专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009023355A3 COMPOSITIONS AND METHODS FOR REDUCING THE TOXICITY OF CERTAIN TOXINS 审中-公开
标题翻译：用于减少某些毒素的毒性的组合物和方法
公开(公告)号：WO2009023355A3
公开(公告)日：2009-07-09
申请号：PCT/US2008064851
申请日：2008-05-27
申请人： IRONWOOD PHARMACEUTICALS INC , KESSLER MARCO , CURRIE MARK G , BUSBY ROBERT
发明人： KESSLER MARCO , CURRIE MARK G , BUSBY ROBERT
IPC分类号： A61K31/195 , A61K38/16 , A61P1/12 , A61P31/04
CPC分类号： A61K31/095 , A61K31/198
摘要： Compositions and methods for reducing the toxic effect of certain peptide toxins by administering an agent that directly or indirectly reduces disulfide bonds that are important for maintaining the toxin in an active conformation. Also described are compositions and methods for reducing the toxic effect of toxins that contain a heavy metal using an agent that destabilizes the binding of a metal ion that is important for toxin activity.
摘要翻译：通过施用直接或间接减少对维持毒素成活性构象重要的二硫键的试剂来降低某些肽毒素的毒性作用的组合物和方法。还描述了使用使对毒素活性重要的金属离子的结合不稳定的试剂降低含有重金属的毒素的毒性作用的组合物和方法。

2. 发明申请

WO2011071927A3 TREATMENTS FOR GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：治疗胃肠疾病
公开(公告)号：WO2011071927A3
公开(公告)日：2011-10-13
申请号：PCT/US2010059294
申请日：2010-12-07
申请人： IRONWOOD PHARMACEUTICALS INC , CURRIE MARK G , ZIMMER DANIEL P , FRETZEN ANGELIKA , KESSLER MARCO , CALI BRIAN M
发明人： CURRIE MARK G , ZIMMER DANIEL P , FRETZEN ANGELIKA , KESSLER MARCO , CALI BRIAN M
IPC分类号： C07K7/08 , A61K38/10
CPC分类号： C07K7/08 , A61K9/0019 , A61K38/00 , A61K38/10 , A61K45/06
摘要： Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein.
摘要翻译：本文描述了用于治疗上消化道障碍和病症（例如消化不良，胃轻瘫，术后胃肠梗阻，功能性食管疾病，功能性胃十二指肠疾病，胃食管返流疾病（GERD）或十二指肠疾病的肽，组合物和相关方法或胃溃疡）以及本文描述的其他病症和障碍。

3. 发明申请

WO2010065524A3 METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID RETENTION DISORDERS 审中-公开
标题翻译：治疗流脓性疾病的方法和组合
公开(公告)号：WO2010065524A3
公开(公告)日：2010-09-02
申请号：PCT/US2009066227
申请日：2009-12-01
申请人： IRONWOOD PHARMACEUTICALS INC , UNIV NORTH CAROLINA , CURRIE MARK G , GOY MICHAEL F , KESSLER MARCO M , MOSS NICHOLAS G , SOLINGA ROBERT MARCEL , ZIMMER DANIEL P
发明人： CURRIE MARK G , GOY MICHAEL F , KESSLER MARCO M , MOSS NICHOLAS G , SOLINGA ROBERT MARCEL , ZIMMER DANIEL P
IPC分类号： A61K38/00
CPC分类号： A61K35/10 , A61K38/00
摘要： Methods of treating fluid retention disorders with the B isomers of guanylin family peptides are described herein. UgnB, when compared to the A isomer (UgnA), exhibits a conventional sigmoidal dose-response relationship in its natriuetic activity. Further, unlike UgnA, UgnB only weakly activates the GC-C receptor. Compositions comprising purified, or mixtures containing B isomers of guanylin family peptides are described herein are therefore useful for the treatment of fluid retention disorders.
摘要翻译：本文描述了用鸟苷蛋白家族肽的B异构体治疗流体保留障碍的方法。当与A异构体（UgnA）相比时，UgnB在其活性中表现出常规的S形剂量 - 反应关系。此外，与UgnA不同，UgnB仅弱活化GC-C受体。因此，本文描述了包含纯化的组合物或含有鸟苷蛋白家族肽的B异构体的混合物，因此可用于治疗流体保留障碍。

4. 发明申请

WO2012170804A1 TREATMENTS FOR GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：胃肠疾病治疗
公开(公告)号：WO2012170804A1
公开(公告)日：2012-12-13
申请号：PCT/US2012041532
申请日：2012-06-08
申请人： IRONWOOD PHARMACEUTICALS INC , CURRIE MARK G , ZIMMER DANIEL P , FRETZEN ANGELIKA , KESSLER MARCO , CALI BRIAN M
发明人： CURRIE MARK G , ZIMMER DANIEL P , FRETZEN ANGELIKA , KESSLER MARCO , CALI BRIAN M
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K7/08 , A61K38/10 , A61K38/51 , A61K45/06
摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.
摘要翻译：本发明提供了治疗较低胃肠道疾病的药物组合物和方法，包括炎性肠病（IBD），憩室炎，结肠癌，炎症性疾病，肥胖，充血性心力衰竭，良性前列腺增生（BPH），疼痛，盐滞留或流体保留。

