or methyl; R is hydrogen, hydroxyl, oxo, or together with R and the carbons to which they are attached form a cyclic carbonate; R is hydrogen, hydroxyl, OR where R is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or together with R5 and the carbons to which they are attached form a cyclic carbonate; R7 is methyl, C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; R is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; and, x is a single or a double bond.
摘要翻译：本发明提供式（I，II，III或IV）的新型大环内酯化合物，其中：R是羟基或甲氧基; R 1选自氢，羟基，卤素，NH 2，OR 9，（a，b，c和d）其中R 9是C 1 -C 10链烯基，C 2 -C 10炔基，芳基或杂芳基，R 10和R 11各自独立地为氢，C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基或芳基; R 2和R 3各自独立地选自氢，C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，芳基，烷芳基，烯基芳基，炔基芳基或R 2， 3>一起形成环烷基或环芳基部分; R 4是氢或甲基; R 5是氢，羟基，氧代或与R 6一起，并且与它们相连的碳形成环状碳酸酯; R 6是氢，羟基，OR 12，其中R 12是C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，或与R 5一起，并且与它们相连的碳形成环状碳酸酯 ; R 7是甲基，C 3 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，烷基芳基，烯基芳基，炔基芳基，酰氨基烷基芳基，酰胺基烯基芳基或酰胺基炔基芳基; R 8是C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，烷基芳基，烯基芳基，炔基芳基，酰氨基烷基芳基，酰氨基烯基芳基或酰胺基炔基芳基; x是单键或双键。

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