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1. 发明申请

WO2009138909A1 A MEDICAL ANALYSIS SYSTEM 审中-公开
标题翻译：医学分析系统
公开(公告)号：WO2009138909A1
公开(公告)日：2009-11-19
申请号：PCT/IB2009/051862
申请日：2009-05-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel, J. , DIMITROVA, Nevenka , KAMALAKARAN, Sitharthan , ALSAFADI, Yasser, H. , BANERJEE, Nilanjana , BUCUR, Anca, I., D. , VAN LEEUWEN, Jasper, J., A. , VARADAN, Vinay, VV
发明人： JANEVSKI, Angel, J. , DIMITROVA, Nevenka , KAMALAKARAN, Sitharthan , ALSAFADI, Yasser, H. , BANERJEE, Nilanjana , BUCUR, Anca, I., D. , VAN LEEUWEN, Jasper, J., A. , VARADAN, Vinay, VV
IPC分类号： G06F19/00
CPC分类号： G16H50/70 , G06F19/00 , G06Q50/22
摘要： The present invention relates to effective diagnosis of patients and assisting clinicians in treatment planning. In particular, invention provides a medical analysis system that enables refinement of molecular classification. The system provides a molecular profiling solution that will allow improved diagnosis, prognosis, response prediction to provide the right chemotherapy, and follow-up to monitor for cancer recurrence.
摘要翻译：本发明涉及患者的有效诊断并协助临床医师进行治疗计划。特别地，本发明提供了能够细化分子分类的医学分析系统。该系统提供了一个分子谱分析解决方案，可以改进诊断，预后，反应预测，提供正确的化学疗法和随访监测癌症复发。

2. 发明申请

WO2010131162A9 DEVICE AND METHOD FOR COMPARING MOLECULAR SIGNATURES 审中-公开
公开(公告)号：WO2010131162A9
公开(公告)日：2010-11-18
申请号：PCT/IB2010/051969
申请日：2010-05-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ALSAFADI, Yasser, H. , BANERJEE, Nilanjana , VARADAN, Vinay, VV , JANEVSKI, Angel, J.
发明人： ALSAFADI, Yasser, H. , BANERJEE, Nilanjana , VARADAN, Vinay, VV , JANEVSKI, Angel, J.
IPC分类号： G06F19/00

3. 发明申请

WO2010038173A1 METHOD OF DETERMINING A RELIABILITY INDICATOR FOR SIGNATURES OBTAINED FROM CLINICAL DATA AND USE OF THE RELIABILITY INDICATOR FOR FAVORING ONE SIGNATURE OVER THE OTHER 审中-公开
标题翻译：确定从临床数据中获取的标志的可靠性指标的方法和使用可靠性指标，以便在其他人身上获得一个签名
公开(公告)号：WO2010038173A1
公开(公告)日：2010-04-08
申请号：PCT/IB2009/054176
申请日：2009-09-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel , BANERJEE, Nilanjana , ALSAFADI, Yasser, H. , VARADAN, Vinay
发明人： JANEVSKI, Angel , BANERJEE, Nilanjana , ALSAFADI, Yasser, H. , VARADAN, Vinay
IPC分类号： G06F19/00
CPC分类号： G06F19/24 , G06F19/00 , G16H50/20 , G16H50/70
摘要： This invention relates to a method and an apparatus for determining a reliability indicator for at least one set of signatures obtained from clinical data collected from a group of samples. The signatures are obtained by detecting characteristics in the clinical data from the group of sample sand each of the signatures generate a first set of stratification values that stratify the group of samples. At least one additional and parallel stratification source to the signatures obtained from group of sample sis provided, the at least one additional and parallel stratification source to the signatures being independent from the signatures and generates a second set of stratification values. A comparison is done for each respective sample, where the first stratification values are compared with a true reference stratification values, and where the second stratification values are compared with the true reference stratification values. The signatures are assigned with similarity measure indicators indicating whether the first and the second stratification values match with the true reference stratification values. These are then implementing as input in determining the reliability of the signatures.
摘要翻译：本发明涉及一种用于确定从从一组样本收集的临床数据中获得的至少一组签名的可靠性指标的方法和装置。通过检测来自样品组的临床数据的特征来获得这些特征，每个签名产生分层样本的第一组分层值。至少一个附加和平行分层源提供从样本组提供的签名，所述签名的至少一个附加和平行分层源独立于签名并产生第二组分层值。对每个相应的样本进行比较，其中将第一分层值与真实的参考分层值进行比较，并且将第二分层值与真实的参考分层值进行比较。赋予签名的相似性度量指示符指示第一和第二分层值是否与真实的参考分层值相匹配。然后在确定签名的可靠性时，将其作为输入。

