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1. 发明申请

WO2010079967A2 METHOD FOR CONTROLLING CODEC MODE IN ALL-IP NETWORK AND TERMINAL USING THE SAME 审中-公开
标题翻译：用于控制全IP网络和终端中编码模式的方法
公开(公告)号：WO2010079967A2
公开(公告)日：2010-07-15
申请号：PCT/KR2010000090
申请日：2010-01-07
申请人： KOREA ELECTRONICS TELECOMM , KOO KI JONG , BAE HYUN JOO , LEE BYUNG SUN
发明人： KOO KI JONG , BAE HYUN JOO , LEE BYUNG SUN
IPC分类号： H04W4/18
CPC分类号： H04W24/10 , G10L19/24 , H04L1/0014 , H04L1/0015 , H04L1/0017 , H04L5/0057 , H04L65/80 , H04W28/22 , H04W80/04 , H04W88/181
摘要： A method of controlling the codec mode of a convergence internet protocol (IP) network and a terminal using the method are provided. The terminal may include a variable bit-rate/mode codec controller including a channel status measurement and management (CSMM) unit which measures the status of a wireless channel and provides the results of the measuring of the wireless channel status as channel quality information, and which measures the transfer performance of a received packet and provides the results of the measuring of the packet transfer performance as packet measurement parameter information, and a service quality control (SQC) unit which measures the quality of a multimedia service based on the channel quality information and the packet measurement parameter information, provides the results of the measuring of the multimedia service quality as service quality information and determines a codec mode of the terminal or a counterpart terminal communicating with the all-IP terminal based on the service quality information. Therefore, it is possible to improve the quality of multimedia services.
摘要翻译：提供了一种使用该方法来控制融合因特网协议（IP）网络和终端的编解码器模式的方法。终端可以包括可变比特率/模式编解码器控制器，其包括测量无线信道的状态并将测量无线信道状态的结果作为信道质量信息的信道状态测量和管理（CSMM）单元，以及其测量接收到的分组的传送性能，并将分组传输性能的测量结果作为分组测量参数信息，以及基于信道质量信息测量多媒体服务的质量的服务质量控制（SQC）单元和分组测量参数信息，将多媒体服务质量的测量结果作为服务质量信息提供，并且基于服务质量信息确定终端或与全IP终端通信的对方终端的编解码器模式。因此，可以提高多媒体业务的质量。

2. 发明申请

WO2009066871A2 MESSAGE SERVICE METHOD AND MESSAGE SERVICE SYSTEM 审中-公开
标题翻译：消息服务方法和消息服务系统
公开(公告)号：WO2009066871A2
公开(公告)日：2009-05-28
申请号：PCT/KR2008006001
申请日：2008-10-10
申请人： KOREA ELECTRONICS TELECOMM , KIM JEONG HWAN , KIM SANG KI , LEE BYUNG SUN
发明人： KIM JEONG HWAN , KIM SANG KI , LEE BYUNG SUN
CPC分类号： H04W4/12
摘要： The present invention relates to a message service method and a message service system. The message service method receives a message and a message transmission request from an open service application user and transmits the message to an appropriate transmission infrastructure such that the message arrives at a destination terminal. To achieve this, the message service system includes an open service application server which sends the message and the message transmission request, an open service gateway which reconstructs the message as one of a short message, a WAP Push message and a multimedia message through message analysis, and transmission infrastructures which transmits messages.
摘要翻译：本发明涉及消息服务方法和消息服务系统。消息服务方法从开放服务应用用户接收消息和消息传输请求，并将消息发送到适当的传输基础设施，使得该消息到达目的地终端。为了实现这一点，消息服务系统包括发送消息和消息传输请求的开放服务应用服务器，通过消息分析将消息重建为短消息，WAP推送消息和多媒体消息之一的开放服务网关以及传输消息的传输基础设施。

