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1. 发明申请

WO2009124189A1 NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION 审中-公开
标题翻译：非入侵系统和用于现场光电转换的方法
公开(公告)号：WO2009124189A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/039300
申请日：2009-04-02
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY , BOURKE, Frederic, A. , VO DINH, Tuan , WALDER, Harold
发明人： BOURKE, Frederic, A. , VO DINH, Tuan , WALDER, Harold
IPC分类号： A61K39/395
CPC分类号： A61N5/062 , A61K41/0057 , A61K41/0061 , A61K47/6923 , A61N5/022 , A61N5/0618 , A61N5/0622 , A61N5/10 , A61N2005/0642 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/1098
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译：用于修饰介导或与生物学活性相关的靶结构的产物，组合物，系统和方法，包括治疗条件，病症或由靶结构如病毒，细胞，亚细胞结构介导或相关的疾病或胞外结构。所述方法可以通过向受试者施加起始能量以非侵入性方式原位进行，从而直接或经由调节剂产生对靶结构的作用或改变。所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在存在一种或多种等离子体激元活性剂的情况下进行，由此产生效应或改变目标结构。包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

2. 发明申请

WO2018222798A1 X-RAY PSORALEN ACTIVATED CANCER THERAPY (X-PACT) WITH ASSOCIATED TREATMENTS 审中-公开
公开(公告)号：WO2018222798A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035279
申请日：2018-05-31
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： BOURKE, Frederic A. , DEWHIRST, Mark , SPECTOR, Neil , YOON, Paul , ADAMSON, Justus , ALCORTA, David , LYERLY, Kim , LIU, Leihua , OSADA, Takuya , OLDHAM, Mark , FATHI, Zakaryae , BEYER, Wayne F. , WALDER, Harold
IPC分类号： A61N5/06 , A61B6/00 , A61K9/00 , A61K49/04 , A61N5/10
摘要： A system (and associated method) for treating a human or animal body. The system has a photoactivatable drug for treating a first diseased site, a first pharmaceutically acceptable carrier including one or more phosphorescent or fluorescent agents which are capable of emitting an activation energy into the body which activates the photoactivatable drug, a first device which infuses the first diseased site with a photoactivatable drug and the first pharmaceutically acceptable carrier, a first energy source which irradiates the diseased site with an initiation energy to thereby initiate emission of the activation energy into the body, and a supplemental treatment device which administers one or both of a therapeutic drug or radiation to the body at a second diseased site or the first diseased site, to provide an immune system stimulation in the body.

3. 发明申请

WO2017136504A1 PHOSPHOR-CONTAINING DRUG ACTIVATOR, SUSPENSION THEREOF, SYSTEM CONTAINING THE SUSPENSION, AND METHODS FOR USE 审中-公开
标题翻译：含磷的药物活化剂，其悬浮液，含有该悬浮液的系统以及使用方法
公开(公告)号：WO2017136504A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/016138
申请日：2017-02-02
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY , NORTH CAROLINA STATE UNIVERSITY
发明人： WALDER, Harold , BOURKE, Frederic A., Jr. , FATHI, Zakaryae , BEYER, Wayne , OLDHAM, Mark , ADAMSON, Justus , NOLAN, Michael
IPC分类号： A61N5/10 , A61K41/00 , A61K49/04
CPC分类号： A61N5/10 , A61K41/0066 , A61N5/062 , A61N2005/0661 , A61N2005/1098
摘要： A phosphor-containing drug activator and suspension thereof are provided. The suspension at least includes two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays. The two or more phosphors include Zn2SiO4:M12+and (3Ca3 (PO4)2Ca(F, CI)2:Sb3*, Mn2+) at a ratio NP-200:GTP-4300 of from 1:10 to 10:1, and each of the two phosphors have an ethylene cellulose coating and/or a diamond-like carbon coating. The suspension further includes a pharmaceutically acceptable carrier. A system for treating a disease in a subject in need thereof includes a) the above-noted suspension, b) a photoactivatable drug containing 8-methoxypsoralen (8-MOP or UVADEX) untethered from the two or more phosphors, c) one or more devices which infuse the photoactivatable drug and the suspension including the pharmaceutically acceptable carrier into a diseased site in the subject, and d) an x-ray source which is controlled to deliver a dose of x-rays to the subject for production of the ultraviolet light.
摘要翻译：提供了含有荧光剂的药物活化剂及其悬浮液。悬浮液至少包括两种或更多种能够在与X射线相互作用时发射紫外线和可见光的荧光体。两种或更多种磷光体包括比例为1:10至10:1的NP-200:GTP-4300的Zn2SiO4：M12 +和（3Ca3（PO4）2Ca（F，Cl）2：Sb3 *，Mn2 +）和两种磷光体中的每一种具有乙烯纤维素涂层和/或类金刚石碳涂层。该悬浮液还包含药学上可接受的载体。用于治疗有此需要的受试者中的疾病的系统包括a）上述悬浮液，b）含有从两种或更多种磷光体未缠结的8-甲氧基补骨脂素（8-MOP或UVADEX）的可光活化药物，c）一种或多种将可光活化药物和包含药学上可接受的载体的悬浮液注入受试者患病部位的装置，以及d）x射线源，其被控制以将一定剂量的x射线输送至受试者用于产生紫外光

