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1. 发明申请

WO2011027268A3 DEVICES AND METHODS FOR MICROARRAY SELECTION 审中-公开
标题翻译： MICROARRAY选择的设备和方法
公开(公告)号：WO2011027268A3
公开(公告)日：2011-06-16
申请号：PCT/IB2010053839
申请日：2010-08-26
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER ZAAG PIETER JAN , FEITSMA HARMA MARTINE , DEN TOONDER JACOB MARINUS JAN , WIMBERGER-FRIEDL REINHOLD
发明人： VAN DER ZAAG PIETER JAN , FEITSMA HARMA MARTINE , DEN TOONDER JACOB MARINUS JAN , WIMBERGER-FRIEDL REINHOLD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q2537/149 , C12Q2527/107
摘要： The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.
摘要翻译：本发明涉及用于特异性选择靶分子的装置，其包括：（a）包含微阵列的至少一个反应区，其中所述微阵列包含其上固定有一种或多种捕获分子的底物，其包含一个或更多温度控制和/或调节单元，用于控制和/或调节该区域内的温度; （b）至少一个非反应区，包括一个或多个温度控制和/或调节单元，用于控制和/或调节与反应区流体连通的区域内的温度; 和（c）能够产生和/或调节所述反应区（a）和包括一个或多个温度控制和/或调节单元（b）的所述非反应区之间的流体流动的至少一个输送装置。本发明还涉及用于特异性选择靶分子的装置，其中固定的捕获分子以斑点，细长斑点和/或线的形式组织在微阵列中。在另一方面，本发明涉及一种特异性选择靶分子的方法，包括向这种装置中引入培养基，在反应区中进行相互作用反应，将不相互作用或不结合的靶分子传输到允许重新激活目标分子，并在反应区域与再活化的靶分子进行额外的相互作用反应，以及使用这种用于特异性选择靶分子的装置，例如对于目标富集，文献中也称为基于微阵列的基因组选择（MGS）。

2. 发明申请

WO2007034404A2 A MICROFLUIDIC REGULATING DEVICE 审中-公开
标题翻译：微流控制器件
公开(公告)号：WO2007034404A2
公开(公告)日：2007-03-29
申请号：PCT/IB2006053357
申请日：2006-09-19
申请人： KONINKL PHILIPS ELECTRONICS NV , WIMBERGER-FRIEDL REINHOLD , HIKMET RIFAT ATA MUSTAFA , VAN BOMMEL TIES , DEN TOONDER JACOB MARINUS JAN , YAVUZ MEIKE
发明人： WIMBERGER-FRIEDL REINHOLD , HIKMET RIFAT ATA MUSTAFA , VAN BOMMEL TIES , DEN TOONDER JACOB MARINUS JAN , YAVUZ MEIKE
IPC分类号： B01L3/00
CPC分类号： F15C3/04 , B01L3/502738 , B01L2200/12 , B01L2400/0487 , B01L2400/0633 , B01L2400/0638 , Y10T137/2191 , Y10T137/2202 , Y10T137/2213
摘要： The invention relates to a microfluidic regulating device, comprising a first layer having a first microfluidic channel defined therein, a second layer having a second microfluidic channel defined therein, a fluid flow regulating layer disposed between the first and the second microfluidic channel, which layer comprises a movable valve member which in open position allows fluid communication between the first and second channel and in closed position seals against a valve seat, whereby at least part of the valve member and of the valve seat is magnetic. The device is able to store small quantities of liquids at microfluidic cartridges and access these on demand in a well controlled and simple way.
摘要翻译：本发明涉及一种微流体调节装置，其包括具有限定在其中的第一微流体通道的第一层，其中限定有第二微流体通道的第二层，设置在第一和第二微流体通道之间的流体流动调节层，该层包括处于打开位置的可移动阀构件允许第一和第二通道之间的流体连通并且在关闭位置中密封抵靠阀座，由此阀构件和阀座的至少一部分是磁性的。该设备能够在微流控盒中储存少量液体，并以良好控制和简单的方式随时访问。

