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1. 发明申请

WO2013001471A3 DISPLAYING A PLURALITY OF REGISTERED IMAGES 审中-公开
公开(公告)号：WO2013001471A3
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053259
申请日：2012-06-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
发明人： BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
IPC分类号： G06T7/00 , G06T19/20
摘要： A system for displaying a plurality of registered images is disclosed. A first viewport unit (1) displays a representation of a first image dataset (4) in a first viewport (201). A second viewport unit (2) displays a representation of a second image dataset (5) in a second viewport (202). A position indication unit (7) enables a user to indicate a position in the first dataset (4) displayed in the first viewport (201), to obtain a user-indicated position. A corresponding position determining unit (8) determines a position in the second image dataset (5) corresponding to the user-indicated position, to obtain a corresponding position in the second image dataset (5), based on correspondence information (9) mapping positions in the first image dataset (4) to corresponding positions in the second image dataset (5). The second viewport unit (2) displays an indication of the corresponding position in the second viewport (202).

2. 发明申请

WO2012156862A1 GENERATING A SLICING SCHEME FOR SLICING A SPECIMEN 审中-公开
标题翻译：生成一个样本的SLI方案
公开(公告)号：WO2012156862A1
公开(公告)日：2012-11-22
申请号：PCT/IB2012/052276
申请日：2012-05-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , MEETZ, Kirsten , BERGTHOLDT, Martin , BUELOW, Thomas , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
发明人： MEETZ, Kirsten , BERGTHOLDT, Martin , BUELOW, Thomas , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
IPC分类号： G01N1/06 , A61B10/00 , G06F9/30
CPC分类号： G01N1/31 , A61B10/0041 , G01N1/06 , G01N2001/2873 , G06T7/0012
摘要： A system for generating a slicing scheme for slicing a specimen is disclosed. A parameter unit (1) is arranged for determining at least one parameter of a lesion in a specimen, based on an image dataset (14) representing at least part of the specimen. A slicing scheme unit (2) is arranged for determining a slicing scheme (15) for pathologic examination of the specimen, based on the at least one parameter. A specimen preparation unit (3) is arranged for determining a slicing preparation protocol, based on the image dataset, wherein the slicing preparation protocol comprises a representation of preparation steps relating to the specimen. A segmentation unit (5) is arranged for segmenting the lesion in the image dataset (14), wherein the parameter unit (1) is arranged for determining the at least one parameter, based on the segmented lesion.
摘要翻译：公开了一种用于产生用于切片试样的切片方案的系统。基于表示至少部分样本的图像数据集（14），配置参数单元（1），用于确定样本中病变的至少一个参数。基于所述至少一个参数，设置切片方案单元（2），用于确定用于所述样本的病理检查的切片方案（15）。一种样本制备单元（3），用于基于图像数据集来确定切片制备方案，其中切片制备方案包括与试样有关的准备步骤的表示。分割单元（5）被布置用于分割图像数据集（14）中的病变，其中参数单元（1）被布置用于基于分割的病变确定至少一个参数。

3. 发明申请

WO2012176100A1 SYSTEM AND METHOD FOR PROCESSING A MEDICAL IMAGE 审中-公开
标题翻译：用于处理医学图像的系统和方法
公开(公告)号：WO2012176100A1
公开(公告)日：2012-12-27
申请号：PCT/IB2012/053007
申请日：2012-06-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
发明人： BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt , WIEMKER, Rafael
IPC分类号： G06T7/00
CPC分类号： G06F3/04845 , G06F3/0485 , G06T7/10 , G06T2207/20092 , G06T2207/20112
摘要： A system (100) for processing a medical image (102), the system being arranged for establishing a region of interest 104 in the medical image, and the system comprising segmentation means (120) for applying a plurality of different segmentation methods (124) to the region of interest for obtaining an associated plurality of segmentation results (122), visualization means (140) for simultaneously displaying the plurality of segmentation results to a user, and a user input (160) for receiving from the user a selection command (162) indicative of a selection of one of the plurality of segmentation results for establishing an associated one of the plurality of different segmentation methods as a selected segmentation method (164).
摘要翻译：一种用于处理医学图像（102）的系统（100），所述系统被布置成用于在医学图像中建立感兴趣区域104，并且所述系统包括用于应用多个不同分割方法（124）的分割装置（120）到用于获得相关联的多个分割结果（122）的感兴趣区域，用于将多个分割结果同时显示给用户的可视化装置（140）和用户输入（160），用于从用户接收选择命令 162），其指示所述多个分割结果之一的选择，用于建立所述多个不同分割方法中的相关联的分割方法作为选择的分割方法（164）。

