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1. 发明申请

WO2010090810A3 DIAGNOSTIC DEVICE AND METHOD 审中-公开
标题翻译：诊断装置及方法
公开(公告)号：WO2010090810A3
公开(公告)日：2010-11-25
申请号：PCT/US2010021295
申请日：2010-01-17
申请人： HYDRADX INC , O'CONNOR STEPHEN D
发明人： O'CONNOR STEPHEN D
IPC分类号： G01N33/52 , G01N33/53 , G01N33/84
CPC分类号： G01N33/52 , C12Q1/40 , G01N33/686 , G01N33/84 , G01N2333/928
摘要： Diagnostic devices and methods involve comparison of relative levels of first and second components and/or characteristics of a fluid sample (e.g., saliva), preferably using bound antibodies arranged to interact with selected components, and colorimetric indicators that are released in proportion to relative concentration or amount of the components or characteristics, as indicative of a health condition such as dehydration state, shock state, stress state, disease state, drug consumption, and drug metabolization. Amylase and IgA may be selected as specific salivary components of interest.
摘要翻译：诊断装置和方法包括比较流体样品（例如唾液）的第一和第二组分的相对水平和/或特征，优选使用与选定组分相互作用的结合抗体，以及与相对浓度成比例地释放的比色指示剂作为指示健康状况如脱水状态，休克状态，应激状态，疾病状态，药物消耗和药物代谢的组分或特征的量。可以选择淀粉酶和IgA作为感兴趣的特定唾液成分。

2. 发明申请

WO0178893A9 FLUIDIC IMPEDANCES IN MICROFLUIDIC SYSTEM 审中-公开
标题翻译：微流控系统中的流体阻碍
公开(公告)号：WO0178893A9
公开(公告)日：2002-07-04
申请号：PCT/US0112244
申请日：2001-04-13
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , DANTSKER GENE , PEZZUTO MARCI
发明人： O'CONNOR STEPHEN D , DANTSKER GENE , PEZZUTO MARCI
IPC分类号： G01N37/00 , B01J19/00 , B01L3/00 , B81B1/00 , B81C1/00 , F15C1/02 , F15C5/00 , F15D1/02 , F16K99/00
CPC分类号： B01L3/502738 , B01L3/502746 , B01L2200/0605 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B01L2400/0688 , F15C1/02 , F15D1/02 , F16K99/0001 , F16K99/0017 , F16K99/0028 , F16K99/0049 , F16K99/0055 , F16K99/0057 , F16K2099/008 , Y10T137/0491 , Y10T137/2191 , Y10T137/2224 , Y10T137/598 , Y10T137/8242 , Y10T137/86035
摘要： The invention provides microfluidic devices with embedded fluidic impedances. Such impedancesdo not allow fluid to pass at a low differential pressure, but allow fluid to flow at a higher differential pressure. Impedances are formed by the three dimensional overlap of two or more channels contained within layers of the device. Such devices can be rapidly protyped and can be assembled to contain multiple fluidic impedances to perform complex fluid handling tasks, including metering defined volumes of samples and dividing samples into aliquots.
摘要翻译：本发明提供具有嵌入式流体阻抗的微流体装置。这种阻抗不允许流体在低压差下通过，而是允许流体以较高的压差流动。通过包含在器件的层内的两个或更多个沟道的三维重叠形成阻抗。这样的装置可以快速制成并且可以被组装成包含多个流体阻抗以执行复杂的流体处理任务，包括计量定义的体积的样品并将样品分成等分试样。

