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1. 发明申请

WO2002103065A3 METHOD FOR SEGMENTATION OF DIGITAL IMAGES 审中-公开
公开(公告)号：WO2002103065A3
公开(公告)日：2002-12-27
申请号：PCT/IB2002/002349
申请日：2002-06-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WIEMKER, Rafael , PEKAR, Vladimir
发明人： WIEMKER, Rafael , PEKAR, Vladimir
IPC分类号： G06T5/00
摘要： The invention relates to a computationally efficient method for the automated detection of intensity transitions in 2D or 3D image data. Contrasting boundaries in the image are indicated as global or local maxima of a gradient integral function, which is calculated by applying a Laplace operator to the intensity values of each pixel or voxel of the image data set. Only one pass through the image data set is required if the gradient integral function is computed by means of a cumulative histogram technique. The detected intensity thresholds can advantageously be employed for the specification of rendering parameters for visualization purposes. The method of the invention is also well-suited for the rendering and measurement of lung nodules, as the detection of correct intensity thresholds turns out to be crucial for the reproducible and consistent interpretation of medical image data.

2. 发明申请

WO2009016530A3 INTERACTIVE ATLAS TO IMAGE REGISTRATION 审中-公开
公开(公告)号：WO2009016530A3
公开(公告)日：2009-02-05
申请号：PCT/IB2008/052812
申请日：2008-07-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , PEKAR, Vladimir , VIK, Torbjoern , SCHULZ, Heinrich , JAFFRAY, David
发明人： PEKAR, Vladimir , VIK, Torbjoern , SCHULZ, Heinrich , JAFFRAY, David
IPC分类号： G06T7/00
摘要： When modeling anatomical structures in a patient for diagnosis or therapeutic planning, an atlas (26) of predesigned anatomical structure models can be accessed, and model of one or more such structures can be selected and overlaid on an a 3D image of corresponding structure(s) in a clinic image of a patient. A user can click and drag a cursor on the model to deform the model to align with the clinical image. Additionally, a processor (16) can generate a volumetric deformation function using splines, parametric techniques, or the like, and can deform the model to fit the image in real time, in response to user manipulation of the model.

3. 发明申请

WO2008065598A2 A METHOD, AN APPARATUS AND A COMPUTER PROGRAM FOR DATA PROCESSING 审中-公开
标题翻译：一种用于数据处理的方法，装置和计算机程序
公开(公告)号：WO2008065598A2
公开(公告)日：2008-06-05
申请号：PCT/IB2007/054788
申请日：2007-11-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , YOUNG, Stewart , BYSTROV, Daniel , NETSCH, Thomas , KAUS, Michael , PEKAR, Vladimir
发明人： YOUNG, Stewart , BYSTROV, Daniel , NETSCH, Thomas , KAUS, Michael , PEKAR, Vladimir
IPC分类号： G06T7/60
CPC分类号： G06T7/149 , G06T7/12 , G06T7/70 , G06T2207/30016
摘要： The invention relates to a method for data processing. At stage 3 the position of the reference object in the reference image and its relation to a set of reference landmarks in the reference image is established at step 6. In order to enable this, the reference imaging of learning examples may be performed at step 2 and each reference image may be analyzed at step 4, the results may be stored in a suitably arranged database. In order to process the image under consideration, the image is accessed at step 11, the suitable landmark corresponding to the reference landmark in the reference image is identified at step 13 and the spatial relationship established at step 6 is applied to the landmark thereby providing the initial position of the object in the actual image. In case when for the object an imaging volume is selected, the method 1 according to the invention follows to step 7, whereby the scanning 17 is performed within the boundaries given by the thus established scanning volume. In case when for the object a model representative of the target is selected, the method 1 follows to the image segmentation step 19, whereby a suitable segmentation is performed. In case when for the model a deformable model is selected, the segmentation is performed by deforming the model thereby providing spatial boundaries of the target area. The invention further relates to an apparatus and a computer program for image processing.
摘要翻译：本发明涉及一种数据处理方法。在阶段3，在步骤6中建立参考图像中的参考对象的位置及其与参考图像中的一组参考标记的关系。为了实现这一点，可以在步骤2执行学习示例的参考成像并且可以在步骤4分析每个参考图像，结果可以存储在适当布置的数据库中。为了处理所考虑的图像，在步骤11访问图像，在步骤13识别与参考图像中的参考标记相对应的合适地标，并将在步骤6建立的空间关系应用于地标，从而提供物体在实际图像中的初始位置。在对于物体选择成像体积的情况下，根据本发明的方法1遵循步骤7，由此在由这样建立的扫描体积给出的边界内执行扫描17。在针对对象的情况下，选择了表示目标的模型，则对图像分割步骤19进行方法1，由此执行适当的分割。在为模型选择可变形模型的情况下，通过使模型变形从而提供目标区域的空间边界来执行分割。本发明还涉及一种用于图像处理的装置和计算机程序。

