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1. 发明申请

WO2007132366A3 MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS 审中-公开
标题翻译：用于浓度测量的微电子传感器装置
公开(公告)号：WO2007132366A3
公开(公告)日：2008-03-27
申请号：PCT/IB2007051505
申请日：2007-04-24
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR , VEEN JEROEN , DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
发明人： NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR , VEEN JEROEN , DE BOER BART MICHIEL , JANSEN THEODORUS PETRUS HENRIC
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01R33/093 , B82Y25/00 , G01N27/745 , G01R33/1269
摘要： The invention relates to a method and a magnetic sensor device for the determination of the concentration of target particles (2) in a sample fluid, wherein the amount of the target particles (2) in a sensitive region (14) is observed by sampling measurement signals with associated sensor units (10a-10d). The target particles (2) may optionally be bound to binding sites (3) in the sensitive region, and a parametric binding curve, e.g. a Langmuir isotherm, may be fitted to the sampled measurement signals to determine the desired particle concentration in the sample. Moreover, parameters like the sampling rate and the size of the sensitive region (14) can be dynamically fitted during the ongoing sampling process to improve the signal-to-noise ratio. In another embodiment of the invention, single events corresponding to the movement of target particles into, out of, or within the sensitive region are detected and counted.
摘要翻译：本发明涉及一种用于确定样品流体中目标颗粒（2）的浓度的方法和磁传感器装置，其中通过采样测量观察敏感区域（14）中的目标颗粒（2）的量信号与相关联的传感器单元（10a-10d）。目标颗粒（2）可以任选地结合到敏感区域中的结合位点（3），参与结合曲线，例如， Langmuir等温线可以适应于采样的测量信号，以确定样品中所需的颗粒浓度。此外，在持续采样过程中，可以动态拟合诸如采样率和敏感区域（14）的尺寸的参数，以提高信噪比。在本发明的另一个实施例中，检测并计数与目标颗粒移动到敏感区域之外或之内的单个事件。

2. 发明申请

WO2007132384A3 MAGNETIC SENSOR DEVICE WITH FIELD GENERATORS AND SENSORS 审中-公开
标题翻译：具有现场发电机和传感器的磁传感器装置
公开(公告)号：WO2007132384A3
公开(公告)日：2008-01-24
申请号：PCT/IB2007051640
申请日：2007-05-02
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR
发明人： NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR
IPC分类号： G01R33/09 , G01N15/06 , G01N33/543
CPC分类号： G01N33/54326 , B82Y25/00 , G01N15/0656 , G01N27/745 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising magnetic field generators (11, 13) for generating a magnetic excitation field (B) in an investigation region and a magnetic sensor element (12) for measuring magnetic reactions fields (B') generated by magnetized particles (2) that are bound to binding sites (3) in the investigation region. Both the magnetic field generators (11, 13) and the magnetic sensor element (12) are driven with electrical power, wherein the ratio of the power that is dissipated in said components is kept in a predetermined interval. The magnetic field generators may preferably be realized by excitation wires (11, 13) and the sensor element (12) by a magneto-resistive element, for example a GMR element. In this case, it is preferred that about equal amounts of power are dissipated in the excitation wires (11, 13) and the GMR element (12).
摘要翻译：本发明涉及一种磁传感器装置（10），包括用于在调查区域中产生磁场（B）的磁场发生器（11,13）和用于测量磁反应场（B'）的磁传感器元件（12）由在调查区域中与结合位点（3）结合的磁化颗粒（2）产生。磁力发生器（11,13）和磁性传感器元件（12）都用电力驱动，其中在所述部件中耗散的功率的比率保持在预定的间隔。磁场发生器可以优选地通过激磁线（11,13）和传感器元件（12）由磁阻元件（例如GMR元件）来实现。在这种情况下，优选在激励线（11,13）和GMR元件（12）中消耗大约相等的功率。

3. 发明申请

WO2008007291A3 MAGNETIC SENSOR DEVICE 审中-公开
标题翻译：磁性传感器装置
公开(公告)号：WO2008007291A3
公开(公告)日：2008-03-06
申请号：PCT/IB2007052558
申请日：2007-07-02
申请人： KONINKL PHILIPS ELECTRONICS NV , KAHLMAN JOSEPHUS ARNOLDUS HENR , PRINS MENNO WILLEM JOSE , NIEUWENHUIS JEROEN HANS
发明人： KAHLMAN JOSEPHUS ARNOLDUS HENR , PRINS MENNO WILLEM JOSE , NIEUWENHUIS JEROEN HANS
IPC分类号： G01R33/09 , G01N33/543
CPC分类号： G01R33/093 , B82Y25/00 , G01N27/745 , G01N33/54333 , G01R33/12 , G01R33/1269
摘要： The present invention provides a magnetic sensor device comprising means (11, 14) for increasing a binding possibility of magnetic or magnetizable objects (15) e.g. magnetic particles, onto the binding sites by applying a moving magnetic field. The present invention furthermore provides a biochip (40) comprising at least one such magnetic sensor and a method for detecting and/or quantifying target moieties in a sample fluid by using such a magnetic sensor.
摘要翻译：本发明提供一种磁性传感器装置，其包括用于增加例如磁性或可磁化物体（15）的结合可能性的装置（11,14）。通过施加移动的磁场将磁性颗粒施加到结合位点上。本发明还提供了包括至少一个这种磁性传感器的生物芯片（40）以及通过使用这种磁性传感器来检测和/或定量样品流体中的靶部分的方法。