3. 发明申请

WO02094441A3 FLUIDIC SYSTEMS WITH NON-PLANAR MICROFLUIDIC DEVICES 审中-公开
标题翻译：具有非平面微流体装置的流体系统
公开(公告)号：WO02094441A3
公开(公告)日：2003-04-10
申请号：PCT/US0218357
申请日：2002-05-14
申请人： NANOSTREAM INC , KARP CHRISTOPH D , GUSTAFSON VINCENT K , O'CONNOR STEPHEN D , HOBBS STEVEN E
发明人： KARP CHRISTOPH D , GUSTAFSON VINCENT K , O'CONNOR STEPHEN D , HOBBS STEVEN E
IPC分类号： B01L3/00 , B01L3/02 , B81B1/00 , G01N35/10 , B01J19/00 , G01N27/447
CPC分类号： B01L3/0217 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , G01N2035/1062 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
摘要： A fluidic system includes a vessel 250 having at least one nonplanar wall 253 defining a first aperture 252 therein and a microfluidic device having a port 220, wherein at least a portion of the microfluidic device 200 conforms to at least a portion of the nonplanar wall 253, with the port being co-located with the aperture 252to fluidically couple the device to the vessel. Various embodiments are directed to coupling microfluidic devices with syringes, vials, and pipes. Microfluidic devices may be fabricated constructed with stencil layers. Flexible materials are preferred, including materials having one or self-adhesive surfaces including adhesive tapes. Certain embodiments provide continuously wrapped, rewindable, and/or detachable microfluidic devices.
摘要翻译：流体系统包括容器250，容器250具有至少一个在其中限定第一孔252的非平面壁253和具有端口220的微流体装置，其中微流体装置200的至少一部分符合非平面壁253的至少一部分，其中端口与孔252共同定位，以将装置流体地耦合到容器。各种实施例涉及将微流体装置与注射器，小瓶和管道连接。微流体装置可以用模板层制造。柔性材料是优选的，包括具有一个或自粘表面的材料，包括胶带。某些实施例提供连续包裹的，可重新缠绕的和/或可拆卸的微流体装置。

4. 发明申请

WO02055198A3 MICROFLUIDIC FLOW CONTROL DEVICES 审中-公开
标题翻译：微流控流量装置
公开(公告)号：WO02055198A3
公开(公告)日：2003-03-13
申请号：PCT/US0142981
申请日：2001-11-06
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , DANTSKER EUGENE
发明人： O'CONNOR STEPHEN D , KARP CHRISTOPH D , DANTSKER EUGENE
IPC分类号： B01L3/00 , B81B3/00 , F15C5/00 , F16K99/00 , B01J19/00 , F16K7/17
CPC分类号： B01L3/5025 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0689 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/0638 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0028 , F16K99/0044 , F16K99/0046 , F16K99/0051 , F16K99/0055 , F16K99/0059 , F16K99/0061 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , Y10T137/2496 , Y10T137/2559 , Y10T137/2663 , Y10T137/87249
摘要： Various microfluidic flow control devices are provided. In one embodiment, a regulating device includes overlapping channel segments (139,143) separated by a deformable membrane (133) in fluid communication with one another. In another embodiment, a normally open microfluidic valve provides latching valve operation with at least one adhesive surface. A stencil-based microfluidic valve may be operated by deforming a membrane against a seating surface to prevent flow through an aperture. Configurable microfluidic devices permit flow control among an interconnected microfluidic channel network. Magnetic elements may be integrated into flexible membranes to provide magnetically actuated microfluidic flow control device.
摘要翻译：提供各种微流控流量控制装置。在一个实施例中，调节装置包括由可变形膜（133）分开的彼此流体连通的重叠通道段（139,143）。在另一个实施例中，常开微流体阀提供至少一个粘合剂表面的闭锁操作。基于模板的微流体阀可以通过使膜抵靠阀座表面变形来防止流过孔。可配置的微流体装置允许在互连的微流体通道网络之间进行流量控制。磁性元件可以集成到柔性膜中以提供磁致动微流体流量控制装置。

5. 发明申请

WO2010048036A3 SYSTEMS AND METHODS FOR MANAGING UTILITY CONSUMPTION 审中-公开
标题翻译：用于管理实用消费的系统和方法
公开(公告)号：WO2010048036A3
公开(公告)日：2010-07-22
申请号：PCT/US2009060925
申请日：2009-10-15
申请人： TERRATRIM INC , O'CONNOR STEPHEN D , GAMBLE RONALD C , SUCHTER RICHARD A
发明人： O'CONNOR STEPHEN D , GAMBLE RONALD C , SUCHTER RICHARD A
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06
摘要： A system and method for monitoring and managing utility consumption includes use of (A) one or more sensors arranged to monitor an operating condition and/or utility consumption of at least one segment or appliance of a first facility; (B) a memory including at least one of (i) stored utility consumption information correlated or normalized to at least one designated parameter affecting utility consumption or (ii) hypothetical utility consumption; (C) a processor to compare the monitored information with the stored information, and (D) an output medium to store and/or display the comparison information. Stored consumption information may relate to the first facility or a second facility. Hypothetical utility consumption information may relate to a segment or appliance of the first facility operated according to optimized conditions, or an upgraded segment or appliance.
摘要翻译：一种用于监测和管理公用事业消耗的系统和方法包括使用（A）布置成监测第一设施的至少一个段或设备的运行状况和/或公用事业消耗的一个或多个传感器; （B）存储器，其包括以下中的至少一个：（i）与影响公用事业消耗的至少一个指定参数相关联或归一化的存储的公用设施消耗信息;（ii）假设的公用事业消费; （C）处理器，用于将所监视的信息与存储的信息进行比较，以及（D）存储和/或显示比较信息的输出介质。存储的消费信息可能与第一设施或第二设施有关。假设效用消耗信息可以涉及根据优化条件操作的第一设施的段或设备，或升级的段或设备。