3. 发明申请

WO2011090305A2 LIQUID FORMULATIONS FOR LONG-ACTING G-CSF CONJUGATE 审中-公开
标题翻译：用于长效G-CSF共轭物的液体制剂
公开(公告)号：WO2011090305A2
公开(公告)日：2011-07-28
申请号：PCT/KR2011000369
申请日：2011-01-18
申请人： HANMI HOLDINGS CO LTD , LEE MI JI , LEE JAE MIN , LEE BYUNG SUN , BAE SUNG MIN , KWON SE CHANG
发明人： LEE MI JI , LEE JAE MIN , LEE BYUNG SUN , BAE SUNG MIN , KWON SE CHANG
IPC分类号： A61K9/38 , A61K9/08 , A61K9/14 , A61K47/42
CPC分类号： A61K9/0019 , A61K38/193 , A61K47/12 , A61K47/26 , A61K47/6813 , A61K47/6835 , C07K14/535
摘要： Disclosed is a liquid formulation which allows long-acting G-CSF conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting G-CSF conjugates.
摘要翻译：公开了一种液体制剂，其允许具有改善的体内持续时间和稳定性的长效G-CSF缀合物在长时间储存时稳定。它包含以缓冲液和甘露糖醇为特征的稳定剂组合物。由于不含人体血清白蛋白和其他对身体有害的潜在因素，该液体制剂不受病毒感染的担忧，并确保长效G-CSF缀合物具有出色的储存稳定性。

4. 发明申请

WO2012057527A3 METHOD FOR MASS PRODUCTION OF FACTOR VII/VIIA 审中-公开
标题翻译：大量生产VII / VIIA因子的方法
公开(公告)号：WO2012057527A3
公开(公告)日：2012-07-26
申请号：PCT/KR2011008040
申请日：2011-10-26
申请人： HANMI SCIENCE CO LTD , KIM CHANG HWAN , HONG SUNG KAP , LEE BYUNG SUN , HONG SUNG HWAN , KWON SE CHANG
发明人： KIM CHANG HWAN , HONG SUNG KAP , LEE BYUNG SUN , HONG SUNG HWAN , KWON SE CHANG
IPC分类号： C12N15/85 , C07K14/745 , C12N15/12
CPC分类号： C12N9/6437 , C07K14/745 , C12N15/85 , C12N2830/85
摘要： Disclosed is a method for the mass production of human coagulation factor VII. The method comprises a) constructing an expression vector carrying i) a dihydrofolate reductase promoter devoid of one or more CCGCC repeat sequences from the GC-rich region thereof and a dihydrofolate reductase (DHFR) gene operably linked thereto and ii) a cytomegalovirus (CMV) promoter and a human coagulation factor VII gene operably linked thereto; b) transfecting the expression vector of step a) into an animal cell line; c) culturing the transfected animal cell line of step b) in the presence of a dihydrofolate reductase inhibitor to select cells which express human coagulation factor VII with high efficiency; and d) adding sodium butyrate to the selected animal cells of step c), and a cell line for mass production of human coagulation factor VII. Employing a vector carrying a DHFR promoter devoid of GC-rich repeating sequences, the method can produce human coagulation factor VII at high efficiency on a large scale, which contributes to the treatment of hemophilia.
摘要翻译：公开了大量生产人凝血因子VII的方法。该方法包括：a）构建表达载体，其携带i）没有来自其富含GC的区域的一个或多个CCGCC重复序列的二氢叶酸还原酶启动子和与其可操作地连接的二氢叶酸还原酶（DHFR）基因，和ii）巨细胞病毒（CMV）启动子和与之有效连接的人凝血因子VII基因; b）将步骤a）的表达载体转染到动物细胞系中; c）在二氢叶酸还原酶抑制剂的存在下培养步骤b）的转染的动物细胞系以选择以高效率表达人凝血因子VII的细胞; 和d）向步骤c）的选定动物细胞中加入丁酸钠，以及大量生产人凝血因子VII的细胞系。携带携带没有富含GC的重复序列的DHFR启动子的载体，该方法可大规模高效地产生人凝血因子VII，这有助于血友病的治疗。

