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1. 发明申请

WO2010105995A2 ZOO-TECHNICAL DRUG DELIVERY DEVICE 审中-公开
标题翻译： ZOO技术药物递送装置
公开(公告)号：WO2010105995A2
公开(公告)日：2010-09-23
申请号：PCT/EP2010/053240
申请日：2010-03-15
申请人： INTERVET INTERNATIONAL B.V. , N.V. ORGANON , DRIANCOURT, Marc-Antoine , DE GRAAFF, Wouter , ZEEMAN, Raymond
发明人： DRIANCOURT, Marc-Antoine , DE GRAAFF, Wouter , ZEEMAN, Raymond
IPC分类号： A61K9/00
CPC分类号： A61K9/5073 , A61K9/0024 , A61K9/0036 , A61K31/565 , A61K31/567 , A61K31/57 , A61K45/06 , A61K47/32 , A61K2300/00
摘要： The present invention relates to a veterinary zoo-technical drug delivery system (device) for the simultaneous release of two or more active substances, which system releases the active substances in a substantially constant ratio over a prolonged period of time. The drug delivery system can be in different forms, such as e.g. an implant, or a intravaginal device such as a helical coil, a spring or a ring.
摘要翻译：本发明涉及用于同时释放两种或多种活性物质的兽用动物园技术药物递送系统（装置），该系统在长时间内以基本恒定的比例释放活性物质。药物递送系统可以是不同的形式，例如，植入物或阴道内装置，例如螺旋线圈，弹簧或环。

2. 发明申请

WO2008061963A2 HELICALLY-SHAPED DRUG DELIVERY SYSTEM 审中-公开
标题翻译：简单形式的药物递送系统
公开(公告)号：WO2008061963A2
公开(公告)日：2008-05-29
申请号：PCT/EP2007/062514
申请日：2007-11-19
申请人： N.V. ORGANON , INTERVET INTERNATIONAL B.V. , DRIANCOURT, Marc-Antoine , DE GRAAFF, Wouter , BUTTAFOCO, Laura , PAYOT, Fabrice , VEENSTRA, Harm , VOSS, René
发明人： DRIANCOURT, Marc-Antoine , DE GRAAFF, Wouter , BUTTAFOCO, Laura , PAYOT, Fabrice , VEENSTRA, Harm , VOSS, René
IPC分类号： A61K9/00
CPC分类号： A61K9/0036 , A61K31/575 , A61K47/32
摘要： The present invention relates to a helically-shaped medicated veterinary system suitable for delivery of a drug to the vaginal cavity of a female non-human mammal and to a method of manufacture. The drug delivery system is helically-shaped and comprises a three layered polymer fibre. The polymer fibre comprises a polymer core, a polymer intermediate layer comprising a drug, and a polymer skin. The medicated system provides a controlled delivery of drug to the vaginal cavity of the mammal. The present invention also relates to a process of making the springs.
摘要翻译：本发明涉及一种适合于将药物递送至女性非人哺乳动物的阴道腔的螺旋形药物兽医系统及其制造方法。药物递送系统是螺旋形的并且包括三层聚合物纤维。聚合物纤维包括聚合物芯，包含药物的聚合物中间层和聚合物皮肤。药物系统提供药物到哺乳动物的阴道腔的受控递送。本发明还涉及制造弹簧的方法。

3. 发明申请

WO2009036999A1 DRUG DELIVERY SYSTEM 审中-公开
标题翻译：药物递送系统
公开(公告)号：WO2009036999A1
公开(公告)日：2009-03-26
申请号：PCT/EP2008/007975
申请日：2008-09-22
申请人： N.V. ORGANON , DE GRAAFF, Wouter , ZEEMAN, Raymond
发明人： DE GRAAFF, Wouter , ZEEMAN, Raymond
IPC分类号： A61F6/06 , A61F6/14 , A61K9/00 , A61P15/18
CPC分类号： A61K9/5073 , A61F6/06 , A61F6/142 , A61K9/0036 , A61K9/0039 , A61K9/5089 , A61K31/565 , A61K31/57 , A61K31/573 , A61K2300/00
摘要： The subject invention provides a drug delivery system comprising at least one compartment comprising (i) a drug-loaded thermoplastic polymer core layer, (ii) a drug-loaded thermoplastic polymer intermediate layer and (iii) a non-medicated thermoplastic polymer skin covering the intermediate layer, wherein said core layer is loaded with crystals of a first (pharmaceutically) active compound and said intermediate layer is loaded with crystals of the second (pharmaceutically) active compound.
摘要翻译：本发明提供了一种药物递送系统，其包括至少一个隔室，其包含（i）药物加载的热塑性聚合物核心层，（ii）药物负载的热塑性聚合物中间层和（iii）非药物热塑性聚合物皮肤，中间层，其中所述芯层装载有第一（药学上）活性化合物的晶体，并且所述中间层装载有第二（药学上）活性化合物的晶体。