6. 发明申请

WO2012177366A2 METHODS FOR CLEANING WATER FILTRATION MEDIA 审中-公开
标题翻译：清洗水过滤介质的方法
公开(公告)号：WO2012177366A2
公开(公告)日：2012-12-27
申请号：PCT/US2012040010
申请日：2012-05-30
申请人： BLUE EARTH LABS LLC , O'CONNOR STEPHEN D , YU C J
发明人： O'CONNOR STEPHEN D , YU C J
IPC分类号： B01D35/22 , B01D24/46 , B01D29/62 , B01D33/44 , B01D35/20
CPC分类号： C02F1/001 , C02F1/283 , C02F2303/16
摘要： A method of removing contaminants from water filtration media is disclosed, including (a) applying a granular cleaner to the water filtration media, and (b) after step (a), applying multiple discrete doses of an activator to the water filtration media at predetermined time intervals. Further disclosed is a method of cleaning water filtration media, including (a) applying a granular cleaner to the water filtration media that is reactive with at least one first inorganic contaminant; (b) after step (a), applying a liquid cleaner to the water filtration media that is compositionally different from the granular cleaner and reactive with at least one second inorganic contaminant; and (c) after step (b), applying an activator to the water filtration media that is reactive with an organic contaminant. A method of cleaning water filtration media is also disclosed including agitating at least a portion of the water filtration media.
摘要翻译：公开了一种从水过滤介质中除去污染物的方法，包括（a）向水过滤介质施加颗粒状清洁剂，和（b）在步骤（a）之后，将多个离散剂量的活化剂施加到水过滤介质上，时间间隔。进一步公开了一种清洁水过滤介质的方法，包括（a）将颗粒状清洁剂施加到与至少一种第一无机污染物反应的水过滤介质中; （b）在步骤（a）之后，将液体清洁剂施加到组合物上不同于颗粒清洁剂并与至少一种第二无机污染物反应的水过滤介质; 和（c）步骤（b）之后，将活化剂施加到与有机污染物反应的水过滤介质中。还公开了一种清洁水过滤介质的方法，包括搅拌至少一部分水过滤介质。

7. 发明申请

WO2005062340A3 HIGH THROUGHPUT SYSTEMS AND METHODS FOR PARALLEL SAMPLE ANALYSIS 审中-公开
标题翻译：高通量系统和并行样品分析方法
公开(公告)号：WO2005062340A3
公开(公告)日：2006-07-06
申请号：PCT/US2004023980
申请日：2004-07-23
申请人： NANOSTREAM INC , HOBBS STEVEN E , O'CONNOR STEPHEN D , GAMBLE RONALD C
发明人： HOBBS STEVEN E , O'CONNOR STEPHEN D , GAMBLE RONALD C
IPC分类号： H01J49/00 , B01J19/00 , B01L3/00 , G01N30/60 , G01N30/72 , H01J49/02 , H01J49/04
CPC分类号： G01N30/6043 , B01L3/5027 , G01N30/6095 , G01N30/72 , H01J49/009 , H01J49/04
摘要： Systems and methods for analyzing multiple samples in parallel using mass spectrometry preferably coupled with fluid phase separation techniques are provided. A modular mass spectrometer includes a vacuum enclosure, multiple sample inlets, multiple common vacuum pumping elements, and multiple mass analysis modules disposed substantially within the enclosure, with each module preferably including a mass analyzer and a transducer. In one embodiment, the modules mate with the vacuum enclosure to define multiple sequential vacuum regions, with each vacuum region having an associated common vacuum pumping element. At least one multi-pole ion transfer optic element is preferably associated with each module. Fluid phase separation devices for use with a multi-analyzer spectrometer may include microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods to process raw samples into prepared samples to be ionized and injected into a multi-channel mass spectrometer.
摘要翻译：提供了使用优选与流体相分离技术结合的质谱分析多个样品并行的系统和方法。模块化质谱仪包括真空外壳，多个样品入口，多个共同的真空抽吸元件和基本上设置在外壳内的多个质量分析模块，每个模块优选地包括质量分析器和换能器。在一个实施例中，模块与真空外壳配合以限定多个连续的真空区域，每个真空区域具有相关联的共同真空泵送元件。至少一个多极离子转移光学元件优选地与每个模块相关联。用于多分析仪光谱仪的流体相分离装置可以包括利用色谱，电泳或其它分离方法的微流体装置，以将原始样品处理成待离子化并注入多通道质谱仪的制备样品。