3. 发明申请

WO2006067715A3 METHOD FOR CONTROLLING THE FLOW OF LIQUIDS CONTAINING BIOLOGICAL MATERIAL BY INDUCING ELECTRO- OR MAGNETO-RHEOLOGICAL EFFECT 审中-公开
标题翻译：通过诱导电磁流变效应来控制含有生物材料的液体的流动方法
公开(公告)号：WO2006067715A3
公开(公告)日：2006-09-14
申请号：PCT/IB2005054283
申请日：2005-12-16
申请人： KONINKL PHILIPS ELECTRONICS NV , HIKMET RIFAT , WIMBERGER-FRIEDL REINHOLD
发明人： HIKMET RIFAT , WIMBERGER-FRIEDL REINHOLD
IPC分类号： B01L3/00 , F15C5/00
CPC分类号： F15B21/001 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0816 , B01L2400/0677 , B01L2400/082 , F16K99/0001 , F16K99/0021 , F16K99/0046 , F16K99/0051 , F16K99/0053 , F16K2099/0073 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N35/1097 , Y10T436/25
摘要： The invention provides a method for controlling or manipulating the flow of a solution or liquid comprising biological material or biomolecules. Therefore, particles are added to the solution or liquid for providing the solution or liquid with rheological properties. The solution or liquid comprising the particles is provided in a microchannel and by applying an electric and/or magnetic field to the microchannel, the flow of the liquid or solution can be controlled.
摘要翻译：本发明提供了一种用于控制或操纵包含生物材料或生物分子的溶液或液体的流动的方法。因此，将颗粒加入溶液或液体中以提供具有流变性质的溶液或液体。包含颗粒的溶液或液体设置在微通道中并通过向微通道施加电场和/或磁场，可以控制液体或溶液的流动。

4. 发明申请

WO2008012706A3 MULTI-COLOR BIOSENSOR 审中-公开
标题翻译：多色生物传感器
公开(公告)号：WO2008012706A3
公开(公告)日：2008-07-03
申请号：PCT/IB2007052634
申请日：2007-07-05
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DIJK ERIK M H P , BOAMFA MARIUS I , WIMBERGER-FRIEDL REINHOLD
发明人： VAN DIJK ERIK M H P , BOAMFA MARIUS I , WIMBERGER-FRIEDL REINHOLD
IPC分类号： G01N21/64 , G02B27/00
CPC分类号： G01N21/6428 , G01J3/02 , G01J3/021 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6463
摘要： A detection system is described (100) for detecting luminescence sites on a substrate (6). The detection system (100) typically comprises an irradiation unit (102) for generating at least one excitation irradiation beam for exciting luminescence sites on the substrate (6). The at least one excitation irradiation beam may be a plurality of excitation irradiation beams. The detection system (100) also comprises a first optical element, e.g. refractive element (25), adapted for receiving at least two irradiation beams of different wavelengths or wavelength ranges, the at least two irradiation beams being excitation irradiation beam(s) to be focused on a substrate and/or luminescence irradiation beam(s) to be collected from the excited luminescence sites on the substrate (6). The detection system (100) also comprises an optical compensator for adjusting at least one of the at least two irradiation beams of different wavelengths or wavelength ranges so as to reduce or compensate for optical aberrations. The present invention also relates to a corresponding method for detecting, a phase plate and a method for designing such a phase plate.
摘要翻译：描述了用于检测衬底（6）上的发光部位的检测系统（100）。检测系统（100）通常包括用于产生用于激发衬底（6）上的发光位点的至少一个激发照射束的照射单元（102）。所述至少一个激发照射光束可以是多个激发照射光束。检测系统（100）还包括第一光学元件，例如，折射元件（25），其适于接收不同波长或波长范围的至少两个照射光束，所述至少两个照射光束是被聚焦在衬底上的激发照射光束和/或发光照射光束从基底（6）上的激发的发光部位收集。检测系统（100）还包括用于调整不同波长或波长范围的至少两个照射束中的至少一个的光学补偿器，以便减少或补偿光学像差。本发明还涉及用于检测相位板和相位板的设计方法的相应方法。

