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    • 3. 发明申请
    • THERAPEUTIC INSERT AND THERAPEUTIC METHOD
    • 治疗插入和治疗方法
    • WO03022308A3
    • 2003-05-30
    • PCT/GB0204185
    • 2002-09-13
    • SCIENT GENERICS LTDMILLER NICHOLASHEMBER MILES WILLIAM NOEL
    • MILLER NICHOLASHEMBER MILES WILLIAM NOEL
    • A61K41/00A61K49/04A61K51/12A61N1/40A61N5/10
    • A61K51/1282A61K41/0052A61K49/048A61N1/406A61N2005/1024
    • A thin preformed therapeutic implant contains minute particles, and has a polymeric material at least on the outside. The particles may be radioactive for radiotherapy, radio-opaque for easy imaging, and ferromagnetic for thermal therapy, and are preferably ferrite particles. The particles and the implant as a whole may be biodegradable, and drugs or other chemicals may be associated with the particles or otherwise combined in the implant to allow combination therapies. The implant may be in the form of seeds, a filament, a ribbon or a sheet, and therapeutic performance can be tailored by a non-uniform distribution of particles in the implant. The ferrite particles can be used in localised heat therapy either in the implants or separately, to provide a combination of heat therapy with radiotherapy and/or chemotherapy.
    • 薄的预成型治疗植入物包含微小的颗粒,并且至少在外部具有聚合材料。 颗粒可以放射性用于放射治疗,不透射线用于易于成像,并且用于热疗的铁磁性材料,并且优选为铁氧体颗粒。 颗粒和植入物作为整体可以是可生物降解的,并且药物或其它化学物质可能与颗粒结合或以其他方式组合在植入物中以允许组合治疗。 植入物可以是种子,丝,丝带或片的形式,并且可以通过植入物中的颗粒的不均匀分布来调节治疗性能。 铁氧体颗粒可以在植入物或分开的局部热疗中使用,以提供热疗与放射治疗和/或化学疗法的组合。