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1. 发明申请

WO2005079821A1 WOUND HEALING PROFILE 审中-公开
标题翻译：创伤治疗概况
公开(公告)号：WO2005079821A1
公开(公告)日：2005-09-01
申请号：PCT/GB2005/000511
申请日：2005-02-14
申请人： INTERCYTEX LIMITED , KEMP, Paul , TALAS, Györgyi , SUTHERLAND, Jennifer , BATTEN, Margaret , JOHNSON, Penelope, Ann , SHERING, Andrew , MCWHAN, Michael
发明人： KEMP, Paul , TALAS, Györgyi , SUTHERLAND, Jennifer , BATTEN, Margaret , JOHNSON, Penelope, Ann , SHERING, Andrew , MCWHAN, Michael
IPC分类号： A61K35/36
CPC分类号： A61K35/33 , A61K35/34 , A61K35/36 , A61K45/06 , A61L27/3804 , A61L27/3895 , A61L27/60 , G01N33/56966 , A61K2300/00
摘要： The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides wound healing composition characterised by the higher expression levels of phenotypic marker genes such as apolipoprotein D, matrix metalloprotease (2), collagen 3al and smooth muscle actin than the housekeeping gene ribosomal protein L32. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
摘要翻译：本发明涉及用于组织再生的组合物和方法，特别是用于治疗皮肤损伤如伤口。一方面，本发明提供伤口愈合组合物，其特征在于表型标记基因如载脂蛋白D，基质金属蛋白酶（2），胶原蛋白3和平滑肌肌动蛋白的表达水平高于持家基因核糖体蛋白L32。本发明的组合物和方法特别适用于辅助伤口愈合过程，特别是慢愈合或抗愈合的慢性开放病变。

2. 发明申请

WO2005079822A2 WOUND HEALING COMPOSITION 审中-公开
标题翻译：创伤治疗组合物
公开(公告)号：WO2005079822A2
公开(公告)日：2005-09-01
申请号：PCT/GB2005/000523
申请日：2005-02-14
申请人： INTERCYTEX LIMITED , KEMP, Paul , TALAS, Györgyi , SUTHERLAND, Jennifer , BATTEN, Margaret , JOHNSON, Penelope, Ann , SHERING, Andrew , MCWHAN, Michael
发明人： KEMP, Paul , TALAS, Györgyi , SUTHERLAND, Jennifer , BATTEN, Margaret , JOHNSON, Penelope, Ann , SHERING, Andrew , MCWHAN, Michael
IPC分类号： A61K35/36
CPC分类号： A61K35/33 , A61K35/34 , A61K35/36 , A61K45/06 , A61L27/3804 , A61L27/3895 , A61L27/60 , G01N33/56966 , A61K2300/00
摘要： The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides a wound healing composition comprising living cells such as fibroblasts within a support matrix such as fibrin, in which the cells have a wound healing phenotype, and in which the composition is single layered and has been incubated for up to about 8 days to allow development of the wound healing phenotype. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
摘要翻译：本发明涉及用于组织再生的组合物和方法，特别是用于治疗皮肤损伤如伤口。在一个方面，本发明提供一种伤口愈合组合物，其包含活细胞，例如载体基质如纤维蛋白中的成纤维细胞，其中细胞具有伤口愈合表型，并且其中组合物是单层的并且已经孵育达约8天允许发展伤口愈合表型。本发明的组合物和方法特别适用于辅助伤口愈合过程，特别是慢愈合或抗愈合的慢性开放病变。

3. 发明申请

WO2009037474A1 EPIDERMAL STIMULATION TO ENHANCE HAIR FOLLICLE FORMATION 审中-公开
标题翻译：皮肤刺激以增强头发的形成
公开(公告)号：WO2009037474A1
公开(公告)日：2009-03-26
申请号：PCT/GB2008/003186
申请日：2008-09-18
申请人： INTERCYTEX LIMITED , KEMP, Paul , TEUMER, Jeffrey , COOLEY, Jerry
发明人： KEMP, Paul , TEUMER, Jeffrey , COOLEY, Jerry
IPC分类号： A61K35/36 , A61K8/98 , A61Q7/00 , C12N5/06
CPC分类号： A61Q7/00 , A61K8/02 , A61K8/985 , A61K35/12 , C12N5/0627
摘要： The present invention features a method for improving the efficiency of hair formation by follicular cell implantation. The method includes the use of epidermal stimulation (ES) to stimulate keratinocytes in a subject's skin in order to make them more receptive to hair inductive signals originating from implanted follicular cells (e.g. dermal papilla cells, dermal sheath cells, and/or outer root sheath cells).
摘要翻译：本发明的特征在于通过滤泡细胞植入提高毛发形成效率的方法。该方法包括使用表皮刺激（ES）刺激受试者的皮肤中的角质形成细胞，以使它们更容易接受来自植入的滤泡细胞（例如真皮乳头细胞，真皮鞘细胞和/或外根鞘）的毛发诱导信号细胞）。

