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1. 发明申请

WO2016124539A1 A SYSTEM AND A METHOD FOR LABELING OBJECTS IN MEDICAL IMAGES 审中-公开
标题翻译：一种用于在医学图像中标记物体的系统和方法
公开(公告)号：WO2016124539A1
公开(公告)日：2016-08-11
申请号：PCT/EP2016/052061
申请日：2016-02-01
申请人： KONINKLIJKE PHILIPS N.V.
发明人： WANG, Lu , HE, Zhenwei , KESWARPU, Payal , NAIK, Sarif Kumar , SETH, Subhendu , GUPTA, Vipin
IPC分类号： G06F19/00 , A61B1/303 , A61B5/00
CPC分类号： G06F19/321 , A61B1/00009 , A61B1/00039 , A61B1/00043 , G06F19/00 , G16H15/00
摘要： The invention relates to a system for labeling objects in images. The system of the invention comprises a lesion tool for identifying and providing lesion sites from at least one of the image; a biopsy tool for identifying the biopsy sites from the said at least one image and/or of the said lesion sites, the said lesion tool and biopsy tool are integrated therein along with a knowledge base and Graphical User Interface (GUI), to identify the lesion sites and of the biopsy sites therefrom. The comparison of the lesion sites detected by the lesion tool is automatically compared with the images captured by the biopsy tool. The invention also relates to a method for labeling objects in images, performed by the system of the invention.
摘要翻译：本发明涉及一种用于在图像中标记物体的系统。本发明的系统包括用于从至少一个图像识别并提供病变部位的病变工具; 用于从所述至少一个图像和/或所述损伤部位识别活检部位的活检工具，所述病变工具和活检工具与知识库和图形用户界面（GUI）一起集成在其中，以识别病变部位及其活检部位。病灶工具检测到的病变部位的比较与活检工具捕获的图像进行自动比较。本发明还涉及由本发明的系统执行的用于标记图像中的对象的方法。

2. 发明申请

WO2016193125A2 CRYOTHERAPY SYSTEMS 审中-公开
标题翻译： CRYOTHERAPY系统
公开(公告)号：WO2016193125A2
公开(公告)日：2016-12-08
申请号：PCT/EP2016/061946
申请日：2016-05-26
申请人： KONINKLIJKE PHILIPS N.V.
发明人： CHAKRABARTI, Biswaroop , SETH, Subhendu , VAJINEPALLI, Pallavi , KESWARPU, Payal , SUBBARAMAN, Karthik
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00041 , A61B2018/00702 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00898
摘要： A cryo-ablation systems with a probe body (P) having a treatment head (TH) with a tip portion (TP) for contacting tissue at a region of contact and configured for imparting a temperature change to the tissue at said region of contact. A plurality of electrodes (E j ) are arranged spaced apart from said tip portion and around said tip portion, configured to measure an electrical property of the tissue in a neighborhood around said region of contact. Adhesion management means are also envisaged.
摘要翻译：一种具有探针体（P）的冷冻消融系统，所述探针体（P）具有治疗头（TH），所述治疗头具有尖端部分（TP），所述尖端部分用于在接触区域处接触组织并且被配置为在所述接触区域对所述组织施加温度变化。多个电极（Ej）被布置成与所述尖端部分隔开并且围绕所述尖端部分被配置成测量围绕所述接触区域的附近的组织的电特性。也设想了粘附管理手段。

3. 发明申请

WO2014170199A1 ACQUIRING CERVICAL IMAGES 审中-公开
标题翻译：获取图像
公开(公告)号：WO2014170199A1
公开(公告)日：2014-10-23
申请号：PCT/EP2014/057241
申请日：2014-04-10
申请人： KONINKLIJKE PHILIPS N.V.
发明人： WANG, Lu , SETH, Subhendu , VAJINEPALLI, Pallavi , GUPTA, Vipin , KESWARPU, Payal , NAIK, Sarif Kumar
IPC分类号： A61B1/00 , A61B1/303
CPC分类号： A61B5/4331 , A61B1/00009 , A61B1/00045 , A61B1/0005 , A61B1/00055 , A61B1/04 , A61B1/303 , A61B5/0084 , A61B5/7221 , A61B5/7425 , A61B5/743
摘要： The invention provides a system (100) for acquiring cervical images which comprises an image acquisition subsystem (120) for acquiring cervical images (122) of a cervical region of a patient during a colposcopy procedure, and a display subsystem (160) for displaying the cervical images on a display (060) by providing image data (162) of the cervical images to the display. According to the invention, the image acquisition subsystem (120) is arranged for, when operating in an interval mode, acquiring the cervical images (122) at predetermined time intervals to obtain a time-series of cervical images showing changes in the cervical region over time, and reporting a progress of said acquiring to the display subsystem. Moreover, the display subsystem (160) is arranged for establishing a progress indicator (400-416) on the display by generating indicator data (164) and providing the indicator data to the display (060), the progress indicator providing visual feedback on the progress of said acquiring to a user. Accordingly, the user is provided with visual feedback on a status of the acquiring of the cervical images. In particular, the progress indicator avoids that the user experiences a loss of control or confusion.
摘要翻译：本发明提供了一种用于获取子宫颈图像的系统（100），其包括用于在阴道镜检查过程期间获取患者的子宫颈区域的颈部图像（122）的图像采集子系统（120），以及显示子系统（160）通过将宫颈图像的图像数据（162）提供给显示器，在显示器（060）上的子宫颈图像。根据本发明，图像采集子系统（120）被布置为当以间隔模式操作时，以预定的时间间隔获取子宫颈图像（122），以获得显示子宫颈区域变化的子宫颈图像的时间序列时间，并将所述获取的进度报告给显示子系统。此外，显示子系统（160）被安排用于通过产生指示符数据（164）在显示器上建立进度指示器（400-416）并将指示符数据提供给显示器（060），进度指示器提供关于所述获取进展到用户。因此，向用户提供关于获取子宫颈图像的状态的视觉反馈。特别是，进度指标避免了用户失去控制或混乱。