5. 发明申请

WO2005048245A3 METHOD OF PRODUCING A FLUORESCENT OPTICAL INFORMATION CARRIER AND THE APPARATUS AND CARRIER THEREOF 审中-公开
标题翻译：生产荧光光信息载体的方法及其装置及载体
公开(公告)号：WO2005048245A3
公开(公告)日：2006-04-13
申请号：PCT/IB2004003729
申请日：2004-11-09
申请人： KONINKL PHILIPS ELECTRONICS NV , WIMBERGER-FRIEDL REINHOLD , SAALMINK MILAN , DECRE MICHEL MARCEL JOSE
发明人： WIMBERGER-FRIEDL REINHOLD , SAALMINK MILAN , DECRE MICHEL MARCEL JOSE
IPC分类号： G11B7/26 , B29C33/56 , B29C35/08 , B29C41/00 , B29C41/04 , B29C41/08 , G11B7/007 , G11B7/24038 , G11B7/24047
CPC分类号： G11B7/263 , B29C41/003 , B29C41/045 , B29C41/085 , G11B7/24038 , G11B7/24047
摘要： The present invention relates to a method of producing high contrast optical storage discs. The method comprises usage of so-called liquid embossing technology process steps that turn out to be beneficial for mass-producing fluorescent optical data storage discs. The present invention also relates to a high contrast optical storage disc comprising an information layer that includes a fluorescent dye on a substrate. The information layer comprises a structure of lands and pits and wherein the lands have a thickness of substantially zero; and the pits have a finite thickness. The optical storage disc may well be multi-layered. The present invention also relates to an apparatus suitable for producing high contrast optical fluorescent storage discs
摘要翻译：本发明涉及一种生产高对比度光学存储盘的方法。该方法包括使用所谓的液体压花技术工艺步骤，其有利于批量生产荧光光学数据存储盘。本发明还涉及一种高对比度光存储盘，其包括在基板上包括荧光染料的信息层。信息层包括焊盘和凹坑的结构，并且其中焊盘的厚度基本为零; 并且凹坑具有有限的厚度。光学存储盘可以是多层的。本发明还涉及适用于制造高对比度光学荧光存储盘的装置

6. 发明申请

WO2006123267A2 FUNCTIONAL ASSEMBLY AND METHOD OF OBTAINING IT 审中-公开
标题翻译：功能组件及其获取方法
公开(公告)号：WO2006123267A2
公开(公告)日：2006-11-23
申请号：PCT/IB2006051401
申请日：2006-05-04
申请人： KONINKL PHILIPS ELECTRONICS NV , WIMBERGER-FRIEDL REINHOLD
发明人： WIMBERGER-FRIEDL REINHOLD
CPC分类号： B81B1/002 , B01L3/502707 , B01L3/502715 , B01L2200/02 , B01L2300/0645 , B81B2201/0214 , B81B2201/058
摘要： The invention relates to a functional assembly, for instance a biosensor, and to a method to obtain it. The assembly comprises a functional element, aimed to interact at its functional side with a sample fluid, and, electrically connected thereto through electrical connection means, an interconnect substrate for supporting the element and transmitting signals. The interconnect substrate is provided with an opening that gives access to the functional side of the functional element. The transition of the opening to the functional element is formed by a sidewall, extending substantially over the circumference of the opening, whereby the average slope of the sidewall with respect to the plane of the functional element is less than 60 degrees. The assembly provides a transition to the functional element, having smooth and self-stratifying sidewalls, which allows a homogeneous filling of only small amounts of sample fluids.
摘要翻译：本发明涉及功能组件，例如生物传感器，以及获得它的方法。组件包括功能元件，其目的是在其功能侧与样品流体相互作用，并且通过电连接装置与其电连接，用于支撑元件和传输信号的互连基板。互连基板设置有允许进入功能元件的功能侧的开口。开口到功能元件的过渡由基本上在开口的圆周上延伸的侧壁形成，由此侧壁相对于功能元件的平面的平均斜率小于60度。组件提供到功能元件的过渡，具有平滑且自分层的侧壁，其允许均匀填充仅少量样品流体。

