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1. 发明申请

WO2009088255A3 METHOD FOR PREPARING ANTIGEN EFFECTIVE FOR PREVENTING ANTHRAX INFECTION 审中-公开
标题翻译：制备抗原有效预防肛门感染的方法
公开(公告)号：WO2009088255A3
公开(公告)日：2009-09-11
申请号：PCT/KR2009000134
申请日：2009-01-09
申请人： KOREA CT FOR DISEASE CONTROL A , GREEN CROSS CORP , OH HEE-BOK , KIM BONG-SU , RHIE GI-EUN , CHUN JEONG-HOON , KIM HUN , YEO SINKOO , PARK MAHNHOON , CHANG CHONG-HWAN JONATHAN , AHN MI SUN
发明人： OH HEE-BOK , KIM BONG-SU , RHIE GI-EUN , CHUN JEONG-HOON , KIM HUN , YEO SINKOO , PARK MAHNHOON , CHANG CHONG-HWAN JONATHAN , AHN MI SUN
IPC分类号： A61K39/00 , A61K39/02 , A61K39/07 , C07H21/04 , C07K14/32 , C12N1/21
CPC分类号： C07K14/32 , A61K39/00
摘要： The method of the present invention comprising successive column chromatography processes for the purification of an anthrax protective antigen can achieve an improved purity of the anthrax protective antigen product by effectively removing impurities (e.g., cellular residual proteins in the culture solution) without the loss of anthrax protective antigen. Therefore, the method of the present invention can be advantageously used for economically producing the anthrax protective antigen on a large scale.
摘要翻译：包含用于纯化炭疽保护性抗原的连续柱层析方法的本发明方法可通过有效去除杂质（例如培养溶液中的细胞残余蛋白）而不损失炭疽实现炭疽保护性抗原产物的纯度提高保护性抗原。因此，本发明的方法可以有利地用于大规模经济地生产炭疽保护性抗原。

2. 发明申请

WO2012033328A3 MDCK-DERIVED CELL LINES ADAPTED TO SERUM-FREE CULTURE AND SUSPENSION CULTURE AND METHOD FOR PREPARING VACCINE VIRUS USING THE CELLS 审中-公开
标题翻译：适用于无血清培养和悬浮培养的MDCK衍生细胞系和使用细胞制备疫苗病毒的方法
公开(公告)号：WO2012033328A3
公开(公告)日：2012-06-28
申请号：PCT/KR2011006589
申请日：2011-09-06
申请人： SK CHEMICALS CO LTD , PARK YONG WOOK , LEE KUN SE , LEE BONG-YONG , PARK MAHNHOON , KIM HUN , KIM YUN-HEE , LEE SU-JEEN
发明人： PARK YONG WOOK , LEE KUN SE , LEE BONG-YONG , PARK MAHNHOON , KIM HUN , KIM YUN-HEE , LEE SU-JEEN
IPC分类号： C12N5/071 , A61K39/145 , C12N5/02
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5254 , C12N5/0686 , C12N2500/90 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/16171 , C12N2760/16234 , C12N2760/16251 , C12N2760/16252 , C12N2760/16271
摘要： Disclosed is a Madin-Darby canine kidney (MDCK)-derived cell line. The MDCK-derived cell line is derived from MDCK cells deposited under accession number ATCC CCL-34. The MDCK-derived cell line can be prepared by serum-free culture and suspension culture. Preferably, the MDCK-derived cell line has low or no tumorigenicity. The MDCK-derived cell line is preferably selected from MDCK Sky1023, MDCK Sky10234 and MDCK Sky3851. Further disclosed are a culture method for growing the MDCK-derived cells and a method for producing a vaccine virus using the MDCK-derived cells.
摘要翻译：公开了一种Madin-Darby犬肾（MDCK）来源的细胞系。来自MDCK的细胞系来源于以保藏号ATCC CCL-34保藏的MDCK细胞。 MDCK来源的细胞系可以通过无血清培养和悬浮培养来制备。优选地，来自MDCK的细胞系具有低或无致瘤性。 MDCK衍生的细胞系优选选自MDCK Sky1023，MDCK Sky10234和MDCK Sky3851。进一步公开了用于生长MDCK衍生的细胞的培养方法和使用MDCK衍生的细胞产生疫苗病毒的方法。

3. 发明申请

WO2010131865A2 ANTIMICROBIAL COMPOSITION WITH AN ACTIVITY AGAINST AN ANTIBIOTIC-RESISTANT STRAIN 审中-公开
标题翻译：具有抗生素抗性活性的抗微生物组合物
公开(公告)号：WO2010131865A2
公开(公告)日：2010-11-18
申请号：PCT/KR2010002845
申请日：2010-05-04
申请人： UNIV CHUNG ANG IND , KIM JONG-KEE , KIM HUN , LIM SOO-YEON , LEE SOO-SEONG
发明人： KIM JONG-KEE , KIM HUN , LIM SOO-YEON , LEE SOO-SEONG
IPC分类号： A61K31/26 , A61P31/00 , A61P31/04
CPC分类号： A61K31/26
摘要： The present invention relates to an antimicrobial composition against an antibiotic-resistant strain containing, as active ingredients, one or more elements selected from a group consisting of sulforaphene and sulforaphane. More particularly, the present invention relates to an antimicrobial composition which contains, as active ingredients, one or more elements selected from a group consisting of sulforaphene and sulforaphane, and which acts on methicillin-resistant staphylococcus, vancomycin-resistant enterococcus or antibiotic-resistant colon bacillus, pneumobacillus, salmonella typhimurium and enterococcus faecalis and the like to inhibit the growth of an antibiotic-resistant strain. The antimicrobial composition of the present invention inhibits the growth of gram-negative bacillus and gram-positive bacillus having a resistance to beta-lactam antibiotics such as vancomycin, penicillin, methicillin and the like or against non-beta-lactam antibiotics, and therefore can be used in the prevention and treatment of various infectious diseases caused by antibiotic-resistant bacterial infections, and can be valuably used as antibiotics against super-bacteria.
摘要翻译：本发明涉及一种抗生素抗性菌株的抗微生物组合物，其含有选自由磺基吡咯和萝卜硫素组成的组中的一种或多种元素作为活性成分。更具体地说，本发明涉及一种抗微生物组合物，其含有作为活性成分的一种或多种选自由磺基芴和萝卜硫素组成的组分，并且其作用于耐甲氧西林葡萄球菌，万古霉素耐药性肠球菌或抗生素耐药结肠杆菌，肺炎杆菌，鼠伤寒沙门氏菌和粪肠球菌等，以抑制抗生素抗性菌株的生长。本发明的抗微生物组合物抑制对β-内酰胺抗生素如万古霉素，青霉素，甲氧西林等具有抗性或针对非β-内酰胺抗生素的革兰氏阴性杆菌和革兰氏阳性杆菌的生长，因此可以用于预防和治疗由抗生素抵抗细菌感染引起的各种感染性疾病，可以有价值地用作抗细菌的抗生素。

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