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1. 发明申请

WO2012168810A3 CROSS-MODAL APPLICATION OF COMBINATION SIGNATURES INDICATIVE OF A PHENOTYPE 审中-公开
公开(公告)号：WO2012168810A3
公开(公告)日：2012-12-13
申请号：PCT/IB2012/052551
申请日：2012-05-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka , SURYANARAYANAN, Sankararaman
发明人： JANEVSKI, Angel , KAMALAKARAN, Sitharthan , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka , SURYANARAYANAN, Sankararaman
IPC分类号： G06F19/18
摘要： The present invention relates to a method of adapting a composite signature of a phenotype. The method comprises the steps of providing for a composite signature of a phenotype with at least two different data types, which were respectively generated by two different modalities of measuring a specimen. Due to an adaption of one part of the signature of the phenotype the resulting adapted phenotype signature can be used as an input for a signature evaluation tool that was derived from data measured by a third modality of measurement.

2. 发明申请

WO2012093363A2 INTEGRATED ACCESS TO AND INTERATION WITH MULTIPLICITY OF CLINICA DATA ANALYTIC MODULES 审中-公开
标题翻译：综合访问和与临床数据分析模块的多重性相关联
公开(公告)号：WO2012093363A2
公开(公告)日：2012-07-12
申请号：PCT/IB2012/050041
申请日：2012-01-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , REICHELT, Christian , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka
发明人： JANEVSKI, Angel , KAMALAKARAN, Sitharthan , REICHELT, Christian , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka
IPC分类号： G06F9/30
CPC分类号： G06F19/3443 , G06F19/00 , G06F19/325 , G16H40/63 , G16H50/70
摘要： A state machine (22) stores a current state (30) comprising a clinical context defined by available patient-related information relating to a medical patient, and identifies one or more available analytical tools of a set of analytical tools (24) that are applicable to the current state. A graphical user interface module (16) receives a user selection of an available analytical tool. The state machine loads patient-related information (40) to the user-selected available analytical tool (24 sel ) and invokes the user-selected available analytical tool to operate on the loaded patient-related information to generate additional patient-related information relating to the medical patient and/or graphical patient-related content relating to the medical patient. The state machine transitions from the current state (30) to a next state (30') and/or invokes the graphical user interface module to display the graphical patient related content.
摘要翻译：状态机（22）存储当前状态（30），其包括由与医疗患者有关的可用患者相关信息定义的临床上下文，并且识别可应用的一组分析工具（24）中的一个或多个可用分析工具到目前状态。图形用户界面模块（16）接收可用分析工具的用户选择。状态机将患者相关信息（40）加载到用户选择的可用分析工具（24sel），并且调用用户选择的可用分析工具对所加载的患者相关信息进行操作，以生成与患者相关的附加信息与患者有关的医疗病人和/或图形患者相关内容。状态机从当前状态（30）转换到下一状态（30'）和/或调用图形用户界面模块以显示图形的患者相关内容。

3. 发明申请

WO2012104764A3 METHOD FOR ESTIMATION OF INFORMATION FLOW IN BIOLOGICAL NETWORKS 审中-公开
公开(公告)号：WO2012104764A3
公开(公告)日：2012-08-09
申请号：PCT/IB2012/050405
申请日：2012-01-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VARADAN, Vinay , MITTAL, Prateek , KAMALAKARAN, Sitharthan , DIMITROVA, Nevenka , JANEVSKI, Angel , BANERJEE, Nilanjana
发明人： VARADAN, Vinay , MITTAL, Prateek , KAMALAKARAN, Sitharthan , DIMITROVA, Nevenka , JANEVSKI, Angel , BANERJEE, Nilanjana
IPC分类号： G06F19/12 , G06F19/20 , G06F19/24
摘要： The present invention relates to a method for stratifying a patient into a clinically relevant group comprising the identification of the probability of an alteration within one or more sets of molecular data from a patient sample in comparison to a database of molecular data of known phenotypes, the inference of the activity of a biological network on the basis of the probabilities, the identification of a network information flow probability for the patient via the probability of interactions in the network, the creation of multiple instances of network information flow for the patient sample and the calculation of the distance of the patient from other subjects in a patient database using multiple instances of the network information flow. The invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy wherein the biomedical marker or group of biomedical markers comprises altered biological pathway markers, as well as to an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer. Furthermore, a corresponding clinical decision support system is provided.