7. 发明申请

WO2005057255A2 COLLIMATOR 审中-公开
公开(公告)号：WO2005057255A2
公开(公告)日：2005-06-23
申请号：PCT/IB2004052708
申请日：2004-12-08
申请人： KONINKL PHILIPS ELECTRONICS NV , HIKMET RIFAT A M , VAN BOMMEL TIES , VAN DE WITTE PETER , WIMBERGER-FRIEDL REINHOLD , BURDINSKI DIRK
发明人： HIKMET RIFAT A M , VAN BOMMEL TIES , VAN DE WITTE PETER , WIMBERGER-FRIEDL REINHOLD , BURDINSKI DIRK
IPC分类号： F21V11/08 , G02B5/00 , G02B5/20 , G02B27/30 , G21K1/02
CPC分类号： B82Y30/00 , G02B5/005 , G02B5/206 , G02B27/30 , G21K1/025
摘要： A collimator panel comprises: a solid panel having a first face for receiving uncollimated radiation and a second opposite face for providing collimated radiation; and a plurality of elongate particles disposed in the panel and orientated to provide the collimating function. A method of manufacturing a collimator panel comprises the steps of: suspending a plurality of elongate particles in a liquid; applying an electric or magnetic field to the suspension to orientate the particles; and solidifying the liquid to fix the orientation of the particles, thereby forming a collimator panel. A method of manufacturing the elongate particles is also provided.
摘要翻译：准直器面板包括：具有用于接收未预激射辐射的第一面的实心面板和用于提供准直辐射的第二相对面; 以及设置在面板中并且定向以提供准直功能的多个细长颗粒。制造准直器面板的方法包括以下步骤：将多个细长颗粒悬浮在液体中; 对悬浮液施加电场或磁场以使颗粒定向; 并固化液体以固定颗粒的取向，由此形成准直板。还提供了制造细长颗粒的方法。

8. 发明申请

WO2005059655A3 A PROCESS FOR THE FABRICATION OF OPTICAL MICROSTRUCTURES 审中-公开
标题翻译：制造光学微结构的方法
公开(公告)号：WO2005059655A3
公开(公告)日：2006-05-18
申请号：PCT/IB2004052760
申请日：2004-12-10
申请人： KONINKL PHILIPS ELECTRONICS NV , WIMBERGER-FRIEDL REINHOLD , DE BRUIN JOHAN G , VERSTEGEN EMILE J K
发明人： WIMBERGER-FRIEDL REINHOLD , DE BRUIN JOHAN G , VERSTEGEN EMILE J K
IPC分类号： G02B3/00 , C08L33/04 , C08L63/00 , G02B1/04 , G03F7/00 , G03F9/00
CPC分类号： G03F7/001 , C08L33/04 , C08L63/00 , C08L2314/00 , G02B1/041 , C08L2666/22
摘要： The invention relates to a process for the fabrication of a polymeric optical microstructure, being supported or not by a substrate, starting from a thermoplastic polymer, wherein a thermoplastic polymer is blended with an UV curable resin and a thermally stable photo-initiator, to obtain a blend having a lower viscosity than the viscosity of said polymer, said blend being molded and the molded blend being cured by means of UV radiation to obtain a polymeric optical microstructure. Such a process prevents the common problems, which arise with molding of conventional thermoplastic polymers and conventional UV curing when only one of the components of the blend is used.
摘要翻译：本发明涉及从热塑性聚合物开始制造聚合物光学微结构的方法，由聚合物支撑或不被基底支撑，其中将热塑性聚合物与UV固化树脂和热稳定的光引发剂共混以获得具有比所述聚合物的粘度低的粘度的共混物，所述共混物被模制，并且所述模制共混物通过UV辐射固化以获得聚合物光学微结构。这种方法防止了当仅使用共混物的一种组分时常规热塑性聚合物的成型和常规的UV固化而产生的常见问题。