4. 发明申请

WO2005089723A1 DRUG DELIVERY SYSTEM BASED ON POLYETHYLENE VINYLACETATE COPOLYMERS 审中-公开
标题翻译：基于聚乙烯乙酰乙酸酯共聚物的药物输送系统
公开(公告)号：WO2005089723A1
公开(公告)日：2005-09-29
申请号：PCT/EP2005/051189
申请日：2005-03-16
申请人： AKZO NOBEL N.V. , DE GRAAFF, Wouter , GROEN, Janneke, Sophie , KRUFT, Marc Anton , VAN LAARHOVEN, Johannes, Antonius, Hendrikus , VROMANS, Herman , ZEEMAN, Raymond
发明人： DE GRAAFF, Wouter , GROEN, Janneke, Sophie , KRUFT, Marc Anton , VAN LAARHOVEN, Johannes, Antonius, Hendrikus , VROMANS, Herman , ZEEMAN, Raymond
IPC分类号： A61K9/22
CPC分类号： A61K9/0036 , A61K31/565 , A61K31/57 , A61K47/32
摘要： A drug delivery system consisting of one or more compartments and comprising a progestogenic compound dissolved in a thermoplastic polyethylene vinylacetate copolymer whereby, if the delivery system consists of one compartment, the compartment comprises (i) a core of a thermoplastic polyethylene vinylacetate copolymer comprising the progestogenic compound, such progestogenic compound being dissolved in the polyethylene vinylacetate copolymer up to a concentration below the saturation level at 25°C, and an estrogenic compound; and (ii) a skin of a thermoplastic polyethylene vinylacetate copolymer covering the core, said skin being permeable for both compounds;- if the delivery system consists of more than one compartment, only one compartment comprises (iii) the progestogenic compound, such progestogenic compound being dissolved in a core of a thermoplastic polyethylene vinylacetate copolymer up to a concentration below the saturation level at 25°C, and an estrogenic compound; and (iv) a skin of a thermoplastic polyethylene vinylacetate copolymer covering the core, said skin being permeable for both compounds.
摘要翻译：一种由一个或多个隔室组成并包含溶解在热塑性聚乙烯乙酸乙烯酯共聚物中的孕激素化合物的药物递送系统，其中如果递送系统由一个隔室组成，则隔室包含（i）包含孕激素的热塑性聚乙烯乙酸乙烯酯共聚物的核心化合物，这种孕激素化合物溶解在聚乙烯乙酸乙烯酯共聚物中，直到在25℃下低于饱和水平的浓度，和雌激素化合物; 和（ii）覆盖芯的热塑性聚乙烯乙酸乙烯酯共聚物的皮肤，所述皮肤对于两种化合物是可渗透的; - 如果递送系统由多于一个隔室组成，则仅一个隔室包含（iii）孕激素化合物，例如孕激素化合物溶解在热塑性聚乙烯乙酸乙烯酯共聚物的芯中，其浓度低于25℃的饱和水平，以及雌激素化合物; 和（iv）覆盖所述芯的热塑性聚乙烯乙酸乙烯酯共聚物的皮肤，所述皮肤对于这两种化合物是可渗透的。

