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1. 发明申请

WO02078720A3 ANTIBIOTICS FROM BACTERIA ISOLATED FROM AMPHIBIAN SKIN 审中-公开
标题翻译：来自大分子皮肤分离的细菌的抗生素
公开(公告)号：WO02078720A3
公开(公告)日：2002-12-05
申请号：PCT/US0200217
申请日：2002-01-04
申请人： KEMIN IND INC , PLETHODON RES L L C
发明人： AUSTIN RICHARD M JR , VAN HEMEL JOHAN , SAS BENEDIKT , VANDERKERCKHOVE JAN
IPC分类号： G01N33/50 , A61K35/74 , A61K45/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , C12P1/04 , C12Q1/02 , C12Q1/04 , C12Q1/18 , G01N33/15 , G01N33/569 , A61K35/00 , A61K38/43 , C12P1/00 , C12P39/00 , G01N33/567
CPC分类号： C12R1/01 , A61K35/74 , A61K35/744 , C12P1/04 , C12Q1/025 , C12Q1/04 , C12Q1/18 , G01N33/56911 , G01N33/56961 , G01N33/56988 , G01N2333/005 , G01N2333/16 , G01N2333/21 , G01N2333/245 , G01N2333/265 , G01N2333/31 , G01N2333/315 , G01N2333/37 , G01N2333/38 , G01N2333/40 , G01N2333/4606 , G01N2500/20
摘要： This invention discloses extracts including a biologically active compound or combination of compounds derived from microorganisms isolated from mucous-producing organisms that respire at least partially through their skin. Rod-shaped bacteria isolated from the skin of salamanders and frogs are found to produce compound(s) that have antiviral, antitumor, antibacterial and antifungal properties. These compounds have an inhibitory effect on opportunistic human pathogens, including Candida sp., Microsporum sp., Staphylococcus sp., Pseudomonas sp., Escherichia sp.,and Enterococcus sp., as well as on HIV strains and tumor cell lines.
摘要翻译：本发明公开了一种提取物，其包括生物活性化合物或衍生自从至少部分地通过其皮肤呼出的粘液生成生物分离的微生物的化合物的组合。发现从蝾螈和青蛙的皮肤分离的棒状细菌产生具有抗病毒，抗肿瘤，抗菌和抗真菌性质的化合物。这些化合物对机体性人类病原体具有抑制作用，包括假丝酵母属，微孢子菌属，葡萄球菌属，假单胞菌属，埃希氏菌属，肠球菌属，以及HIV菌株和肿瘤细胞系。

2. 发明申请

WO0130299A3 METHOD OF SYNTHESIZING ALKYL GALLATES 审中-公开
标题翻译：合成谷氨酸盐的方法
公开(公告)号：WO0130299A3
公开(公告)日：2002-01-31
申请号：PCT/US0029510
申请日：2000-10-26
申请人： KEMIN IND INC
发明人： SAS BENEDIKT , COPPENS BRUNO , VAN HEMEL JOHAN
IPC分类号： C07C67/08 , C07C69/88
CPC分类号： C07C67/08 , C07C69/84
摘要： A method for synthesizing alkyl gallates. Gallic acid and an alkyl alcohol of the order of the desired gallate are heated in a reaction vessel in the presence of a catalyst such as sulfuric acid or para-toluene sulfonic acid. Water is generated, forming an azeotrope with the alkyl alcohol. Distillation or Soxhlet extraction using a drying agent removes the formed water. Upon completion of the reaction, the reaction mixture is added while stirring to an alkane solvent and cooled to produce crystals of the desired alkyl gallate. The crystals may be further recrystallized and washed to improve their purity.
摘要翻译：合成没食子酸烷基酯的方法。在催化剂如硫酸或对甲苯磺酸的存在下，在反应容器中加热没食子酸和所需的没食子酸酯的顺序的烷基醇。产生水，与烷基醇形成共沸物。使用干燥剂的蒸馏或索格利特提取物除去形成的水。反应完成后，将反应混合物在搅拌下加入到烷烃溶剂中并冷却以产生所需的没食子酸烷基酯的晶体。晶体可进一步重结晶并洗涤以提高它们的纯度。

