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1. 发明申请

WO2011007290A2 MULTIPLE COMPONENT MATERIALS HAVING A COLOR-CHANGING COMPOSITION 审中-公开
标题翻译：具有变色组合物的多组分材料
公开(公告)号：WO2011007290A2
公开(公告)日：2011-01-20
申请号：PCT/IB2010053033
申请日：2010-07-02
申请人： KIMBERLY CLARK CO , SONG XUEDONG , ALES III THOMAS M
发明人： SONG XUEDONG , ALES III THOMAS M
IPC分类号： A61F13/511 , A61F13/42 , A61L15/48 , A61L15/56 , C09B69/00 , G01N33/493
CPC分类号： A61L15/56 , A61F13/42 , C09B7/00 , G01N21/29 , G01N21/78 , G01N21/80 , G01N21/81 , G01N21/8483 , G01N31/22 , G01N31/222 , G01N33/525 , G01N33/54386 , G01N33/566 , G01N33/84 , Y10T428/24802 , Y10T428/2481
摘要： The present invention relates to a multiple-component material including a substrate and a printed layer on the substrate. The printed layer includes a color- changing composition to indicate a change in condition, such as a change in pH. The color-changing composition includes a matrix-forming component, a colorant, a surfactant and a pH adjuster. The pH adjuster includes a low molecular weight organic acid and a high molecular weight organic acid.
摘要翻译：本发明涉及一种多组分材料，其包括基材和在该基材上的印刷层。印刷层包含颜色改变组合物以指示状况的改变，例如pH的改变。变色组合物包含基质形成组分，着色剂，表面活性剂和pH调节剂。 pH调节剂包括低分子量有机酸和高分子量有机酸。

2. 发明申请

WO2012023071A3 DEHYDRATION SENSORS WITH ION-RESPONSIVE AND CHARGED POLYMERIC SURFACTANTS 审中-公开
标题翻译：具有反应性和充电聚合物表面活性剂的脱水传感器
公开(公告)号：WO2012023071A3
公开(公告)日：2012-06-07
申请号：PCT/IB2011053313
申请日：2011-07-25
申请人： KIMBERLY CLARK CO , SONG XUEDONG , WEI NING , PHILLIPS RONNIE L
发明人： SONG XUEDONG , WEI NING , PHILLIPS RONNIE L
IPC分类号： G01N33/493 , G01N21/80 , G01N31/22 , G01N33/52
CPC分类号： G01N33/558 , A61F13/42 , A61F13/84 , A61F2013/00429 , A61F2013/0094 , A61F2013/00948 , A61F2013/15081 , A61F2013/15154 , A61F2013/8473
摘要： A lateral flow assay device for determining the relative ionic strength of urine is described. The device includes a buffering zone having a polyelectrolyte disposed therein, and an indicator zone having a pH indicator non-diffusively immobilized therein, the indicator zone being separate from the buffering zone and positioned adjacent to and in fluid communication with the buffering zone. A detection zone is part of the buffering zone, and has a buffering component comprising a weak polymeric acid and weak polymeric base with a pKa = 10-3, and a class of charged polymeric surfactants that are responsive to relative ion concentrations in a sample solution, and a charged pH indicator with a charge opposite to that of the charged polymeric surfactant. The charged polymeric surfactant is soluble in amounts of greater than or equal to about 1% by weight (= 1wt. % solute) in water and aqueous solutions of low ionic concentration of = 0.1 wt. % salts, but insoluble ( 0.1 wt. % salts. The present invention also describes absorbent articles incorporating such an assay device and methods of monitoring dehydration or testing ion strength of a urine sample using such a test format.
摘要翻译：描述了用于确定尿液的相对离子强度的侧流测定装置。该装置包括其中布置有聚电解质的缓冲区和具有非扩散固定在其中的pH指示剂的指示区，指示区与缓冲区分离并且定位成与缓冲区相邻并且与缓冲区流体连通。检测区是缓冲区的一部分，并且具有包含弱聚合酸和pKa = 10-3的弱聚合物碱的缓冲组分和对样品溶液中的相对离子浓度有反应的一类带电聚合物表面活性剂和带电荷的pH指示剂，其电荷与带电聚合物表面活性剂的电荷相反。带电的聚合物表面活性剂可溶于大约或等于约1重量％（= 1重量％溶质）的水和低离子浓度= 0.1重量％的水溶液。％盐，但不溶于（<1重量％溶质）在高离子浓度> 0.1重量％的水溶液中。％盐。本发明还描述了结合这种测定装置的吸收制品以及使用这种测试形式监测尿样的脱水或测试离子强度的方法。