4. 发明申请

WO2009010907A1 DECISION SUPPORT SYSTEM FOR ACUTE DYNAMIC DISEASES 审中-公开
标题翻译：急性动态疾病决策支持系统
公开(公告)号：WO2009010907A1
公开(公告)日：2009-01-22
申请号：PCT/IB2008/052800
申请日：2008-07-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHAFFER, James, D. , SIMPSON, Mark, R. , CHBAT, Nicolas, W. , BANERJEE, Nilanjana , ALSAFADI, Yasser, H.
发明人： SCHAFFER, James, D. , SIMPSON, Mark, R. , CHBAT, Nicolas, W. , BANERJEE, Nilanjana , ALSAFADI, Yasser, H.
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G06F19/00
摘要： The present invention relates to a medical apparatus (901, 100) for assisting clinicians, nurses or other use.rs in choosing an intervention for the treatment of a patent suffering from an acute dynamic disease, e.g. sepsis. The medical apparatus is based on a method where a model of the disease is adapted or personalised to the patient. To ensure that the apparatus remains capable of predicting the health of the patient, the apparatus is continuously- provided with new patient values and the model is continuously adapted to the new patient values. Since the medical apparatus is configured to be continuously adapted to current state of health, the apparatus is able to assist the user by generating disease management information, e.g. suggestions for medications, to an output device (902, 104).
摘要翻译：本发明涉及一种医疗设备（901,100），用于帮助临床医生，护士或其他使用者选择用于治疗患有急性动态疾病的专利的干预措施，例如，败血症。该医疗装置是基于对患者的疾病模型进行适应或个性化的方法。为了确保该装置能够预测患者的健康状态，该装置被连续地提供新的患者值，并且该模型连续适应于新的患者值。由于医疗装置被配置为连续地适应当前健康状态，因此该装置能够通过产生疾病管理信息来辅助用户，例如，对药物的建议，输出设备（902,104）。

5. 发明申请

WO2012168810A3 CROSS-MODAL APPLICATION OF COMBINATION SIGNATURES INDICATIVE OF A PHENOTYPE 审中-公开
公开(公告)号：WO2012168810A3
公开(公告)日：2012-12-13
申请号：PCT/IB2012/052551
申请日：2012-05-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka , SURYANARAYANAN, Sankararaman
发明人： JANEVSKI, Angel , KAMALAKARAN, Sitharthan , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka , SURYANARAYANAN, Sankararaman
IPC分类号： G06F19/18
摘要： The present invention relates to a method of adapting a composite signature of a phenotype. The method comprises the steps of providing for a composite signature of a phenotype with at least two different data types, which were respectively generated by two different modalities of measuring a specimen. Due to an adaption of one part of the signature of the phenotype the resulting adapted phenotype signature can be used as an input for a signature evaluation tool that was derived from data measured by a third modality of measurement.

6. 发明申请

WO2012001576A1 PATHWAY ANALYSIS FOR PROVIDING PREDICTIVE INFORMATION 审中-公开
标题翻译：路径分析提供预测信息
公开(公告)号：WO2012001576A1
公开(公告)日：2012-01-05
申请号：PCT/IB2011/052705
申请日：2011-06-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COLD SPRING HARBOR LABORATORY , BANERJEE, Nilanjana , DIMITROVA, Nevenka , LUCITO, Robert
发明人： BANERJEE, Nilanjana , DIMITROVA, Nevenka , LUCITO, Robert
IPC分类号： G06F19/12
CPC分类号： G06F19/18 , C12Q1/6809 , G06F19/12 , G06F19/20 , G06F19/24
摘要： A method for assigning ranking scores to pathways in a set of pathways for classifying patients is disclosed. The method comprises the steps of comparing biomolecular datasets from different groups of patients and performing an analysis in order to assign ranking scores to pathways in a set of pathways. Furthermore, a method for using cancer pathway evaluation to support clinical decision making is disclosed. This assessment is further used for stratifying ovarian cancer patients based on chemosensitivity to platinum based drugs, the standard chemotherapy. We present the method for evaluation and ranking of the most relevant pathways responsible for platinum sensitivity. Clinical decision support software system should be able to then visualize this information for a clinician, contextualize it within a patient data set and help make a final decision on the potential responsiveness.
摘要翻译：公开了一种用于将排序评分分配给用于分类患者的一组途径中的途径的方法。该方法包括比较来自不同组患者的生物分子数据集并执行分析以便将一系列途径中的路径分配评级的步骤。此外，公开了一种使用癌症途径评估来支持临床决策的方法。该评估进一步用于基于对铂类药物（标准化学疗法）的化学敏感性对卵巢癌患者进行分层。我们介绍了负责铂敏感性的最相关途径的评估和排名方法。临床决策支持软件系统应该能够为临床医生可视化这些信息，并在病人数据集内进行语境化，并帮助对潜在的反应能力做出最终决定。