4. 发明申请

WO2015195896A1 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES 审中-公开
标题翻译：用PSORALEN衍生物治疗细胞增殖障碍的方法和系统
公开(公告)号：WO2015195896A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036401
申请日：2015-06-18
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： TOONE, Eric, J. , GOODEN, David , BOURKE, Frederic, A. , WALDER, Harold
IPC分类号： A61K31/37 , A61N5/06 , A61N5/10
CPC分类号： A61N5/062 , A61K31/37 , A61K39/39 , A61N5/0601 , A61N5/0616 , A61N5/10 , A61N2005/0612 , A61N2005/063 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/1098 , C07D493/04
摘要： Psoralen compounds of compounds having formulae 1A-10A, 1B-10B, 1C-10C, 1D- 10D, 1E-10E, 1F-10F, 1G-10G, and 1H-5H as shown in Fig. 1, and pharmaceutically acceptable salts thereof; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an auto vaccine effect in a subject using the method.
摘要翻译：具有式1A-10A，1B-10B，1C-10C，1D-10D，1E-10E，1F-10F，1G-10G和1H-5H的化合物的补骨脂素化合物如图1所示。 1及其药学上可接受的盐; 以及它们在治疗受试者细胞增殖障碍的方法中的用途，含有补骨脂素衍生物的药物组合物，用于进行该方法的试剂盒以及使用该方法在受试者中引起自身疫苗效果的方法。

5. 发明申请

WO2015164487A1 INTERIOR ENERGY-ACTIVATION OF PHOTO-REACTIVE SPECIES INSIDE A MEDIUM OR BODY USING AN X-RAY SOURCE EMITTING LOW ENERGY X-RAYS AS INITIATION ENERGY SOURCE 审中-公开
标题翻译：使用X射线源发射低能量X射线作为发射能源的中等或体内的光反应物质的内部能量活化
公开(公告)号：WO2015164487A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/027060
申请日：2015-04-22
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： OLDHAM, Mark , SAMEI, Ehsan , BOURKE, Frederic, A., Jr. , WALDER, Harold , FATHI, Zakaryae , DEWHIRST, Mark, W. , ADAMSON, Justus
IPC分类号： A61K41/00 , A61N5/10 , G01N21/64
CPC分类号： A61N5/062 , A61K41/0042 , A61K41/0057 , A61K49/0423 , A61N5/1071 , A61N2005/1089 , A61N2005/1091 , A61N2005/1098
摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 200 kVp, and a plurality of energy-converting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact witht least one photoactivatable agent in the medium. The method introduces the plurality of energy-converting particles into the medium, radiates the energy-converting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 200 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.
摘要翻译：介质内光刺激的系统和方法。该系统具有被配置为从等于或低于200kVp的施加阴极施加电压产生X射线的降低电压x射线源，以及介质中的多个能量转换粒子，其在来自X射线源的辐射以比x射线源低的能量辐射以与介质中的至少一种可光活化剂相互作用。该方法将多个能量转换粒子引入到介质中，用等于或低于200kVp的施加阴极电压产生的x射线照射介质中的能量转换粒子; 并且发射比x射线源更低的能量以与介质或介质中的至少一种可光活化剂相互作用。

6. 发明申请

WO2018026816A1 PHOSPHOR-CONTAINING DRUG ACTIVATOR ACTIVATABLE BY A MONTE CARLO DERIVED X-RAY EXPOSURE, SYSTEM CONTAINING THE ACTIVATOR, AND METHODS FOR USE 审中-公开
标题翻译：蒙特卡罗衍生X射线曝光可激活的含磷药物激活剂，含有激活剂的系统和使用方法
公开(公告)号：WO2018026816A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/044901
申请日：2017-08-01
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： WALDER, Harold , BOURKE, Frederic, A. Jr. , FATHI, Zakaryae , BEYER, Wayne , OLDHAM, Mark , ADAMSON, Justus , YOON, Paul
IPC分类号： A61N5/10 , A61N5/06 , A61K41/00
CPC分类号： A61N5/062 , A61K33/42 , A61K41/00 , A61K41/0057 , A61N5/10 , A61N2005/1098 , A61P35/00
摘要： A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose distribution. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose comprising a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor.
摘要翻译：可从蒙特卡洛衍生的x射线暴露激活的用于治疗患病部位的含磷光体的药物活化剂。活化剂包括一种或多种能够在与x射线相互作用时发射紫外光和可见光的磷光体的混合物或悬浮液，其中磷光体在患病靶位点中的分布基于蒙特卡洛（Monte Carlo）衍生的x射线剂量分布。用于治疗有需要的受试者的疾病的系统包括药物活化剂和可光活化药物，一种或多种将可光活化药物和包括药学上可接受的载体的活化剂注入受试者患病部位的装置; 以及X射线源，该X射线源被控制以将Monte Carlo衍生的X射线暴露递送给受试者以在受试者体内产生紫外线和可见光以激活可光活化药物并诱导持久治疗反应，该剂量包含脉冲序列的X射线从0.5-2 Gy放射至肿瘤。

