专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996040048A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 审中-公开
标题翻译：用于甲状腺激素或甲状腺激素类化合物的新用途
公开(公告)号：WO1996040048A2
公开(公告)日：1996-12-19
申请号：PCT/US1996009975
申请日：1996-06-07
申请人： KARO BIO AB , LAVIN, Thomas, N. , VAHLQUIST, Anders, B.
发明人： KARO BIO AB
IPC分类号： A61K07/48
CPC分类号： A61K8/44 , A61K8/64 , A61K31/055 , A61K31/137 , A61K31/192 , A61K31/195 , A61K31/341 , A61K31/343 , A61K31/425 , A61K31/44 , A61K31/505 , A61K31/53 , A61Q19/00 , A61Q19/004 , A61Q19/06 , A61Q19/08 , A61K2300/00
摘要： This invention relates to the use of topically applied thyroid hormones and thyroid hormone-like compounds which are receptor binding ligands, either agonists or antagonists, to improve the appearance of the skin and underlying subcutaneous fat and improve certain medical conditions when applied topically. These compounds can be used to treat skin conditions such as stria, cellulite, roughened skin, actinic skin damage, intrinsically aged skin, photodamaged skin, lichen planus, ichthyosis, acne, psoriasis, wrinkled skin, and to diminish the size and improve the appearance of skin scarring from surgical or naturally occurring wounds, and to reduce the incidence of hyperkeratotic scarring. These hormones or hormone analogs will also increase the rate of epithelialization and collagen production. The thyroid agonists and antagonists may also promote differentiation and amelioration of dedifferentiated skin in premalignant lesions. The thyroid agonists and antagonists can be active in all organisms which contain the thyroid hormone receptors, notably amphibians, birds and subjects. Combination with Vitamin D analogs glucocorticoid and retinoids will potentiateand modify the effects of the thyroid hormones for increased benefit. Side effects of thyroid hormones which occur when the hormone is given orally and prevent usefulness for the above conditions are prevented when the hormone is topically applied.
摘要翻译：本发明涉及作为受体结合配体的激动剂或拮抗剂的局部施用的甲状腺激素和甲状腺激素样化合物在外用时改善皮肤外观和改善某些医学状况的用途。这些化合物可用于治疗皮肤状况，如纹状体，脂肪团，粗糙皮肤，光化性皮肤损伤，皮肤老化，光损伤皮肤，扁平苔藓，鱼鳞病，痤疮，牛皮癣，皱纹皮肤，并减小体型和改善外观的皮肤由外科手术或天然存在的伤口瘢痕形成，并减少角化过度瘢痕形成的发生。这些激素或激素类似物也将增加上皮形成和胶原蛋白生成的速率。甲状腺激动剂和拮抗剂也可促进恶化前病变中去分化皮肤的分化和改善。甲状腺激动剂和拮抗剂可以在含有甲状腺激素受体的所有生物中起主要作用，特别是两栖动物，鸟类和受试者。与维生素D类似物组合，糖皮质激素和类维生素A将加强并修饰甲状腺激素的作用，增加益处。当荷尔蒙被局部施用时，当激素被口服给药时发生的甲状腺激素的副作用和预防上述病症的有用性被阻止。

2. 发明申请

WO1996017927A2 REPORTER CELL LINE 审中-公开
标题翻译：报告器细胞线
公开(公告)号：WO1996017927A2
公开(公告)日：1996-06-13
申请号：PCT/EP1995004819
申请日：1995-12-05
申请人： KARO BIO AB , NILSSON, Stefan
发明人： KARO BIO AB
IPC分类号： C12N05/10
CPC分类号： C12Q1/6897 , A61K38/00 , C07K14/61 , C12N15/67
摘要： The present invention provides a cell line including a first reporter gene arranged to express an assayable first gene product, expression of the first reporter gene being AP-1 mediated, and a second reporter gene arranged to express a second assayable gene product, expression of the second reporter gene being mediated by NF kappa B. Thus the present invention provides a convenient one cell line-based assay system which can be used to rapidly test a large number of compounds for potential anti-inflammatory activity. According to a further aspect of the invention there is provided a method of testing a compound for both AP1 and NF kappa B inhibitory activity, the method comprising providing cells in accordance with the first aspect of the invention, stimulating AP1 and NF kappa B activity in the cells and contacting the cells with the compound to be tested and monitoring expression of the first and second gene products wherein inhibition of AP1 expression of the first gene product, and inhibition of NF kappa B mediated expression of the second gene product is indicative that the compound has both AP1 and NF kappa B-inhibitory activity.
摘要翻译：本发明提供一种细胞系，其包括布置成表达可测定的第一基因产物的第一报道基因，介导的AP-1的第一报道基因的表达，以及排列成表达第二可测定基因产物的第二报道基因，第二报告基因由NFκB介导。因此，本发明提供了一种方便的一种基于细胞系的测定系统，其可用于快速测试大量化合物用于潜在的抗炎活性。根据本发明的另一方面，提供了测试AP1和NFκB抑制活性化合物的方法，所述方法包括提供根据本发明第一方面的细胞，其刺激AP1和NFκB活性细胞并使细胞与待测化合物接触并监测第一和第二基因产物的表达，其中抑制第一基因产物的AP1表达和抑制NFκB介导的第二基因产物的表达表明，化合物具有AP1和NFκB抑制活性。

