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1. 发明申请

WO2020246650A1 CALCIUM PHOSPHATE COATED WITH HUMIC ACID OR PHENOLIC POLYMER AND USES THEREOF 审中-公开
公开(公告)号：WO2020246650A1
公开(公告)日：2020-12-10
申请号：PCT/KR2019/006906
申请日：2019-06-07
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY , CONSIGLIO NAZIONALE DELLE RICERCHE
发明人： JEON, Jong-rok , YOON, Ho Young , ADAMIANO, Alessio , IAFISCO, Michele
IPC分类号： C05G3/00 , C05B3/00
摘要： The present invention relates to a slow-releasing fertilizer composition and a composition for increasing plant growth and plant tolerance to salt stress which comprise, as an effective ingredient, hydroxyapatite or in mixture with a tricalcium phosphate obtained from chemical synthesis or thermal treatment of bones, coated with humic acid or a polymer of monomeric phenol.

2. 发明申请

WO2016102576A1 PRODUCTS FOR THE DELIVERY OF THERAPEUTIC/DIAGNOSTIC COMPOUNDS TO THE HEART 审中-公开
标题翻译：用于向心脏递送治疗/诊断化合物的产品
公开(公告)号：WO2016102576A1
公开(公告)日：2016-06-30
申请号：PCT/EP2015/080991
申请日：2015-12-22
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE , ISTITUTO NAZIONALE ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO
发明人： CATALUCCI, Daniele , MIRAGOLI, Michele , IAFISCO, Michele , TAMPIERI, Anna
IPC分类号： A61K9/14 , A61K9/51
CPC分类号： A61K9/5115 , A61K9/007 , A61K9/143 , A61K9/5192 , A61K31/7105 , A61K38/03 , A61K47/52 , A61K47/6929 , C12N15/113 , C12N2310/141 , C12N2320/32
摘要： The invention relates to a process for the preparation of a product comprising one or more nanoparticles of calcium phosphate (CaP-NP) with negative surface charge having a ζ-potential in the range from -41.0 mV to -27.0 mV comprising the steps of: a) maintaining a mixture having a pH in the range from 7 to 10 and comprising an aqueous solution of calcium, an aqueous solution of phosphate and a solution of citrate ions at a temperature in the range from 20 °C to 40 °C for a time in the range from 30 seconds to 10 minutes; b) removing non-reacted ions from the solution of step a), thus obtaining a suspension of one or more nanoparticles of calcium phosphate (CaP-NP); c) recovering the product of one or more nanoparticles of calcium phosphate (CaP-NP) from the suspension of step b). In an advantageous embodiment, the process of the invention provides, in the mixture of step a), also an aqueous solution of one or more therapeutic/diagnostic compounds. The product of the invention may be used as a vehicle for one or more diagnostic/therapeutic compounds for the treatment of cardiovascular diseases through inhalation administration.
摘要翻译：本发明涉及一种制备包含一种或多种具有负电荷的磷酸钙（CaP-NP）的纳米颗粒的产品的方法，所述磷酸钙（CaP-NP）具有-41.0mV至-27.0mV范围内的ζ电位，包括以下步骤： a）保持pH在7至10范围内的混合物，并在20℃至40℃的温度范围内包含钙水溶液，磷酸盐水溶液和柠檬酸根离子溶液，用于时间范围从30秒到10分钟; b）从步骤a）的溶液中除去未反应的离子，从而获得一种或多种磷酸钙（CaP-NP）纳米颗粒的悬浮液; c）从步骤b）的悬浮液中回收一种或多种磷酸钙（CaP-NP）纳米颗粒的产物。在有利的实施方案中，本发明的方法在步骤a）的混合物中还提供一种或多种治疗/诊断化合物的水溶液。本发明的产品可以用作一种或多种用于通过吸入给药治疗心血管疾病的诊断/治疗化合物的载体。

3. 发明申请

WO2022053955A1 POWDER COMPOSITION BASED ON MICROPARTICLES EMBEDDING NANOPARTICLES FOR THE DELIVERY OF THERAPEUTIC/DIAGNOSTIC COMPOUNDS 审中-公开
公开(公告)号：WO2022053955A1
公开(公告)日：2022-03-17
申请号：PCT/IB2021/058184
申请日：2021-09-09
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE , PLUMESTARS S.R.L.
发明人： CATALUCCI, Daniele , IAFISCO, Michele , COLOMBO, Paolo , QUARTA, Eride
IPC分类号： A61K9/00 , A61K9/16 , A61K47/02 , A61K47/26 , A61K38/00
摘要： This invention relates to a powder composition for inhalation use comprising a plurality of microparticles comprising at least one water-soluble pharmaceutically acceptable carrier embedding at least one nanoparticle of calcium phosphate for the delivery of therapeutic/diagnostic compounds.