5. 发明申请

WO2012008779A3 A LIQUID FORMULATION OF LONG-ACTING HUMAN GROWTH HORMONE CONJUGATE 审中-公开
标题翻译：长效人生长激素共轭物的液体制剂
公开(公告)号：WO2012008779A3
公开(公告)日：2012-05-24
申请号：PCT/KR2011005194
申请日：2011-07-14
申请人： HANMI HOLDINGS CO LTD , HONG SUNG HEE , LEE BYUNG SUN , IM DAE SEONG , LEE JAE MIN , BAE SUNG MIN , KWON SE CHANG
发明人： HONG SUNG HEE , LEE BYUNG SUN , IM DAE SEONG , LEE JAE MIN , BAE SUNG MIN , KWON SE CHANG
IPC分类号： A61K9/08 , A61K9/22 , A61K38/27 , A61K47/36
CPC分类号： A61K47/48415 , A61K9/0019 , A61K9/08 , A61K38/27 , A61K47/12 , A61K47/26 , A61K47/60 , A61K47/68 , C07K2319/30
摘要： Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0~6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.
摘要翻译：公开了一种不含白蛋白的长效人生长激素（hGH）缀合物的液体制剂，其在长时间储存时可保证长效hGH缀合物的稳定性，其中长效人生长激素缀合物包括与免疫球蛋白Fc区连接的人生长激素，并且与天然形式相比具有延长的体内稳定性。包含pH5.0〜6.0缓冲液，糖醇，盐和非离子表面活性剂的hGH缀合物的液体制剂不含人类血清白蛋白和可能被病毒污染的其他有害因素，并且可以提供优良的储存稳定性对于与天然相比具有更高分子量和体内耐久性的由hGH多肽和免疫球蛋白Fc区组成的长效hGH缀合物。

6. 发明申请

WO2011122922A3 LONG-ACTING HUMAN FOLLICLE-STIMULATING HORMONE FORMULATION USING IMMUNOGLOBULIN FRAGMENT 审中-公开
标题翻译：使用免疫抑制蛋白片段长效人体激素激素配方
公开(公告)号：WO2011122922A3
公开(公告)日：2012-03-08
申请号：PCT/KR2011002332
申请日：2011-04-04
申请人： HANMI HOLDINGS CO LTD , KIM CHANG HWAN , HONG SUNG KAP , LEE BYUNG SUN , KWAK SOO YOUNG , LEE MI JI , CHOI IN YOUNG , KWON SE CHANG
发明人： KIM CHANG HWAN , HONG SUNG KAP , LEE BYUNG SUN , KWAK SOO YOUNG , LEE MI JI , CHOI IN YOUNG , KWON SE CHANG
IPC分类号： A61K9/22 , A61K47/34 , A61K47/40
CPC分类号： A61K47/48215 , A61K47/60 , A61K47/68
摘要： The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
摘要翻译：本发明涉及具有改善的体内持续时间和稳定性的长效促卵泡激素制剂，其包含人促卵泡激素缀合物，其通过非激素共价连接人卵泡刺激激素与免疫球蛋白Fc区而制备 - 肽基聚合物及其制备方法。本发明的长效人促卵泡激素制剂在较高水平维持人卵泡刺激激素的体内活性，并且显着增加其血清半衰期。

7. 发明申请

WO2010082804A3 METHOD FOR PRODUCING PHYSIOLOGICALLY ACTIVE PROTEIN OR PEPTIDE USING IMMUNOGLOBULIN FRAGMENT 审中-公开
标题翻译：使用免疫球蛋白片段生产生理活性蛋白或肽的方法
公开(公告)号：WO2010082804A3
公开(公告)日：2010-11-25
申请号：PCT/KR2010000342
申请日：2010-01-19
申请人： HANMI HOLDINGS CO LTD , KIM JIN-SUN , JUNG SUNG YOUB , LEE JONG-SOO , LEE BYUNG SUN , KWON SE CHANG , LEE GWAN SUN
发明人： KIM JIN-SUN , JUNG SUNG YOUB , LEE JONG-SOO , LEE BYUNG SUN , KWON SE CHANG , LEE GWAN SUN
IPC分类号： C12N15/62 , C07K19/00 , C12N15/09 , C12N15/52
CPC分类号： C07K14/00 , C07K2319/30
摘要： The present invention provides a method for mass-producing a physiologically active protein or peptide using a fusion protein composed of the physiologically active protein or peptide and an immunoglobulin fragment. The present invention also provides such a fusion protein, a DNA encoding the fusion protein, an expression vector comprising the DNA, and a microorganism transformed with the expression vector.
摘要翻译：本发明提供使用由生理活性蛋白质或肽组成的融合蛋白质和免疫球蛋白片段大规模生产生理活性蛋白质或肽的方法。本发明还提供了这样的融合蛋白，编码融合蛋白的DNA，包含DNA的表达载体和用表达载体转化的微生物。

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