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1. 发明申请

WO2009063339A3 METHOD FOR FOLLOWING PEDIATRIC DEVELOPMENT 审中-公开
标题翻译：儿童发展之后的方法
公开(公告)号：WO2009063339A3
公开(公告)日：2009-12-23
申请号：PCT/IB2008053562
申请日：2008-09-03
申请人： INDICARE , INBAR MICHAEL , BELSKY ZIV
发明人： INBAR MICHAEL , BELSKY ZIV
IPC分类号： G06Q50/00
CPC分类号： G06F19/324 , G16H50/20 , G16H50/50
摘要： Method for indicating the pediatric growth status of a patient based on a single combined indication value. The single combined indication value is obtained by performing weight, height and head circumference measurements, using these measurements to compute a set of slow average weighted percentile values and a set of fast average weighted percentile values, computing a set of difference values from differences between the fast average and the slow average weighted percentile values, computing a set of weight, height and head circumference augmented values from the difference values and computing the single combined indication value from the set of weight, height and head circumference augmented values.
摘要翻译：用于基于单个组合指示值来指示患者的儿科生长状态的方法。通过执行体重，身高和头围测量，使用这些测量结果来计算一组慢速平均加权百分位数值和一组快速平均加权百分位数值，从一组快速平均加权百分位数值计算一组合的指示值，快速平均值和慢平均加权百分比值，根据差值计算一组重量，高度和头围增大值，并从该组重量，身高和头围增大值计算单个组合指示值。

2. 发明申请

WO2006064502A3 LOCAL DELIVERY OF DRUGS OR SUBSTANCES USING ELECTRONIC PERMEABILITY INCREASE 审中-公开
标题翻译：本地交付使用电子渗透性增加的药物或物质
公开(公告)号：WO2006064502A3
公开(公告)日：2006-09-21
申请号：PCT/IL2005001346
申请日：2005-12-14
申请人： PILL PHARMA LTD E , BELSKY ZIV , TSADKIN-TAMIR MARINA
发明人： BELSKY ZIV , TSADKIN-TAMIR MARINA
IPC分类号： A61K9/22
CPC分类号： A61K9/48 , A61B5/4839 , A61K9/0053 , A61K9/0097 , A61M31/002
摘要： Apparatus is provided for use in conjunction with a drug (36) delivered to a gastrointestinal (GI) tract of a subject. The apparatus includes an ingestible capsule (30), which includes one or more electrodes (16), and a control component (14), adapted to drive the elctrodes (16) to apply an electrical current that induces local delivery of the drug (36) in target tissue of the GI tract. Additional embodiments are also described.
摘要翻译：提供了与递送到受试者的胃肠道（GI）的药物（36）一起使用的装置。该设备包括可摄入胶囊（30）和控制部件（14），该可摄入胶囊包括一个或多个电极（16），该控制部件适于驱动电极（16）以施加诱导药物局部递送的电流（36 ）在胃肠道的目标组织中。还描述了另外的实施例。

3. 发明申请

WO2006064503A2 PROLONGED TRANSIT TIME OF PERMEABILITY-ENHANCING DRUG ELUTING PILL 审中-公开
标题翻译：渗透性增强药物治疗药丸的延长运输时间
公开(公告)号：WO2006064503A2
公开(公告)日：2006-06-22
申请号：PCT/IL2005001347
申请日：2005-12-14
申请人： PILL PHARMA LTD E , BELSKY ZIV , PELED SHAHAR
发明人： BELSKY ZIV , PELED SHAHAR
IPC分类号： A61M31/00
CPC分类号： A61K9/48 , A61B5/4839 , A61K9/0053 , A61K9/0097 , A61M31/002
摘要： Apparatus is provided for drug administration. The apparatus includes an ingestible capsule (30), which includes a drug (36), stored by the capsule (30). The apparatus also includes an environmentally-sensitive mechanism, adapted to change a state thereof responsively to a disposition of the capsule (30) within a gastrointestinal (GI) tract of a subject; one or more drug-passage facilitation electrodes (16); and a control component (14), adapted to facilitate passage of the drug (36), in response to a change of state of the environmentally-sensitive mechanism, by driving the drug-passage facilitation electrodes (16) to apply an electrical current. The apparatus further includes a velocity-reduction element adapted to reduce a velocity of the capsule (30) through the GI tract for at least a portion of the time that the control component (14) is facilitating the passage of the drug (36). Additional embodiments are also described.
摘要翻译：提供用于药物给药的装置。该装置包括可摄入胶囊（30），其包括由胶囊（30）储存的药物（36）。该装置还包括环境敏感的机构，其适于根据受试者的胃肠（GI）道内的胶囊（30）的配置来改变其状态; 一个或多个药物通道促进电极（16）; 以及控制部件（14），其适于响应于所述环境敏感性机构的状态的改变而促进所述药物（36）的通过，通过驱动所述药物通道促进电极（16）施加电流。该装置还包括速度减小元件，其适于在控制组件（14）促进药物（36）通过的至少一部分时间内减小胶囊（30）通过胃肠道的速度。还描述了另外的实施例。

