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1. 发明申请

WO2009156916A2 MELTING CURVE MEASUREMENT DURING AMPLIFICATION 审中-公开
标题翻译：在放大期间调整曲线测量
公开(公告)号：WO2009156916A2
公开(公告)日：2009-12-30
申请号：PCT/IB2009/052599
申请日：2009-06-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , KLUNDER, Derk, J., W. , STAPERT, Hendrik, R. , BOAMFA, Marius, I. , SCHROEDERS, Richard, J., M.
发明人： PIERIK, Anke , KLUNDER, Derk, J., W. , STAPERT, Hendrik, R. , BOAMFA, Marius, I. , SCHROEDERS, Richard, J., M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6837 , C12Q2561/113 , C12Q2531/113 , C12Q2527/107
摘要： The present invention relates to a process for conducting melting curve measurement during amplification. The invention is especially suited for conducting melting curve measurement during simultaneous identification of multiple nucleic acids present in a sample, e.g. a biological sample. The methods of the present invention may be used for clinical diagnostics, for point-of-care diagnostics, for bio-molecular diagnostics, for gene or protein expression arrays, for environmental sensors, and for food quality sensors
摘要翻译：本发明涉及在扩增期间进行熔解曲线测量的方法。本发明特别适用于在同时鉴定样品中存在的多种核酸的情况下进行熔解曲线测量。生物样品。本发明的方法可用于临床诊断，点护理诊断，生物分子诊断，基因或蛋白质表达阵列，环境传感器和食品质量传感器

2. 发明申请

WO2010119396A1 CARTRIDGE FOR AN AMPLIFICATION PROCESS 审中-公开
标题翻译：用于放大过程的盒
公开(公告)号：WO2010119396A1
公开(公告)日：2010-10-21
申请号：PCT/IB2010/051584
申请日：2010-04-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J., W. , PIERIK, Anke , SCHROEDERS, Richard, J., M. , BOAMFA, Marius, I.
发明人： KLUNDER, Derk, J., W. , PIERIK, Anke , SCHROEDERS, Richard, J., M. , BOAMFA, Marius, I.
IPC分类号： B01L7/00 , B01L3/00
CPC分类号： B01L3/5027 , B01J2219/00608 , B01L7/52 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/141 , B01L2300/0609 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0887 , G01N2035/00158 , Y10T29/49826
摘要： The invention relates to real-time array PCR cartridges. The cartridge (100) has a fluid chamber (101) for a fluid bath (102) and a first support element (200) for fixing a microarray (103) in the fluid chamber (101). Thereby the first support element (200) fixes the microarray (103) in such a way that a change of a size of the microarray (103) due to thermal expansion of the microarray (103) is possible without inducing substantial mechanical stress to the cartridge (100). Thereby the cartridge materials chosen independently from thermal expansion coefficients of different microarrays that are to be inserted and fixed into the cartridge (100).
摘要翻译：本发明涉及实时阵列PCR盒。盒（100）具有用于流体槽（102）的流体室（101）和用于将微阵列（103）固定在流体室（101）中的第一支撑元件（200）。因此，第一支撑元件（200）以这样的方式固定微阵列（103），使得由于微阵列（103）的热膨胀而导致的微阵列（103）的尺寸变化是可能的，而不会对盒子造成实质的机械应力（100）。由此，盒材料独立于不同微阵列的热膨胀系数而被选择，其将被插入和固定到盒（100）中。