3. 发明申请

WO2008075217A2 LATERAL FLOW ASSAY DEVICE AND ABSORBENT ARTICLE CONTAINING SAME 审中-公开
标题翻译：侧流测试装置和吸收装置
公开(公告)号：WO2008075217A2
公开(公告)日：2008-06-26
申请号：PCT/IB2007053963
申请日：2007-09-28
申请人： KIMBERLY CLARK CO , SONG XUEDONG
发明人： SONG XUEDONG
IPC分类号： A61F13/15 , A61F13/44 , A61F13/84
CPC分类号： A61F13/42 , A61F13/44 , G01N33/528 , G01N33/54313 , G01N33/558 , G01N33/72 , Y10T436/146666
摘要： A lateral flow assay device for testing a bodily fluid, such as urine, blood, mucous, saliva, etc., is provided. The lateral flow assay device includes a chromatographic medium (e.g., porous membrane) that defines a detection zone that provides a signal indicative of the presence or amount of bilirubin or urobilinogen. The device may also include a control zone that provides a signal indicative of whether a sufficient amount of bodily fluid has been provided and tested. In one embodiment, the device is integrated into an absorbent article to provide a user or caregiver with rapid information about a health condition. For example, the device may be integrated into a diaper to provide information about the presence of bilirubin and/or urobilinogen. This information may provide an early warning system to allow the user or caregiver to seek additional testing and/or treatment. Alternatively, semi-quantitative or quantitative results may be derived from the test.
摘要翻译：提供了用于测试诸如尿液，血液，粘液，唾液等体液的侧流测定装置。侧流测定装置包括限定提供指示胆红素或尿胆素原的存在或量的信号的检测区的色谱介质（例如多孔膜）。该装置还可以包括提供指示是否已经提供和测试了足够量的体液的信号的控制区域。在一个实施例中，该装置被集成到吸收制品中以向使用者或护理者提供关于健康状况的快速信息。例如，该装置可以整合到尿布中以提供关于胆红素和/或尿胆素原的存在的信息。该信息可以提供预警系统，以允许用户或看护者寻求额外的测试和/或治疗。或者，可以从测试中得到半定量或定量结果。

4. 发明申请

WO2007113702A3 ENZYMATIC DETECTION TECHNIQUES 审中-公开
标题翻译： ENZYMATIC检测技术
公开(公告)号：WO2007113702A3
公开(公告)日：2008-03-13
申请号：PCT/IB2007050880
申请日：2007-03-14
申请人： KIMBERLY CLARK CO , SONG XUEDONG
发明人： SONG XUEDONG
IPC分类号： G01N33/558
CPC分类号： C12Q1/00 , G01N33/558
摘要： A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes substrate conjugates to facilitate the detection of the enzyme or enzyme inhibitor via direct detection of the substrate and/or a product formed in an enzyme-catalyzed reaction of the substrate. The substrate conjugates include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle). In this embodiment, the substrate provides a cleavage target for an enzyme. Specifically, upon contacting the substrate conjugate, the enzyme catalyzes a reaction with the substrate and forms a product conjugate that includes the product of the enzyme catalyzed reaction joined to the reporter. The signal exhibited by the reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.
摘要翻译：提供了用于检测酶或酶抑制剂的存在或数量的诊断测试试剂盒。诊断试剂盒利用底物共轭物，以便通过直接检测底物和/或在酶催化的底物反应中形成的产物来促进酶或酶抑制剂的检测。底物缀合物包括与报告物结合（例如共价键合，物理吸附等）的底物。在一个实施方案中，例如，将肽，蛋白质或糖蛋白底物与报告物（例如，染色的胶乳颗粒）连接。在该实施方案中，底物提供酶的切割靶。具体地说，在接触底物缀合物时，酶催化与底物的反应，并形成包含与报告物连接的酶催化反应的产物的产物缀合物。记者所展示的信号可用于指示测试样品中酶或酶抑制剂的存在或数量。

