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1. 发明申请

WO2012074234A3 FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER AND METHOD FOR CONCENTRATING IONS FOR FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY 审中-公开
标题翻译：傅立叶变换离子回旋共振质谱仪及其离子回旋共振质谱分析方法
公开(公告)号：WO2012074234A3
公开(公告)日：2012-07-26
申请号：PCT/KR2011008866
申请日：2011-11-21
申请人： KOREA BASIC SCIENCE INST , CHOI MYOUNG CHOUL , PARK A LEUM , KIM HYUN SIK , KIM SEUNG YONG , YOO JONG SHIN
发明人： CHOI MYOUNG CHOUL , PARK A LEUM , KIM HYUN SIK , KIM SEUNG YONG , YOO JONG SHIN
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/065 , H01J49/38
摘要： A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) includes: an ionization source generating ions; a deceleration lens, on which the ions generated by the ionization source and spatially dispersed are incident, selectively decelerating the incident ions so as to decrease the distance between the ions; and an ion cyclotron resonance cell on which the ions passing through the deceleration lens are incident. By preventing dispersing of ions due to mass difference and converging the ions using the deceleration lens, the mass range that can be measured at one time can be extended. Also, measurement sensitivity can be improved since the ions are effectively introduced to the ICR cell.
摘要翻译：傅立叶变换离子回旋共振质谱仪（FT-ICR MS）包括：产生离子的电离源; 一个减速透镜，在该减速透镜上，由电离源产生并在空间上分散的离子入射，有选择地使入射离子减速，从而减小离子之间的距离; 以及其上通过减速透镜的离子入射在其上的离子回旋共振单元。通过防止因质量差引起的离子扩散并使用减速透镜会聚离子，可以延长一次可测量的质量范围。而且，由于离子被有效地引入ICR单元，所以可以提高测量灵敏度。

2. 发明申请

WO2011081352A2 APPARATUS FOR ELECTROSPRAY IONIZATION AND METHOD FOR ELECTROSPRAY IONIZATION USING THE SAME 审中-公开
标题翻译：用于电泳电离的装置和使用该装置进行电泳电离的方法
公开(公告)号：WO2011081352A2
公开(公告)日：2011-07-07
申请号：PCT/KR2010009254
申请日：2010-12-23
申请人： KOREA BASIC SCIENCE INST , KANG DUK JIN , CHOI MYOUNG CHOUL , YOO JONG SHIN , KIM HYUN SIK
发明人： KANG DUK JIN , CHOI MYOUNG CHOUL , YOO JONG SHIN , KIM HYUN SIK
IPC分类号： G01N27/26 , G01N33/48 , G01N33/68 , H01J49/04
CPC分类号： H01J49/165 , H01J49/045
摘要： An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.
摘要翻译：一种用于电喷雾电离的设备可以包括：平台，其包括入口端口，连接到入口端口的第一通道，连接到第一通道的第二通道和连接到第二通道的出口端口; 雾化器，其设置在所述第一通道中并且被配置为将惰性气体喷射到通过所述入口喷射到所述第一通道中的样品; 以及聚焦透镜，其设置在第二通道中并且被配置为将从喷射样本产生的离子聚焦到出口端口。

3. 发明申请

WO2011078544A2 ION INJECTOR, MASS SPECTROMETER COMPRISING THE SAME AND METHOD FOR FOCUSING IONS USING THE SAME 审中-公开
标题翻译：包含其的离子注射器，质谱仪和使用其聚焦离子的方法
公开(公告)号：WO2011078544A2
公开(公告)日：2011-06-30
申请号：PCT/KR2010009141
申请日：2010-12-21
申请人： KOREA BASIC SCIENCE INST , CHOI MYOUNG CHOUL , KIM HYUN SIK , YOO JONG SHIN
发明人： CHOI MYOUNG CHOUL , KIM HYUN SIK , YOO JONG SHIN
IPC分类号： H01J37/30 , H01J49/26
CPC分类号： H01J37/08 , H01J49/0404 , H01J49/067 , H01J2237/083
摘要： An ion injector may include: a first electrode comprising a first region allowing ions to pass; and a second electrode disposed to enclose one end of the first electrode. The second electrode may include: a second region aligned with the first region to allow the ions to pass; and a protruding portion extending along the path of the ions passing through the second region. A mass spectrometer may be configured by disposing the ion injector adjacent to a skimmer.
摘要翻译：离子注入器可以包括：第一电极，其包括允许离子通过的第一区域; 以及设置成包围第一电极的一端的第二电极。第二电极可以包括：与第一区域对准的第二区域以允许离子通过; 以及沿着穿过第二区域的离子的路径延伸的突出部分。可以通过将离子注入器邻近于撇渣器来配置质谱仪。