3. 发明申请

WO1996035785A3 TRANSGENIC ANIMALS HAVING A DEFECTIVE THYROID HORMONE RECEPTOR BETA GENE 审中-公开
公开(公告)号：WO1996035785A3
公开(公告)日：1996-11-14
申请号：PCT/EP1996001983
申请日：1996-05-10
申请人： KARO BIO AB , FORREST, Douglas , CURRAN, Thomas
发明人： KARO BIO AB
IPC分类号： C12N15/12

4. 发明申请

WO1996033408A1 ON-LINE COUPLING OF BIOCHEMICAL DETECTION TO CONTINUOUS-FLOW SEPARATION TECHNIQUES 审中-公开
标题翻译：生化检测在连续流技术分离中的在线耦合
公开(公告)号：WO1996033408A1
公开(公告)日：1996-10-24
申请号：PCT/EP1995001523
申请日：1995-04-21
申请人： RIJKSUNIVERSITEIT LEIDEN , KARO BIO AB , VAN DER GREEF, Jan , IRTH, Hubertus , VAN DER VLICS, Erik , OOSTERKAMP, Aaike , HAGGBLAD, Johan
发明人： RIJKSUNIVERSITEIT LEIDEN , KARO BIO AB
IPC分类号： G01N33/53
CPC分类号： G01N33/53 , G01N30/84 , G01N2030/8435 , G01N2030/8813
摘要： The present invention relates to an on-line detection method comprising the on-line coupling of a fractionation and a biochemical detection technique, which method comprises the addition of a controlled amount of an affinity molecule to the effluent of the fractionation step to react with analytes in the effluent, the subsequent addition of a controlled amount of a detectable ligand capable of binding to the affinity molecule, and detection of the affinity molecule/detectable ligand complex. Further, the invention is directed to an on-line method for the screening of compounds on their binding capability to a known affinity molecule, which method comprises a fractionation step providing an effluent, the addition of a controlled amount of said affinity molecule to the effluent of the fractionation step and effecting a contact time sufficient to allow a reaction with or interaction between the compounds in the effluent, the subsequent addition of a controlled amount of a detectable ligand capable of binding to the affinity molecule, and detection of the affinity molecule/detectable ligand complex.
摘要翻译：在线检测生物化学检测或分馏技术的在线检测方法。该方法包括向分馏步骤的流出物中添加受控量的亲和分子，使得所述分子与流出物中存在的分析物反应，然后添加受控量的能够结合亲和分子的可检测配体，和检测可检测配体/亲和分子复合物。本发明进一步涉及用于确定化合物结合已知亲和力分子的能力的在线方法，所述方法包括产生流出物的分馏步骤，添加受控量的所述分子与来自分馏步骤的流出物具有亲和力，接触时间足以允许化合物与流出物之间的反应或相互作用，随后加入受控量的可检测配体，其能够结合亲和分子和检测可检测配体/亲和分子复合物。