4. 发明申请

WO2015101496A1 METHOD AND APPARATUS FOR CERVICAL IMAGE ANALYSIS WITH IMPROVED RELIABILITY 审中-公开
标题翻译：用于具有改善的可靠性的图像分析的方法和装置
公开(公告)号：WO2015101496A1
公开(公告)日：2015-07-09
申请号：PCT/EP2014/078181
申请日：2014-12-17
申请人： KONINKLIJKE PHILIPS N.V.
发明人： SETH, Subhendu , VAJINEPALLI, Pallavi , KESWARPU, Payal
IPC分类号： A61B1/303 , A61B5/00
CPC分类号： G06T7/0012 , A61B5/0059 , A61B5/4331 , A61B2576/00 , A61M5/007 , G06T2207/10016 , G06T2207/10024 , G06T2207/30096
摘要： The invention relates to a method and an apparatus for cervical image analysis, wherein a transformation zone is identified in an acetic acid image by registering with its Lugol's iodine counterpart. Then, regions in the transformation zone which show significant changes in whiteness are identified as aceto-white regions and registered with the corresponding Lugol's iodine image, and it is determined if the identified regions in the Lugol's iodine image are iodine negative or positive. Based thereon, the aceto-white region can be categorized as one of metaplasia, inflammation or premalignant lesion region.
摘要翻译：本发明涉及一种用于颈部图像分析的方法和装置，其中通过与其Lugol碘对应物配准在乙酸图像中鉴定转化区。然后，显示白度显着变化的转化区的区域被鉴定为乙酰白色区域并且与相应的卢戈碘图像一起登记，并且确定Lugol碘图像中的鉴定区域是碘阴性还是阳性。基于此，乙酰白区可以分为化化，炎症或恶化前病变区之一。

5. 发明申请

WO2014024154A1 CENTRIFUGAL MICROFLUIDIC DEVICE AND METHODS OF USE 审中-公开
标题翻译：离心微流体装置及其使用方法
公开(公告)号：WO2014024154A1
公开(公告)日：2014-02-13
申请号：PCT/IB2013/056479
申请日：2013-08-08
申请人： KONINKLIJKE PHILIPS N.V.
发明人： JAYAVANTH, Sanjay , KESWARPU, Payal , VARMA, Manoj
IPC分类号： B01L3/00
CPC分类号： G01N1/4077 , B01L3/50273 , B01L2300/0806 , B01L2400/0409 , G01N21/07 , G01N21/78 , G01N2001/4083
摘要： Provided herein are systems and methods for separation of heterogeneous analyte. In some embodiments, the systems and methods herein utilize an analyte holding portion that receives a volume of analyte. The analyte holding portion may include an analyte receiving portion and a microfluidic separation channel, A rotatable carrier holding the analyte holding portion may be rotated by a rotational actuator so as to apply a centrifugal force to the volume of analyte such that the analyte is separated into at least two components.
摘要翻译：本文提供了用于分离异质分析物的系统和方法。在一些实施方案中，本文的系统和方法利用接收一定体积的分析物的分析物保持部分。分析物保持部分可以包括分析物接收部分和微流体分离通道。保持分析物保持部分的可旋转载体可以由旋转致动器旋转，以便将分析物体分离成离心力，至少两个组件。