3. 发明申请

WO2009156915A1 DETECTION OF TAPPED ALIQUOTS OF AMPLIFIED NUCLEIC ACIDS 审中-公开
标题翻译：检测放大的核酸的尖端化合物
公开(公告)号：WO2009156915A1
公开(公告)日：2009-12-30
申请号：PCT/IB2009/052597
申请日：2009-06-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J., W. , PIERIK, Anke , KOLESNYCHENKO, Aleksey , BOAMFA, Marius, I. , SCHROEDERS, Richard, J., M.
发明人： KLUNDER, Derk, J., W. , PIERIK, Anke , KOLESNYCHENKO, Aleksey , BOAMFA, Marius, I. , SCHROEDERS, Richard, J., M.
IPC分类号： B01L1/00 , C12Q1/68
CPC分类号： C12Q1/6837 , B01L3/502 , B01L3/5027 , B01L2200/10 , B01L2300/0636 , B01L2300/1822 , C12Q1/686
摘要： The present invention relates to a process for conducting amplification and detection of nucleic acid sequences employing methods and devices with distinct temperature zones, particularly amplification zone and hybridizations zones. The methods and devices of the present invention may be used for quantitative analysis of target nucleic acid sequences, for simultaneous quantitative analysis of multiple target nucleic acid sequences or for analyzing a sample for the presence of a target nucleic acid.
摘要翻译：本发明涉及使用具有不同温度区，特别是扩增区和杂交区的方法和装置进行核酸序列的扩增和检测的方法。本发明的方法和装置可用于靶核酸序列的定量分析，用于同时定量分析多个靶核酸序列或用于分析样品中靶核酸的存在。

4. 发明申请

WO2009156895A1 AMPLIFICATION OF NUCLEIC ACIDS USING TEMPERATURE ZONES 审中-公开
标题翻译：使用温度区的核酸的放大
公开(公告)号：WO2009156895A1
公开(公告)日：2009-12-30
申请号：PCT/IB2009/052548
申请日：2009-06-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J., W. , PIERIK, Anke , KOLESNYCHENKO, Aleksey , BOAMFA, Marius, I. , SCHROEDERS, Richard, J., M.
发明人： KLUNDER, Derk, J., W. , PIERIK, Anke , KOLESNYCHENKO, Aleksey , BOAMFA, Marius, I. , SCHROEDERS, Richard, J., M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , B01L7/525 , B01L7/54 , B01L2300/088 , B01L2300/0883 , C12Q1/686 , C12Q2565/519 , C12Q2561/113 , C12Q2527/101
摘要： The present invention relates to the amplification and detection of amplified nucleic acid sequences employing methods and devices with distinct temperature zones. The methods and devices of the present invention may be used for quantitative analysis of target nucleic acid sequences, for simultaneous quantitative analysis of multiple target nucleic acid sequences or for analyzing a sample for the presence of a target nucleic acid.
摘要翻译：本发明涉及使用具有不同温度区的方法和装置扩增和检测扩增的核酸序列。本发明的方法和装置可用于靶核酸序列的定量分析，用于同时定量分析多个靶核酸序列或用于分析样品中靶核酸的存在。

5. 发明申请

WO2010058342A1 REAL TIME MULTIPLEX PCR DETECTION ON SOLID SURFACES USING DOUBLE STRANDED NUCLEIC ACID SPECIFIC DYES 审中-公开
标题翻译：使用双重棒状核酸特异性染料对固体表面进行实时多重PCR检测
公开(公告)号：WO2010058342A1
公开(公告)日：2010-05-27
申请号：PCT/IB2009/055119
申请日：2009-11-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , KLUNDER, Derk, J., W. , BOAMFA, Marius, L. , SCHROEDERS, Richard, J., M. , STAPERT, Hendrik, R. , CLOUT, Danielle, E., W.
发明人： PIERIK, Anke , KLUNDER, Derk, J., W. , BOAMFA, Marius, L. , SCHROEDERS, Richard, J., M. , STAPERT, Hendrik, R. , CLOUT, Danielle, E., W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2565/519 , C12Q2565/101 , C12Q2561/113
摘要： The present invention provides method allowing for real time detection of a multitude of target nucleic acids of interest in one reaction (multiplexing) using dyes that are specific for double stranded nucleic acids.
摘要翻译：本发明提供允许使用对双链核酸特异性的染料的一次反应（多重）中实时检测大量目标核酸的方法。