9. 发明申请

WO2008012724A3 OPTICAL TRACKING AND POSITION DETERMINATION FOR DETECTION METHODS AND SYSTEMS 审中-公开
标题翻译：检测方法和系统的光学跟踪和位置确定
公开(公告)号：WO2008012724A3
公开(公告)日：2008-05-02
申请号：PCT/IB2007052800
申请日：2007-07-13
申请人： KONINKL PHILIPS ELECTRONICS NV , BOAMFA MARIUS I , VAN DIJK ERIK M H P , WIMBERGER-FRIEDL REINHOLD , DE WITZ CHRISTIANNE R M
发明人： BOAMFA MARIUS I , VAN DIJK ERIK M H P , WIMBERGER-FRIEDL REINHOLD , DE WITZ CHRISTIANNE R M
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , B01L3/545 , B01L9/50 , B01L2300/0819
摘要： A tracking system (106) is described for tracking areas on a substrate (104) using an irradiation beam. The irradiation beam typically has an irradiation beam projection (202) on the substrate (104) whereby at least one dimension of the irradiation beam projection (202) is substantially larger than a wavelength of the irradiation beam. The tracking system (106) typically comprises a detecting means (108) adapted for detecting a variation of an optical characteristic of at least part of the irradiation beam induced by interaction with different regions (204, 206) of the substrate having different irradiation modulating properties, for locating said irradiation beam with respect to said substrate (104). The tracking system typically is adapted to cooperate with a substrate. The invention also relates to a position determination system for obtaining position related information from a modulation of the irradiation beam induced by the substrate, a corresponding method and substrates for use therewith.
摘要翻译：描述了跟踪系统（106），用于使用照射束跟踪衬底（104）上的区域。照射束通常在衬底（104）上具有照射束投影（202），由此照射束投影（202）的至少一个维度实质上大于照射束的波长。跟踪系统（106）典型地包括检测装置（108），其适于检测由与具有不同照射调制特性的衬底的不同区域（204,206）相互作用引起的照射束的至少一部分的光学特性的变化，用于相对于所述衬底（104）定位所述辐射束。跟踪系统通常适于与衬底协作。本发明还涉及一种用于从由衬底引起的照射束的调制获得位置相关信息的位置确定系统，相应的方法以及与其一起使用的衬底。

10. 发明申请

WO2008010120A3 EMPLOYING BEAM SCANNING FOR OPTICAL DETECTION 审中-公开
标题翻译：采用光束扫描进行光学检测
公开(公告)号：WO2008010120A3
公开(公告)日：2008-05-02
申请号：PCT/IB2007052499
申请日：2007-06-27
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DIJK ERIK M H P , BOAMFA MARIUS I , BALISTRERI MARCELLO L M , WIMBERGER-FRIEDL REINHOLD
发明人： VAN DIJK ERIK M H P , BOAMFA MARIUS I , BALISTRERI MARCELLO L M , WIMBERGER-FRIEDL REINHOLD
IPC分类号： G01N21/64
CPC分类号： G01N21/6452
摘要： A detection system is described allowing scanning of an excitation irradiation beam over a substrate (8) for detecting luminescence sites. The scanning thereby is performed by using an optical deflector (5) for varying an angle of incidence of the excitation irradiation beam on a single focusing element (7) on an irradiation path between the deflector (5) and the substrate (8). By varying the angle of incidence on the single focusing element (7), the focus point of the excitation irradiation beam is shifted in the focal plane of the focusing element (7), where the substrate (8) is positioned. The latter allows fast scanning of the excitation irradiation beam. In a preferred embodiment, an additional scanning motion in a substantially different direction is furthermore superimposed, resulting in the possibility for scanning an appropriate area of the substrate (8). The additional scanning motion may be obtained using a split optics system, whereby substantially only the single focusing element (7) and the optical deflector (5) are moved with respect to the substrate (8), whereas other optical components typically are fixed with respect to the substrate (8) during the scanning.
摘要翻译：描述了一种检测系统，其允许在用于检测发光部位的基板（8）上扫描激发照射束。通过使用用于改变偏转器（5）和基板（8）之间的照射路径上的单个聚焦元件（7）上的激发照射光束的入射角的光学偏转器（5）来进行扫描。通过改变单个聚焦元件（7）上的入射角，激发照射光束的焦点在基底（8）所在的聚焦元件（7）的焦平面上移动。后者允许激发照射束的快速扫描。在优选实施例中，进一步叠加基本不同方向的附加扫描运动，导致扫描基板（8）的适当区域的可能性。可以使用分离光学系统获得附加的扫描运动，从而基本上只有单个聚焦元件（7）和光学偏转器（5）相对于基板（8）移动，而其它光学部件通常相对于在扫描期间到基板（8）。

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