4. 发明申请

WO2012046191A2 IDENTIFICATION OF MULTI-MODAL ASSOCIATIONS BETWEEN BIOMEDICAL MARKERS 审中-公开
标题翻译：鉴定生物医学标记之间的多模式协会
公开(公告)号：WO2012046191A2
公开(公告)日：2012-04-12
申请号：PCT/IB2011/054366
申请日：2011-10-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COLD SPRING HARBOR LABORATORY , BANERJEE, Nilanjana , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , VARADAN, Vinay , DIMITROVA, Nevenka , LUCITO, Robert
发明人： BANERJEE, Nilanjana , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , VARADAN, Vinay , DIMITROVA, Nevenka , LUCITO, Robert
IPC分类号： G06F19/12
CPC分类号： G06F19/20 , G06F19/12 , G06F19/18
摘要： The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said biomedical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10,FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, 1 diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer, is provided, as well as a corresponding method for classifying a subject comprising and a medical decision support system.
摘要翻译：本发明涉及一种用于识别生物医学标记之间的多模式关联的方法，其允许确定网络节点和/或高排名网络成员或其组合，指示具有用于医疗状况的诊断，预后或预测值，特别是卵巢癌。本发明还涉及与受试者对癌症治疗（优选基于铂的癌症治疗）的高反应性的高可能性相关联的生物医学标记物或生物医学标记物组，其中所述生物医学标记物或生物医学标记物组包含至少1， 2，3，4，5，6，7，8，9，10，11，12，13，14，15，16，17，8，19，20或者所有选自PKMYT1，SKIL，RAB8A，HIRIP3， CTNNB1，NGFR，ZCCHC11，LSP1，CD200，PAX8，CYBRD1，HOXC11，TCEAL1，FZD10，FZD1，BBS4，IRS2，TLX3，TSPAN2，TXN和CFLAR。此外，提供了用于检测，诊断，毕业，监测或预测医学状况或用于检测1诊断，监测或预测受试者对于针对所述医学病症，特别是卵巢癌的治疗的反应性的测定法，作为以及用于分类受试者的相应方法以及医疗决策支持系统。

5. 发明申请

WO2011128820A8 METHODS FOR THE ANALYSIS OF BREAST CANCER DISORDERS 审中-公开
公开(公告)号：WO2011128820A8
公开(公告)日：2011-10-20
申请号：PCT/IB2011/051517
申请日：2011-04-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DIMITROVA, Nevenka , KAPAETTU, Satyamoorthy , GORTHI, Aparna , KABEKKODU, Shama Prasada , CHAKRABARTY, Sanjiban , KESWARPU, Payal , BANERJEE, Nilanjana , JANEVSKI, Angel , HEBBAR, Prashantha , KHANDIGE, Surabhi
发明人： DIMITROVA, Nevenka , KAPAETTU, Satyamoorthy , GORTHI, Aparna , KABEKKODU, Shama Prasada , CHAKRABARTY, Sanjiban , KESWARPU, Payal , BANERJEE, Nilanjana , JANEVSKI, Angel , HEBBAR, Prashantha , KHANDIGE, Surabhi
IPC分类号： C12Q1/68
摘要： The present invention relates to methods, arrays and computer programs for assisting in classifying breast cancer diseases. In particular the invention relates to classifying breast cancer disorders by determining the methylation status of one or more sequences according to SEQ ID NO: 1-111. The classification may be further strengthened by also taking the expression levels of one or more proteins into account.

