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    • 7. 发明申请
    • PERITONEAL DIALYSIS METHODS AND APPARATUS
    • WO2007089855A2
    • 2007-08-09
    • PCT/US2007/002664
    • 2007-01-30
    • THE REGENTS OF THE UNIVERSITY OF CALIFORNIAROBERTS, MartinLEE, David B.N.
    • ROBERTS, MartinLEE, David B.N.
    • A61M1/00
    • A61M1/1696A61M1/1686A61M1/28
    • A peritoneal-based ("bloodless") artificial kidney processes peritoneal fluid without need for additional fluids ("waterless"). Fluid is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s) ("dialysate-pheresis"). It is then reconstituted with additives and returned into the peritoneal cavity, thereby reducing protein-loss and providing oncotic-pressure for ultrafiltration. The protein-free stream is used to produce free water, and an alkaline or acid fluid for optimization of the composition of the regenerated stream. The unused protein-free stream can be used to "reverse flush" the separator to maintain its patency and the excess discarded for fluid-balance regulation. Compared to prior art, immobilization of urease allows more protein rich fluid to be regenerated and re-circulated into the peritoneal cavity for toxin removal and allows practicable development of portable and wearable artificial kidneys.
    • 腹膜(“无血”)人造肾处理腹膜液,无需额外的液体(“无水”)。 将流体分离成富含蛋白质的流和无蛋白质的流。 使用吸附剂组件再生富含蛋白质的流,并且可以通过去除所选择的蛋白质(“透析液”)来修饰其蛋白质组合物。 然后用添加剂重新配制并返回腹膜腔,从而减少蛋白质损失并提供超滤的渗透压。 无蛋白质流用于产生游离水,以及用于优化再生流的组成的碱性或酸性流体。 未使用的不含蛋白质的流可用于“反向冲洗”分离器以保持其通畅性,并将多余的物质丢弃用于流体平衡调节。 与现有技术相比,尿素酶的固定允许更多的富含蛋白质的液体被再生并再循环到腹腔中去除毒素,并允许便携式和可穿戴的人造肾的可行开发。