4. 发明申请

WO2020193750A1 PHYSICAL SUNSCREEN COMPRISING HYDROXYAPATITE OR MODIFIED HYDROXYAPATITE OBTAINED FROM FISHERIES AND AQUACULTURE WASTE, PROCESS FOR ITS PRODUCTION AND PHOTOPROTECTIVE COMPOSITIONS COMPRISING IT 审中-公开
公开(公告)号：WO2020193750A1
公开(公告)日：2020-10-01
申请号：PCT/EP2020/058694
申请日：2020-03-27
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE
发明人： IAFISCO, Michele , ADAMIANO, Alessio , PICCIRILLO, Clara
IPC分类号： A61K8/24 , A01N59/00 , A61K8/27 , A61Q17/04 , A61K8/98 , A61K8/19
摘要： It is described a process, starting from fishbones, for the production of a material having properties of physical type solar filter and photoprotective boosting agent, formed by particles of hydroxyapatite or hydroxyapatite substituted with metal ions, optionally mixed with calcium triphosphate and with metal oxides. Are also described the material obtained through the process and cosmetic or plant sunscreen compositions that comprise said material.

5. 发明申请

WO2016012452A1 PROCESS FOR OBTAINING FLUORIDE-DOPED CITRATE-COATED AMORPHOUS CALCIUM PHOSPHATE NANOPARTICLES 审中-公开
标题翻译：用于获得氟化物掺杂的柠檬酸钙非晶态磷酸钙纳米粒子的方法
公开(公告)号：WO2016012452A1
公开(公告)日：2016-01-28
申请号：PCT/EP2015/066651
申请日：2015-07-21
申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) , CONSIGLIO NAZIONALE DELLE RICERCHE
发明人： DELGADO LÓPEZ, José, Manuel , GÓMEZ MORALES, Jaime , FERNÁNDEZ PENAS, Raquel , IAFISCO, Michele , TAMPIERI, Anna , PANSERI, Silvia
IPC分类号： A61K9/19 , A61K6/00 , A61K9/51 , A61L24/00
CPC分类号： A61K33/42 , A61K6/0008 , A61K6/0017 , A61K6/0038 , A61K6/0643 , A61K8/21 , A61K8/24 , A61K8/362 , A61K9/167 , A61K9/1682 , A61K9/19 , A61K9/5115 , A61K9/5123 , A61K9/5192 , A61K31/194 , A61K33/16 , A61K2800/413 , A61K2800/621 , A61K2800/70 , A61K2800/84 , A61L24/0015 , A61L24/02 , A61L2430/02 , A61L2430/12 , A61Q11/00 , C01B25/32
摘要： Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles. This material has applications in biomedicine due to its biodegradability and bioactivity; it also promotes cell adhesion and osteogeneration. In dentistry, it may be used in toothpastes, mouthwashes, chewing gums, gels and fluoride varnishes as a remineralising agent of dentine and enamel. It is based on two solutions formed by calcium chloride and sodium citrate on the one hand, and by sodium monohydrogenophosphate and sodium carbonate with a fluoride compound on the other, which are mixed at room temperature. The process is eco-efficient and eco-friendly, as it does not leave any acid residue; it consists of a single stage and it is the first time that an amorphous calcium phosphate coated with citrate and doped with fluoride, which enhances its remineralising action, is obtained.
摘要翻译：获得氟化物掺杂的柠檬酸盐涂覆的无定形磷酸钙纳米粒子的方法。该材料由于其生物降解性和生物活性而在生物医药中具有应用; 它还促进细胞粘附和骨生成。在牙科中，它可用于牙膏，漱口水，口香糖，凝胶和氟化物清漆，作为牙质和牙釉质的再矿化剂。它是由氯化钙和柠檬酸钠一方面形成的两种溶液，另一方面由一水合磷酸钠和一种含氟化合物的碳酸钠组成，它们在室温下混合。该过程是生态高效和环保的，因为它不会留下任何酸残留物; 它由单一阶段组成，并且是第一次获得涂覆有柠檬酸盐并掺杂氟化物的无定形磷酸钙，其增强其再矿化作用。

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