4. 发明申请

WO2004109580A2 ANALYSIS OF PULMONARY CT DATA 审中-公开
标题翻译：脉搏CT数据分析
公开(公告)号：WO2004109580A2
公开(公告)日：2004-12-16
申请号：PCT/IB2004/050805
申请日：2004-05-28
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , WIEMKER, Rafael , BLAFFERT, Thomas , PEKAR, Vladimir
发明人： WIEMKER, Rafael , BLAFFERT, Thomas , PEKAR, Vladimir
IPC分类号： G06F19/00
CPC分类号： G06T7/0012
摘要： Ground glass opacities in the lung are non-solid nebular-like shadows in the parenchyma tissue of the lung, which may be precursors of a lung cancer. According to the present invention, ground glass opacities may automatically be determined on the basis of a texture analysis of the parenchyma. Advantageously, according to the present invention, a robust and reliable determination of ground glass opacities may be provided, even if vessels, lung walls, airspace or bronchi walls are present within the local neighborhood of the ground glass opacity.
摘要翻译：肺中的玻璃不透明度是肺实质组织中非固体的星状样阴影，可能是肺癌的前体。根据本发明，可以根据实质的纹理分析自动确定研磨玻璃的不透明度。有利地，根据本发明，即使在玻璃不透明度的局部邻域内存在容器，肺壁，空气或支气管壁，也可以提供坚实可靠的磨玻璃不透明度测定。

5. 发明申请

WO2008139374A1 METHOD FOR PLANNING 2D X-RAY EXAMINATIONS 审中-公开
标题翻译：用于规划2D X射线检查的方法
公开(公告)号：WO2008139374A1
公开(公告)日：2008-11-20
申请号：PCT/IB2008/051785
申请日：2008-05-07
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , PEKAR, Vladimir , WIEMKER, Rafael , BYSTROV, Daniel , OPFER, Roland , VON BERG, Jens , KUHN, Michael, H.
发明人： PEKAR, Vladimir , WIEMKER, Rafael , BYSTROV, Daniel , OPFER, Roland , VON BERG, Jens , KUHN, Michael, H.
IPC分类号： A61B6/04 , A61B6/08
CPC分类号： A61B6/04 , A61B6/08 , A61B6/488
摘要： It is described a method for automatically determine the optimal patient pose and system positioning for X-ray radiographic examinations. The method is based on a first acquiring of one or more ultra- low-dose scout images, which are automatically analyzed by an image processing system. The aim is to compute the parameters for optimal positioning of the patient and the X-ray system such that the diagnostic image corresponds optimally either to an earlier examination in a follow-up study, or to predefined examination-specific standard pose.
摘要翻译：描述了一种用于自动确定X射线照相检查的最佳患者姿势和系统定位的方法。该方法基于第一次获取由图像处理系统自动分析的一个或多个超低剂量侦察图像。目的是计算用于患者和X射线系统的最佳定位的参数，使得诊断图像最佳地对应于随访研究中的较早检查，或预定义的检查特定标准姿态。

6. 发明申请

WO2009093146A1 INTERACTIVE IMAGE SEGMENTATION 审中-公开
标题翻译：互动图像分割
公开(公告)号：WO2009093146A1
公开(公告)日：2009-07-30
申请号：PCT/IB2009/050042
申请日：2009-01-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GREWER, Ruediger , DRIES, Sebastian , BYSTROV, Daniel , PEKAR, Vladimir , VIK, Torbjoern , SCHULZ, Heinrich , KAUS, Michael
发明人： GREWER, Ruediger , DRIES, Sebastian , BYSTROV, Daniel , PEKAR, Vladimir , VIK, Torbjoern , SCHULZ, Heinrich , KAUS, Michael
IPC分类号： G06T7/00
CPC分类号： G06T7/11 , G06T2207/20101 , G06T2207/20128 , G06T2207/30004
摘要： When adapting models of anatomical structures in a patient for diagnosis or therapeutic planning, an atlas (26) of predesigned anatomical structure models or image volumes can be accessed, and a segmentation of one or more such structures can be selected and overlaid on an a 3D image of corresponding structure(s) in a clinical image (52) of a patient. A user can click on an initially unapproved segmentation 5 landmark (72) on the patient image (52), reposition the unapproved landmark, and approve the repositioned landmark. Remaining unapproved landmarks (72) are then repositioned as a function of the position of the approved landmark (92) using one or more interpolation techniques to adapt the model to the patient image on the fly.
摘要翻译：当适应用于诊断或治疗计划的患者中的解剖结构的模型时，可以访问预先设计的解剖结构模型或图像体积的图集（26），并且可以选择并覆盖在3D上的一个或多个这样的结构的分割在患者的临床图像（52）中的相应结构的图像。用户可以点击患者图像（52）上的最初未被批准的分割5地标（72），重新定位未经批准的地标，并批准重新定位的地标。然后通过使用一种或多种内插技术将剩余的未经批准的地标（72）重新定位为批准的地标（92）的位置的函数，以便将模型随时适应患者图像。