6. 发明申请

WO2010038173A1 METHOD OF DETERMINING A RELIABILITY INDICATOR FOR SIGNATURES OBTAINED FROM CLINICAL DATA AND USE OF THE RELIABILITY INDICATOR FOR FAVORING ONE SIGNATURE OVER THE OTHER 审中-公开
标题翻译：确定从临床数据中获取的标志的可靠性指标的方法和使用可靠性指标，以便在其他人身上获得一个签名
公开(公告)号：WO2010038173A1
公开(公告)日：2010-04-08
申请号：PCT/IB2009/054176
申请日：2009-09-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel , BANERJEE, Nilanjana , ALSAFADI, Yasser, H. , VARADAN, Vinay
发明人： JANEVSKI, Angel , BANERJEE, Nilanjana , ALSAFADI, Yasser, H. , VARADAN, Vinay
IPC分类号： G06F19/00
CPC分类号： G06F19/24 , G06F19/00 , G16H50/20 , G16H50/70
摘要： This invention relates to a method and an apparatus for determining a reliability indicator for at least one set of signatures obtained from clinical data collected from a group of samples. The signatures are obtained by detecting characteristics in the clinical data from the group of sample sand each of the signatures generate a first set of stratification values that stratify the group of samples. At least one additional and parallel stratification source to the signatures obtained from group of sample sis provided, the at least one additional and parallel stratification source to the signatures being independent from the signatures and generates a second set of stratification values. A comparison is done for each respective sample, where the first stratification values are compared with a true reference stratification values, and where the second stratification values are compared with the true reference stratification values. The signatures are assigned with similarity measure indicators indicating whether the first and the second stratification values match with the true reference stratification values. These are then implementing as input in determining the reliability of the signatures.
摘要翻译：本发明涉及一种用于确定从从一组样本收集的临床数据中获得的至少一组签名的可靠性指标的方法和装置。通过检测来自样品组的临床数据的特征来获得这些特征，每个签名产生分层样本的第一组分层值。至少一个附加和平行分层源提供从样本组提供的签名，所述签名的至少一个附加和平行分层源独立于签名并产生第二组分层值。对每个相应的样本进行比较，其中将第一分层值与真实的参考分层值进行比较，并且将第二分层值与真实的参考分层值进行比较。赋予签名的相似性度量指示符指示第一和第二分层值是否与真实的参考分层值相匹配。然后在确定签名的可靠性时，将其作为输入。

7. 发明申请

WO2010055487A2 COMPOSITIONS AND METHODS FOR MICRO-RNA EXPESSION PROFILING OF COLORECTAL CANCER 审中-公开
标题翻译：组合物和方法用于微小RNA显色分析
公开(公告)号：WO2010055487A2
公开(公告)日：2010-05-20
申请号：PCT/IB2009/055057
申请日：2009-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WU, Ying , ZHU, Hongguang , LI, Jian , XU, Liang , VERHAEGH, Wilhelmus, F., J. , REN, Yiping , JANEVSKI, Angel , VARADAN, Vinay , LI, Zhaoyong , DIMITROVA, Nevenka
发明人： WU, Ying , ZHU, Hongguang , LI, Jian , XU, Liang , VERHAEGH, Wilhelmus, F., J. , REN, Yiping , JANEVSKI, Angel , VARADAN, Vinay , LI, Zhaoyong , DIMITROVA, Nevenka
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12N2330/31 , C12Q1/6816 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结肠直肠癌的微小RNA（miRNA）表达谱的组合物和方法。特别地，本发明涉及用于鉴定表现出或具有发生结肠直肠癌倾向的一种或多种哺乳动物靶细胞的分子标记用诊断试剂盒，所述试剂盒包含多个核酸分子，编码miRNA序列的每个核酸分子，其中所述多个核酸分子中的一个或多个在靶细胞和一个或多个对照细胞中差异表达，并且其中所述一个或多个差异表达的核酸分子一起表示指示存在的核酸表达特征或发生结肠直肠癌的倾向。本发明还涉及使用这种核酸表达特征鉴定一种或多种表现出或具有发生结肠直肠癌倾向的哺乳动物靶细胞以及预防或治疗这种病症的相应方法。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