5. 发明申请

WO2008124505A3 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS 审中-公开
标题翻译：用于治疗脂肪相关疾病的可溶性葡萄糖环化酶（SGC）调节剂
公开(公告)号：WO2008124505A3
公开(公告)日：2009-08-20
申请号：PCT/US2008059272
申请日：2008-04-03
申请人： IRONWOOD PHARMACEUTICALS INC , CURRIE MARK G , ZIMMER DANIEL P
发明人： CURRIE MARK G , ZIMMER DANIEL P
IPC分类号： A61K31/04 , A61K31/165 , A61K31/192 , A61K31/21 , A61K31/34 , A61K31/40 , A61K31/407 , A61K31/5377 , A61K31/541 , A61P9/00
CPC分类号： A61K31/34 , A61K31/04 , A61K31/165 , A61K31/192 , A61K31/21 , A61K31/40 , A61K31/407 , A61K31/5377 , A61K31/541
摘要： Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more sGC modulators alone or in combination with one or more lipid altering agents and/or PDE inhibitors.
摘要翻译：本文公开了用于治疗或预防与脂质代谢相关的多种病症和病症的新型组合物和方法。所述方法通常包括向有需要的患者施用治疗有效量的药物组合物，其包含单独一种或多种sGC调节剂或与一种或多种脂质改变剂和/或PDE抑制剂组合。

6. 发明申请

WO2008080092A8 COMPOSITIONS COMPRISING BILE ACID SEQUESTRANTS FOR TREATING ESOPHAGEAL DISORDERS 审中-公开
标题翻译：包含用于治疗食管疾病的双酸性序列的组合物
公开(公告)号：WO2008080092A8
公开(公告)日：2009-03-05
申请号：PCT/US2007088624
申请日：2007-12-21
申请人： IRONWOOD PHARMACEUTICALS INC , CURRIE MARK G
发明人： CURRIE MARK G
IPC分类号： A61K9/00 , A61K31/195 , A61K31/27 , A61K31/341 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4439 , A61K31/444 , A61K31/575 , A61K31/785 , A61K33/08 , A61K33/10 , A61K45/06 , A61P1/04
CPC分类号： A61K9/0065 , A61K31/195 , A61K31/27 , A61K31/341 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4439 , A61K31/444 , A61K31/575 , A61K31/785 , A61K33/08 , A61K33/10 , A61K45/06 , C08F226/02 , A61K2300/00
摘要： Disclosed herein are novel compositions for treating or preventing upper GI tract disorders and protecting stratified squamous epithelium against injury by a noxious substance. The pharmaceutical composition comprises at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, -aminobutyricacid-b (GABA-B) agonists,, prodrugs of GABA-B agonists, and protease inhibitors.
摘要翻译：本文公开了用于治疗或预防上GI道障碍并保护分层鳞状上皮免受有害物质损伤的新型组合物。药物组合物包含至少一种胆汁酸多价螯合剂，单独或与至少一种质子泵抑制剂组合，以及任选的一种或多种选自抗酸剂，组胺H2受体拮抗剂，氨基丁酸-B（GABA-B）激动剂，，GABA-B激动剂的前药和蛋白酶抑制剂。

7. 发明申请

WO2009158625A3 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING GASTROINTESTINAL DISORDERS AND GERD-RELATED RESPIRATORY DISORDERS 审中-公开
标题翻译：用于治疗或预防胃肠疾病和胃肠相关呼吸道疾病的组合物和方法
公开(公告)号：WO2009158625A3
公开(公告)日：2010-05-06
申请号：PCT/US2009048870
申请日：2009-06-26
申请人： IRONWOOD PHARMACEUTICALS INC , CURRIE MARK G
发明人： CURRIE MARK G
IPC分类号： A61K31/785 , A61K31/56 , A61K33/10 , A61P1/04 , A61P11/00
CPC分类号： A61K31/785 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are novel compositions and methods for treating or preventing GI tract disorders and/or GERD-related respiratory disorders as well as protecting stratified squamous epithelium against injury by a noxious substance. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, ?-aminobutyricacid-b (GABA-B) agonists, prodrugs of GABA-B agonists, and protease inhibitors.
摘要翻译：本文公开了用于治疗或预防胃肠道疾病和/或GERD相关呼吸障碍以及保护分层鳞状上皮免受有害物质损伤的新型组合物和方法。所述方法通常包括向有需要的患者施用治疗有效量的包含至少一种胆汁酸多价螯合剂的药物组合物，其单独或与至少一种质子泵抑制剂组合，以及任选的一种或多种选自抗酸剂，组胺 H2-受体拮抗剂，γ-氨基丁酸-B（GABA-B）激动剂，GABA-B激动剂的前药和蛋白酶抑制剂。