6. 发明申请

WO2010046807A1 REAL-TIME HIGH MULTIPLEX DETECTION BY PRIMER EXTENSION ON SOLID SURFACES 审中-公开
标题翻译：实时高灵敏度检测由固体表面扩展
公开(公告)号：WO2010046807A1
公开(公告)日：2010-04-29
申请号：PCT/IB2009/054490
申请日：2009-10-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , STAPERT, Hendrik, R. , KLUNDER, Derk, J., W.
发明人： PIERIK, Anke , STAPERT, Hendrik, R. , KLUNDER, Derk, J., W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/686 , C12Q2565/537 , C12Q2531/113 , C12Q2565/519 , C12Q2565/501
摘要： The present invention provides a method that allows for real-time detection of a multitude of target nucleic acids of interest in one reaction (multiplexing) using detectable labels of a single color. The method comprises directly amplifying one or more target nucleic acids on a solid substrate thus providing an enhanced signal to noise ratio and reduced assay times. Further provided is a kit for monitoring the amplification of one or more target nucleic acids.
摘要翻译：本发明提供一种允许使用单一颜色的可检测标记在一个反应（多路复用）中实时检测大量目标核酸的方法。该方法包括直接扩增固体底物上的一种或多种靶核酸，从而提供增强的信噪比和减少的测定时间。还提供了用于监测一种或多种靶核酸的扩增的试剂盒。

7. 发明申请

WO2007063459A1 INK JET DEVICE AND METHOD FOR PRODUCING A BIOLOGICAL ASSAY SUBSTRATE BY RELEASING A PLURALITY OF SUBSTANCES ONTO THE SUBSTRATE 审中-公开
标题翻译：用于通过将大量物质释放到基底上来生产生物测定基底的墨水喷射装置和方法
公开(公告)号：WO2007063459A1
公开(公告)日：2007-06-07
申请号：PCT/IB2006/054402
申请日：2006-11-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DIJKSMAN, Johan, F. , PIERIK, Anke , WISMANS, Antonius, J., J. , VAN DEN BESSELAAR, Leonardus, J., C. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J. , VERBEEK, Roy, G., F., A.
发明人： DIJKSMAN, Johan, F. , PIERIK, Anke , WISMANS, Antonius, J., J. , VAN DEN BESSELAAR, Leonardus, J., C. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J. , VERBEEK, Roy, G., F., A.
IPC分类号： B01J19/00 , B01L11/00 , B01L3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01L99/00 , B01L2200/14 , B01L2200/143 , B01L2300/0819 , B01L2400/0439 , G01N35/00663 , G01N35/1002 , G01N2035/1006 , G01N2035/1041
摘要： The invention provides an ink jet device (10) for producing a biological assay- substrate by releasing a plurality of substances onto the substrate, the device comprising printing means (20) , detection means (30,32,45,45' ), filling means and cleaning means (120) , and wherein the ink jet device further comprises control means for an automated production such that the production of the biological assay substrate is error tolerant for a multitude of error sources.
摘要翻译：本发明提供了一种用于通过将多种物质释放到基底上来生产生物测定基板的喷墨装置（10），该装置包括印刷装置（20），检测装置（30,32,45,45'），填充物装置和清洁装置（120），并且其中所述喷墨装置还包括用于自动化生产的控制装置，使得所述生物测定基板的生产对于许多误差源是错误的。

8. 发明申请

WO2009004588A1 POROUS BIOLOGICAL ASSAY SUBSTRATE AND METHOD FOR PRODUCING SUCH SUBSTRATE 审中-公开
标题翻译：多孔生物测定基板及其制造方法
公开(公告)号：WO2009004588A1
公开(公告)日：2009-01-08
申请号：PCT/IB2008/052661
申请日：2008-07-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , DIJKSMAN, Johan, F. , KURT, Ralph , STAPERT, Hendrik, R.
发明人： PIERIK, Anke , DIJKSMAN, Johan, F. , KURT, Ralph , STAPERT, Hendrik, R.
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N33/54393
摘要： The invention provides a porous biological assay substrate suitable for detecting at least one analyte in at least one sample fluid. The substrate is provided with capture probes in plural spot areas, the capture probes being able to each specifically bind at least one target analyte. The substrate comprises a top layer provided with a plurality of holes in a pattern that matches the spot areas. The substrate thereby shows improved binding efficiency. The invention also relates to a method and device for producing the biological assay substrate, and to a method for examining analyte fluids using the substrate.
摘要翻译：本发明提供适用于检测至少一种样品流体中的至少一种分析物的多孔生物测定底物。底物在多个斑点区域中提供捕获探针，捕获探针能够各自特异性结合至少一种靶分析物。衬底包括设置有与斑点区域匹配的图案中的多个孔的顶层。因此，底物显示出提高的结合效率。本发明还涉及用于生产生物测定底物的方法和装置，以及使用该基质检查分析物流体的方法。