4. 发明申请

WO2012143913A3 TISSUE CLOSURE DEVICE 审中-公开
标题翻译：组织闭合装置
公开(公告)号：WO2012143913A3
公开(公告)日：2012-12-13
申请号：PCT/IB2012052033
申请日：2012-04-23
申请人： NOVOGATE MEDICAL LTD , BELSKY ZIV , HIZKIYAHU GILAD , BOLOTIN GIL
发明人： BELSKY ZIV , HIZKIYAHU GILAD , BOLOTIN GIL
IPC分类号： A61B17/00
CPC分类号： A61B17/12013 , A61B17/0057 , A61B17/0644 , A61B17/068 , A61B2017/00557 , A61B2017/00579 , A61B2017/00584 , A61B2017/00592 , A61B2017/00623 , A61B2017/00668 , A61B2017/00862 , A61B2017/00867 , A61B2017/0641
摘要： The present invention relates generally to a tissue closure device and in particular to a tissue closure device having a plurality of configurations providing for delivery and use in minimally invasive proce dures. A tissue closure device (100) is provided from shape memory or super-elastic materials for closing a tissue site opening (50), the device comprising a plurality of tissue anchors (130) extending from a closed loop surface (110) wherein the plane of said tissue anchors is provided at an angle essentially perpendicular with respect to the plane of said closed loop surface;a. wherein said plurality of tissue an chors (130) comprise a proximal end (130p) and a distal end (130d); said distal end provided for anchoring said device onto tissue (50); and wherein said proximal end (130p) is fluid with and extends from said closed loop surface (110); and b. said closed loop surface (110) having a plurality of configurations including: a delivery configura tion (lOOd), an open configuration (1000 ) and a closed configuration (100c) wherein said closed loop surface (110) may undergo a trans formation between one of said plurality of configurations to another; said delivery configuration (lOOd) defining a low profile of said device (100) and adapted for delivery to a tissue site (50) through a small profile access point having a first diameter and wherein said closure device is utilized to close a tissue site having a second diameter such that said second diameter is larger than said first diameter.
摘要翻译：本发明一般涉及一种组织闭合装置，特别涉及一种组织封闭装置，该组织封闭装置具有提供用于微创手术的输送和使用的多种构型。从形状记忆体或超弹性材料提供组织闭合装置（100），用于封闭组织部位开口（50），所述装置包括从闭环表面（110）延伸的多个组织锚（130），其中平面所述组织锚固件以相对于所述闭环表面的平面基本垂直的角度设置; a。其中所述多个组织中的一个（130）包括近端（130p）和远端（130d）; 所述远端用于将所述装置固定在组织（50）上; 并且其中所述近端（130p）与所述闭环表面（110）流体并且从所述闭环表面延伸。和b。所述闭环表面（110）具有多个构造，包括：输送配置（100d），打开构型（1000）和闭合构型（100c），其中所述闭环表面（110）可经历一个的所述多个配置; 所述输送构型（100d）限定所述装置（100）的低轮廓并且适于通过具有第一直径的小轮廓接入点输送到组织部位（50），并且其中所述闭合装置用于封闭具有第二直径使得所述第二直径大于所述第一直径。