4. 发明申请

WO2012069990A1 IMAGE PROCESSING APPARATUS 审中-公开
标题翻译：图像处理设备
公开(公告)号：WO2012069990A1
公开(公告)日：2012-05-31
申请号：PCT/IB2011/055232
申请日：2011-11-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WIEMKER, Rafael , BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt
发明人： WIEMKER, Rafael , BUELOW, Thomas , BERGTHOLDT, Martin , MEETZ, Kirsten , CARLSEN, Ingwer-Curt
IPC分类号： G06T11/00
CPC分类号： G06T11/60 , G06T11/00
摘要： Image processing apparatus (100) for creating an overlaid presentation of a first input image (101) and a second input image (102) in an output image (108), the first input image comprising input values, the output image comprising vectors of output values, the vectors of output values representing colors of the output image, and the apparatus comprising an input (110) for obtaining the first input image and the second input image, a rendering unit (140) configured for rendering the first input image in the output image by using a first mapping function for representing the input values in the vectors of output values, a predictor (120) configured for predicting the second input image from the first input image for obtaining a predicted second input image (104), a residual calculator (130) configured for calculating a residual image (106) from the second input image and the predicted second input image, the residual image comprising residual values representing prediction errors of the predicted second input image, and the rendering unit being further configured for rendering the residual image in the output image by using a second mapping function for representing the residual values in the vectors of output values, the second mapping function being different from the first mapping function for distinguishing the residual image from the first input image.
摘要翻译：用于在输出图像（108）中创建第一输入图像（101）和第二输入图像（102）的叠加呈现的图像处理装置（100），所述第一输入图像包括输入值，所述输出图像包括输出矢量值，表示输出图像的颜色的输出值的矢量，以及包括用于获得第一输入图像和第二输入图像的输入（110）的装置，被配置为将第一输入图像呈现在通过使用用于表示输出值的向量中的输入值的第一映射函数来输出图像;预测器（120），被配置为从第一输入图像预测第二输入图像以获得预测的第二输入图像（104），剩余计算器（130），被配置为从所述第二输入图像和所述预测的第二输入图像计算残差图像（106），所述残差图像包括表示所述第二输入图像的预测误差的残差值预测的第二输入图像，并且再现单元还被配置为通过使用用于表示输出值的向量中的残差的第二映射函数来渲染输出图像中的残差图像，第二映射函数不同于第一映射函数用于区分残留图像与第一输入图像。

