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1. 发明申请

WO9831805A3 HUMAN ZINC BINDING PROTEINS 审中-公开
标题翻译：人类锌结合蛋白
公开(公告)号：WO9831805A3
公开(公告)日：1998-11-05
申请号：PCT/US9801181
申请日：1998-01-20
申请人： INCYTE PHARMA INC , HILLMAN JENNIFER L , AU YOUNG JANICE , COLEMAN ROGER , GOLI SURYA K
发明人： HILLMAN JENNIFER L , AU-YOUNG JANICE , COLEMAN ROGER , GOLI SURYA K
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , A61K38/17 , C07K16/18 , C12N9/00 , C12N15/11 , C12Q1/68
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides three zinc binding proteins (designated individually as ZB-1, ZB-2, and ZB-3, and collectively as ZB) and polynucleotides which identify and encode ZB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding ZB and a method for producing ZB. The invention also provides for use of ZB and agonists, antibodies, or antagonists specifically binding ZB, in the prevention and treatment of diseases associated with expression of ZB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding ZB for the treatment of diseases associated with the expression of ZB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding ZB.

2. 发明申请

WO9802456A3 HUMAN C-TYPE LECTIN 审中-公开
标题翻译：人C型LECTIN
公开(公告)号：WO9802456A3
公开(公告)日：2002-10-17
申请号：PCT/US9712342
申请日：1997-07-15
申请人： INCYTE PHARMA INC , AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , GOLI SURYA K , HILLMAN JENNIFER L
发明人： AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , GOLI SURYA K , HILLMAN JENNIFER L
IPC分类号： A61K38/00 , C07K14/47 , C12N15/54 , C12N1/21 , C12N9/12 , C12N15/70
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides a polynucleotide (mctl) which identifies and encodes a novel human C-type lectin (MCTL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MCTL. The invention also provides for the use of substantially purified MCTL and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of MCTL. Additionally, the invention provides for the use of antisense molecules to mctl in pharmaceutical compositions for treatment of diseases associated with the expression of MCTL. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of mctl. The present invention also relates to anti-MCTL antibodies which specifically bind to MCTL.
摘要翻译：本发明提供鉴定和编码新型人C型凝集素（MCTL）的多核苷酸（mct1）。本发明提供了包含编码MCTL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在商业生产重组蛋白质和用于治疗与MCTL表达相关的疾病的药物组合物中使用基本上纯化的MCTL及其激动剂。另外，本发明提供了用于治疗与MCTL表达相关的疾病的药物组合物中的mct1的反义分子的用途。本发明还描述了使用包含与mct1的基因组序列或转录物杂交的多核苷酸，其片段或其互补体的诊断组合物的诊断测定法。本发明还涉及特异性结合MCTL的抗MCTL抗体。

3. 发明申请

WO9804585A3 Novel human macrophage antigen 审中-公开
标题翻译：新型人巨噬细胞抗原
公开(公告)号：WO9804585A3
公开(公告)日：1998-03-12
申请号：PCT/US9713077
申请日：1997-07-22
申请人： INCYTE PHARMACEUTICAL INC , HILLMAN JENNIFER L , AU-YOUNG JANICE , GOLI SURYA K
发明人： HILLMAN JENNIFER L , AU-YOUNG JANICE , GOLI SURYA K
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P37/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12
CPC分类号： C07K14/7056 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human macrophage antigen (TMAH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding TMAH. The invention also provides for the use of substantially purified TMAH and its agonists, antibodies, antagonists or inhibitors in pharmaceutical compositions for treatment of diseases associated with expression of TMAH. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the genomic sequence or transcripts encoding TMAH and anti-TMAH antibodies which specifically bind to TMAH.

4. 发明申请

WO9806841A3 TWO HUMAN NSP-LIKE PROTEINS 审中-公开
标题翻译：两种人类NSP样蛋白
公开(公告)号：WO9806841A3
公开(公告)日：1998-05-07
申请号：PCT/US9713469
申请日：1997-07-24
申请人： INCYTE PHARMA INC , BANDMAN OLGA , AU YOUNG JANICE , GOLI SURYA K , HILLMAN JENNIFER
发明人： BANDMAN OLGA , AU-YOUNG JANICE , GOLI SURYA K , HILLMAN JENNIFER
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/28 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/28 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/08 , A61K31/70 , A61K38/17 , C12Q1/68
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K2319/00
摘要： The present invention provides polynucleotides which identify and encode two human NSP-like proteins (NSPLP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NSPLP. The invention also provides for the use of substantially purified NSPLP, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of NSPLP. Additionally, the invention provides for the use of antisense molecules to NSPLP in pharmaceutical compositions for treatment of diseases associated with the expression of NSPLP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NSPLP or anti-NSPLP antibodies which specifically bind to NSPLP.