5. 发明申请

WO1996019739A2 ASSAY APPARATUS 审中-公开
标题翻译：测定装置
公开(公告)号：WO1996019739A2
公开(公告)日：1996-06-27
申请号：PCT/EP1995005132
申请日：1995-12-22
申请人： KARO BIO AB , HAGGBLAD, Johan , ÖSTERLUND, Marie
发明人： KARO BIO AB
IPC分类号： G01T01/29
CPC分类号： B01L3/5023 , B01L2300/12 , B01L2400/0406 , G01T1/203 , G01T1/2942
摘要： The invention provides a solid support for example for use in a radioligand binding assay, the solid support comprising a plurality of interconnected elements arranged to provide interstitial spaces in which a liquid can flow. When a liquid sample is applied to a surface of the support of the invention it spreads across the surface of the support to a certain extent and also flows into the support on the surfaces of the interconnected elements which form the support and into the interstitial spaces therebetween. The support of the invention may be used as a support for a chemical reaction or for cell growth.
摘要翻译：本发明提供了例如用于放射性配体结合测定中的固体支持物，所述固体支持物包括多个互连元件，所述多个互连元件布置成提供液体可以在其中流动的间隙空间。当将液体样品施加到本发明的支撑体的表面上时，其在一定程度上分布在支撑体的表面上，并且也流入形成支撑件的互连元件的表面中的支撑件中并进入其间的间隙空间。本发明的载体可用作化学反应或细胞生长的载体。

6. 发明申请

WO1996012011A1 REPORTER CELL LINE 审中-公开
标题翻译：报告器细胞线
公开(公告)号：WO1996012011A1
公开(公告)日：1996-04-25
申请号：PCT/EP1995004032
申请日：1995-10-12
申请人： KARO BIO AB , NILSSON, Stefan
发明人： KARO BIO AB
IPC分类号： C12N05/10
CPC分类号： C12Q1/6897
摘要： The invention provides a cell line including a first reporter gene arranged to express an assayable first gene product, expression of the first reporter gene being AP-1 mediated, and a second reporter gene arranged to express a second assayable gene product, expression of the second reporter gene being mediated by the glucocorticoid receptor (GR). The invention also provides a method of testing a compound for glucocorticoid-like activity comprising providing cells in accordance with the first aspect of the invention, stimulating AP1 activity in the cells and contacting the cells with the compound and monitoring expression of the first and second gene products.
摘要翻译：本发明提供了一种细胞系，其包括布置成表达可测定的第一基因产物的第一报道基因，第一报告基因的表达是AP-1介导的，第二报告基因排列成表达第二可测定基因产物，第二报告基因表达第二报告基因由糖皮质激素受体（GR）介导。本发明还提供了一种测试糖皮质激素样活性化合物的方法，包括提供根据本发明第一方面的细胞，刺激细胞中的AP1活性并使细胞与化合物接触并监测第一和第二基因的表达产品。

7. 发明申请

WO1995017383A1 INDOLE DERIVATIVES AS ANTI-ESTROGENS 审中-公开
标题翻译：作为抗雌激素的衍生物
公开(公告)号：WO1995017383A1
公开(公告)日：1995-06-29
申请号：PCT/EP1994004250
申请日：1994-12-23
申请人： KARO BIO AB , NORINDER, Ulf
发明人： KARO BIO AB
IPC分类号： C07D209/12
CPC分类号： C07D403/06 , C07D209/12
摘要： The invention relates to an indole derivative of formula (I), wherein R1 and R2 independently represent hydroxy, methoxy or fluorine, preferably hydroxy; n represents an integer of 9 to 12; and X represents a member of the group consisting of CONR4R5, CSNR4R5, NR4COR5, NR4R5, SO2NR4R5, NR4SO2R5, 1-R4-5-tetrazole, wherein R4 and R5 are independently selected from the group of hydrogen and lower alkyls or R4 and R5 together form a bridge of the formula -(CH2)y- wherein y represents an integer 4 or 5, are disclosed. The invention also relates to a pharmaceutical preparation comprising one or more of said indole derivatives and to the use of said derivatives as a medicament are described. Also disclosed is the use of said indole derivatives for the preparation of a medicament for the therapeutic or prophylactic treatment of an estrogen related disorder or disease, such as in estrogen replacement therapy and/or breast cancer.
摘要翻译：本发明涉及式（I）的吲哚衍生物，其中R 1和R 2独立地表示羟基，甲氧基或氟，优选羟基; n表示9〜12的整数，并且X表示由CONR4R5，CSNR4R5，NR4COR5，NR4R5，SO2NR4R5，NR4SO2R5,1-R4-5-四唑组成的组的成员，其中R4和R5独立地选自氢和低级烷基或R4和R5一起形成式 - （CH 2）y - 的桥，其中y表示整数4或5。本发明还涉及包含一种或多种所述吲哚衍生物和所述衍生物作为药物的用途的药物制剂。还公开了所述吲哚衍生物在制备用于治疗或预防性治疗雌激素相关病症或疾病例如雌激素替代疗法和/或乳腺癌的药物中的用途。