5. 发明申请

WO2005105053A3 ACTIVE DRUG DELIVERY IN THE GASTROINTESTINAL TRACT 审中-公开
标题翻译：活性药物在胃肠道手术中的输送
公开(公告)号：WO2005105053A3
公开(公告)日：2006-05-18
申请号：PCT/IL2005000301
申请日：2005-03-16
申请人： PILL PHARMA LTD E , GROSS YOSSI , SELA YORAM , BELSKY ZIV , LEV RINA , GOLDSTEIN DANIEL
发明人： GROSS YOSSI , SELA YORAM , BELSKY ZIV , LEV RINA , GOLDSTEIN DANIEL
IPC分类号： A61K9/22 , A61B1/05 , A61B5/00 , A61B5/03 , A61B5/07 , A61B17/32 , A61B18/02 , A61B18/14 , A61B18/20 , A61B19/00 , A61J3/07 , A61K9/00 , A61K9/48 , A61M31/00 , A61N1/05 , A61N1/30 , A61N1/32 , A61N1/36 , A61N1/372 , A61N1/375 , G01K13/00
CPC分类号： A61B1/041 , A61B1/00016 , A61B1/00156 , A61B5/0008 , A61B5/01 , A61B5/036 , A61B5/073 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/4839 , A61B17/3203 , A61B18/02 , A61B18/14 , A61B18/20 , A61B34/70 , A61B34/72 , A61J3/07 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K9/4808 , A61M31/002 , A61N1/05 , A61N1/306 , A61N1/325 , A61N1/327 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/3756 , G01K13/002
摘要： Apparatus (30) for drug administration is provided, including an ingestible capsule (32), which includes a drug (36), stored by the capsule (32), and an environmentally-sensitive mechanism (18), adapted to change a state thereof responsively to a disposition of the capsule (32) within a gastrointestinal (GI) tract (50) of a subject. The capsule (32) further includes first and second electrodes (16), and a control component (14), adapted to facilitate passage of the drug (36), in response to a change of state of the environmentally-sensitive mechanism (18), through an epithelial layer of the GI tract (50) by driving the first and second electrodes (16) to apply a series of pulses at a current of less than about 10 mA, at a frequency of between about 12 Hz and about 24 Hz, and with a pulse duration of between about 0.5 milliseconds and about 3 milliseconds. Other embodiments are also described.
摘要翻译：提供了用于药物给药的装置（30），包括可吸收胶囊（32），其包括由胶囊（32）储存的药物（36）和适于改变其状态的环境敏感性机构（18）响应于胶囊（32）在受试者的胃肠（GI）道（50）内的布置。胶囊（32）还包括响应于环境敏感机构（18）的状态改变而适于促进药物（36）通过的第一和第二电极（16）和控制部件（14）通过驱动第一和第二电极（16）通过GI道（50）的上皮层以约12Hz至约24Hz的频率施加小于约10mA的电流的一系列脉冲并且脉冲持续时间在约0.5毫秒至约3毫秒之间。还描述了其它实施例。