6. 发明申请

WO2013132400A1 APPARATUS FOR DETERMINING A PROPERTY OF A TISSUE 审中-公开
标题翻译：用于确定组织属性的装置
公开(公告)号：WO2013132400A1
公开(公告)日：2013-09-12
申请号：PCT/IB2013/051652
申请日：2013-03-01
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MÜLLER, Manfred , LUCASSEN, Gerhardus Wilhelmus , REICH, Christian , KESWARPU, Payal
IPC分类号： A61B5/00
CPC分类号： A61B5/444 , A61B5/0084 , A61B5/14546 , A61B5/14551 , A61B5/443 , A61B5/4872 , A61B5/7278 , A61B5/7282 , A61B2562/0238 , A61B2562/0242 , A61B2576/00
摘要： The invention relates to an apparatus for determining a property of a tissue, particularly cancer of cervical tissue. A light providing unit (7, 8, 9) provides light for illuminating the tissue (6) and a light detection unit (10) detects light from the tissue, wherein a first signal being indicative of light (11) having been influenced by an epithelium region (R1), a second signal being indicative of light (12) having been influenced by a boundary region (R2) and a third signal being indicative of light (13) having been influenced by a stroma region (R3) are generated, and wherein a tissue property is determined based on the first, second and third signals. This allows for an determination of a tissue property, which is based on a combination of optical properties measured in the three different regions, resulting in an improved determination of the tissue property, in particular in improved cancer detection.
摘要翻译：本发明涉及一种用于确定组织，特别是宫颈组织癌症的性质的装置。光提供单元（7,8,9）提供用于照亮组织（6）的光，并且光检测单元（10）检测来自组织的光，其中指示已经受到产生表示受边界区域（R2）影响的光（12）的第二信号和表示已被基质区域（R3）影响的光（13）的第三信号的上皮区域（R1）并且其中基于所述第一，第二和第三信号确定组织属性。这允许基于在三个不同区域中测量的光学性质的组合来确定组织性质，导致组织性质的改进的确定，特别是在改进的癌症检测中。

7. 发明申请

WO2013150419A1 QUALITY-CHECK DURING MEDICAL IMAGING PROCEDURE 审中-公开
标题翻译：医学成像过程中的质量检查
公开(公告)号：WO2013150419A1
公开(公告)日：2013-10-10
申请号：PCT/IB2013/052455
申请日：2013-03-27
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN LEEUWEN, Marinus Bastiaan , KESWARPU, Payal , FIRTION, Celine , VAJINEPALLI, Pallavi , GUPTA, Vipin , SHAN, Caifeng , VINK, Jelte Peter
IPC分类号： A61B1/00 , A61B1/04 , G06T7/00
CPC分类号： A61B1/00009 , A61B1/04 , G06K9/4652 , G06T7/0012 , G06T7/20 , G06T2207/10068 , G06T2207/20076 , G06T2207/30028 , G06T2207/30092 , G06T2207/30168
摘要： A medical imaging system comprises a colposcope with a camera and a monitoring sub-system. The monitoring sub-system is operative to monitor the quality of the images captured by the camera in order to check whether or not the quality is adequate for subjecting the images to a medical diagnosis.
摘要翻译：医疗成像系统包括具有照相机的阴道镜和监视子系统。监视子系统可操作以监视由照相机拍摄的图像的质量，以便检查质量是否足以对图像进行医学诊断。

8. 发明申请

WO2013121331A1 PHOTONIC PROBE APPARATUS WITH INTEGRATED TISSUE MARKING FACILITY 审中-公开
标题翻译：具有集成组织标记设备的光电探测器
公开(公告)号：WO2013121331A1
公开(公告)日：2013-08-22
申请号：PCT/IB2013/051063
申请日：2013-02-08
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MULLER, Manfred , KESWARPU, Payal , GUPTA, Vipin , FIRTION, Celine
IPC分类号： A61B1/00 , A61B5/00 , A61B1/04 , A61B1/06
CPC分类号： A61B18/14 , A61B1/00165 , A61B1/00179 , A61B1/043 , A61B1/0623 , A61B1/07 , A61B5/0062 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/7275 , A61B5/7282 , A61B5/7405 , A61B5/742 , A61B5/7475 , A61B2017/00473 , A61B2018/00589 , A61B2018/00982 , A61B2560/0443 , A61B2562/0238 , A61B2576/00
摘要： The invention relates to a photonic probe apparatus and a method for probing tissue to detect and mark biological tissue with cancerous or precancerous states. The apparatus involves a probe for illuminating tissue and collecting light from an illuminated tissue region through the probe, a unit for analyzing collected light to determine whether a threshold measure of probability of a cancerous or precancerous lesion in the probed tissue region in contact with the probe is exceeded, and an integrated tissue marking facility which can be activated to mark the probed tissue region through the probe when the threshold measure is exceeded. The photonic probe apparatus and the method are especially suitable for probing regions in squamous and columnar epithelia to detect and mark regions with cervical cancer or cervical intraepithelial neoplasia (CIN).
摘要翻译：本发明涉及一种光子探针装置和一种用于探测组织以检测和标记具有癌性或癌前状态的生物组织的方法。该装置包括用于照射组织并通过探针收集来自照射的组织区域的光的探针，用于分析所收集的光的单元，以确定在与探针接触的探测组织区域中的癌性或癌前病变的概率的阈值度量以及当超过阈值测量时可以被激活以通过探针标记探测组织区域的集成组织标记设备。光子探针装置和方法特别适用于鳞状和柱状上皮的探查区域，以检测和标记具有子宫颈癌或子宫颈上皮内瘤变（CIN）的区域。

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