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1. 发明申请

WO2017011837A3 MULTIVALENT AND MULTISPECIFIC DR5-BINDING FUSION PROTEINS 审中-公开
标题翻译：多价和多特异性DR5-结合融合蛋白
公开(公告)号：WO2017011837A3
公开(公告)日：2017-03-02
申请号：PCT/US2016042862
申请日：2016-07-18
申请人： INHIBRX LP , TIMMER JOHN C , JONES KYLE S , RAZAI AMIR S , HUSSAIN ABRAHIM , WILLIS KATELYN M , DEVERAUX QUINN , ECKELMAN BRENDAN P
发明人： TIMMER JOHN C , JONES KYLE S , RAZAI AMIR S , HUSSAIN ABRAHIM , WILLIS KATELYN M , DEVERAUX QUINN , ECKELMAN BRENDAN P
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/33 , C07K2317/35 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/75
摘要： The disclosure relates generally to molecules that specifically engage death receptor 5 (DR5), a member of the TNF receptor superfamily (TNFRSF). More specifically the disclosure relates to multivalent and multispecific molecules that bind at least DR5.
摘要翻译：本公开一般涉及特异性参与TNF受体超家族（TNFRSF）成员死亡受体5（DR5）的分子。更具体地，本公开涉及结合至少DR5的多价和多特异性分子。

2. 发明申请

WO2013003649A2 WAP DOMAIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译： WAP域融合多肽及其使用方法
公开(公告)号：WO2013003649A2
公开(公告)日：2013-01-03
申请号：PCT/US2012044742
申请日：2012-06-28
申请人： INHIBRX LLC , TIMMER JOHN C , ECKELMAN BRENDAN P , GUENTHER GRANT B , NGUY PETER L , CHAN HENRY , DEVERAUX QUINN
发明人： TIMMER JOHN C , ECKELMAN BRENDAN P , GUENTHER GRANT B , NGUY PETER L , CHAN HENRY , DEVERAUX QUINN
IPC分类号： A61K38/55 , A61K39/395 , A61P29/00 , C07K19/00
CPC分类号： C07K14/811 , A61K38/00 , C07K14/7151 , C07K14/7155 , C07K14/765 , C07K14/8121 , C07K14/8125 , C07K16/241 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2319/00 , C07K2319/30 , C07K2319/31 , C07K2319/70
摘要： This invention relates to fusion proteins that include a whey acidic protein (WAP) domain-containing polypeptide and a second polypeptide. Additionally, the invention relates to fusion proteins that include a WAP domain-containing polypeptide, a second polypeptide, and a third polypeptide. The second and/or third polypeptides of the fusion proteins of the invention are an Fc polypeptide; an albumin polypeptide; a cytokine targeting polypeptide; or a serpin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.
摘要翻译：本发明涉及包含含乳清酸性蛋白（WAP）结构域的多肽和第二多肽的融合蛋白。此外，本发明涉及包含含有WAP结构域的多肽，第二种多肽和第三种多肽的融合蛋白。本发明融合蛋白的第二和/或第三多肽是Fc多肽; 白蛋白多肽; 细胞因子靶向多肽; 或丝氨酸蛋白酶抑制剂多肽本发明还涉及在各种治疗和诊断指征中使用这种分子的方法，以及产生这种分子的方法。

