专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007053526A1 COMPOSITIONS AND METHODS FOR IDENTIFYING MODULATORS OF TRPV2 审中-公开
标题翻译：用于鉴定TRPV2调节剂的组合物和方法
公开(公告)号：WO2007053526A1
公开(公告)日：2007-05-10
申请号：PCT/US2006/042241
申请日：2006-10-30
申请人： JANSSEN PHARMACEUTICA N.V. , QIN, Ning , LIU, Yi , FLORES, Christopher, M. , HUTCHINSON, Tasha , NEEPER, Michael, P.
发明人： QIN, Ning , LIU, Yi , FLORES, Christopher, M. , HUTCHINSON, Tasha , NEEPER, Michael, P.
IPC分类号： G01N33/68 , A61P39/00 , A61K31/352 , A61K31/05
CPC分类号： G01N33/6872 , A61K31/05 , A61K31/352 , G01N33/5058 , G01N33/948 , G01N2500/02
摘要： It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.
摘要翻译：现在已经发现某些大麻素特异性地激活TRPV2通道活性。基于发现，用于筛选，鉴定和表征增加或降低TRPV2生物活性的化合物的新型组合物和方法。

2. 发明申请

WO2008109596A2 CANINE TRANSIENT RECEPTOR POTENTIAL V2 (CTRPV2) AND METHODS OF SCREENING FOR TRPV2 CHANNEL MODULATORS 审中-公开
标题翻译：可能的瞬态受体电位V2（CTRPV2）和TRPV2通道调制器的筛选方法
公开(公告)号：WO2008109596A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/055782
申请日：2008-03-04
申请人： JANSSEN PHARMACEUTICA N.V. , QIN, Ning , FLORES, Christopher, M. , NEEPER, Michael, P.
发明人： QIN, Ning , FLORES, Christopher, M. , NEEPER, Michael, P.
IPC分类号： C07K14/43
CPC分类号： C07K14/705 , G01N33/6872 , G01N2500/10 , G01N2800/2842
摘要： A recombinant canine TRPV2 channel which has been prepared by cDNA cloning and polymerase chain reaction techniques is disclosed. Expression systems for these channels and an assay using the expression systems are also disclosed. The recombinant TRPV2 channel can be used in assays to evaluate compounds which directly or indirectly interact with or bind to TRPV2 channel.
摘要翻译：公开了通过cDNA克隆和聚合酶链反应技术制备的重组犬TRPV2通道。还公开了这些通道的表达系统和使用表达系统的测定法。重组TRPV2通道可用于测定直接或间接与TRPV2通道相互作用或结合TRPV2通道的化合物。

3. 发明申请

WO2005100386A2 CANINE COLD-AND MENTHOL-SENSITIVE RECEPTOR 1 审中-公开
标题翻译：犬肠冷敏感受体1
公开(公告)号：WO2005100386A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/011391
申请日：2005-04-06
申请人： JANSSEN PHARMACEUTICA N.V. , FLORES, Christopher M. , LIU, Yi , LUBIN, Mary Lou , QIN, Ning
发明人： FLORES, Christopher M. , LIU, Yi , LUBIN, Mary Lou , QIN, Ning
IPC分类号： C07K14/435
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays and screening assays.
摘要翻译：本发明提供了描述新的犬冷和薄荷醇敏感受体（这里称为犬CMR1（cCMR1））的核酸和多肽序列。本发明的分离的核酸或多肽分子可用于检测测定和筛选测定。

4. 发明申请

WO2009012430A1 SULFONAMIDES AS TRPM8 MODULATORS 审中-公开
标题翻译：磺酰胺作为TRPM8调节剂
公开(公告)号：WO2009012430A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/070425
申请日：2008-07-18
申请人： JANSSEN PHARMACEUTICA N.V. , BRANUM, Shawn T. , COLBURN, Raymond W. , DAX, Scott L. , FLORES, Christopher M. , JETTER, Michele C. , LIU, Yi , LUDOVICI, Donald , MACIELAG, Mark J. , MATTHEWS, Jay M. , MCNALLY, James J. , REANEY, Laura M. , RUSSELL, Ronald K. , QIN, Ning , WELLS, Kenneth M. , YOUELLS, Scott C. , YOUNGMAN, Mark A.
发明人： BRANUM, Shawn T. , COLBURN, Raymond W. , DAX, Scott L. , FLORES, Christopher M. , JETTER, Michele C. , LIU, Yi , LUDOVICI, Donald , MACIELAG, Mark J. , MATTHEWS, Jay M. , MCNALLY, James J. , REANEY, Laura M. , RUSSELL, Ronald K. , QIN, Ning , WELLS, Kenneth M. , YOUELLS, Scott C. , YOUNGMAN, Mark A.
IPC分类号： C07D333/36 , C07D495/04 , A61K31/381 , A61P13/00
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： ABSTRACT Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, B, G, Y, R 1 , R 2 , R 3, and R 4 are defined herein.
摘要翻译：摘要公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。这样的化合物由式（I）表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。