4. 发明申请

WO2006125991A1 TISSUE REPAIR USING ALLOGENIC DERMAL FIBROBLASTS 审中-公开
标题翻译：使用同种异体纤维的组织修复
公开(公告)号：WO2006125991A1
公开(公告)日：2006-11-30
申请号：PCT/GB2006/001916
申请日：2006-05-25
申请人： INTERCYTEX LIMITED , LEEK, Mike , KEMP, Paul
发明人： LEEK, Mike , KEMP, Paul
IPC分类号： A61F2/00 , A61L27/38 , A61L27/58 , A61L27/60
CPC分类号： A61K8/981 , A61K8/985 , A61K2800/91 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/58 , A61L27/60 , A61Q19/08
摘要： The present invention provides a method for the repair of subcutaneous or dermal tissue in a subject, comprising in one aspect the injection of a suspension of allogeneic dermal fibroblasts into the subject. By injecting a suspension of allogeneic cells, the invention provides, for example, long-term augmentation of the subadjacent tissue without the disadvantages that accompany the preparation and/or use of presently available materials such as autologous fibroblasts cells or collagen. According to a first aspect of the invention there is provided a method for the augmentation of subcutaneous or dermal tissue in a subject, which method comprises the steps of: (i) providing a suspension of allogeneic dermal fibroblasts; and (ii) injecting an effective volume of the suspension into tissue subadjacent to the subcutaneous or dermal tissue so that the tissue is augmented. The method is preferably cosmetic.
摘要翻译：本发明提供了修复受试者皮下或皮肤组织的方法，其包括在一方面将同种异体真皮成纤维细胞的悬浮液注射入受试者。通过注射同种异体细胞的悬浮液，本发明提供了例如长期增加下面的组织，而不伴随着制备和/或使用目前可获得的材料如自体成纤维细胞细胞或胶原蛋白的缺点。根据本发明的第一方面，提供了一种用于增加受试者皮下或皮肤组织的方法，该方法包括以下步骤：（i）提供同种异体真皮成纤维细胞的悬浮液; 和（ii）将有效体积的悬浮液注射到与皮下或皮肤组织相邻的组织中，使得组织被增强。该方法优选为化妆品。

5. 发明申请

WO2006097701A2 SKIN EQUIVALENT CULTURE 审中-公开
标题翻译：皮肤等效培养
公开(公告)号：WO2006097701A2
公开(公告)日：2006-09-21
申请号：PCT/GB2006/000890
申请日：2006-03-14
申请人： INTERCYTEX LIMITED , KEMP, Paul , SHERING, David , JOHNSON, Penny , MARSHALL, Damian
发明人： KEMP, Paul , SHERING, David , JOHNSON, Penny , MARSHALL, Damian
IPC分类号： C12N5/06 , A61L27/60
CPC分类号： C12N5/0698 , A61L27/20 , A61L27/225 , A61L27/24 , A61L27/3687 , A61L27/3691 , A61L27/3804 , A61L27/3839 , A61L27/3886 , A61L27/3895 , A61L27/54 , A61L27/60 , C12N2500/25 , C12N2500/30 , C12N2500/32 , C12N2501/11 , C12N2501/15 , C12N2502/094 , C12N2502/1323 , C12N2533/56
摘要： Methods of forming soft connective tissue compositions such as skin equivalents, compositions made by the methods and their uses. In particular, a method of forming a connective tissue equivalent, comprising the steps of: (i) incubating collagen-producing cells in or on a support matrix; (ii) inducing and/or enhancing collagen production by the collagen-producing cells to form a collagenous construct and degradation and replacement of the support matrix; (iii) freeze-drying the construct; and (iv) re-populating the freeze-dried construct with collagen-producing cells and/or epithelial cells and/or endothelial cells and/or mesenchymal cells, thereby forming a connective tissue equivalent, wherein: (a) the collagen-producing cells are substantially fibroblasts; for example human neonatal dermal fibroblasts; (b) the support matrix is a provisional support matrix in which the support matrix is a fibrin matrix, for example formed by thrombin-mediated polymerisation of fibrinogen; and (c) as a result of the collagen production by the collagen-producing cells the provisional fibrin support matrix is digested by the cells and is replaced by collagen, thereby essentially replacing the provisional fibrin matrix with a collagen matrix synthesised in situ by the cells.
摘要翻译：形成软结缔组织组合物例如皮肤等同物的方法，通过所述方法及其用途制备的组合物。具体而言，一种形成结缔组织等效物的方法，包括以下步骤：（i）将产生胶原蛋白的细胞孵育在支持基质中或上; （ii）诱导和/或增强胶原产生细胞的胶原产生以形成胶原构建体并降解和置换支持基质; （iii）冷冻干燥该构建体; 和（iv）用胶原产生细胞和/或上皮细胞和/或内皮细胞和/或间充质细胞重新填充冷冻干燥的构建体，由此形成结缔组织等效物，其中：（a）胶原产生细胞基本上是成纤维细胞; 例如人类新生儿真皮成纤维细胞; （b）支撑基质是临时支撑基质，其中支撑基质是纤维蛋白基质，例如通过凝血酶介导的纤维蛋白原聚合形成; （c）作为胶原产生细胞产生胶原蛋白的结果，临时纤维蛋白载体基质被细胞消化并被胶原代替，从而基本上用细胞原位合成的胶原基质代替临时纤维蛋白基质