8. 发明申请

WO2010086782A2 METHODS FOR THE SUBCLASSIFICATION OF BREAST TUMOURS 审中-公开
标题翻译：乳腺肿瘤再分类方法
公开(公告)号：WO2010086782A2
公开(公告)日：2010-08-05
申请号：PCT/IB2010/050316
申请日：2010-01-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COLD SPRING HARBOR LABORATORY , KAMALAKARAN, Sitharthan , JANEVSKI, Angel , HICKS, James, B.
发明人： KAMALAKARAN, Sitharthan , JANEVSKI, Angel , HICKS, James, B.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/112 , C12Q2600/154 , Y10T436/143333 , C12Q2537/165
摘要： Provided is a method for the analysis of breast cancer disorders, comprising determining the genomic methylation status of one or more CpG dinucleotides. Furthermore, a computer program product stored on a computer-readable medium comprising software code adapted to perform the steps of the method when executed on a data-processing apparatus is provided. A device comprising means for supporting a clinician is also provided.
摘要翻译：提供了一种用于分析乳腺癌疾病的方法，包括测定一种或多种CpG二核苷酸的基因组甲基化状态。此外，提供了存储在计算机可读介质上的计算机程序产品，其包括适于在数据处理装置上执行时执行所述方法的步骤的软件代码。还提供了一种包括用于支撑临床医生的装置的装置。

9. 发明申请

WO2003084229A1 METHOD AND SYSTEM FOR PROVIDING COMPLEMENTARY INFORMATION FOR A VIDEO PROGRAM 审中-公开
标题翻译：为视频节目提供补充信息的方法和系统
公开(公告)号：WO2003084229A1
公开(公告)日：2003-10-09
申请号：PCT/IB2003/001344
申请日：2003-04-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZIMMERMAN, John , DIMITROVA, Nevenka , LI, Dongge , BONT, Johanna, M. , LAMERS, Andreas, H., E. , JANEVSKI, Angel , NIKOLOVSKA, Lira
发明人： ZIMMERMAN, John , DIMITROVA, Nevenka , LI, Dongge , BONT, Johanna, M. , LAMERS, Andreas, H., E. , JANEVSKI, Angel , NIKOLOVSKA, Lira
IPC分类号： H04N7/16
CPC分类号： H04N21/454 , H04N5/445 , H04N7/163 , H04N7/17318 , H04N21/4307 , H04N21/4331 , H04N21/4532 , H04N21/4622 , H04N21/4722 , H04N21/4782 , H04N21/482 , H04N21/6581 , H04N21/84 , H04N21/8586
摘要： A method for providing complementary information 226 for a video program is provided that includes receiving complementary information 226 for a video program. A query is received from a consumer. The query is related to a specified portion of the complementary information 226. A query response is provided to the consumer based on the specified portion of the complementary information 226.
摘要翻译：提供了一种用于为视频节目提供补充信息226的方法，其包括为视频节目接收补充信息226。从消费者接收到查询。查询与补充信息226的指定部分相关。基于补充信息226的指定部分向消费者提供查询响应。

10. 发明申请

WO2003084230A1 METHOD AND SYSTEM FOR PROVIDING PERSONALIZED NEWS 审中-公开
标题翻译：提供个性化新闻的方法和系统
公开(公告)号：WO2003084230A1
公开(公告)日：2003-10-09
申请号：PCT/IB2003/001375
申请日：2003-04-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZIMMERMAN, John , NIKOLOVSKA, Lira , DE BONT, Johanna, M. , LAMERS, Andreas, H., E. , DIMITROVA, Nevenka , JANEVSKI, Angel , AGNIHOTRI, Lalitha
发明人： ZIMMERMAN, John , NIKOLOVSKA, Lira , DE BONT, Johanna, M. , LAMERS, Andreas, H., E. , DIMITROVA, Nevenka , JANEVSKI, Angel , AGNIHOTRI, Lalitha
IPC分类号： H04N7/16
CPC分类号： H04N21/454 , H04N5/445 , H04N7/163 , H04N21/25891 , H04N21/4331 , H04N21/4532 , H04N21/458 , H04N21/4622 , H04N21/488 , H04N21/8126 , H04N21/858
摘要： A method for providing personalized news to a consumer is provided that includes receiving news from a plurality of external sources. A subset of the received news is identified based on a consumer profile for the consumer. The identified news is stored. The stored news is prioritized. At least a portion of the prioritized news is provided to the consumer.
摘要翻译：提供了一种向消费者提供个性化消息的方法，其包括从多个外部源接收消息。基于消费者的消费者资料识别收到的消息的一个子集。存储已识别的消息。储存的新闻优先。向消费者提供至少一部分优先消息。

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