5. 发明申请

WO2007053570A2 A POLYPEPTIDE COMPLEX OF TRPM8 AND CALMODULIN AND ITS USES THEREOF 审中-公开
标题翻译： TRPM8和钙调蛋白的多肽复合物及其用途
公开(公告)号：WO2007053570A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/042361
申请日：2006-10-31
申请人： JANSSEN PHARMACEUTICA N.V. , QIN, Ning , FLORES, Christopher, M.
发明人： QIN, Ning , FLORES, Christopher, M.
IPC分类号： C07K14/435 , C07K14/705
CPC分类号： C07K14/705 , G01N33/6872 , G01N2333/4727 , G01N2500/02
摘要： The present invention discovered that a mammalian TRPM8 binds to calmodulin. The present invention provides a polypeptide complex comprising a cold-menthol receptor (TRPM8) or an active fragment or derivative of TRPM8 and a calmodulin or an active fragment or derivative of calmodulin, and the uses of the polypeptide complex.
摘要翻译：本发明发现哺乳动物TRPM8结合钙调蛋白。本发明提供了包含冷 - 薄荷醇受体（TRPM8）或TRPM8的活性片段或衍生物和钙调蛋白或钙调蛋白的活性片段或衍生物的多肽复合物，以及该多肽复合物的用途。

6. 发明申请

WO2007134107A3 COLD MENTHOL RECEPTOR-1 ANTAGONISTS 审中-公开
公开(公告)号：WO2007134107A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/068566
申请日：2007-05-09
申请人： JANSSEN PHARMACEUTICA N.V. , COLBURN, Raymond, W. , DAX, Scott, L. , FLORES, Christopher , MATTHEWS, Jay , QIN, Ning , YOUNGMAN, Mark, A. , TELEHA, Christopher , REANY, Laura
发明人： COLBURN, Raymond, W. , DAX, Scott, L. , FLORES, Christopher , MATTHEWS, Jay , QIN, Ning , YOUNGMAN, Mark, A. , TELEHA, Christopher , REANY, Laura
IPC分类号： C07F9/40 , C07F9/572 , C07F9/655 , C07F9/6553 , A61K31/00
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

7. 发明申请

WO2004074311A3 HUMAN CYCLOOXYGENASE-3 AND USES THEREOF 审中-公开
公开(公告)号：WO2004074311A3
公开(公告)日：2004-09-02
申请号：PCT/IB2004/001039
申请日：2004-02-20
申请人： JANSSEN PHARMACEUTICA N.V.
发明人： QIN, Ning , FLORES, Christopher , ZHANG, Sui-Po , CODD, Ellen, E.
IPC分类号： C12N9/02
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cycloosygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.

8. 发明申请

WO2015039321A1 HIGH PRESSURE TRANSDUCER FOR HEAD-UP-DISPLAY DEVICE ON SELF CONTAINED BREATHING APPARATUS 审中-公开
标题翻译：用于自吸式呼吸装置上显示装置的高压传感器
公开(公告)号：WO2015039321A1
公开(公告)日：2015-03-26
申请号：PCT/CN2013/083850
申请日：2013-09-19
申请人： HONEYWELL INTERNATIONAL INC. , ZHENG, Jimmy , HAN, Abel , LIU, Bruce , QIN, Ning , LU, Kevin , HUA, Mark , LIN, Frank , WANG, Elwin
发明人： ZHENG, Jimmy , HAN, Abel , LIU, Bruce , QIN, Ning , LU, Kevin , HUA, Mark , LIN, Frank , WANG, Elwin
IPC分类号： A62B7/00 , A42B3/30
CPC分类号： A62B9/006
摘要： Embodiments relate generally to methods, systems, and devices for monitoring and/or indicating the pressure levels within a self-contained breathing apparatus (SCBA) (100). Applicants have found that incorporation of a transducer system (300) into a high-pressure hose (120) of an SCBA (100) may be beneficial to monitoring and indicating the pressure level of air within the SCBA (100), wherein the high-pressure hose (120) may be coupled to a pressure gauge (118) and optionally a warning whistle (119). In some embodiments, a transducer (300) may be operable to sense or detect the pressure of high-pressure air flowing through the transducer (300). Additionally, the transducer (300) may comprise a processor (510) operable to transmit signal referencing the pressure to a heads-up display device (HUD) (140), wherein the HUD (140) may indicate the pressure level to a user of the SCBA (100).
摘要翻译：实施例总体上涉及用于监测和/或指示自给式呼吸器（SCBA）（100）内的压力水平的方法，系统和装置。申请人已经发现，将换能器系统（300）并入SCBA（100）的高压软管（120）中可能有益于监测和指示SCBA（100）内的空气的压力水平，其中，压力软管（120）可联接到压力计（118）和任选的警告口哨（119）。在一些实施例中，换能器（300）可操作以感测或检测流过换能器（300）的高压空气的压力。另外，换能器（300）可以包括处理器（510），其可操作以将参考压力的信号传送到平视显示装置（HUD）（140），其中HUD（140）可以向用户指示压力水平 SCBA（100）。