4. 发明申请

WO2011081298A3 APPARATUS AND METHOD FOR CONTROLLING A PIPELINE-TYPE ION CYCLOTRON RESONANCE MASS SPECTROMETER 审中-公开
标题翻译：控制管式离子回旋共振质谱仪的装置和方法
公开(公告)号：WO2011081298A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010008079
申请日：2010-11-16
申请人： KOREA BASIC SCIENCE INST , KIM SEUNG YONG , KIM HYUN SIK , YOO JONG SHIN
发明人： KIM SEUNG YONG , KIM HYUN SIK , YOO JONG SHIN
IPC分类号： H01J49/34 , G01N27/62 , H01J49/26
CPC分类号： H01J49/38 , H01J49/022
摘要： The present invention relates to an apparatus and method for controlling a pipeline-type ion cyclotron resonance mass spectrometer, in which an ion trap unit of the ion cyclotron resonance mass spectrometer is capable of using two digitizers at the same time, thus enabling a measurement process for detecting an electrical signal which indicates the mass of ions corresponding to a specific purpose, and another measurement process for detecting another electrical signal which indicates the mass of ions corresponding to another specific purpose, to be simultaneously performed. Accordingly, it is an aim of the present invention to provide an apparatus and method for controlling a pipeline-type ion cyclotron resonance mass spectrometer, which can overcome the problems of time delay among control procedures, and can present a signal detection step wherein an excitation electrode is utilized to improve the sensitivity and speed of signal detection.
摘要翻译：本发明涉及一种用于控制管道型离子回旋共振质谱仪的装置和方法，其中离子回旋共振质谱仪的离子阱单元能够同时使用两个数字转换器，从而能够进行测量过程用于检测指示对应于特定目的的离子的质量的电信号以及用于检测指示与另一特定目的对应的离子的质量的另一电信号的另一测量过程被同时执行。因此，本发明的一个目的是提供一种用于控制流水线式离子回旋共振质谱仪的装置和方法，该装置和方法可以克服控制过程中时间延迟的问题，并且可以提供一种信号检测步骤，其中激励电极用于提高信号检测的灵敏度和速度。

5. 发明申请

WO2011081329A3 METHOD FOR DISCOVERING PHARMACOLOGICALLY ACTIVE SUBSTANCE OF NATURAL PRODUCTS USING HIGH RESOLUTION MASS SPECTROMETRY AND PHARMACOLOGICAL ACTIVITY TEST 审中-公开
标题翻译：使用高分辨质谱法和药理活性测试发现天然产物的药物活性物质的方法
公开(公告)号：WO2011081329A3
公开(公告)日：2011-11-17
申请号：PCT/KR2010008988
申请日：2010-12-15
申请人： KOREA BASIC SCIENCE INST , PARK KYU HWAN , KIM HYUN SIK , KWON KYUNG HOON , YOO JONG SHIN
发明人： PARK KYU HWAN , KIM HYUN SIK , KWON KYUNG HOON , YOO JONG SHIN
IPC分类号： G01N30/72 , B01D15/08 , G01N33/15
CPC分类号： G01N30/06 , G01N30/8686 , G01N30/96 , G01N33/6848 , G01N2030/8809 , G01N2030/8813 , G01N2500/00 , Y10T436/174614 , Y10T436/24 , Y10T436/25 , Y10T436/25375
摘要： Disclosed is a method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining a mass profile based on a mass spectrum resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The disclosed method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.
摘要翻译：公开了一种从天然产物中高速发现药理活性物质的方法，包括：通过测试多个样品的药理活性来获得活性谱; 基于通过质谱分析样品得到的质谱获得质量曲线; 并通过比较和分析活性谱和质量分布来确定药理学活性物质的分子量。所公开的方法允许通过对包括在天然产物的提取物样品中的许多组分执行高分辨率质谱法并与活性测试数据进行比较来快速发现药理学活性物质。关于天然产物的药理活性物质的活性强度的信息允许有效利用天然产物。