5. 发明申请

WO2007027234A3 ENZYME DETECTION TECHNIQUE 审中-公开
标题翻译：酶检测技术
公开(公告)号：WO2007027234A3
公开(公告)日：2007-06-07
申请号：PCT/US2006016907
申请日：2006-04-27
申请人： KIMBERLY CLARK CO , SONG XUEDONG
发明人： SONG XUEDONG
IPC分类号： C12Q1/44 , G01N33/52 , G01N33/558 , G01N33/573
CPC分类号： C12Q1/44 , G01N33/52 , G01N33/558 , G01N33/573
摘要： A diagnostic test kit for detecting the presence or absence of an enzyme (e.g., leukocyte esterase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the enzyme to release a nucleophilic aromatic compound. The kit also comprises a lateral flow device that comprises a chromatographic medium. The chromatographic medium defines a detection zone within which is contained a first reagent (e.g., diazonium ion) that is capable of reacting with the nucleophilic aromatic compound to form a second reagent (e.g., aromatic azo compound). The second reagent exhibits a color that is different than the color of the first reagent. The lateral flow device also includes an absorbent material located adjacent to the chromatographic medium, the absorbent material receiving the test sample after flowing through the chromatographic medium.
摘要翻译：提供了用于检测测试样品中酶（如白细胞酯酶）的存在或不存在的诊断测试试剂盒。测试试剂盒包括能够在酶存在下被切割以释放亲核芳族化合物的底物。试剂盒还包括含有色谱介质的侧流装置。色谱介质限定了检测区，其中含有能够与亲核芳族化合物反应以形成第二试剂（例如芳族偶氮化合物）的第一试剂（例如重氮离子）。第二试剂显示与第一试剂的颜色不同的颜色。侧流装置还包括邻近色谱介质定位的吸收材料，吸收材料在流经色谱介质后接受测试样品。

6. 发明申请

WO2013038278A2 WETNESS INDICATOR HAVING VARIED HUES 审中-公开
标题翻译：具有不同味道的湿润指示剂
公开(公告)号：WO2013038278A2
公开(公告)日：2013-03-21
申请号：PCT/IB2012053943
申请日：2012-08-01
申请人： KIMBERLY CLARK CO , SONG XUEDONG , GOEDERS KAREN MELOY , WEI NING
发明人： SONG XUEDONG , GOEDERS KAREN MELOY , WEI NING
IPC分类号： G01N31/22 , G01N21/81
CPC分类号： A61L15/56 , B01L3/5023 , B01L2300/0816 , G01N21/78 , G01N30/88 , G01N31/22 , G01N31/222 , G01N33/18 , G01N33/50 , G01N33/52 , G01N33/525
摘要： A wetness indicator material may be used on a substrate to form a wetness sensor. The sensor may show either the presence or absence of an aqueous- based fluid or water-containing medium, such as vaginal fluid or urine in a personal hygiene article. The wetness sensor may be incorporated into the article. The wetness indicator material includes a standard colorant that does not change color when wetted. The standard colorant increases the range of hues exhibited by the wetness indicator material.
摘要翻译：润湿指示剂材料可用于基底上以形成湿度传感器。传感器可以显示在个人卫生制品中存在或不存在基于水的流体或含水介质，例如阴道液或尿液。湿度传感器可以并入到制品中。湿度指示剂材料包括标准着色剂，其在润湿时不改变颜色。标准着色剂增加湿度指示剂材料表现的色调范围。