8. 发明申请

WO1997009348A2 ORPHAN RECEPTOR 审中-公开
标题翻译： ORPHAN受体
公开(公告)号：WO1997009348A2
公开(公告)日：1997-03-13
申请号：PCT/EP1996003933
申请日：1996-09-09
申请人： KARO BIO AB , KUIPER, George, G., J., M. , ENMARK, Eva , GUSTAFSSON, Jan-Ake
发明人： KARO BIO AB
IPC分类号： C07K14/705
CPC分类号： C07K14/721
摘要： This invention relates to a novel estrogen receptor-related nuclear receptor, hereinafter termed "ER beta " having the amino acid sequence of Figs. 1, 13A or 14A or substantially the same amino acid sequence as the amino acid sequence shown in Figs. 1, 13A or 13B or an amino acid sequence functionally similar to that sequence. The invention also relates to DNA sequences encoding the receptor. The receptor may be useful in isolating molecules for the treatment of disorders such as prostate cancer, benign prostatic hyperplasia, osteoporosis or cardiovascular disorders and in the testing of substances for estrogenic and other hormonal effects.
摘要翻译：本发明涉及一种新颖的雌激素受体相关的核受体，下文称为“ERβ”，其具有图1和2的氨基酸序列。 1，13A或14A或与图1和图2所示的氨基酸序列基本相同的氨基酸序列。 1,13A或13B或与该序列功能相似的氨基酸序列。本发明还涉及编码该受体的DNA序列。该受体可用于分离用于治疗诸如前列腺癌，良性前列腺增生症，骨质疏松症或心血管疾病的疾病的分子，以及用于雌激素和其他激素作用的物质的测试。

9. 发明申请

WO1996030500A1 CULTURE MEDIUM FOR INSECT CELLS 审中-公开
标题翻译：文化培养基用于细胞培养
公开(公告)号：WO1996030500A1
公开(公告)日：1996-10-03
申请号：PCT/EP1996001281
申请日：1996-03-21
申请人： KARO BIO AB , ÖHMAN, Lars , HÄGGSTRÖM, Lena
发明人： KARO BIO AB
IPC分类号： C12N05/06
CPC分类号： C12N5/0601 , C12N9/2471 , C12N2500/05 , C12N2500/32 , C12Y302/01023
摘要： A culture medium for insect cells, particularly for culturing insect cells for the expression of proteins using a baculovirus expression system, characterized in that the medium does not contain glutamine.
摘要翻译：用于昆虫细胞的培养基，特别是用于培养使用杆状病毒表达系统表达蛋白质的昆虫细胞，其特征在于所述培养基不含有谷氨酰胺。

10. 发明申请

WO1996021728A2 TRANSGENIC ANIMALS HAVING A DEFECTIVE THYROID HORMONE RECEPTOR GENE 审中-公开
标题翻译：具有缺陷性甲状腺激素受体基因的转基因动物
公开(公告)号：WO1996021728A2
公开(公告)日：1996-07-18
申请号：PCT/EP1996000161
申请日：1996-01-15
申请人： KARO BIO AB , VENNSTROM, Bjorn
发明人： KARO BIO AB
IPC分类号： C12N15/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/721
摘要： According to one aspect of the invention there is provided a transgenic animal which is heterozygous for an at least partially defective thyroid hormone receptor gene. The defective gene may be inactivated for example by an insertion, deletion, substitution or inversion or other suitable genetic manipulation. According to other aspects of the invention there are provided cells derived from the transgenic mammal of the invention and methods of testing the agonist/antagonist properties of a compound using the transgenic mammal of the invention or such cells.
摘要翻译：根据本发明的一个方面，提供了对于至少部分缺陷的甲状腺激素受体基因是杂合的转基因动物。缺陷基因可以例如通过插入，缺失，取代或倒位或其他合适的遗传操作而失活。根据本发明的其他方面，提供了源自本发明的转基因哺乳动物的细胞和使用本发明的转基因哺乳动物或这种细胞测试化合物的激动剂/拮抗剂性质的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式