5. 发明申请

WO2009060077A2 INTRAUTERINE DEPOSIT 审中-公开
标题翻译：内毒素沉积
公开(公告)号：WO2009060077A2
公开(公告)日：2009-05-14
申请号：PCT/EP2008/065149
申请日：2008-11-07
申请人： N.V. Organon , DE GRAAFF, Wouter , VEENSTRA, Harm , MULDERS, Titia
发明人： DE GRAAFF, Wouter , VEENSTRA, Harm , MULDERS, Titia
IPC分类号： A61F6/14 , A61F6/18 , A61K9/00
CPC分类号： A61F6/142 , A61F6/14 , A61F6/144 , A61F6/18 , A61K9/0039 , Y10T29/4998 , Y10T29/49982
摘要： An intrauterine system for the retention of a biologically active compound within the uterus of a female mammal is formed by a frame defining an interior space for receipt of a deposit of the compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit and the deposit has a rate controlling structure that controls a rate of release of the compound within the uterus. Retention elements are provided on the frame for retaining the frame within the uterus.
摘要翻译：通过限定用于接收化合物沉积物的内部空间的框架形成用于将生物活性化合物保留在雌性哺乳动物子宫内的子宫内系统。框架具有允许进入沉积物的外表面的大部分的开放结构，并且沉积物具有速率控制结构，其控制化合物在子宫内的释放速率。保持元件设置在框架上，用于将框架保持在子宫内。

6. 发明申请

WO2008062021A1 VAGINAL DELIVERY SYSTEM FOR MIRTAZAPINE 审中-公开
标题翻译： MIRTAZAPINE的VAGINAL递送系统
公开(公告)号：WO2008062021A1
公开(公告)日：2008-05-29
申请号：PCT/EP2007/062654
申请日：2007-11-21
申请人： N.V. ORGANON , DE GRAAFF, Wouter , SZEGEDI, Armin
发明人： DE GRAAFF, Wouter , SZEGEDI, Armin
IPC分类号： A61K31/55 , A61K9/70
CPC分类号： A61K9/0036 , A61K31/55
摘要： This invention relates to an extended release formulation comprising solid mirtazapine, which formulation is a vaginal device having a skin and which device comprises an inner compartment made of a thermoplastic polymer, which polymer is containing mirtazapine. The polymer is preferably made of ethylene-vinyl acetate copolymer.
摘要翻译：本发明涉及包含固体米氮平的延长释放制剂，该制剂是具有皮肤的阴道装置，并且该装置包括由热塑性聚合物制成的内隔室，该聚合物含有米氮平。聚合物优选由乙烯 - 乙酸乙烯酯共聚物制成。

7. 发明申请

WO2008062008A1 DELIVERY SYSTEM FOR A NON-STEROIDAL NON-IONIZED HYDROPHILIC DRUG 审中-公开
标题翻译：非离子非离子水解药物输送系统
公开(公告)号：WO2008062008A1
公开(公告)日：2008-05-29
申请号：PCT/EP2007/062626
申请日：2007-11-21
申请人： N.V. ORGANON , DE GRAAFF, Wouter , SZEGEDI, Armin
发明人： DE GRAAFF, Wouter , SZEGEDI, Armin
IPC分类号： A61M31/00 , A61K9/02
CPC分类号： A61K31/517 , A61K9/0036
摘要： This invention relates to an extended release formulation comprising a solid non-steroidal non-ionized hydrophilic drug, having a molecular weight below 500 Dalton and having a solubility of at least 0.1 wt% in ethylene vinyl acetate copolymer having a vinyl acetate content of 28%, which formulation is a vaginal device having a skin and which device comprises an inner compartment made of a thermoplastic polymer, which polymer is containing the drug. The polymer is preferably made of ethylene-vinyl acetate copolymer.
摘要翻译：本发明涉及包含固体非甾体非离子化亲水性药物的延长释放制剂，其具有低于500道尔顿并且具有至少0.1重量％的溶解度的乙酸乙烯酯共聚物的乙酸乙烯酯含量为28％该制剂是具有皮肤的阴道装置，并且该装置包括由热塑性聚合物制成的内隔室，该聚合物含有药物。聚合物优选由乙烯 - 乙酸乙烯酯共聚物制成。