7. 发明申请

WO2015164485A1 TUMOR IMAGING USING PHOTON-EMITTING PHOSPHORUS HAVING THERAPEUTIC PROPERTIES 审中-公开
标题翻译：使用具有治疗性质的磷光体发生肿瘤成像
公开(公告)号：WO2015164485A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/027058
申请日：2015-04-22
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY , NORTH CAROLINA STATE UNIVERSITY
发明人： WALDER, Harold , BOURKE, Frederic, A. , FATHI, Zakaryae , BEYER, Wayne, F. , DEWHIRST, Mark, W. , OLDHAM, Mark , ADAMSON, Justus , NOLAN, Michael
IPC分类号： A61K41/00 , A61N5/06 , A61N5/10
CPC分类号： A61N5/062 , A61K41/0042 , A61K41/0057 , A61K49/0423 , A61N5/1071 , A61N2005/1089 , A61N2005/1091 , A61N2005/1098
摘要： A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x- ray contrast. The system includes one or more devices which infuse a diseased site with a photoactivatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x- rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.
摘要翻译：用于在人或动物体内成像或治疗疾病的系统和方法。该系统向人体或动物体提供包括一种或多种磷光体的药物载体，其能够将紫外线或可见光发射到体内并提供X射线对比度。该系统包括一个或多个装置，其将病变部位注入可光活化药物和药物载体，引发能量源包括x射线或高能量源，其用x射线，γ射线中的至少一种照射患病部位或电子，从而开始将所述紫外线或可见光发射到体内;以及处理器，被编程为以下中的至少一个：1）产生患病部位的图像，或2）控制所述X射线，γ射线或电子到患病部位，以在病变部位产生所述紫外线或可见光，以活化可光活化药物。

8. 发明申请

WO2019014413A1 METHODS FOR RADIOTHERAPY TO TRIGGER LIGHT ACTIVATED DRUGS 审中-公开
公开(公告)号：WO2019014413A1
公开(公告)日：2019-01-17
申请号：PCT/US2018/041753
申请日：2018-07-12
申请人： IMMUNOLIGHT, LLC , DUKE, University
发明人： OLDHAM, Mark , ADAMSON, Justus , DEWHIRST, Mark, W. , YOON, Paul , WALDER, Harold , BOURKE, Frederic, A., Jr. , FATHI, Zakaryae , BEYER, Wayne, F.
IPC分类号： A61K41/00
摘要： A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.

9. 发明申请

WO2018098158A1 DRUG ACTIVATOR AND SYSTEM ACTIVATABLE BY A MONTE CARLO DERIVED X-RAY EXPOSURE 审中-公开
公开(公告)号：WO2018098158A1
公开(公告)日：2018-05-31
申请号：PCT/US2017/062801
申请日：2017-11-21
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： WALDER, Harold , BOURKE, Fredric, A. , FATHI, Zakaryae , BEYER, Wayne, F. , OLDHAM, Mark , ADAMSON, Justus , YOON, Paul
IPC分类号： A61N5/06 , A61N5/10
CPC分类号： A61N5/1031 , A61K31/37 , A61K41/0057 , A61K41/0066 , A61K49/0423 , A61N5/1077 , A61N2005/1034 , A61N2005/1098 , A61P35/00 , C09K11/02 , C09K11/595 , C09K11/73
摘要： A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug.

10. 发明申请

WO2017075057A1 METHODS FOR RADIOTHERAPY TO TRIGGER LIGHT ACTIVATION DRUGS 审中-公开
标题翻译：放射治疗激发光活性药物的方法
公开(公告)号：WO2017075057A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/058868
申请日：2016-10-26
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： OLDHAM, Mark , ADAMSON, Justus , DEWHIRST, Mark, W. , YOON, Paul , WALDER, Harold , BOURKE, Frederic, A. , FATHI, Zakaryae , BEYER, Wayne, F.
IPC分类号： A61B5/00 , A61K33/02 , A61K41/00 , A61K49/04 , A61M36/02 , A61N5/06 , A61N5/10
CPC分类号： A61K31/655 , A61K31/352 , A61K31/403 , A61K31/409 , A61K31/525 , A61K33/02 , A61K41/0066 , A61N5/062 , A61N5/0624 , A61N2005/065 , A61N2005/1095 , A61N2005/1098 , Y02A50/393
摘要： A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.
摘要翻译：用于治疗患有病症的受试者的方法和系统，所述病症在受试者内提供用于治疗受试者的至少一种可光活化药物，施用来自至少一种来源的起始能量以在受试者内部产生优先用于产生能够激活至少一种可光活化药物的切伦科夫辐射（CR）光的X射线通量和来自CR光的X射线通量，在受试者体内激活至少一种可光活化药物，从而治疗病症。

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