3. 发明申请

WO2007064741A3 THE USE OF BACILLUS PB6 FOR THE PROPHYLAXIS OR TREATMENT OF GASTROINTESTINAL AND IMMUNO-RELATED DISEASES 审中-公开
标题翻译： BACILLUS PB6用于预防或治疗胃肠道疾病和免疫相关疾病
公开(公告)号：WO2007064741A3
公开(公告)日：2008-05-08
申请号：PCT/US2006045755
申请日：2006-11-29
申请人： KEMIN IND INC , SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
发明人： SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
IPC分类号： A01N63/00
CPC分类号： A61K35/742 , A23L33/135 , A61K38/164 , C12R1/07 , C12R1/125
摘要： Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).
摘要翻译： sp。的细菌。发现产生脂肽的芽孢杆菌当作为益生菌施用时在治疗和预防胃肠疾病方面是有效的。具体而言，鉴定为PB6的芽孢杆菌属细菌菌株在作为益生菌施用时可用于治疗抗生素相关性腹泻（AAD）或更严重的病症性艰难梭菌相关性腹泻（CDAD）。此外，这些细菌已被发现有效治疗免疫相关疾病，如炎症性肠病（IBD）。

4. 发明申请

WO2007064741A8 THE USE OF BACILLUS PB6 FOR THE PROPHYLAXIS OR TREATMENT OF GASTROINTESTINAL AND IMMUNO-RELATED DISEASES 审中-公开
标题翻译： BACILLUS PB6用于预防或治疗胃肠疾病和免疫相关疾病的使用
公开(公告)号：WO2007064741A8
公开(公告)日：2008-01-31
申请号：PCT/US2006045755
申请日：2006-11-29
申请人： KEMIN IND INC , SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
发明人： SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
IPC分类号： A61K31/74
CPC分类号： A61K35/742 , A23L33/135 , A61K38/164 , C12R1/07 , C12R1/125
摘要： Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).
摘要翻译：细菌发现产生脂肽的芽孢杆菌在作为益生菌施用时可有效地治疗和预防胃肠道疾病。特别地，当作为益生菌施用时，鉴定为PB6的芽孢杆菌菌株可用于治疗抗生素相关性腹泻（AAD）或更严重的艰难梭菌相关性腹泻（CDAD）。另外，已经发现这些细菌对于治疗免疫反应性疾病如炎症性肠病（IBD）是有效的。

5. 发明申请

WO0149248A3 METHOD OF CRYSTALLIZING AND PURIFYING ALKYL GALLATES 审中-公开
标题翻译：结晶和纯化阿尔茨格洛尔的方法
公开(公告)号：WO0149248A3
公开(公告)日：2002-03-07
申请号：PCT/US0035585
申请日：2000-12-28
申请人： KEMIN IND INC
发明人： SAS BENEDIKT , COPPENS BRUNO , VAN HEMEL JOHAN
IPC分类号： C07C67/52 , C07C69/86
CPC分类号： C07C67/52 , C07C69/84
摘要： A method for crystallizing and purifying alkyl gallates formed by esterification of gallic acid. A brine solution is added to the reaction mixture of the alkyl gallate. The treated mixture is then separated, and the fraction of the reaction mixture containing the alkyl gallate is reserved. An alkane solvent, preferably petroleum ether, is added to the separated fraction. The reaction mixture is then cooled to produce crystals of the desired alkyl gallate. The crystals may be further recrystallized and washed to improve their purity.
摘要翻译：通过没食子酸的酯化形成的没食子酸烷基酯的结晶和纯化的方法。将盐水溶液加入到没食子酸烷基酯的反应混合物中。然后分离处理的混合物，并保留含有没食子酸烷基酯的反应混合物的级分。将烷烃溶剂，优选石油醚加入到分离的馏分中。然后将反应混合物冷却以产生所需的没食子酸烷基酯的晶体。晶体可进一步重结晶并洗涤以提高它们的纯度。

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