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1. 发明申请

WO2013061257A1 FILTERING PARTICLES FROM BLOOD OR OTHER MEDIA 审中-公开
标题翻译：从血液或其他媒体过滤颗粒
公开(公告)号：WO2013061257A1
公开(公告)日：2013-05-02
申请号：PCT/IB2012/055844
申请日：2012-10-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V.
发明人： WIMBERGER-FRIEDL, Reinhold , VAN DE STOLPE, Anja , VAN HEMERT, Freek
IPC分类号： G01N15/14 , B01L3/00
CPC分类号： G01N15/1475 , B01L3/502753
摘要： A filter element (200) and a method are disclosed for retaining particles of a medium, for example (rare) cells of blood. The filter element (200) comprises at least one opening (220) that (i) has an elongate cross section and/or (ii) has a cross section that decreases in flow direction (x) and/or (iii) is bordered by a transparent wall. Preferably, the filter element (100, 200, 300) is provided with a plurality of elongate openings (220) of stepwise decreasing cross section that are arranged on a common transparent slide. Thus high flow rates can be realized throughout the filtering process, and the retained particles are immediately ready for visual inspection without a need for a further transfer.
摘要翻译：公开了一种过滤元件（200）和方法，用于保持介质的颗粒，例如（稀有）血液细胞。过滤元件（200）包括至少一个开口（220），其中（i）具有细长的横截面和/或（ii）具有沿流动方向（x）减小的横截面和/或（iii）一个透明的墙。优选地，过滤元件（100,200,300）设置有布置在共同的透明载玻片上的多个逐步减小横截面的细长开口（220）。因此，在整个过滤过程中可以实现高流速，并且保留的颗粒立即准备好进行目视检查，而不需要进一步的转移。

2. 发明申请

WO2013008142A1 FILTER SUPPORT WITH A PHASE-CHANGING MEDIUM 审中-公开
标题翻译：过滤器支持与相位变化中
公开(公告)号：WO2013008142A1
公开(公告)日：2013-01-17
申请号：PCT/IB2012/053408
申请日：2012-07-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRINS, Menno Willem Jose , OVSYANKO, Mikhail Mikhaylovich , VAN HEMERT, Freek , VAN DOORN, Arie Rombertus
发明人： PRINS, Menno Willem Jose , OVSYANKO, Mikhail Mikhaylovich , VAN HEMERT, Freek , VAN DOORN, Arie Rombertus
IPC分类号： G01N1/36 , G01N1/28 , G02B21/34 , G01N33/48
CPC分类号： G01N1/30 , G01N1/2813 , G01N1/36 , G01N33/48 , G01N33/569 , G02B21/34
摘要： The present invention relates to a method for processing isolated cells, in particular rare cells such as circulating tumor cells, to render them suitable for optical imaging, comprising the steps of (a) depositing filter material comprising captured cells on a phase-change medium; (b) melting said phase-change medium until the medium is spread out below said filter material; and (c) lowering the temperature of said phase-change medium until the medium solidifies, resulting in an optically flat filter comprising said cells at a fixed position. The method may additionally comprise an initial step of capturing a cell on a filter material. The phase-change medium, preferably paraffin wax, may comprise a porous, or mesh-like structure allowing the passage of a fluid through the medium. The phase-change medium may further be mounted on a carrier such as a glass carrier or a polymer material carrier. The present invention further relates to processed filter material comprising isolated cells suitable for optical imaging, which is obtainable by the method; the use of such filter material for diagnostic, histological, microbiological, biochemical, oncologic, or hematologic analysis, as well as a device for isolating cells or processing cells to render them suitable for optical imaging.
摘要翻译：本发明涉及一种用于处理分离的细胞，特别是稀有细胞例如循环肿瘤细胞以使其适合于光学成像的方法，包括以下步骤：（a）将包含捕获的细胞的过滤材料沉积在相变介质上; （b）熔化所述相变介质，直到介质在所述过滤材料之下展开; 和（c）降低所述相变介质的温度，直到介质凝固，得到包含所述电池在固定位置的光学平面滤光器。该方法可以另外包括在过滤材料上捕获细胞的初始步骤。相变介质，优选石蜡，可以包括允许流体通过介质的多孔或网状结构。相变介质还可以安装在诸如玻璃载体或聚合物材料载体的载体上。本发明还涉及包含可通过该方法获得的适于光学成像的分离的细胞的经处理过滤材料; 使用这种过滤材料进行诊断，组织学，微生物学，生物化学，肿瘤学或血液学分析，以及用于分离细胞或处理细胞以使其适合于光学成像的装置。

3. 发明申请

WO2012172503A1 PROCESSING OF BIOLOGICAL SAMPLE COMPONENTS 审中-公开
标题翻译：生物样品成分的处理
公开(公告)号：WO2012172503A1
公开(公告)日：2012-12-20
申请号：PCT/IB2012/053005
申请日：2012-06-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , OVSYANKO, Mikhail, Mikhaylovich , VAN HEMERT, Freek , PRINS, Menno, Willem, Jose , VAN DE STOLPE, Anja , WIMBERGER-FRIEDL, Reinhold
发明人： OVSYANKO, Mikhail, Mikhaylovich , VAN HEMERT, Freek , PRINS, Menno, Willem, Jose , VAN DE STOLPE, Anja , WIMBERGER-FRIEDL, Reinhold
IPC分类号： B03C1/01 , B03C1/28 , G01N33/543
CPC分类号： G01N33/54333 , B03C1/01 , B03C1/288 , B03C1/30 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N33/57492 , Y10T436/255
摘要： The invention relates to means for processing a sample fluid containing different components, particularly magnetic particles (M) and targets (cells) (C+M) labeled with magnetic particles. A processing device(100) according to the invention comprises a container (110) with a first compartment (120) that can be filled with a sample fluid and that is separated from a second compartment (130) by a filtering element (140). The filtering element (140) allows the passage of only at least one selected component(M) of the sample. Moreover, an optical surface (150), for example a microscopy slide, is provided in one (120) of the compartments. Components (C+M) of the sample that are in this compartment (120) collect on the optical surface (150). The migration of sample components (M, C+M) is preferably assisted by magnetic fields (B1, B2).
摘要翻译：本发明涉及用于处理含有用磁性颗粒标记的不同组分，特别是磁性颗粒（M）和靶（细胞）（C + M）的样品流体的装置。根据本发明的处理装置（100）包括具有第一隔室（120）的容器（110），所述第一隔室可以填充有样品流体，并且通过过滤元件（140）与第二隔室（130）分离。过滤元件（140）允许只有样品的至少一个选定组分（M）通过。此外，在一个（120）隔室中提供光学表面（150），例如显微镜载玻片。在该隔室（120）中的样品的组分（C + M）聚集在光学表面（150）上。样品组分（M，C + M）的迁移优选由磁场（B1，B2）辅助。

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