6. 发明申请

WO2011081369A2 CANCER DIAGNOSIS MARKER USING THE ABERRANT GLYCOSYLATION OF A PROTEIN 审中-公开
标题翻译：使用蛋白质的ABERRANT GLYCOSYLATION的癌症诊断标记
公开(公告)号：WO2011081369A2
公开(公告)日：2011-07-07
申请号：PCT/KR2010009323
申请日：2010-12-24
申请人： KOREA BASIC SCIENCE INST , AHN YEONG HEE , YOO JONG SHIN
发明人： AHN YEONG HEE , YOO JONG SHIN
IPC分类号： G01N33/68 , G01N30/72 , G01N33/574
CPC分类号： G01N33/574 , G01N30/7233 , G01N2030/8831 , G01N2333/4724 , G01N2440/38
摘要： The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein. More particularly, the present invention relates to a cancer diagnosis peptide marker which is screened by: a step of separating, using a lectin, a glycoprotein which is aberrantly glycosylated in accordance with the occurrence of cancer; and a step of selecting a hydrolyzed peptide marker derived from the aberrantly glycosylated glycoprotein using the quantitative change in the separated glycoprotein. The present invention also relates to a method for diagnosing cancer using the peptide marker as an agent.
摘要翻译：本发明涉及使用关于糖蛋白异常糖基化的信息来诊断癌症的方法。更具体地，本发明涉及通过以下步骤进行筛选的癌症诊断肽标记：使用凝集素分离根据癌症发生异常糖基化的糖蛋白的步骤; 以及使用分离的糖蛋白的定量变化来选择来自异常糖基化糖蛋白的水解肽标记物的步骤。本发明还涉及使用肽标记作为试剂诊断癌症的方法。

7. 发明申请

WO2011081310A3 PEPTIDE MARKER FOR CANCER DIAGNOSIS, AND CANCER DIAGNOSIS METHOD USING SAME 审中-公开
标题翻译：用于癌症诊断的肽标记物和使用相同的癌症诊断方法
公开(公告)号：WO2011081310A3
公开(公告)日：2011-10-27
申请号：PCT/KR2010008666
申请日：2010-12-06
申请人： KOREA BASIC SCIENCE INST , AHN YEONG HEE , YOO JONG SHIN
发明人： AHN YEONG HEE , YOO JONG SHIN
IPC分类号： G01N33/68 , G01N30/72 , G01N33/574
CPC分类号： G01N33/57484 , G01N33/5014 , G01N33/5047 , G01N2500/10
摘要： The present invention relates to a peptide marker for cancer diagnosis, and to a cancer diagnosis method using same, and more particularly, to a screened peptide marker for cancer diagnosis, comprising the steps of: separating and concentrating glycoproteins including a certain glycol chain related to the occurrence of cancer; hydrolyzing the glycoproteins to obtain polypeptides; and quantitatively analyzing the polypeptides to identify certain polypeptides that can track quantitative changes in glycoproteins glycosylated in a specific manner by the occurrence of cancer, and to a cancer diagnosis method using the peptide marker.
摘要翻译：本发明涉及用于癌症诊断的肽标记物和使用其的癌症诊断方法，并且更具体地涉及用于癌症诊断的筛选的肽标记物，所述方法包括以下步骤：分离和浓缩糖蛋白，所述糖蛋白包括与癌症的发生; 水解糖蛋白以获得多肽; 并定量分析多肽以鉴定某些可以追踪通过癌症的发生以特定方式糖基化的糖蛋白中的定量变化的多肽以及使用该肽标记物的癌症诊断方法。

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