3. 发明申请

WO2013003641A2 SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译： SERPIN融合多肽及其使用方法
公开(公告)号：WO2013003641A2
公开(公告)日：2013-01-03
申请号：PCT/US2012044730
申请日：2012-06-28
申请人： INHIBRX LLC , ECKELMAN BRENDAN P , TIMMER JOHN C , NGUY PETER L , GUENTHER GRANT B , DEVERAUX QUINN
发明人： ECKELMAN BRENDAN P , TIMMER JOHN C , NGUY PETER L , GUENTHER GRANT B , DEVERAUX QUINN
IPC分类号： A61K38/55 , A61K39/395 , A61K39/40 , A61K39/42 , A61P1/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P21/00 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/06 , C07K19/00
CPC分类号： C07K14/8125 , A61K38/00 , C07K14/525 , C07K14/7151 , C07K14/7155 , C07K14/76 , C07K14/765 , C07K14/811 , C07K14/8121 , C07K16/241 , C07K16/40 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2319/00 , C07K2319/30 , C07K2319/31 , C07K2319/70
摘要： This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.
摘要翻译：本发明涉及分子，特别是多肽，更具体地涉及包含丝氨酸蛋白酶抑制蛋白多肽或衍生自丝氨酸蛋白酶抑制蛋白的氨基酸序列的融合蛋白，和第二多肽，其包含至少一种以下物质：Fc多肽或氨基酸序列来源于Fc多肽; 细胞因子靶向多肽或源自细胞因子靶向多肽的序列; 含WAP多肽或衍生自含WAP多肽的序列的WAP域; 和白蛋白多肽或源自血清白蛋白多肽的氨基酸序列。本发明还涉及在各种治疗和诊断指征中使用这种分子的方法，以及产生这种分子的方法。

4. 发明申请

WO2017015623A3 MULTIVALENT AND MULTISPECIFIC GITR-BINDING FUSION PROTEINS 审中-公开
标题翻译：多价和多特异性GITR结合融合蛋白
公开(公告)号：WO2017015623A3
公开(公告)日：2017-03-23
申请号：PCT/US2016043717
申请日：2016-07-22
申请人： INHIBRX LP
发明人： TIMMER JOHN C , JONES KYLE S , RAZAI AMIR S , HUSSAIN ABRAHIM , WILLIS KATELYN M , DEVERAUX QUINN , ECKELMAN BRENDAN P
IPC分类号： C07K16/28 , A61K39/395 , C07K14/525
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： This disclosure generally provides molecules that specifically engage glucocorticoid-induced TNFR-related protein (GITR), a member of the TNF receptor superfamily (TNFRSF). More specifically, the disclosure relates to multivalent and/or multispecific molecules that bind at least GITR.
摘要翻译：本公开通常提供特异性参与糖皮质激素诱导的TNFR相关蛋白（GITR）的分子，所述TNFR相关蛋白是TNF受体超家族（TNFRSF）的成员。更具体而言，本公开涉及结合至少GITR的多价和/或多特异性分子。

5. 发明申请

WO2016179101A3 TYPE III SECRETION SYSTEM TARGETING MOLECULES 审中-公开
标题翻译：第三类靶向分子的分泌系统
公开(公告)号：WO2016179101A3
公开(公告)日：2016-12-15
申请号：PCT/US2016030429
申请日：2016-05-02
申请人： INHIBRX LP
发明人： HOLLANDS ANDREW , TIMMER JOHN C , DEVERAUX QUINN , ECKELMAN BRENDAN P
IPC分类号： C07K16/12 , A61K39/40 , A61K45/06
CPC分类号： C07K16/1214 , A61K38/00 , C07K14/21 , C07K2317/31 , C07K2317/76
摘要： This invention relates generally to molecules that specifically bind bacterial V-tip proteins of the type III secretion system of Gram negative bacteria such as PcrV from Pseudomonas aeruginosa. More specifically, this invention relates to molecules that block the injection of effector molecules into target cells. This invention also relates to molecules that specifically bind to bacterial lipoproteins, such as Oprl. The molecules of the present invention are monospecific or multispecific and can bind their target antigen in a monovalent or multivalent manner. The invention also relates generally to molecules that specifically bind bacterial cell surface proteins such as Oprl, and to methods of use these molecules in a variety of therapeutic, diagnostic, and/or prophylactic indications.
摘要翻译：本发明一般涉及特异性结合革兰氏阴性细菌的III型分泌系统如来自铜绿假单胞菌的PcrV的细菌V型尖端蛋白的分子。更具体地说，本发明涉及阻断效应分子注入靶细胞的分子。本发明还涉及与细菌脂蛋白例如Opr1特异性结合的分子。本发明的分子是单特异性或多特异性的，并且可以以单价或多价方式结合它们的靶抗原。本发明通常还涉及特异性结合细菌细胞表面蛋白例如Opr1的分子，并且涉及在各种治疗，诊断和/或预防适应症中使用这些分子的方法。

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