9. 发明申请

WO2015172315A1 REUSABLE MASK WITH FILTER WITH ELASTIC EDGE 审中-公开
标题翻译：具有弹性边缘的过滤器的可重复使用的面罩
公开(公告)号：WO2015172315A1
公开(公告)日：2015-11-19
申请号：PCT/CN2014/077383
申请日：2014-05-13
申请人： HONEYWELL INTERNATIONAL INC. , ZHANG, Jianxiong , JIN, Zhao Xia , ZHU, Jie , QIN, Ning , LI, Oliver
发明人： ZHANG, Jianxiong , JIN, Zhao Xia , ZHU, Jie , QIN, Ning , LI, Oliver
IPC分类号： A62B18/02 , A62B9/06 , A41D13/11
CPC分类号： A62B18/08 , A41D13/1138 , A62B23/025
摘要： Embodiments relate generally to the design of a partially reusable dust mask comprising a reusable mask frame and a replaceable filter. The reusable mask frame comprises a groove around its edge, and the replaceable filter comprises an elastic portion operable to fit into the groove of the mask frame to hold the filter to the frame.
摘要翻译：实施例总体上涉及包括可重复使用的掩模框架和可替换的过滤器的部分可重复使用的防尘掩模的设计。可重复使用的掩模框架包括围绕其边缘的槽，并且可更换过滤器包括可操作以装配到掩模框架的凹槽中以将过滤器保持在框架上的弹性部分。

10. 发明申请

WO2011098807A1 Apparatus and Method for Aerodynamic Drag Reduction 审中-公开
标题翻译：用于气动阻力减小的装置和方法
公开(公告)号：WO2011098807A1
公开(公告)日：2011-08-18
申请号：PCT/GB2011/050234
申请日：2011-02-09
申请人： THE UNIVERSITY OF SHEFFIELD , QIN, Ning
发明人： QIN, Ning
IPC分类号： B64C23/04
CPC分类号： B64C23/04
摘要： An apparatus and method for reducing aerodynamic drag is disclosed. The apparatus and method is adapted to reduce wave drag and profile (form) drag associated with aerodynamic bodies, wings, rotor blades, or other aerodynamic surfaces operating in the transonic regime. In one embodiment, a three dimensional bump (100, 500) is disclosed, adapted for location on the surface of an aerodynamic body, having a curved upper surface (120, 140, 160, 180, 200) which redistributes the pressure of a normal shockwave generated on the aerodynamic body and at least one integral vortex generator (300, 550) arranged to generate a stream-wise vortex downstream of the bump. The combined effect of the bump (100, 500) and the vortex generator (300, 550) is to reduce the wave drag associated with the shock wave and to avoid or delay the post-shock boundary layer separation, thereby reducing form drag.
摘要翻译：公开了一种用于减小气动阻力的装置和方法。该装置和方法适于减少与空气动力学体，翼，转子叶片或在跨音速状态下操作的其它空气动力学表面相关联的波浪阻力和轮廓（形式）阻力。在一个实施例中，公开了适于位于空气动力体的表面上的三维凸起（100,500），其具有弯曲的上表面（120,140,160,180,200），该上表面重新分布正常的压力在空气动力体上产生的冲击波和至少一个积分涡流发生器（300,550），其布置成在凸块的下游产生流向涡流。凸起（100,500）和涡流发生器（300,550）的组合效果是减小与冲击波相关联的波浪阻力，并避免或延迟冲击后边界层分离，从而减少形状阻力。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式