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1. 发明申请

WO2016166550A1 EMBOLIZATION PARTICLE 审中-公开
标题翻译：嵌入颗粒
公开(公告)号：WO2016166550A1
公开(公告)日：2016-10-20
申请号：PCT/GB2016/051059
申请日：2016-04-15
申请人： ISIS INNOVATION LIMITED
发明人： TOWNLEY, Helen Elizabeth , BUSH, Rachel Anne
IPC分类号： A61L24/00 , A61L24/02 , A61L24/06 , A61K41/00
CPC分类号： A61K41/0038 , A61L24/001 , A61L24/02 , A61L2400/12 , A61L2430/36
摘要： The present invention relates to an embolization particle comprising a microparticle coated with a plurality of nanoparticles, which nanoparticles comprise a metal oxide doped with one or more rare earth elements, wherein the metal oxide is titanium dioxide, zinc oxide or cerium dioxide. An embolization particle of the invention for use in the treatment of cancer in combination with X-ray radiation or proton beam radiation, or use in embolization, is also described. The invention also relates to a process for producing an embolization particle comprising a microparticle coated with a plurality of nanoparticles, which nanoparticles comprise a metal oxide doped with one or more rare earth elements, wherein the metal oxide is titanium dioxide, zinc oxide or cerium dioxide, which process comprises: (i) providing a microparticle; (ii) contacting the microparticle with a plurality of the nanoparticles; and (iii) heating the microparticle and the nanoparticles to form the embolization particle.
摘要翻译：本发明涉及包含涂覆有多个纳米颗粒的微粒的栓塞颗粒，该纳米颗粒包含掺杂有一种或多种稀土元素的金属氧化物，其中金属氧化物是二氧化钛，氧化锌或二氧化铈。还描述了本发明的用于治疗癌症的结合X射线辐射或质子束辐射或用于栓塞的栓塞颗粒。本发明还涉及一种用于生产包含涂覆有多个纳米颗粒的微粒的栓塞颗粒的方法，该纳米颗粒包含掺杂有一种或多种稀土元素的金属氧化物，其中金属氧化物是二氧化钛，氧化锌或二氧化铈，该方法包括：（i）提供微粒; （ii）使微粒与多个纳米粒子接触; 和（iii）加热微粒和纳米颗粒以形成栓塞颗粒。

2. 发明申请

WO2015044673A1 METHODS, MATERIALS AND PRODUCTS FOR DELIVERING BIOCIDES 审中-公开
标题翻译：方法，用于输送生物的材料和产品
公开(公告)号：WO2015044673A1
公开(公告)日：2015-04-02
申请号：PCT/GB2014/052916
申请日：2014-09-26
申请人： ISIS INNOVATION LIMITED , CHAN, Andrea Chiu Yee , TOWNLEY, Helen Elizabeth , THOMPSON, Ian Patrick
发明人： CHAN, Andrea Chiu Yee , TOWNLEY, Helen Elizabeth , THOMPSON, Ian Patrick
IPC分类号： A01N25/28 , A01N35/02 , A01N47/46 , A01N65/00 , A01P1/00 , A01P3/00 , A01P15/00
CPC分类号： A01N25/28 , A01N35/02 , A01N47/46 , A01N65/00
摘要： A delivery system for a biocide, wherein: the delivery system comprises a core material(which may be porous or substantially non-porous); a biocide is located within or on the core material; and the delivery system further comprises a capping material applied to the core material so as to contain the biocide within or on the core material, and to enable exposure (e.g. release) of the biocide when the capping material is broken down or opened up. Methods of designing and/or manufacturing such a delivery system and of delivering biocides are also provided, as are examples of products embodying the delivery system.
摘要翻译：一种用于杀生物剂的递送系统，其中：递送系统包括芯材料（其可以是多孔的或基本上无孔的）; 杀生物剂位于芯材中或芯材上; 并且所述递送系统还包括施加到所述芯材料上的封盖材料，以便在所述芯材料中包含所述杀生物剂，并且在所述封盖材料分解或打开时能够暴露（例如，释放）所述杀生物剂。还提供了设计和/或制造这样的递送系统和递送杀生物剂的方法，以及体现递送系统的产品的实例。

3. 发明申请

WO2014102539A1 DELIVERY METHOD USING MESOPOROUS SILICA NANOPARTICLES 审中-公开
标题翻译：使用MESOPOROUS二氧化硅纳米粒子的交付方法
公开(公告)号：WO2014102539A1
公开(公告)日：2014-07-03
申请号：PCT/GB2013/053394
申请日：2013-12-20
申请人： ISIS INNOVATION LIMITED
发明人： COWARD, Kevin , JONES, Celine , KASHIR, Junaid , BARKALINA, Natalia , TOWNLEY, Helen Elizabeth
IPC分类号： B82Y5/00 , B82Y15/00 , A61K9/51 , A61K47/48 , C12N9/16 , A61K38/46 , C12N15/87
CPC分类号： B82Y15/00 , A61K9/5115 , A61K38/465 , B82Y5/00 , C12N15/87
摘要： The invention relates to a method for delivering a molecule to a reproductive cell or an embryonic cell. The invention uses mesoporous silica nanoparticles.
摘要翻译：本发明涉及将分子递送至生殖细胞或胚胎细胞的方法。本发明使用介孔二氧化硅纳米粒子。

4. 发明申请

WO2011070324A1 PARTICLES FOR THE TREATMENT OF CANCER IN COMBINATION WITH RADIOTHERAPY 审中-公开
标题翻译：用于治疗癌症与放射治疗组合的颗粒
公开(公告)号：WO2011070324A1
公开(公告)日：2011-06-16
申请号：PCT/GB2010/002247
申请日：2010-12-08
申请人： ISIS INNOVATION LIMITED , DOBSON, Peter James , WAKEFIELD, Gareth , TOWNLEY, Helen Elizabeth
发明人： DOBSON, Peter James , WAKEFIELD, Gareth , TOWNLEY, Helen Elizabeth
IPC分类号： A61K33/24 , A61K41/00
CPC分类号： A61K33/24 , A61K41/0038 , A61K45/06 , B82Y5/00 , A61K2300/00
摘要： The invention provides a particle comprising a metal oxide which is doped with at least one rare earth element, wherein the metal oxide is selected from titanium dioxide, zinc oxide, cerium oxide and mixtures of two or more thereof. The invention also provides a pharmaceutical composition comprising the particles, and to uses of the particles and composition in the treatment and diagnosis of cancer.
摘要翻译：本发明提供一种包含掺杂有至少一种稀土元素的金属氧化物的颗粒，其中金属氧化物选自二氧化钛，氧化锌，氧化铈及其两种或更多种的混合物。本发明还提供包含颗粒的药物组合物，以及颗粒和组合物在治疗和诊断癌症中的用途。

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