7. 发明申请

WO2010049829A3 ABSORBENT ARTICLES WITH IMPENDING LEAKAGE SENSORS 审中-公开
标题翻译：带有泄漏传感器的吸收性物品
公开(公告)号：WO2010049829A3
公开(公告)日：2010-07-01
申请号：PCT/IB2009053880
申请日：2009-09-04
申请人： KIMBERLY CLARK CO , SONG XUEDONG , RANGANATHAN SRIDHAR
发明人： SONG XUEDONG , RANGANATHAN SRIDHAR
IPC分类号： A61F13/42 , A61F13/15
CPC分类号： A61F13/42
摘要： A steering column assembly having a shroud comprises a first member 1 having an end portion which is received within a second member 2 having at least one slit through its wall extending partially along its length, a guide bush 20 located between the first member and the second member and fixed relative to one of the members and providing a surface over which the other member can slide to alter the overall length of the shroud and a clamp mechanism 7 which squeezes the second member 2 onto the guide bush 20 which is in turn squeezed onto the first member 1. The cross section of the guide bush 20 varies along its length to vary the resistance it provides to crushing by the action of the clamp mechanism when the shroud is at its greatest length and the resistance it provides when the shroud is clamped at its shortest length.
摘要翻译：具有护罩的转向柱组件包括第一构件1，该第一构件1具有容纳在第二构件2内的端部，该第二构件2具有穿过其部分沿其长度延伸的壁的至少一个狭缝，位于第一构件和第二构件之间的导套20 并且相对于其中一个构件固定并且提供一个表面，另一个构件可以在该表面上滑动以改变护罩的总长度;以及夹紧机构7，其将第二构件2挤压到导向套筒20上，该套筒又被挤压到第一部件1.导套20的横截面沿其长度变化，以改变当护罩处于其最大长度时由于夹紧机构的作用而产生的挤压阻力，以及当护罩被夹紧时其提供的阻力在其最短的长度。

8. 发明申请

WO2009077885A2 WETNESS SENSORS 审中-公开
标题翻译：湿度传感器
公开(公告)号：WO2009077885A2
公开(公告)日：2009-06-25
申请号：PCT/IB2008053676
申请日：2008-09-11
申请人： KIMBERLY CLARK CO , SONG XUEDONG , TIPPEY DAROLD D , VAN HANDEL JESSICA SARA
发明人： SONG XUEDONG , TIPPEY DAROLD D , VAN HANDEL JESSICA SARA
CPC分类号： G01N21/80 , A61F13/42 , G01N31/22 , G01N33/84
摘要： In accordance with one embodiment of the present disclosure a method for detecting the presence of urine is described. The method includes providing a urine indicating sensor with a porous matrix, the matrix having a pH indicator non- diffusively immobilized thereon, the pH indicator being capable of a color transition when in contact with urine. Urine is contacted with the matrix of the sensor and the presence of urine is determined based on whether the pH indicator undergoes a color transition.
摘要翻译：根据本公开的一个实施例，描述了一种用于检测尿液存在的方法。所述方法包括提供具有多孔基质的尿液指示传感器，所述基质具有非扩散固定在其上的pH指示剂，所述pH指示剂在与尿液接触时能够发生颜色转变。尿液与传感器的基质接触，基于pH指示剂是否经历颜色转变来确定尿液的存在。