6. 发明申请

WO2011140297A2 APPARATUS AND METHOD FOR MATERIAL BLENDING 审中-公开
标题翻译：用于材料混合的装置和方法
公开(公告)号：WO2011140297A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/035292
申请日：2011-05-05
申请人： E-LOADERS COMPANY, LLC , KEMP, Roger , KIPP, Chris , KEMP, Paul , NELSON, Andrew, M.
发明人： KEMP, Roger , KIPP, Chris , KEMP, Paul , NELSON, Andrew, M.
IPC分类号： B01F15/02 , B01F3/12 , B01F15/04
CPC分类号： B01F15/0429 , B01F3/188 , B01F5/0062 , B01F15/0238
摘要： A material blender and method for blending a plurality of ingredient materials to make a single heterogeneous material. The material blender may comprise a blending apparatus, a control system, and a pneumatic delivery system. The pneumatic delivery system may comprise a plurality of conduits each provided with a pneumatic flow therethrough to pneumatically convey one of the ingredient materials to the blending apparatus. The delivery system may also comprise one or more valves configured to independently vary the pneumatic flow through one of the conduits. The control system may be configured to provide signals to the valves, commanding the valves to oscillate between varying degrees of openness based on a desired percentage or ratio of each of the ingredient materials to be output to the blending apparatus. The control system may calculate signals to send to the valves based on stored calibration information.
摘要翻译：一种用于混合多种成分材料以制备单一异质材料的材料混合器和方法。材料混合器可以包括混合装置，控制系统和气动输送系统。气动输送系统可以包括多个导管，每个导管设置有穿过其中的气动流，以将配料中的一种材料气动地输送到混合装置。输送系统还可以包括配置成独立地改变通过其中一个导管的气流的一个或多个阀。控制系统可以被配置为向阀提供信号，基于要输出到混合装置的每种成分材料的期望百分比或比例来指示阀在不同程度的开度之间振荡。控制系统可以基于存储的校准信息计算发送到阀的信号。

7. 发明申请

WO2015055987A1 NEURONAL STEM CELL DIFFERENTIATION 审中-公开
标题翻译：神经干细胞分化
公开(公告)号：WO2015055987A1
公开(公告)日：2015-04-23
申请号：PCT/GB2014/053064
申请日：2014-10-13
申请人： UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED , KEMP, Paul , ALLEN, Nicholas
发明人： KEMP, Paul , ALLEN, Nicholas
IPC分类号： C12N5/0793
CPC分类号： C12N5/0619 , C12N2500/14 , C12N2500/38 , C12N2501/01 , C12N2501/13 , C12N2501/40 , C12N2501/415 , C12N2501/42 , C12N2501/845 , C12N2501/999 , C12N2506/08
摘要： The invention relates to at least one novel neural cell differentiation medium for the production of neural cells from at least one precursor cell capable of lineage specific differentiation; a method for neural cell differentiation using said medium; the use of said medium and said method for lineage specific differentiation of at least one precursor cell towards a neural cell fate; and a kit of parts comprising said at least one said neural cell differentiation medium.
摘要翻译：本发明涉及至少一种用于从至少一种能够谱系特异性分化的前体细胞产生神经细胞的新型神经细胞分化培养基; 使用所述培养基的神经细胞分化方法; 所述培养基的使用和所述方法用于至少一种前体细胞对神经细胞命运的谱系特异性分化; 以及包含所述至少一种所述神经细胞分化培养基的试剂盒。

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