5. 发明申请

WO0006728A8 PHOSPHORYLATION EFFECTORS 审中-公开
标题翻译：磷化效应
公开(公告)号：WO0006728A8
公开(公告)日：2001-07-05
申请号：PCT/US9917132
申请日：1999-07-28
申请人： INCYTE PHARMA INC , HILLMAN JENNIFER L , LAL PREETI , TANG Y TOM , CORLEY NEIL C , GUEGLER KARL J , BAUGHN MARIAH R , PATTERSON CHANDRA , BANDMAN OLGA , AU YOUNG JANICE , GORGONE GINA A , YUE HENRY , AZIMZAI YALDA , REDDY ROOPA , LU DYUNG AINA M , SHIH LEO L
发明人： HILLMAN JENNIFER L , LAL PREETI , TANG Y TOM , CORLEY NEIL C , GUEGLER KARL J , BAUGHN MARIAH R , PATTERSON CHANDRA , BANDMAN OLGA , AU-YOUNG JANICE , GORGONE GINA A , YUE HENRY , AZIMZAI YALDA , REDDY ROOPA , LU DYUNG AINA M , SHIH LEO L
IPC分类号： A61K38/00 , C07K14/47 , C12N9/12 , C12N15/12 , A61K38/17 , C07K16/18 , C12N5/10
CPC分类号： C12N9/12 , A61K38/00 , C07K14/4702
摘要： The invention provides human phosphorylation effectors (PHSP) and polynucleotides which identify and encode PHSP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of PHSP.
摘要翻译：本发明提供鉴定和编码PHSP的人磷酸化作用子（PHSP）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与PHSP表达相关的障碍的方法。

6. 发明申请

WO0012711A8 HUMAN MEMBRANE CHANNEL PROTEINS 审中-公开
标题翻译：人膜通道蛋白
公开(公告)号：WO0012711A8
公开(公告)日：2001-05-10
申请号：PCT/US9920468
申请日：1999-09-02
申请人： INCYTE PHARMA INC , AU YOUNG JANICE , BANDMAN OLGA , TANG Y TOM , REDDY ROOPA , HILLMAN JENNIFER L , YUE HENRY , LAL PREETI , CORLEY NEIL C , GUEGLER KARL J , GORGONE GINA , BAUGHN MARIAH R , AZIMZAI YALDA
发明人： AU-YOUNG JANICE , BANDMAN OLGA , TANG Y TOM , REDDY ROOPA , HILLMAN JENNIFER L , YUE HENRY , LAL PREETI , CORLEY NEIL C , GUEGLER KARL J , GORGONE GINA , BAUGHN MARIAH R , AZIMZAI YALDA
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N15/12 , A61K38/17 , C07K16/18 , C07K16/28 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705
摘要： The invention provides new human membrane channel proteins (MECHP) and polynucleotides which identify and encode MECHP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of MECHP.
摘要翻译：本发明提供新的人膜通道蛋白（MECHP）和识别和编码MECHP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与MECHP表达相关的紊乱的方法。

7. 发明申请

WO0034477A3 NEURON-ASSOCIATED PROTEINS 审中-公开
标题翻译：神经元相关蛋白
公开(公告)号：WO0034477A3
公开(公告)日：2000-11-09
申请号：PCT/US9930408
申请日：1999-12-10
申请人： INCYTE PHARMA INC , TANG Y TOM , YUE HENRY , BAUGHN MARIAH R , HILLMAN JENNIFER L , LAL PREETI , AU YOUNG JANICE , YANG JUNMING , LU DYUNG AINA M , AZIMZAI YALDA
发明人： TANG Y TOM , YUE HENRY , BAUGHN MARIAH R , HILLMAN JENNIFER L , LAL PREETI , AU-YOUNG JANICE , YANG JUNMING , LU DYUNG AINA M , AZIMZAI YALDA
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N37/00 , A61K38/17
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要： The invention provides human neuron-associated proteins (NEUAP) and polynucleotides which identify and encode NEUAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of NEUAP.
摘要翻译：本发明提供了鉴定和编码NEUAP的人神经元相关蛋白（NEUAP）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与NEUAP表达相关的病症的方法。