6. 发明申请

WO0130436A3 DEVICE FOR CARDIAC THERAPY 审中-公开
标题翻译：心脏治疗设备
公开(公告)号：WO0130436A3
公开(公告)日：2002-01-17
申请号：PCT/IL0000682
申请日：2000-10-25
申请人： IMPULSE DYNAMICS NV , PRUTCHI DAVID , DARVISH NISSIM , ROUTH ANDRE G , HALUSKA EDWARD , BELSKY ZIV
发明人： PRUTCHI DAVID , DARVISH NISSIM , ROUTH ANDRE G , HALUSKA EDWARD , BELSKY ZIV
IPC分类号： A61N1/362 , A61N1/39 , A61N1/365
CPC分类号： A61N1/39 , A61N1/3621 , A61N1/3627 , A61N1/3956
摘要： A multi-modal cardiotherapy device (100) includes an anti-arrhythmic unit (118) for delivering multiple types of anti-arrhythmic therapy to a heart, a cardiac contractility modulating unit (108) for delivering cardiac contractility modulating signals to the heart, and for applying anti-arrhythmic cardiac contractility modulating signal therapy to the heart, one or more sensing units (112) for sensing electrical signals related to electrical activity of the heart to provide an output signal, one or more detecting units (116) operatively connected to the sensing unit(s) (112) for detecting in the output signal cardiac events of the heart, a controller unit (106) operatively connected to the anti-arrhythmic unit (118), the cardiac contractility modulating unit (108) and the detecting unit(s) (116). The controller unit (106) processes the output of the detecting unit(s) (116) to detect a cardiac arrhythmia or indications of a possible arrhythmia in the heart and controls the application of anti-arrhythmic therapy, anti-arrhythmic cardiac contractility modulating signal therapy, and cardiac contractility modulating therapy to the heart. The device may be an implantable device or a non-implantable device. The device (100) may also include a pacing unit (102). Methods are disclosed for using the device for delivering multi-modal cardiotherapy to the heart.
摘要翻译：多模式心脏治疗装置（100）包括用于向心脏递送多种类型的抗心律失常治疗的抗心律不齐装置（118），用于将心脏收缩调节信号输送到心脏的心脏收缩力调节单元（108），以及用于向心脏施加抗心律失常心脏收缩调节信号治疗，一个或多个感测单元（112），用于感测与心脏的电活动相关的电信号以提供输出信号;一个或多个检测单元（116），其可操作地连接到用于在输出信号中检测心脏心脏事件的感测单元（112），可操作地连接到抗心律失调单元（118）的心脏收缩力调节单元（108）和检测器单位（116）。控制器单元（106）处理检测单元（116）的输出以检测心脏心律失常或心脏中可能的心律不齐的指示，并控制抗心律不齐治疗，抗心律失常心脏收缩调节信号的应用治疗和心脏收缩力调节治疗心脏。该装置可以是可植入装置或非植入装置。设备（100）还可以包括起搏单元（102）。公开了使用用于向心脏递送多模式心脏治疗的装置的方法。

7. 发明申请

WO2006123346A3 INGESTIBLE DEVICE FOR NITRIC OXIDE PRODUCTION IN TISSUE 审中-公开
标题翻译：用于组织中氮氧化物生产的不可利用的装置
公开(公告)号：WO2006123346A3
公开(公告)日：2007-06-07
申请号：PCT/IL2006000593
申请日：2006-05-18
申请人： PILL PHARMA LTD E , ALON RUTH , LEV RINA , BELSKY ZIV
发明人： ALON RUTH , LEV RINA , BELSKY ZIV
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/205 , A61N1/37205 , A61N1/3756
摘要： Apparatus is provided including an ingestible device (10), which includes two or more electrodes (22), and a signal controller (20), configured to drive the electrodes (22) to apply an electrical signal to an inner surface of a wall of a gastrointestinal (GI) tract of a subject, and to configure the signal to induce local endogenous release of nitric oxide (NO). Other embodiments are also described.
摘要翻译：提供了包括可摄取装置（10）的装置，其包括两个或多个电极（22）和信号控制器（20），其被配置为驱动电极（22）将电信号施加到壁的内表面一个受试者的胃肠道（GI），并配置该信号以诱导局部内源性释放一氧化氮（NO）。还描述了其它实施例。

8. 发明申请

WO0074552A3 METHOD FOR DETERMINIG ALERT WINDOW PARAMETERS FOR ETC SIGNAL DELIVERY 审中-公开
标题翻译：用于确定用于ETC信号传递的窗口参数的方法
公开(公告)号：WO0074552A3
公开(公告)日：2003-03-13
申请号：PCT/IL0000310
申请日：2000-05-30
申请人： IMPULSE DYNAMICS NV , MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , ROUTH ANDRE G
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , ROUTH ANDRE G
IPC分类号： A61B5/0402 , A61N1/362 , A61N1/37 , A61N1/39 , H01L21/68 , H01L23/31
CPC分类号： A61B5/0402 , A61B5/7203 , A61N1/3627 , A61N1/3962 , H01L21/568 , H01L21/6835 , H01L23/3107 , H01L2924/0002 , H01L2924/00
摘要： A method for obtaining data (76) from a patient's heart useful for on-line setting of parameters (80) of a detection window in an excitable tissue control device.
摘要翻译：一种用于从患者心脏获取数据（76）的方法，其可用于可兴奋组织控制装置中检测窗口的参数（80）的在线设置。