9. 发明申请

WO2010038191A1 METHOD FOR TESTING AND QUALITY CONTROLLING OF NUCLEIC ACIDS ON A SUPPORT 审中-公开
标题翻译：用于支持核酸的测试和质量控制的方法
公开(公告)号：WO2010038191A1
公开(公告)日：2010-04-08
申请号：PCT/IB2009/054259
申请日：2009-09-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , STAPERT, Hendrik, R.
发明人： PIERIK, Anke , STAPERT, Hendrik, R.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/518 , C12Q2525/173
摘要： The present invention relates to a method for testing nucleic acids on a support, comprising the immobilization of one or more nucleic acids via crosslinking, wherein each of the immobilized nucleic acids includes a stretch of nucleotides of only one basetype, the provision of labeled oligonucleotides complementary to said stretch of nucleotides, and the determination of a value indicative for the condition of said nucleic acids. The present invention further relates to a kit for testing nucleic acids on a support comprising an array of nucleic acids immobilized on a solid support, wherein each of the immobilized nucleic acids includes a stretch of nucleotides of only one basetype and a labeled oligonucleotide complementary to said stretch of nucleotides. The invention additionally concerns the use of a labeled oligonucleotide complementary to a stretch of nucleotides of only one basetype for testing the condition of nucleic acids immobilized on a solid support.
摘要翻译：本发明涉及一种用于在载体上测试核酸的方法，其包括通过交联固定一种或多种核酸，其中每个固定的核酸包括仅一种碱基类型的一段核苷酸，提供标记的寡核苷酸互补到所述核苷酸区段，以及确定指示所述核酸条件的值。本发明还涉及用于在载体上测试核酸的试剂盒，其包含固定在固体支持物上的核酸阵列，其中每个固定化的核酸包括仅一个碱基型的一段核苷酸和与所述核苷酸延伸。本发明还涉及使用与仅一种碱基类型的一段核苷酸互补的标记的寡核苷酸来测试固定在固体支持物上的核酸的状态。

10. 发明申请

WO2009027932A1 ASSAY SUBSTRATE AND A METHOD FOR PREPARATION 审中-公开
标题翻译：测定基板和制备方法
公开(公告)号：WO2009027932A1
公开(公告)日：2009-03-05
申请号：PCT/IB2008/053426
申请日：2008-08-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , COENE, Willem, M., J., M. , STAPERT, Hendrik, R. , KOLESNYCHENKO, Aleksey
发明人： PIERIK, Anke , COENE, Willem, M., J., M. , STAPERT, Hendrik, R. , KOLESNYCHENKO, Aleksey
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834
摘要： The invention relates to a biological assay substrate and a method to prepare such a substrate. By preparing a biological assay substrate provided with an array of spots, wherein at least part of the spots are mixed spots (that comprise at least a first type of specifically binding capture probe and a second type of specifically binding capture probe, a more efficient use of the area of the substrate is achieved, allowing for more different types of capture probes such as DNA, RNA or antibodies using the same amount of spot locations, without compromising the reliability of the assay.
摘要翻译：本发明涉及生物测定底物和制备这种底物的方法。通过制备具有斑点阵列的生物测定底物，其中至少部分斑点是混合斑点（其包含至少第一类型的特异性结合的捕获探针和第二类特异性结合的捕获探针，更有效的用途实现了底物的面积，允许使用相同量的斑点位置的更多不同类型的捕获探针如DNA，RNA或抗体，而不损害测定的可靠性。

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