5. 发明申请

WO2009063390A1 METHOD OF AUTOMATICALLY CORRECTING MIS-ORIENTATION OF MEDICAL IMAGES 审中-公开
标题翻译：自动校正医学影像的方法
公开(公告)号：WO2009063390A1
公开(公告)日：2009-05-22
申请号：PCT/IB2008/054699
申请日：2008-11-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WIEMKER, Rafael , BUELOW, Thomas, B. , BARSCHDORF, Hans , MEETZ, Kirsten , SCHULZ, Heinrich, S.
发明人： WIEMKER, Rafael , BUELOW, Thomas, B. , BARSCHDORF, Hans , MEETZ, Kirsten , SCHULZ, Heinrich, S.
IPC分类号： G06T3/00
CPC分类号： G06T3/0068
摘要： This invention relates to a method and image processing apparatus for automatically correcting mis-orientation of medical images. One or more image processing software modules are used to extract (101) anatomical areas from the medical images. It is determined (103) whether the extracted anatomical areas correspond to reference anatomical areas, but the reference anatomical areas have associated thereto data indicating the orientation of the reference anatomical areas. If the extracted anatomical areas correspond with the reference anatomical areas, the true orientation of the extracted anatomical areas is determined (105) by realigning the medical image until the orientation of the extracted anatomical areas corresponds to the orientation of the reference anatomical areas.
摘要翻译：本发明涉及一种用于自动校正医学图像的错误取向的方法和图像处理装置。使用一个或多个图像处理软件模块从医学图像中提取（101）解剖区域。确定（103）所提取的解剖区域是否对应于参考解剖区域，但是参考解剖区域与其相关联地指示参考解剖区域的取向的数据。如果提取的解剖区域与参考解剖区域相对应，则通过重新对准医学图像来确定提取的解剖区域的真实取向（105），直到提取的解剖区域的取向对应于参考解剖区域的取向。

6. 发明申请

WO2010067219A1 SYNOPSIS OF MULTIPLE SEGMENTATION RESULTS FOR BREAST LESION CHARACTERIZATION 审中-公开
标题翻译：关于乳腺切片特征的多重分期结果概述
公开(公告)号：WO2010067219A1
公开(公告)日：2010-06-17
申请号：PCT/IB2009/055105
申请日：2009-11-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BUELOW, Thomas , WIEMKER, Rafael , BERGTHOLDT, Martin , MEINEL, Lina, Arabash
发明人： BUELOW, Thomas , WIEMKER, Rafael , BERGTHOLDT, Martin , MEINEL, Lina, Arabash
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/136 , G06T2207/10096 , G06T2207/30096
摘要： When characterizing a tumor or lesion as malignant or benign, a system (10) receives an image of the lesion volume (50), employs a processor (12) to perform a raw segmentation of the image, the results of which are stored to memory (14). Then processor then executes a hole-filling procedure to fill in dark areas in the image of the lesion representing necrotic tissue that absorbed little or no contrast agent, and optionally a leakage removal procedure to remove image voxels associated with non-lesion tissue, e.g., blood vessels, in which the contrast agent was present during imaging, to generate a complete lesion volume. A voxel analyzer (18) assesses a number of voxels included in the raw segmentation of the lesion image, and the final segmentation (e.g., after filling and optional leakage removal). A segmentation comparator (20) computes a ratio of dark area voxels related to necrotic tissue detected after the raw segmentation to total voxels detected in the final image segmentation. The ratio is then used to determine a likelihood of malignancy, with a higher ratio indicating a higher likelihood.
摘要翻译：当将肿瘤或病变描绘为恶性或良性时，系统（10）接收病变体积（50）的图像，使用处理器（12）执行图像的原始分割，其结果存储到存储器（14）。然后，处理器然后执行填充填充程序以填充代表坏死组织的损伤图像中的暗区域，其吸收很少或没有造影剂，以及可选地泄漏去除程序以去除与非损伤组织相关联的图像体素，在成像期间存在造影剂的血管，以产生完整的病变体积。体素分析器（18）评估包括在损伤图像的原始分割中的多个体素，以及最终分割（例如在填充和可选的泄漏移除之后）。分割比较器（20）计算与原始分割之后检测到的坏死组织相关的暗区域体素与在最终图像分割中检测到的总体素的比率。然后将该比率用于确定恶性肿瘤的可能性，其中较高的比率表明更高的可能性。

