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1. 发明申请

WO2009063368A3 PLASMON GRATING BIOSENSOR 审中-公开
公开(公告)号：WO2009063368A3
公开(公告)日：2009-05-22
申请号：PCT/IB2008/054645
申请日：2008-11-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE BOER, Ruth, W. I. , VAN DIJK, Erik, M. H. P. , GOMEZ RIVAS, Jaime , KLUNDER, Derk, J. W.
发明人： DE BOER, Ruth, W. I. , VAN DIJK, Erik, M. H. P. , GOMEZ RIVAS, Jaime , KLUNDER, Derk, J. W.
IPC分类号： G01N21/55
摘要： The present invention discloses a novel concept for real-time, high-sensitivity optical biosensing that is suitable for cheap and simple incorporation in existing standard microscopes, and other similar apparatuses. Moreover, the present invention proposes to use surface plasmon polaritons (SPPs) on gold structured surfaces to localize the excitation and/or detection volume in an optical biosensor to a range

2. 发明申请

WO2011058488A1 A CHIP HOLDER KIT FOR A WIRE-GIRD SENSOR. 审中-公开
标题翻译：用于线束传感器的芯片支架套件。
公开(公告)号：WO2011058488A1
公开(公告)日：2011-05-19
申请号：PCT/IB2010/055032
申请日：2010-11-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE BOER, Ruth, W. I. , KLUNDER, Derk, J. W. , VAN HERPEN, Maarten, M. J. W. , PENTERMAN, Roel , LUB, Johan , DE WITZ, Christianne, R. M.
发明人： DE BOER, Ruth, W. I. , KLUNDER, Derk, J. W. , VAN HERPEN, Maarten, M. J. W. , PENTERMAN, Roel , LUB, Johan , DE WITZ, Christianne, R. M.
IPC分类号： G01N21/64 , B01L9/00 , G02B21/34
CPC分类号： G01N21/648 , B01L9/52 , B01L2300/0654 , B01L2300/0819 , B01L2300/0822 , G01N33/54373 , G01N2021/0367 , G01N2201/0245 , G02B21/26 , G02B21/34
摘要： This invention relates to a chip holder kit for a wire-grid sensor, where the chip holder kit includes a base plate, where a first aperture is formed at the front side of the base plate, a second aperture is formed at the rear side of the base plate, and an overlapping region where the first and the second apertures overlap. The second aperture has an area that substantially matches the area of the wire-grid sensor and is adapted to removable receive the wire-grid sensor. The first aperture is adapted to removably receive the polarization structure and the first and second apertures are arranged such that when the wire-grid sensor and the polarizer are received in the overlapping region the polarizer filters any incoming excitation light to a transverse electric mode (TE) polarized excitation light before the wire-grid sensor is illuminated.
摘要翻译：本发明涉及一种用于线栅传感器的芯片保持器套件，其中芯片保持器套件包括基板，其中在基板的前侧形成有第一孔，第二孔形成在底板的后侧基板和第一和第二孔重叠的重叠区域。第二孔具有与线栅传感器的面积基本匹配的区域，并适于可移除地接收线栅传感器。第一孔径适于可移除地接收偏振结构，并且第一和第二孔布置成使得当线栅传感器和偏振器被接收在重叠区域中时，偏振器将任何进入的激发光束滤波成横向电模式（TE ）线栅传感器点亮之前的偏振激发光。

3. 发明申请

WO2009001245A1 IMPROVED SENSORS USING SUB-WAVELENGTH APERTURES OR SLITS. 审中-公开
标题翻译：改进的传感器使用亚波长波形或滑块。
公开(公告)号：WO2009001245A1
公开(公告)日：2008-12-31
申请号：PCT/IB2008/052375
申请日：2008-06-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J. W.
发明人： KLUNDER, Derk, J. W.
IPC分类号： G01N21/64 , G01N21/55 , G01N33/53
CPC分类号： G01N21/648 , B82Y15/00 , G01N21/6428
摘要： According to the invention it is proposed a sensor comprising: - a substrate (1) in which an excitation radiation (101,102) having a predetermined wavelength may propagate, - a wiregrid (2) at a first side of said substrate, having at least one aperture or slit arranged for being filled with a medium (10) which comprises at least one particle (51) to be detected, the latter being to be excited via said excitation radiation, and - at least on reflective means (3) arranged, at a second side of said substrate which is opposite to the first side, to reflect towards the wiregrid at least a part of excitation radiation that propagate into the substrate and that has been reflected at least once by the wiregrid.
摘要翻译：根据本发明，提出了一种传感器，包括： - 衬底（1），其中具有预定波长的激发辐射（101,102）可以传播， - 在所述衬底的第一侧的线栅（2），具有至少一个孔或狭缝布置成填充有介质（10），所述介质包括至少一个待检测的颗粒（51），所述至少一个待被检测的颗粒（51）经由所述激发辐射被激发，以及 - 至少在反射装置（3）上布置，所述衬底的与第一侧相对的第二侧，以向钢丝网反射至少一部分传播到衬底中的激发辐射，并且已被钢丝网反射至少一次。