8. 发明申请

WO2008080092A2 METHODS AND COMPOSITIONS FOR TREATING ESOPHAGEAL DISORDERS 审中-公开
标题翻译：治疗食管障碍的方法和组合
公开(公告)号：WO2008080092A2
公开(公告)日：2008-07-03
申请号：PCT/US2007088624
申请日：2007-12-21
申请人： IRONWOOD PHARMACEUTICALS INC , CURRIE MARK G
发明人： CURRIE MARK G
IPC分类号： A61K9/00 , A61K31/195 , A61K31/27 , A61K31/341 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4439 , A61K31/444 , A61K31/575 , A61K31/785 , A61K33/08 , A61K33/10 , A61K45/06 , A61P1/04
CPC分类号： A61K9/0065 , A61K31/195 , A61K31/27 , A61K31/341 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4439 , A61K31/444 , A61K31/575 , A61K31/785 , A61K33/08 , A61K33/10 , A61K45/06 , C08F226/02 , A61K2300/00
摘要： Disclosed herein are novel compositions and methods for treating or preventing upper GI tract disorders and protecting stratified squamous epithelium against injury by a noxious substance. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, -aminobutyricacid-b (GABA-B) agonists, prodrugs of GABA-B agonists, and protease inhibitors.
摘要翻译：本文公开了用于治疗或预防上胃肠道疾病并保护分层鳞状上皮免受有害物质损伤的新型组合物和方法。所述方法通常包括向有需要的患者施用治疗有效量的包含至少一种胆汁酸多价螯合剂的药物组合物，其单独或与至少一种质子泵抑制剂组合，以及任选的一种或多种选自抗酸剂，组胺 H 2受体拮抗剂，氨基丁酸-b（GABA-B）激动剂，GABA-B激动剂的前药和蛋白酶抑制剂。

9. 发明申请

WO2008002971A3 METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：用于治疗胃肠疾病的方法和组合物
公开(公告)号：WO2008002971A3
公开(公告)日：2008-08-28
申请号：PCT/US2007072223
申请日：2007-06-27
申请人： MICROBIA INC , CURRIE MARK G , ZIMMER DANIEL P
发明人： CURRIE MARK G , ZIMMER DANIEL P
IPC分类号： A01N37/18 , A61K38/00
CPC分类号： C07K14/4705 , A61K38/00
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders and disorders and conditions associated with excess fluid and/or salt retention as well as other conditions and disorders are described. The compositions feature polypeptides that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：（例如胃肠动力障碍，功能性胃肠病症，胃食管反流病（GERD），十二指肠胃反流，克罗恩氏病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括胃肠动力障碍，功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假梗阻），与便秘相关的病症和病症，例如与使用阿片剂止痛药有关的便秘，手术后便秘和与神经病性病症相关的便秘; 描述了与过量的液体和/或盐潴留以及其他病症和病症相关的病症和病症。所述组合物的特征在于活化鸟苷酸环化酶C（GC-C）受体的多肽。

10. 发明申请

WO2007022501A2 USEFUL INDOLE COMPOUNDS 审中-公开
标题翻译：有用的吲哚化合物
公开(公告)号：WO2007022501A2
公开(公告)日：2007-02-22
申请号：PCT/US2006032573
申请日：2006-08-18
申请人： MICROBIA INC , BARTOLINI WILMIN , CALI BRIAN M , CHEN BARBARA , CHIEN YUEH-TYNG , CURRIE MARK G , MILNE G TODD , PEARSON JAMES PHILIP , TALLEY JOHN JEFFREY , YANG JING JING , ZIMMERMAN CRAIG , MONREAL ALEX W
发明人： BARTOLINI WILMIN , CALI BRIAN M , CHEN BARBARA , CHIEN YUEH-TYNG , CURRIE MARK G , MILNE G TODD , PEARSON JAMES PHILIP , TALLEY JOHN JEFFREY , YANG JING JING , ZIMMERMAN CRAIG , MONREAL ALEX W
IPC分类号： A61K31/428
CPC分类号： C07D409/06 , A61K31/33 , A61K31/404 , C07D209/18 , C07D417/06
摘要： Indoles having various activities, including indoles that are CRTH2 are described. The compounds are useful for treating asthma, neuropathic pain, allegic rhinitis and other disorders.
摘要翻译：描述了具有各种活性的吲哚，包括CRTH2的吲哚。该化合物可用于治疗哮喘，神经性疼痛，应激性鼻炎和其他疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式