4. 发明申请

WO2008035252A3 A SENSOR DEVICE FOR AND A METHOD OF SENSING PARTICLES 审中-公开
标题翻译：用于传感颗粒的传感器装置和方法
公开(公告)号：WO2008035252A3
公开(公告)日：2008-05-29
申请号：PCT/IB2007053679
申请日：2007-09-12
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN HANS , PRINS MENNO WILLEM JOSE
发明人： NIEUWENHUIS JEROEN HANS , PRINS MENNO WILLEM JOSE
IPC分类号： G01N15/06 , G01N33/49 , G01N33/543 , G01N35/00 , G01R33/09
CPC分类号： G01N15/12 , G01N15/0656 , G01N15/1056 , G01N2015/1087
摘要： A GMR based sensor device (100) for sensing first particles (504, 505) e.g. magnetic beads for immuno assay of a sample comprising the first particles (504, 505) and second particles (503) e.g. red blood cells, the sensor device (100) comprising a detection unit (11, 12) adapted to detect a signal which depends on a quantity of the first particles (504, 505) and which depends on a quantity of the second particles (503)" based on a measurement performed with the sample comprising the first particles (504, 505) and the second particles (503), an estimation unit (30) for estimating information indicative of the quantity of the second particles (503) e.g. haematocrit based on an impedance measurement, and a determining unit (20) adapted for determining the quantity of the first particles (504, 505) based on the detected signal under consideration of the estimated information. The advantage of this arrangement is that whole blood samples may be used.
摘要翻译：用于感测第一颗粒（504,505）的基于GMR的传感器装置（100）用于免疫测定包含第一颗粒（504,505）和第二颗粒（503）的样品的磁珠。所述传感器装置（100）包括检测单元（11,12），所述检测单元适于检测取决于所述第一颗粒（504,505）的量并且取决于所述第二颗粒（503）的量的信号）基于使用包含第一颗粒（504,505）和第二颗粒（503）的样品进行的测量，估计单元（30），用于估计指示第二颗粒（503）的量的信息，例如基于血细胞比容以及确定单元（20），其适于基于在所述估计信息下考虑的所述检测信号来确定所述第一粒子（504,505）的量，所述排列的优点在于，全血样品可以是用过的。

5. 发明申请

WO2008001263A3 MAGNETIC SENSOR DEVICE WITH FIELD GENERATORS AND SENSOR ELEMENTS 审中-公开
标题翻译：具有现场发电机和传感器元件的磁传感器装置
公开(公告)号：WO2008001263A3
公开(公告)日：2008-08-21
申请号：PCT/IB2007052327
申请日：2007-06-18
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN HANS , ZON HANS , KAHLMAN JOHANNES ARNOLDUS HENR
发明人： NIEUWENHUIS JEROEN HANS , ZON HANS , KAHLMAN JOHANNES ARNOLDUS HENR
IPC分类号： G01R33/09 , G01N15/06 , G01R33/12
CPC分类号： G01R33/12 , B82Y25/00 , G01R33/093 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising (a) excitation wires (11, 13) for generating a magnetic excitation field (B) that magnetizes particles (2) in an investigation region (5), and (b) a magnetic sensor element, for example a GMR sensor (12), for detecting reaction fields (B') generated by the magnetized particles (2). The excitation wires (11, 13) and the GMR element (12) are driven by current pulses such that the average power dissipation is kept constant while the signal-to-noise ratio is optimized. The sampling frequency of said pulses is preferably larger than the thermal time constant (t) of the magnetic sensor device (10).
摘要翻译：本发明涉及一种磁传感器装置（10），它包括：（a）用于产生在调查区域（5）中磁化颗粒（2）的磁激励场（B）的激励线（11,13），以及（b）磁传感器元件，例如GMR传感器（12），用于检测由磁化颗粒（2）产生的反应场（B'）。励磁线（11,13）和GMR元件（12）由电流脉冲驱动，使得平均功率损耗保持恒定，同时信噪比优化。所述脉冲的采样频率优选大于磁传感器装置（10）的热时间常数（t）。

6. 发明申请

WO2008072149A3 A SYSTEM FOR APPLYING MAGNETIC FORCES TO A BIOSENSOR SURFACE BY MECHANICALLY MOVING AT LEAST ONE MAGNET 审中-公开
标题翻译：通过机械移动至少一个磁体将磁力施加到生物传感器表面的系统
公开(公告)号：WO2008072149A3
公开(公告)日：2008-08-07
申请号：PCT/IB2007054967
申请日：2007-12-07
申请人： KONINKL PHILIPS ELECTRONICS NV , KAHLMANN JOSEPHUS ARNOLDUS HEN , IMMINK ALBERT HENDRIK JAN , NIEUWENHUIS JEROEN HANS , VAN DER WIJK THEA , DE THEIJE FEMKE KARINA
发明人： KAHLMANN JOSEPHUS ARNOLDUS HEN , IMMINK ALBERT HENDRIK JAN , NIEUWENHUIS JEROEN HANS , VAN DER WIJK THEA , DE THEIJE FEMKE KARINA
IPC分类号： G01N35/00 , G01N33/543 , H01F7/00
CPC分类号： G01N27/745 , G01N33/54333 , G01N35/0098 , H01F7/0273
摘要： A magnetic system for biosensors or a biosystem, wherein magnetic particles that interact with molecules are brought into a magnetic field, in order to be influenced via magnetic attraction or repulsion forces. The external magnetic field is varied by mechanically moving the magnetic poles of at least one magnetic relative to the sensor or at least its surface to allow the magnetic force to be switched between effective attraction towards the sensor surface and effective repulsion away from the sensor surface.
摘要翻译：用于生物传感器或生物系统的磁系统，其中与分子相互作用的磁性颗粒进入磁场，以便通过磁吸引力或排斥力影响。外部磁场通过相对于传感器或至少其表面机械地移动至少一个磁体的磁极来改变，以允许在对传感器表面的有效吸引力和远离传感器表面的有效排斥之间切换磁力。

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