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    • 9. 发明申请
    • PHOSPHOR-CONTAINING DRUG ACTIVATOR, SUSPENSION THEREOF, SYSTEM CONTAINING THE SUSPENSION, AND METHODS FOR USE
    • 含磷的药物活化剂,其悬浮液,含有该悬浮液的系统以及使用方法
    • WO2017136504A1
    • 2017-08-10
    • PCT/US2017/016138
    • 2017-02-02
    • IMMUNOLIGHT, LLCDUKE UNIVERSITYNORTH CAROLINA STATE UNIVERSITY
    • WALDER, HaroldBOURKE, Frederic A., Jr.FATHI, ZakaryaeBEYER, WayneOLDHAM, MarkADAMSON, JustusNOLAN, Michael
    • A61N5/10A61K41/00A61K49/04
    • A61N5/10A61K41/0066A61N5/062A61N2005/0661A61N2005/1098
    • A phosphor-containing drug activator and suspension thereof are provided. The suspension at least includes two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays. The two or more phosphors include Zn2SiO4:M12+and (3Ca3 (PO4)2Ca(F, CI)2:Sb3*, Mn2+) at a ratio NP-200:GTP-4300 of from 1:10 to 10:1, and each of the two phosphors have an ethylene cellulose coating and/or a diamond-like carbon coating. The suspension further includes a pharmaceutically acceptable carrier. A system for treating a disease in a subject in need thereof includes a) the above-noted suspension, b) a photoactivatable drug containing 8-methoxypsoralen (8-MOP or UVADEX) untethered from the two or more phosphors, c) one or more devices which infuse the photoactivatable drug and the suspension including the pharmaceutically acceptable carrier into a diseased site in the subject, and d) an x-ray source which is controlled to deliver a dose of x-rays to the subject for production of the ultraviolet light.
    • 提供了含有荧光剂的药物活化剂及其悬浮液。 悬浮液至少包括两种或更多种能够在与X射线相互作用时发射紫外线和可见光的荧光体。 两种或更多种磷光体包括比例为1:10至10:1的NP-200:GTP-4300的Zn2SiO4:M12 +和(3Ca3(PO4)2Ca(F,Cl)2:Sb3 *,Mn2 +)和 两种磷光体中的每一种具有乙烯纤维素涂层和/或类金刚石碳涂层。 该悬浮液还包含药学上可接受的载体。 用于治疗有此需要的受试者中的疾病的系统包括a)上述悬浮液,b)含有从两种或更多种磷光体未缠结的8-甲氧基补骨脂素(8-MOP或UVADEX)的可光活化药物,c)一种或多种 将可光活化药物和包含药学上可接受的载体的悬浮液注入受试者患病部位的装置,以及d)x射线源,其被控制以将一定剂量的x射线输送至受试者用于产生紫外光