7. 发明申请

WO2012080900A1 METHOD AND DEVICE FOR ANALYSING A REGION OF INTEREST IN AN OBJECT USING X-RAYS 审中-公开
标题翻译：用于分析使用X-RAYS的对象中的兴趣区域的方法和装置
公开(公告)号：WO2012080900A1
公开(公告)日：2012-06-21
申请号：PCT/IB2011/055463
申请日：2011-12-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , CARLSEN, Ingwer-Curt , KOEHLER, Thomas , MARTENS, Gerhard , RÖSSL, Ewald , WIEMKER, Rafael
发明人： CARLSEN, Ingwer-Curt , KOEHLER, Thomas , MARTENS, Gerhard , RÖSSL, Ewald , WIEMKER, Rafael
IPC分类号： G01N23/04 , G01N23/20
CPC分类号： G06T7/0012 , G01N23/046 , G01N2223/419
摘要： A method and a device for analyzing a region of interest in an object is proposed. The method comprises: (a) providing measurement data by a differential phase contrast X-ray imaging system, and (b) analyzing characteristics of the object in the region of interest. Therein, the measurement data comprise a 2-dimensional or 3 -dimensional set of pixels wherein for each pixel the measurement data comprises three types of image data spatially aligned with each other, including (i) absorption representing image data A, (ii) differential phase contrast representing image data D, and (iii) coherence representing image data C. The analyzing step is based, for each pixel, on a combination of at least two of information comprised in the absorption representing image data A and information comprised in the differential phase contrast representing image data D and information comprised in the coherence representing image data C.
摘要翻译：提出了一种用于分析对象中的感兴趣区域的方法和装置。该方法包括：（a）通过差分相位X射线成像系统提供测量数据，以及（b）分析感兴趣区域中物体的特征。其中，测量数据包括2维或3维像素集合，其中对于每个像素，测量数据包括彼此空间对准的三种类型的图像数据，包括（i）表示图像数据A的吸收，（ii）差分表示图像数据D的相位对比度和（iii）表示图像数据C的相干性。分析步骤基于每个像素，包括在表示图像数据A的吸收中包括的信息中的至少两个信息和差分中包含的信息表示图像数据D的相位对比度和表示图像数据C的相干性中包含的信息。

8. 发明申请

WO2012077014A1 METHOD OF PROVIDING A DISPLAYABLE PIXEL DATA SET FROM MEASUREMENT DATA PROVIDED BY A DIFFERENTIAL PHASE CONTRAST X-RAY IMAGING SYSTEM 审中-公开
标题翻译：通过差分相位X射线成像系统提供的测量数据提供可显示像素数据的方法
公开(公告)号：WO2012077014A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/055305
申请日：2011-11-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WIEMKER, Rafael , CARLSEN, Ingwer-Curt , RÖSSL, Ewald , MARTENS, Gerhard , KOEHLER, Thomas
发明人： WIEMKER, Rafael , CARLSEN, Ingwer-Curt , RÖSSL, Ewald , MARTENS, Gerhard , KOEHLER, Thomas
IPC分类号： G06T11/00
CPC分类号： G06T11/001 , G06T2207/10116
摘要： A method for providing a displayable pixel data set (11) from measurement data (3) provided by a differential phase-contrast X-ray imaging system (1) and a device (7) adapted to perform such method are proposed. The measurement data (3) comprise three types of measurement information: an absorption representing image data set A, a differential phase-contrast representing image data set D and a coherence representing image data set C. Each of the image data sets A, D and C comprises a 2-dimensional or 3-dimensional set of pixels (5) and the three image data sets are spatially aligned with each other. In the method for providing a displayable pixel data set, a colour value corresponding to a position in a 3- dimensional colour space (9) is attributed to each pixel (13) in the displayable pixel data set (11), wherein each of three coordinates HSI of the position in the 3-dimensional colour space (9) is determined based on data values A ij , D ij , C ij of a corresponding pixel (5) in a respective one of the image data sets A, D, C. For example, the coordinates within the colour space (9) may be indicated by an intensity I, a saturation S and a hue H thereby allowing a very intuitive representation of the complex DPCI measurement data to a human observer.
摘要翻译：提出了一种从由差分相位对比度X射线成像系统（1）提供的测量数据（3）和适于执行该方法的装置（7）提供可显示像素数据组（11）的方法。测量数据（3）包括三种类型的测量信息：表示图像数据组A的吸收，表示图像数据组D的差分相位对照和表示图像数据组C的相干。每个图像数据组A，D和 C包括2维或3维像素集合（5），并且三个图像数据集在空间上彼此对准。在提供可显示像素数据集的方法中，与可显示像素数据集合（11）中的每个像素（13）相对应的与三维颜色空间（9）中的位置相对应的颜色值，其中三个基于图像数据组A，D，C的相应一个中的对应像素（5）的数据值A ij，D ij，C ij确定三维颜色空间（9）中的位置的坐标HSI 例如，颜色空间（9）内的坐标可以由强度I，饱和度S和色调H来表示，从而允许对人类观察者的复杂DPCI测量数据的非常直观的表示。