8. 发明申请

WO0000610A3 HUMAN SIGNAL PEPTIDE-CONTAINING PROTEINS 审中-公开
标题翻译：人类信号肽含蛋白质
公开(公告)号：WO0000610A3
公开(公告)日：2000-06-29
申请号：PCT/US9914484
申请日：1999-06-25
申请人： INCYTE PHARMA INC , LAL PREETI , TANG Y TOM , GORGONE GINA A , CORLEY NEIL C , GUEGLER KARL J , BAUGHN MARIAH R , AKERBLOM INGRID E , AU YOUNG JANICE , YUE HENRY , PATTERSON CHANDRA , REDDY ROOPA , HILLMAN JENNIFER L , BANDMAN OLGA
发明人： LAL PREETI , TANG Y TOM , GORGONE GINA A , CORLEY NEIL C , GUEGLER KARL J , BAUGHN MARIAH R , AKERBLOM INGRID E , AU-YOUNG JANICE , YUE HENRY , PATTERSON CHANDRA , REDDY ROOPA , HILLMAN JENNIFER L , BANDMAN OLGA
IPC分类号： G01N33/68 , A61K38/00 , A61K39/395 , A61K45/00 , A61P9/00 , A61P15/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , A61K38/17 , C12N15/11
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which indentify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译：本发明提供含有人信号肽的蛋白（HSPP）和识别和编码HSPP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。

9. 发明申请

WO0055332A3 HUMAN REGULATORS OF INTRACELLULAR PHOSPHORYLATION 审中-公开
标题翻译：细胞内磷酸化的人体调节剂
公开(公告)号：WO0055332A3
公开(公告)日：2002-01-10
申请号：PCT/US0007277
申请日：2000-03-17
申请人： INCYTE PHARMA INC , BANDMAN OLGA , TANG Y TOM , YUE HENRY , HILLMAN JENNIFER L , BAUGHN MARIAH R , AZIMZAI YALDA , LU DYUNG AINA M , AU YOUNG JANICE
发明人： BANDMAN OLGA , TANG Y TOM , YUE HENRY , HILLMAN JENNIFER L , BAUGHN MARIAH R , AZIMZAI YALDA , LU DYUNG AINA M , AU-YOUNG JANICE
IPC分类号： G01N33/50 , A61K38/00 , A61K38/46 , A61K45/00 , A61K48/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P7/04 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/02 , A61P37/08 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N9/16 , C12N15/09 , C12N15/54 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N37/00 , A61K38/45 , C07K16/40 , C12N15/55
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N9/16 , C12N2799/021 , C12Y207/01037 , C12Y207/11013 , C12Y301/03048
摘要： The invention provides human regulators of intracellular phosphorylation (HRIP) and polynucleotides which identify and encode HRIP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HRIP.
摘要翻译：本发明提供了人类调节细胞内磷酸化（HRIP）和识别和编码HRIP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HRIP表达相关的疾病的方法。

10. 发明申请

WO9961471A3 HUMAN TRANSMEMBRANE PROTEINS 审中-公开
标题翻译：人类跨膜蛋白
公开(公告)号：WO9961471A3
公开(公告)日：2000-03-16
申请号：PCT/US9911904
申请日：1999-05-28
申请人： INCYTE PHARMA INC , TANG Y TOM , LAL PREETI , HILLMAN JENNIFER L , YUE HENRY , GUEGLER KARL J , CORLEY NEIL C , BANDMAN OLGA , PATTERSON CHANDRA , GORGONE GINA A , KASER MATTHEW R , BAUGHN MARIAH R , AU YOUNG JANICE
发明人： TANG Y TOM , LAL PREETI , HILLMAN JENNIFER L , YUE HENRY , GUEGLER KARL J , CORLEY NEIL C , BANDMAN OLGA , PATTERSON CHANDRA , GORGONE GINA A , KASER MATTHEW R , BAUGHN MARIAH R , AU-YOUNG JANICE
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P1/04 , A61P1/08 , A61P1/10 , A61P1/12 , A61P1/16 , A61P3/10 , A61P5/24 , A61P7/02 , A61P7/06 , A61P9/10 , A61P11/06 , A61P15/08 , A61P15/10 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , C07K14/705 , C07K16/18 , C12N15/09 , C12P21/02 , C12Q1/68 , C12N15/12 , A61K38/17 , C12N15/63
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K2317/24 , C07K2317/622 , C07K2317/76 , G01N33/68
摘要： The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
摘要翻译：本发明提供了人跨膜蛋白（HTMPN）和识别和编码HTMPN的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与HTMPN表达相关的障碍的方法。

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