8. 发明申请

WO2010128004A1 INTRAUTERINE SYSTEM FOR USE IN MEDICAL TREATMENT 审中-公开
标题翻译：用于医疗治疗的内窥镜系统
公开(公告)号：WO2010128004A1
公开(公告)日：2010-11-11
申请号：PCT/EP2010/055948
申请日：2010-05-03
申请人： N.V. Organon , DE GRAAFF, Wouter , VEENSTRA, Harm , MULDERS, Titia Martine Truce
发明人： DE GRAAFF, Wouter , VEENSTRA, Harm , MULDERS, Titia Martine Truce
IPC分类号： A61F6/14 , A61K9/00
CPC分类号： A61M31/002 , A61F6/144 , A61F13/26 , A61K9/0039 , Y10T29/49826
摘要： An intrauterine system (1) is disclosed for use in the treatment of dysfunctional uterine bleeding; menorraghia; dysmenorrhoea; endometriosis; uterine fibroids; climacteric complaints; osteoporosis; and urogenital atrophy. The system is formed by a frame (16) defining an interior space (20) for receipt of a deposit (22) of a therapeutically effective dose of a biologically active compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit, and the deposit has a rate controlling structure (26) that controls a rate of release of the compound within the uterus. One or more retention elements (6) are provided on the frame for retaining the frame within the uterus of a female mammal.
摘要翻译：公开了用于治疗功能障碍性子宫出血的子宫内系统（1） menorraghia; 痛经; 子宫内膜异位症; 子宫肌瘤; 更年期的投诉骨质疏松症; 和泌尿生殖系萎缩。系统由限定用于接收治疗有效剂量的生物活性化合物的沉积物（22）的内部空间（20）的框架（16）形成。框架具有允许进入沉积物的外表面的大部分的开放结构，并且沉积物具有速率控制结构（26），其控制化合物在子宫内的释放速率。一个或多个保持元件（6）设置在框架上，用于将框架保持在雌性哺乳动物的子宫内。

9. 发明申请

WO2008062009A1 DELIVERY SYSTEM FOR RISPERIDONE 审中-公开
标题翻译： RISPERIDONE交付系统
公开(公告)号：WO2008062009A1
公开(公告)日：2008-05-29
申请号：PCT/EP2007/062628
申请日：2007-11-21
申请人： N.V. ORGANON , DE GRAAFF, Wouter , SZEGEDI, Armin
发明人： DE GRAAFF, Wouter , SZEGEDI, Armin
IPC分类号： A61K31/517 , A61K9/02
CPC分类号： A61K31/517 , A61K9/0036
摘要： This invention relates to an extended release formulation comprising solid risperidone, which formulation is a vaginal device having a skin and which device comprises an inner compartment made of a thermoplastic polymer, which polymer is containing risperidone. The polymer is preferably made of ethylene-vinyl acetate copolymer.
摘要翻译：本发明涉及包含固体利培酮的延长释放制剂，该制剂是具有皮肤的阴道装置，并且该装置包括由聚合物含有利培酮的热塑性聚合物制成的内隔室。聚合物优选由乙烯 - 乙酸乙烯酯共聚物制成。

10. 发明申请

WO2009141309A1 DELIVERY SYSTEM FOR PALIPERIDONE 审中-公开
标题翻译： PALIPERIDONE交付系统
公开(公告)号：WO2009141309A1
公开(公告)日：2009-11-26
申请号：PCT/EP2009/056009
申请日：2009-05-18
申请人： N.V. ORGANON , DE GRAAFF, Wouter , SZEGEDI, Armin
发明人： DE GRAAFF, Wouter , SZEGEDI, Armin
IPC分类号： A61K9/00 , A61K31/519
CPC分类号： A61K9/0036 , A61K31/519
摘要： This invention relates to an extended release formulation comprising paliperidone, which formulation is a vaginal device having a skin and which device comprises an inner compartment made of a thermoplastic polymer, which polymer is containing solid paliperidone. The formulation is preferably made of ethylene-vinyl acetate copolymer.
摘要翻译：本发明涉及包含普利培酮的延长释放制剂，该制剂是具有皮肤的阴道装置，并且该装置包括由热塑性聚合物制成的内隔室，该聚合物含有固体帕培他酮。制剂优选由乙烯 - 乙酸乙烯酯共聚物制成。

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