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1. 发明申请

WO2013119312A1 METHOD OF IDENTIFYING AN AGENT FOR INHIBITING ODOR OF PYRAZINE DERIVATIVES 审中-公开
标题翻译：识别用于抑制吡嗪衍生物的气味的方法
公开(公告)号：WO2013119312A1
公开(公告)日：2013-08-15
申请号：PCT/US2012/067889
申请日：2012-12-05
申请人： KAO CORPORATION
发明人： KATO, Aya , SAITO, Naoko , INOUE, Michiaki , NOMIZU, Kayoko
IPC分类号： G01N33/566
CPC分类号： C12Q1/025 , G01N33/566 , G01N2500/10
摘要： A method to identify an agent for reducing an odor of a pyrazine derivative, comprising: adding a test substance and a pyrazine derivative represented by the following Formula (I) : wherein R 1 represents methyl, ethyl, or acetyl; and R 2 , R 3 , and R4 each independently represent hydrogen or methyl, to an olfactory receptor 0R5K1 or a polypeptide having at least 80% identity to the amino acid sequence of the olfactory receptor 0R5K1; measuring a response of the olfactory receptor to the pyrazine derivative; and identifying a test substance inhibiting the response of the olfactory receptor on the basis of the measured response.
摘要翻译：一种识别用于降低吡嗪衍生物的气味的试剂的方法，包括：加入下式（I）表示的测试物质和吡嗪衍生物：其中R1表示甲基，乙基或乙酰基; 并且R 2，R 3和R 4各自独立地表示氢或甲基，与嗅觉受体0R5K1或与嗅觉受体0R5K1的氨基酸序列具有至少80％同一性的多肽; 测量嗅觉受体对吡嗪衍生物的反应; 并根据测定的反应鉴定抑制嗅觉受体反应的试验物质。

2. 发明申请

WO2013171535A2 AGENT FOR INHIBITING ODOR OF PYRAZINE DERIVATIVES 审中-公开
标题翻译：用于抑制吡嗪衍生物的气味的试剂
公开(公告)号：WO2013171535A2
公开(公告)日：2013-11-21
申请号：PCT/IB2012/003131
申请日：2012-12-29
申请人： KAO CORPORATION , KATO, Aya , SAITO, Naoko , INOUE, Michiaki , NOMIZU, Kayoko
发明人： KATO, Aya , SAITO, Naoko , INOUE, Michiaki , NOMIZU, Kayoko
IPC分类号： C07D241/12
CPC分类号： A61K31/121 , A61K31/045 , A61K31/05 , A61K31/075 , A61K31/09 , A61K31/11 , A61K31/12 , A61K31/122 , A61K31/365 , A61K31/603 , C07D241/12
摘要： Provided is an agent for reducing odors of pyrazine derivatives based on an olfactory receptor antagonism. The agent for reducing odors of pyrazine derivatives includes at least one antagonist of olfactory receptor OR5K1 as an active ingredient.
摘要翻译：提供了一种基于嗅觉受体拮抗作用降低吡嗪衍生物的气味的药剂。用于降低吡嗪衍生物的气味的试剂包括至少一种嗅觉受体OR5K1拮抗剂作为活性成分。

3. 发明申请

WO2013156859A2 SELF-TANNING COSMETIC 审中-公开
标题翻译：自拍化妆品
公开(公告)号：WO2013156859A2
公开(公告)日：2013-10-24
申请号：PCT/IB2013/001088
申请日：2013-04-17
申请人： KAO CORPORATION
发明人： INOUE, Michiaki , NOMIZU, Kayoko , YANUKI, Masayuki , KATO, Aya
CPC分类号： A61K8/35 , A61K8/33 , A61K8/34 , A61K8/342 , A61Q17/04 , A61Q19/04
摘要： A self-tanning cosmetic comprising components (A), (B) and (C), and a self-tanning method reducing an odor derived from a compound represented by the following formula (1), comprising a step of application of the cosmetic to the skin for a browning reaction, wherein the cosmetic comprises: (A) dihydroxyacetone; (B) at least one or more compounds selected from the group consisting of 4-methyl-3-decen-5-ol, 2-ethyl-4- (2, 2, 3- trimethyl- 3 -cyclopenten- 1-yl ) - 2 -buten- 1-ol, 2 -hexyl -3 -phenyl - 2-propenal and 2-methyl-3- (4 -iso-propylphenyl) propanal; and (C) at least one or more compounds selected from the group consisting of 3, 7 -dimethyl- 1, 6 -nonadien- 3 -ol, 1- (2,2,6- trimethyl-2-cyclohexenyl) -2 -buten- 1-one, 1- (5, 5-dimethyl - 1- cyclohexen-l-yl) - 4 -penten- 1 -one, 1- (3, 3-dimethyl-6-cyclohexen- 1-yl) -4 -penten- 1-one, benzaldehyde and gamma-nonalactone; wherein R 1 represents a methyl group, an ethyl group or an acetyl group, and R 2 , R 3 and R 4 represent a hydrogen atom or a methyl group.
摘要翻译：包含组分（A），（B）和（C）的自晒黑化妆品和减少由下式（1）表示的化合物衍生的气味的自鞣方法，包括将化妆品施用于用于褐变反应的皮肤，其中所述化妆品包含：（A）二羟基丙酮; （B）至少一种或多种选自4-甲基-3-癸烯-5-醇，2-乙基-4-（2,2,3-三甲基-3-环戊烯-1-基） 2-丁烯-1-醇，3-己基-3-苯基-2-丙烯醛和2-甲基-3-（4-异丙基苯基）丙醛; 和（C）至少一种或多种选自3,7-二甲基-1,6-壬二烯-3-醇，1-（2,2,6-三甲基-2-环己烯基）-2- 丁烯-1-酮，1-（5,5-二甲基-1-环己烯-1-基）-4-戊烯-1-酮，1-（3,3-二甲基-6-环己烯-1-基） - 4-戊烯-1-酮，苯甲醛和γ-壬内酯; 其中R1表示甲基，乙基或乙酰基，R2，R3和R4表示氢原子或甲基。

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