7. 发明申请

WO2009019630A2 ANATOMICALLY CONSTRAINED IMAGE REGISTRATION 审中-公开
标题翻译：解密图像注册
公开(公告)号：WO2009019630A2
公开(公告)日：2009-02-12
申请号：PCT/IB2008/053042
申请日：2008-07-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , PEKAR, Vladimir , BYSTROV, Daniel
发明人： PEKAR, Vladimir , BYSTROV, Daniel
IPC分类号： G06T7/00 , A61B5/00
CPC分类号： G06K9/3216 , A61B6/503 , A61B6/504 , G06K2209/05 , G06T7/32 , G06T7/33 , G06T7/337 , G06T2207/10072 , G06T2207/20128 , G06T2207/30012
摘要： The invention relates to a system (100) for registering an atlas image from an atlas of multidimensional images with an objective image, the system comprising a generation unit (105) for generating a candidate transformation for transforming a first region of the atlas image, a transformation unit (110) for transforming the first region of the atlas image using the candidate transformation, a similarity unit (120) for computing a measure of similarity of the transformed first region of the atlas image and a corresponding first region of the objective image, an evaluation unit (130) for evaluating the candidate transformation using a criterion based on the computed measure of similarity and determining an optimal transformation based on the evaluation of the candidate transformation, an extension unit (140) for extending the optimal transformation of the first region of the atlas image to a second region of the atlas image, wherein the second region comprises the first region, thereby creating a registration transformation and a registration unit (150) for transforming the second region using the registration transformation, thereby registering the atlas image with the objective image. Advantageously, the system (100) does not require setting landmark positions in the objective image. A further advantage of the system (100) is that since the similarity measure is computed locally, i.e., based on the first region of the atlas image, the registration is fast and thus attractive for clinical use.
摘要翻译：本发明涉及一种用于从具有客观图像的多维图像的图集登记图集图像的系统（100），该系统包括用于生成用于变换图集的第一区域的候选变换的生成单元（105），变换单元（110），用于使用所述候选变换来变换所述图集的第一区域;相似度单元（120），用于计算所述图集的变换的第一区域与所述客观图像的对应的第一区域的相似度的度量，评估单元（130），用于使用基于所计算的相似度的测量的标准来评估候选变换，并且基于候选变换的评估来确定最佳变换;扩展单元（140），用于扩展第一区域的最优变换的图谱图像到图集图像的第二区域，其中第二区域包括第一区域，由此c 重新配准注册变换和注册单元（150），用于使用注册变换来变换第二区域，由此登记具有客观图像的图集图像。有利地，系统（100）不需要在目标图像中设置界标位置。系统（100）的另一个优点在于，由于本地计算相似性度量，即基于图集图像的第一区域，所以登记是快速的，因此对于临床使用是有吸引力的。

8. 发明申请

WO2004063987A1 METHOD OF SEGMENTING A THREE-DIMENSIONAL STRUCTURE 审中-公开
标题翻译：分配三维结构的方法
公开(公告)号：WO2004063987A1
公开(公告)日：2004-07-29
申请号：PCT/IB2003/006255
申请日：2003-12-15
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , VON BERG, Jens , PEKAR, Vladimir , KAUS, Michael , GERARD, Olivier , ROUET, Jean-Michel , MAKRAM-EBEID, Sherif , FRADKIN, Maxim
发明人： VON BERG, Jens , PEKAR, Vladimir , KAUS, Michael , GERARD, Olivier , ROUET, Jean-Michel , MAKRAM-EBEID, Sherif , FRADKIN, Maxim
IPC分类号： G06T5/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/149 , G06T2207/10072 , G06T2207/30008 , G06T2207/30048
摘要： The invention relates to a method for segmentation of a three-dimensional structure in a three-dimensional data set, especially a medical data set. The method uses a three-dimensional deformable model, wherein the surface of the model consists of a net of polygonal meshes. The meshes are split into groups, and a feature term is assigned to each group. After the model has been placed over the structure of interest, the deformable model is recalculated in consideration of the feature terms of each group.
摘要翻译：本发明涉及三维数据集，特别是医学数据集中三维结构分割的方法。该方法使用三维可变形模型，其中模型的表面由多边形网格网组成。网格被分成组，并且将特征项分配给每个组。在将模型放置在感兴趣的结构之后，考虑到每个组的特征项，重新计算可变形模型。

