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1. 发明申请

WO02097735A8 SYSTEM AND METHOD OF ANATOMICAL MODELING 审中-公开
标题翻译：解剖学建模系统与方法
公开(公告)号：WO02097735A8
公开(公告)日：2003-12-18
申请号：PCT/SG0100111
申请日：2001-05-31
申请人： KENT RIDGE DIGITAL LABS , CHEN XUESONG , CHUI CHEE KONG , NOWINSKI WIESLAW L
发明人： CHEN XUESONG , CHUI CHEE KONG , NOWINSKI WIESLAW L
IPC分类号： G06T17/00 , G06T17/10
CPC分类号： G06T17/00
摘要： Methods of modeling anatomical structures, along with pathology including the vasculature, spine and internal organs, for visualization and manipulation in simulation systems. A representation of the human vascular network is built up from medical images and a geometrical model produced therefrom by extracting topological and geometrical information. The model is constructed using topological and geometrical information. The model is constructed using segments containing topology structure information, flow domain information contour domain information and skeletal domain information. A realistic surface is then applied to the geometric model, by generating a trajectory along a central axis of the geometric model, conducting moving trihedron modeling along the generated trajectory and then creating a sweeping surface along the trajectory. A novel joint reconstruction approach is also proposed whereby a part surface sweeping operation is performed across branches of the joint and then a surface created over the resultatn holes therebetween. A 3-D mesh may also be generated, based upon this model, for finite element analysis and pathology creation.
摘要翻译：建模解剖结构的方法，包括脉管系统，脊柱和内脏的病理学，用于模拟系统中的可视化和操纵。通过提取拓扑和几何信息，从医学图像和由其产生的几何模型建立人血管网络的表示。该模型使用拓扑和几何信息构建。该模型使用包含拓扑结构信息，流域信息轮廓域信息和骨架域信息的段来构建。然后通过沿几何模型的中心轴产生轨迹，沿着所产生的轨迹进行移动三面体建模，然后沿着轨迹创建扫掠表面，将现实表面施加到几何模型。还提出了一种新颖的关节重建方法，其中在关节的分支之间执行部分表面扫掠操作，然后在其之间形成的表面上形成表面。也可以基于该模型生成用于有限元分析和病理创建的3-D网格。

2. 发明申请

WO02093292A3 METHODS AND APPARATUS FOR CALCULATING AND PRESENTING THE PROBABILISTIC FUNCTIONAL MAPS OF THE HUMAN BRAIN 审中-公开
标题翻译：用于计算和显示人脑的概率函数的方法和装置
公开(公告)号：WO02093292A3
公开(公告)日：2003-01-30
申请号：PCT/SG0200023
申请日：2002-02-18
申请人： KENT RIDGE DIGITAL LABS , NOWINSKI WIESLAW L , BIALOU DZMITRY
发明人： NOWINSKI WIESLAW L , BIALOU DZMITRY
IPC分类号： A61B5/0476 , G06F20060101 , G06F17/10 , G06F17/18 , G06F19/00 , G06K9/00 , G06F101/14 , G06F159/00
CPC分类号： G06K9/0057
摘要： The present invention proposes a method for calculating, presenting, and combining probabilistic functional maps (PFMs) of the human brain representing the probability of structures existing. The method comprises three major steps: reading of data containing the coordinates of contacts, calculating the PFMs, and presenting he PFMs. The data can be read from a file in text or binary format or from a database as local or remote client. The PFM calculation comprises the following steps: forming 3D models of contacts, normalizing the contact models, voxelizing the contact models, calculating an atlas function, and calculating the PFM. The PFM can be presented alone or along with anatomical atlases. Both 3D and 2D interfaces can be used for presentation. The proposed method also includes different ways of combining the contact data and/or existing PFMs from multiple sources. This mechanism is the basis of an internet portal for stereotactic and functional neurosurgery.
摘要翻译：本发明提出了一种用于计算，呈现和组合表示现有结构概率的人脑的概率功能图（PFM）的方法。该方法包括三个主要步骤：读取包含联系人坐标，计算PFM以及提供PFM的数据。数据可以从文本或二进制格式的文件读取，也可以从本地或远程客户机的数据库读取。 PFM计算包括以下步骤：形成联系人的三维模型，归一化接触模型，使接触模型体素化，计算图谱功能，计算PFM。 PFM可以单独呈现或与解剖图谱一起出现。 3D和2D界面均可用于演示。所提出的方法还包括组合来自多个源的联系人数据和/或现有PFM的不同方式。这种机制是立体定向和功能神经外科的互联网门户的基础。