9. 发明申请

WO2008132620A2 LATERAL FLOW DEVICE FOR ATTACHMENT TO AN ABSORBENT ARTICLE 审中-公开
标题翻译：用于连接吸收物品的侧向流动装置
公开(公告)号：WO2008132620A2
公开(公告)日：2008-11-06
申请号：PCT/IB2008050802
申请日：2008-03-05
申请人： KIMBERLY CLARK CO , SONG XUEDONG
发明人： SONG XUEDONG
IPC分类号： A61B10/00
CPC分类号： A61B5/207 , A61B10/007 , A61B2010/0006 , A61F13/42 , A61F2013/8473 , A61F2013/8488 , G01N33/54306 , G01N33/558 , G01N2800/348
摘要： A lateral flow device for testing a bodily fluid, such as urine, blood, mucous, saliva, etc., is provided. The lateral flow device is configured to be attached to an absorbent article via an attachment mechanism located on the lateral flow device or the absorbent article. The lateral flow device includes a chromatographic medium (e.g., porous membrane) that defines a detection zone that provides a signal indicative of the presence or absence of the analyte. The device may also include a control zone that provides a signal indicative of whether a sufficient amount of bodily fluid has been provided and tested. Regardless of its specific configuration, the lateral flow device is configured to be attached onto the absorbent article to provide a user or caregiver with rapid information about a health condition. For example, the device may be attached onto a diaper to provide information about the presence of enzymes or other compounds often encountered with a patient having a urinary tract infection. This information may provide an early warning system to allow the user or caregiver to seek additional testing and/or treatment. Alternatively, semi-quantitative or quantitative results may be derived from the test.
摘要翻译：提供了用于测试诸如尿液，血液，粘液，唾液等体液的侧流装置。侧流装置构造成经由位于侧流装置或吸收制品上的附接机构附接到吸收制品。侧向流动装置包括限定提供指示分析物存在或不存在的信号的检测区域的色谱介质（例如多孔膜）。该装置还可以包括提供指示是否已经提供和测试了足够量的体液的信号的控制区域。不管其具体构造如何，侧向流动装置构造成附接到吸收制品上以向使用者或护理者提供关于健康状况的快速信息。例如，该装置可以附着在尿布上以提供关于经常与患有尿路感染的患者遇到的酶或其它化合物的存在的信息。该信息可以提供预警系统，以允许用户或看护者寻求额外的测试和/或治疗。或者，可以从测试中得到半定量或定量结果。

10. 发明申请

WO2012104738A2 FEMININE CARE ABSORBENT ARTICLE FOR USE IN WARM CLIMATES 审中-公开
标题翻译：用于温室气候的有机污染物吸收物品
公开(公告)号：WO2012104738A2
公开(公告)日：2012-08-09
申请号：PCT/IB2012050143
申请日：2012-01-11
申请人： KIMBERLY CLARK CO , SONG XUEDONG , CHENG FULIANG
发明人： SONG XUEDONG , CHENG FULIANG
IPC分类号： A61F13/472 , A61F13/505 , A61F13/53 , A61P31/04
CPC分类号： A61L15/56 , A61L15/46 , A61L2300/21 , A61L2300/404
摘要： A feminine care absorbent article (e.g., feminine care pad, sanitary napkin, tampon, etc.) is provided that employs a synergistic combination of an antimicrobial composition for inhibiting the growth of microorganisms (e.g., bacteria, protozoa, yeast, fungi, etc.) and a pH sensor for signaling to the user when the antimicrobial composition is no longer operating at its full capacity. In this manner, the user can initially wear the article without fear of infection. After a certain period of time, the user can visually inspect the color of the pH sensor to obtain an indication of whether the antimicrobial composition is still active and effective in inhibiting microorganism growth, or whether it is time to replace or remove the article.
摘要翻译：提供了一种女性护理吸收制品（例如，女性护理垫，卫生巾，棉条等），其采用抗微生物组合物的协同组合来抑制微生物（例如细菌，原生动物，酵母，真菌等）的生长）和pH传感器，用于当抗微生物组合物不再以其全部容量运行时向用户发信号。以这种方式，用户可以最初佩戴物品而不用担心感染。在一段时间后，用户可以目视检查pH传感器的颜色，以获得抗微生物组合物是否仍然具有活性并且有效抑制微生物生长的指示，或者是否更换或移除物品。

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