9. 发明申请

WO2004047029A1 METHOD AND APPARATUS FOR VISUALIZING A SEQUENCE OF VOLUME IMAGES 审中-公开
标题翻译：用于可视化体积图像序列的方法和装置
公开(公告)号：WO2004047029A1
公开(公告)日：2004-06-03
申请号：PCT/IB2003/005130
申请日：2003-11-13
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , WEESE, Jürgen , HEMPEL, Daniel , PEKAR, Vladimir
发明人： WEESE, Jürgen , HEMPEL, Daniel , PEKAR, Vladimir
IPC分类号： G06T17/00
CPC分类号： G06T15/08
摘要： The invention relates to a method and to an apparatus for visualizing a sequence of volume images of a moving object. Methods and apparatus of this kind are used in cases where a sequence of three-dimensional volume images is to be rendered as a two-dimensional image, for example, for a viewer. The invention utilizes the fact that usually only the volume values of a part of the voxels are relevant for the derivation of a two-dimensional image from a volume image. In the case of a sequence of volume images of a moving object, the derivations of the two dimensional images can be accelerated by storing the voxels which are relevant for the visualization during the visualization of a first volume image and by deriving the relevant two-dimensional image during the visualization of a second volume image exclusively from the volume values of the stored voxels and from voxels neighboring such stored voxels. The selection of volume values of neighboring voxels for use is dependent on the motion of the object. The voxels of the second volume image which are relevant for the visualization are stored again and used accordingly for the visualization of a third volume image. These steps are repeated accordingly for further volume images of the sequence.
摘要翻译：本发明涉及一种用于可视化运动物体的体积图像序列的方法和装置。在将三维体积图像的序列作为二维图像（例如，对于观看者）进行渲染的情况下，可以使用这种方法和装置。本发明利用通常只有一部分体素的体积值与从体积图像推导二维图像相关的事实。在运动物体的体积图像的序列的情况下，可以通过在第一体积图像的可视化期间存储与可视化相关的体素来加速二维图像的导出，并且通过导出相关的二维在第二体积图像可视化期间的图像专门来自存储的体素的体积值和与这样存储的体素相邻的体素。选择使用的相邻体元的体积值取决于对象的运动。与可视化相关的第二卷图像的体素被再次存储并相应地用于第三卷图像的可视化。相应地重复这些步骤用于序列的进一步体积图像。

10. 发明申请

WO2007046047A1 MOTION ESTIMATION AND COMPENSATION OF IMAGE SEQUENCES 审中-公开
标题翻译：图像序列的运动估计和补偿
公开(公告)号：WO2007046047A1
公开(公告)日：2007-04-26
申请号：PCT/IB2006/053784
申请日：2006-10-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , MEETZ, Kirsten , BYSTROV, Daniel , PEKAR, Vladimir
发明人： MEETZ, Kirsten , BYSTROV, Daniel , PEKAR, Vladimir
IPC分类号： G06T7/20
CPC分类号： G06T3/4007 , G06T7/246
摘要： The invention relates to a method, a system and a computer program for dynamic imaging of a moving object. First, motion between the elements of common portions of images I m (t), I m+1 (t) is computed. At step 1 motion compensation the said elements is performed, using a suitable transformation. Assuming that I m+1 is the image that has to be transformed, its motion from m to m+1 is compensated applying the inverse motion estimation Formula (I) resulting in the reformatted image Formula (II) at position m. At step 2 grey value interpolation is performed, based on image I m and the transformed image I ’ m+1 resulting in j interpolated images Formula (III) with o i ≤ j . At step 3 spatial interpolation is carried out yielding a series of images for dynamic imaging of the moving object. The spatial interpolation is calculated placing the images Formula (III) at position i resulting in j images Formula (IV) with 0 i ≤ j and the transformation's weighting factor w = i / j .
摘要翻译：本发明涉及用于移动物体的动态成像的方法，系统和计算机程序。首先，计算图像I m（t），I m + 1（t）的公共部分的元素之间的运动。在步骤1中，使用合适的变换来执行所述元件的运动补偿。假设我

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