7. 发明申请

WO2011128820A8 METHODS FOR THE ANALYSIS OF BREAST CANCER DISORDERS 审中-公开
公开(公告)号：WO2011128820A8
公开(公告)日：2011-10-20
申请号：PCT/IB2011/051517
申请日：2011-04-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DIMITROVA, Nevenka , KAPAETTU, Satyamoorthy , GORTHI, Aparna , KABEKKODU, Shama Prasada , CHAKRABARTY, Sanjiban , KESWARPU, Payal , BANERJEE, Nilanjana , JANEVSKI, Angel , HEBBAR, Prashantha , KHANDIGE, Surabhi
发明人： DIMITROVA, Nevenka , KAPAETTU, Satyamoorthy , GORTHI, Aparna , KABEKKODU, Shama Prasada , CHAKRABARTY, Sanjiban , KESWARPU, Payal , BANERJEE, Nilanjana , JANEVSKI, Angel , HEBBAR, Prashantha , KHANDIGE, Surabhi
IPC分类号： C12Q1/68
摘要： The present invention relates to methods, arrays and computer programs for assisting in classifying breast cancer diseases. In particular the invention relates to classifying breast cancer disorders by determining the methylation status of one or more sequences according to SEQ ID NO: 1-111. The classification may be further strengthened by also taking the expression levels of one or more proteins into account.

8. 发明申请

WO2012093363A2 INTEGRATED ACCESS TO AND INTERATION WITH MULTIPLICITY OF CLINICA DATA ANALYTIC MODULES 审中-公开
标题翻译：综合访问和与临床数据分析模块的多重性相关联
公开(公告)号：WO2012093363A2
公开(公告)日：2012-07-12
申请号：PCT/IB2012/050041
申请日：2012-01-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , REICHELT, Christian , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka
发明人： JANEVSKI, Angel , KAMALAKARAN, Sitharthan , REICHELT, Christian , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka
IPC分类号： G06F9/30
CPC分类号： G06F19/3443 , G06F19/00 , G06F19/325 , G16H40/63 , G16H50/70
摘要： A state machine (22) stores a current state (30) comprising a clinical context defined by available patient-related information relating to a medical patient, and identifies one or more available analytical tools of a set of analytical tools (24) that are applicable to the current state. A graphical user interface module (16) receives a user selection of an available analytical tool. The state machine loads patient-related information (40) to the user-selected available analytical tool (24 sel ) and invokes the user-selected available analytical tool to operate on the loaded patient-related information to generate additional patient-related information relating to the medical patient and/or graphical patient-related content relating to the medical patient. The state machine transitions from the current state (30) to a next state (30') and/or invokes the graphical user interface module to display the graphical patient related content.
摘要翻译：状态机（22）存储当前状态（30），其包括由与医疗患者有关的可用患者相关信息定义的临床上下文，并且识别可应用的一组分析工具（24）中的一个或多个可用分析工具到目前状态。图形用户界面模块（16）接收可用分析工具的用户选择。状态机将患者相关信息（40）加载到用户选择的可用分析工具（24sel），并且调用用户选择的可用分析工具对所加载的患者相关信息进行操作，以生成与患者相关的附加信息与患者有关的医疗病人和/或图形患者相关内容。状态机从当前状态（30）转换到下一状态（30'）和/或调用图形用户界面模块以显示图形的患者相关内容。

9. 发明申请

WO2010134023A2 BIOMARKERS BASED ON SETS OF MOLECULAR SIGNATURES 审中-公开
标题翻译：基于分子信号集的生物标记
公开(公告)号：WO2010134023A2
公开(公告)日：2010-11-25
申请号：PCT/IB2010/052208
申请日：2010-05-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSK, Angel , VARADAN, Vinay , BANERJEE, Nilanjana
发明人： JANEVSK, Angel , VARADAN, Vinay , BANERJEE, Nilanjana
IPC分类号： G06F19/00
CPC分类号： G06F19/24 , G06F19/20

10. 发明申请

WO2012104764A3 METHOD FOR ESTIMATION OF INFORMATION FLOW IN BIOLOGICAL NETWORKS 审中-公开
公开(公告)号：WO2012104764A3
公开(公告)日：2012-08-09
申请号：PCT/IB2012/050405
申请日：2012-01-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VARADAN, Vinay , MITTAL, Prateek , KAMALAKARAN, Sitharthan , DIMITROVA, Nevenka , JANEVSKI, Angel , BANERJEE, Nilanjana
发明人： VARADAN, Vinay , MITTAL, Prateek , KAMALAKARAN, Sitharthan , DIMITROVA, Nevenka , JANEVSKI, Angel , BANERJEE, Nilanjana
IPC分类号： G06F19/12 , G06F19/20 , G06F19/24
摘要： The present invention relates to a method for stratifying a patient into a clinically relevant group comprising the identification of the probability of an alteration within one or more sets of molecular data from a patient sample in comparison to a database of molecular data of known phenotypes, the inference of the activity of a biological network on the basis of the probabilities, the identification of a network information flow probability for the patient via the probability of interactions in the network, the creation of multiple instances of network information flow for the patient sample and the calculation of the distance of the patient from other subjects in a patient database using multiple instances of the network information flow. The invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy wherein the biomedical marker or group of biomedical markers comprises altered biological pathway markers, as well as to an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer. Furthermore, a corresponding clinical decision support system is provided.

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