9. 发明申请

WO0057952A8 APPARATUS AND METHOD FOR TIMING THE DELIVERY OF NON-EXCITATORY ETC SIGNALS TO A HEART 审中-公开
标题翻译：用于定时向非心脏输送非特异性ETC信号的装置和方法
公开(公告)号：WO0057952A8
公开(公告)日：2001-05-25
申请号：PCT/IL0000126
申请日：2000-03-01
申请人： IMPULSE DYNAMICS NV , MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
发明人： MIKA YUVAL , PRUTCHI DAVID , BELSKY ZIV , KIMCHY YOAV
IPC分类号： A61B5/0452 , A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/368 , A61N1/3962
摘要： A method, and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of the heart includes applying electrodes to a plurality of cardiac sites (RA, RV, LV), using a first electrode (2A, 4A) at a first cardiac site (RV, RA) to detect a first electrical depolarization event within a beat cycle, using a second electrode (6A) at a second cardiac site (LV) to detect a second electrical depolarization event within a beat cycle, and applying a non-excitatory signal to the heart near at least the second cardiac site (LV) through at least one of the electrodes (6A) in response to detecting the second electrical depolarization event within an alert window period. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The devices may also be adapted for pacing the heart, and/or for delivering de-defibrillation signals to the heart.
摘要翻译：方法和用于定时递送用于改善心脏心脏收缩力的非兴奋性信号的装置包括使用第一电极（2A，4A）将电极施加到多个心脏部位（RA，RV，LV）心脏位点（RV，RA），以在搏动周期内检测第一电去极化事件，使用第二心脏位点（LV）处的第二电极（6A）来检测搏动周期内的第二电去极化事件，响应于检测到警报窗口周期内的第二电去极化事件，至少通过至少一个电极（6A）向心脏附近的至少第二心脏位点（LV）的心脏信号。从第二次电去极化事件的检测时间开始延迟非兴奋性信号的施加。所述装置还可适于起搏心脏和/或用于将去除颤颤信号递送至心脏。

10. 发明申请

WO2015063609A3 SURGICAL STAPLER 审中-公开
标题翻译：手术装订器
公开(公告)号：WO2015063609A3
公开(公告)日：2015-12-03
申请号：PCT/IB2014002992
申请日：2014-11-04
申请人： MILO SIMCHA , BELSKY ZIV
发明人： MILO SIMCHA , BELSKY ZIV
IPC分类号： A61B17/068
CPC分类号： A61B17/068 , A61B17/0644 , A61B17/0682 , A61B17/105 , A61B17/3421 , A61B2017/00243 , A61B2017/00783 , A61B2017/0645 , A61B2017/3425 , A61B2090/034 , A61B2090/036 , A61B2090/08021
摘要： A surgical stapler includes a control handle having a forward-extending barrel and a stapling device at the distal end of the barrel, where the stapling device has a stapling head part, a stapler body part, and a hinge connection therebetween such that the stapling head part is pivotable relative to the barrel. The stapling head part has a holder region, opposite the hinge connection, configured for holding a surgical staple during positioning and implanting the staple. The proximal end portion of the stapling head part can be pivoted outwardly relative to the barrel to at least about 15° from an at rest position, juxtaposed with the stapler body part, to an active position for implantation of a staple into tissue in a generally proximal direction toward the control handle.
摘要翻译：外科缝合器包括控制手柄，该控制手柄具有向前延伸的筒体和位于筒体的远端处的缝合装置，其中缝合装置具有缝合头部分，订书机主体部分以及它们之间的铰链连接，使得缝合头部部分可相对于筒体枢转。缝合头部分具有与铰链连接相对的保持器区域，该保持器区域构造成在定位和植入缝钉期间保持外科缝合钉。吻合头部分的近端部分可以相对于针筒向外枢转至与钉合器本体部分并置的静止位置至少大约15°到活动位置，以用于将吻合钉植入组织中朝向控制手柄的近侧方向。

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