4. 发明申请

WO2009040746A1 SENSOR DEVICE FOR THE DETECTION OF TARGET COMPONENTS 审中-公开
标题翻译：用于检测目标组件的传感器装置
公开(公告)号：WO2009040746A1
公开(公告)日：2009-04-02
申请号：PCT/IB2008/053886
申请日：2008-09-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J. W. , IMMINK, Albert, H.J.
发明人： KLUNDER, Derk, J. W. , IMMINK, Albert, H.J.
IPC分类号： G01N33/543
CPC分类号： G01N21/47 , B01J2219/00317 , B01J2219/005 , B01J2219/00702 , B01L3/5085 , B01L2200/0668 , B01L2300/0636 , B01L2300/0654 , B01L2300/0851 , G01N21/552 , G01N21/7743 , G01N2021/6439 , G01N2021/7773 , G01N2021/7786
摘要： There is provided a microelectronic sensor device for the detection of target components comprising label-particles, comprising a carrier with a binding surface at which target components can collect; a light source for emitting a light beam incident at the binding surface; a light detector for determining the amount of light in a reflected light beam. In one aspect of the invention, the binding surface is provided by a plurality of aperture defining structures having a smallest in plane aperture dimension (W1 ) smaller than a diffraction limit, the diffraction limit defined by a medium for containing the target components. Preferentially, the sensor device is used, wherein target components are non-luminescent.
摘要翻译：提供了一种微电子传感器装置，用于检测包含标记颗粒的靶组分，包括具有目标组分可以收集的结合表面的载体; 用于发射入射在所述装订表面处的光束的光源; 用于确定反射光束中的光量的光检测器。在本发明的一个方面中，结合表面由多个具有小于衍射极限的平面孔径尺寸（W1）的孔限定结构提供，衍射极限由用于包含目标组分的介质限定。优选地，使用传感器装置，其中目标部件是不发光的。

5. 发明申请

WO2010032157A1 WIRE-GRID SENSOR WITH CONTINUOUSLY CONTROLLABLE HEIGHT OF DETECTION VOLUME 审中-公开
标题翻译：具有连续可控高度检测体积的电缆传感器
公开(公告)号：WO2010032157A1
公开(公告)日：2010-03-25
申请号：PCT/IB2009/053915
申请日：2009-09-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk, J. W.
发明人： KLUNDER, Derk, J. W.
IPC分类号： G01N21/64
CPC分类号： G01N21/648
摘要： The invention relates to a wire-grid biosensor assembly for detecting e.g. particles, beads, or molecules,where the height of the detection volume in the wire-grid can be adjusted by illuminating the wire-grid at angles above the critical angle and controlling the mixture of TE and TM polarized light. The wire-grid is formed on a substrate and has slits with a short axis being smaller than the diffraction limit of the applied radiation and a long axis being larger than the diffraction limit. The wire-grid is irradiated with excitation radiation through the substrate at an angle of incidence larger than the critical angle of the interface between the substrate and a medium that fills the slits. By adjusting a linear polarization state, θ, of the excitation radiation with a polarizer, the height of the detection volume in the slits, or similarly the penetration depth of the evanescent field, can be controlled.
摘要翻译：本发明涉及一种线栅生物传感器组件，用于检测粒子，珠子或分子，其中可以通过以高于临界角度的角度照射线栅并且控制TE和TM偏振光的混合来调节线栅中的检测体积的高度。线栅形成在基板上，并且具有短轴的狭缝小于所施加的辐射的衍射极限，并且长轴大于衍射极限。以大于衬底和填充狭缝的介质之间的界面的临界角的入射角以穿过衬底的激发辐射照射线栅。通过用偏振器调节激发辐射的线性偏振态α，可以控制狭缝中的检测体积的高度，或类似地，渐逝场的穿透深度。

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