9. 发明申请

WO2010018476A3 PROSPECTIVE ADAPTIVE RADIATION THERAPY PLANNING 审中-公开
公开(公告)号：WO2010018476A3
公开(公告)日：2010-02-18
申请号：PCT/IB2009/053187
申请日：2009-07-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , SCHULZ, Heinrich , CARLSEN, Ingwer, C. , WIEMKER, Rafael , MEETZ, Kirsten , YOUNG, Stewart
发明人： SCHULZ, Heinrich , CARLSEN, Ingwer, C. , WIEMKER, Rafael , MEETZ, Kirsten , YOUNG, Stewart
IPC分类号： G06F19/00
摘要： A therapy planner (16) is configured to construct a therapy plan based on a planning image segmented into segments delineating features of a subject. A predictive plan adaptation module (20) is configured to adjust the segments to represent a foreseeable change in the subject and to invoke the therapy planner to construct a therapy plan corresponding to the foreseeable change. A data storage (18) stores a plurality of therapy plans generated for a subject by the therapy planner and the predictive plan adaptation module based on at least one planning image of the subject. A therapy plan selector (30) is configured to select one of the plurality of therapy plans for use in a therapy session based on a preparatory image acquired preparatory to the therapy session.

10. 发明申请

WO2009115935A1 PERFUSION IMAGING 审中-公开
标题翻译：灌注成像
公开(公告)号：WO2009115935A1
公开(公告)日：2009-09-24
申请号：PCT/IB2009/050757
申请日：2009-02-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , MEETZ, Kirsten , CARLSEN, Ingwer , SCHULZ, Heinrich , WIEMKER, Rafael , YOUNG, Stewart
发明人： MEETZ, Kirsten , CARLSEN, Ingwer , SCHULZ, Heinrich , WIEMKER, Rafael , YOUNG, Stewart
IPC分类号： G06F19/00
CPC分类号： G06F19/321 , A61B6/481 , A61B6/504 , A61B6/507 , G06F19/00 , G06T7/0012 , G06T2207/10072 , G06T2207/30016 , G06T2207/30101 , G16H40/63 , G16H50/20 , G16H50/50
摘要： A perfusion analysis system includes a perfusion modeller (120) and a user interface (122). The perfusion modeller (120) generates a patient specific perfusion model based on medical imaging perfusion data for the patient, a general perfusion model, and a quantification of one or more identified pathologies of the patient that affect perfusion in the patient. The user interface (122) accepts an input indicative of a modification to the quantification of the one or more identified pathologies. In response, the perfusion modeller (120) updates the patient specific perfusion model based on the medical imaging perfusion data for the patient, the general perfusion model, and the quantification of the one or more identified pathologies of the patient, including the modification thereto.
摘要翻译：灌注分析系统包括灌注建模器（120）和用户界面（122）。灌注建模器（120）基于患者的医学成像灌注数据，一般灌注模型和影响患者灌注的患者的一个或多个鉴定的病理学的定量产生患者特异性灌注模型。用户界面（122）接受指示对一个或多个所识别的病理学的量化的修改的输入。作为响应，灌注建模器（120）基于患者的医学成像灌注数据，一般灌注模型和患者的一个或多个鉴定的病理学的定量（包括其修改）来更新患者特异性灌注模型。

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