3. 发明申请

WO2008024082A3 LOCALIZATION OF BRAIN LANDMARKS SUCH AS THE ANTERIOR AND POSTERIOR COMMISSURES BASED ON GEOMETRICAL FITTING 审中-公开
标题翻译：作为基于几何配合的前庭和后期委员会的大陆地标的定位
公开(公告)号：WO2008024082A3
公开(公告)日：2008-09-25
申请号：PCT/SG2007000274
申请日：2007-08-24
申请人： AGENCY SCIENCE TECH & RES , VOLKAU IHAR , PRAKASH BHANU KN , NG TING TING , GUPTA VARSHA , NOWINSKI WIESLAW L
发明人： VOLKAU IHAR , PRAKASH BHANU KN , NG TING TING , GUPTA VARSHA , NOWINSKI WIESLAW L
IPC分类号： G06T7/00 , G06T7/60
CPC分类号： G06T7/60 , A61B6/504 , G06T7/75 , G06T7/77 , G06T2207/30016
摘要： A method of estimating the location of the anterior and posterior commissures in a brain scan image is proposed. Firstly, a geometrical object is constructed using points on a brain scan image of an individual which are on the surface of the brain, such as an ellipse fitting the cerebral surface of a sagittal image of the mid-sagittal plane, or an adjacent sagittal plane. The locations on the MSP of the AC and PC landmarks (and optionally other landmarks) are estimated using the five parameters which define the ellipse, plus numerical values obtained in advance from statistical analysis of other individuals.
摘要翻译：提出了一种在脑扫描图像中估计前后连合位置的方法。首先，使用位于脑表面的个体的脑扫描图像上的点构成几何对象，例如适合中矢状面的矢状图像的大脑表面的椭圆或相邻矢状面。使用定义椭圆的五个参数，以及从其他个人的统计分析预先获得的数值，估计AC和PC地标（以及可选的其他地标）的MSP上的位置。

4. 发明申请

WO2007105107A3 METHODS, APPARATUS AND COMPUTER-READABLE MEDIA FOR IMAGE SEGMENTATION 审中-公开
标题翻译：方法，图像分割的装置和计算机可读介质
公开(公告)号：WO2007105107A3
公开(公告)日：2008-01-24
申请号：PCT/IB2007001215
申请日：2007-03-13
申请人： AGENCY SCIENCE TECH & RES , HU QINGMAO , QIAN GUOYU , NOWINSKI WIESLAW L
发明人： HU QINGMAO , QIAN GUOYU , NOWINSKI WIESLAW L
IPC分类号： G06T5/00
CPC分类号： G06T7/174
摘要： A method of thresholding a set of images of an object of interest taken at different relative axial positions, each image in the set of images comprising a plurality of pixels each pixel having an intensity. The method comprises determining based on the intensities of the pixels in plural images from the set of images a global intensity value for the set of images; determinging based on the intensities of the pixels in a first image from the set of images a local intensity value for the first image; establishing for at least one image intermediate the first and second images, a respective lower threshold that is dependent on at least the global intensity value and the local intensity value for the first image; and binarizing the at least one intermedite image according to the respective lower threshold to create a corresponding at least one mask for segmentation of the object of interest.
摘要翻译：一种阈值化在不同相对轴向位置处拍摄的感兴趣对象的一组图像的方法，所述图像集合中的每个图像包括具有强度的每个像素的多个像素。该方法包括基于来自该组图像的多个图像中的像素的强度来确定该组图像的全局强度值; 基于来自该组图像的第一图像中的像素的强度来确定第一图像的局部强度值; 为所述第一和第二图像中的至少一个图像建立至少依赖于第一图像的全局强度值和局部强度值的相应下阈值; 以及根据所述相应的下阈值二值化所述至少一个中间图像，以创建相应的至少一个用于所述感兴趣对象的分割的掩模。

5. 发明申请

WO2004034178A8 STATISTICAL DATA ANALYSIS TOOL 审中-公开
标题翻译：统计数据分析工具
公开(公告)号：WO2004034178A8
公开(公告)日：2007-09-13
申请号：PCT/SG0200231
申请日：2002-10-11
申请人： LAB FOR INFORMATION TECHNOLOGY , HU QINGMAO , NOWINSKI WIESLAW L
发明人： HU QINGMAO , NOWINSKI WIESLAW L
IPC分类号： G06Q90/00 , G06F20060101 , G06F1/00 , G06F17/18 , G06K9/62
CPC分类号： G06K9/6284 , G06F17/18

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