8. 发明申请

WO02083310A8 MICROFLUIDIC METERING SYSTEMS AND METHODS 审中-公开
标题翻译：微流量计系统及方法
公开(公告)号：WO02083310A8
公开(公告)日：2003-05-01
申请号：PCT/US0131790
申请日：2001-10-12
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
发明人： O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
IPC分类号： B01L3/00 , B01L3/02 , B81B1/00 , C40B60/14 , G01N35/08
CPC分类号： G01N35/08 , B01J2219/00315 , B01L3/0241 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , C40B60/14
摘要： Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
摘要翻译：提供了能够计量流体流量的微流体装置。描述了流体塞的中继分支计量的装置和方法，其中从体积流体计量一个或多个限定体积的分支通道。还描述了通过选择第一和第二流体对微流体通道的供应条件来测量至少一个离散塞。第一流体可以是液体，第二流体是气体。提供减小区域通道段以帮助计量一个或多个离散流体塞。在另一方面，通过用流体填充微流体室，密封入口通道，然后提取流体来计量微流体体积。

9. 发明申请

WO0230560A3 FLUIDIC COUPLERS AND MODULAR MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：流体耦合器和模块化微流体系统
公开(公告)号：WO0230560A3
公开(公告)日：2003-01-16
申请号：PCT/US0131563
申请日：2001-10-11
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , DANTSKER EUGENE , KARP CHRISTOPH D , PEZZUTO MARCI
发明人： O'CONNOR STEPHEN D , DANTSKER EUGENE , KARP CHRISTOPH D , PEZZUTO MARCI
IPC分类号： B01L3/00 , B81B1/00 , G01N35/00 , G01N35/10 , B81B7/00 , B81C3/00
CPC分类号： B01L3/5027 , B01L3/502707 , B01L2200/027 , B01L2300/0887 , B01L2400/0487 , G01N35/10 , G01N2035/00326 , Y10T137/2224
摘要： A modular microfluidic system including a plurality of discrete microfluidic modules and at least one microfluidic coupling device for communicating fluid between the modules is described. The microfluidic modules and coupling devices may be constructed according to various techniques. Each coupling device is fabricated from multiple layers and includes a fluidic inlet port, a fluidic outlet port, and at least one sandwiched stencil layer having a microfluidic channel formed therein. Also described are integrated microfluidic systems capable of performing various functions.
摘要翻译：描述了包括多个离散微流体模块和用于在模块之间连通流体的至少一个微流体耦合装置的模块化微流体系统。微流体模块和耦合装置可以根据各种技术构造。每个联接装置由多个层制成并且包括流体入口端口，流体出口端口以及在其中形成有微流体通道的至少一个夹层模板层。还描述了能够执行各种功能的集成微流体系统。

10. 发明申请

WO02083310A2 MICROFLUIDIC METERING SYSTEMS AND METHODS 审中-公开
标题翻译：微流量计系统及方法
公开(公告)号：WO02083310A2
公开(公告)日：2002-10-24
申请号：PCT/US0131790
申请日：2001-10-12
申请人： NANOSTREAM INC , O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
发明人： O'CONNOR STEPHEN D , KARP CHRISTOPH D , PEZZUTO MARCI , DANTSKER EUGENE
IPC分类号： B01L3/00 , B01L3/02 , B81B1/00 , C40B60/14 , G01N35/08
CPC分类号： G01N35/08 , B01J2219/00315 , B01L3/0241 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , C40B60/14
摘要： Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.
摘要翻译：提供了能够计量流体流量的微流体装置。描述了流体塞的中继分支计量的装置和方法，其中从体积流体计量一个或多个限定体积的分支通道。还描述了通过选择第一和第二流体对微流体通道的供应条件来测量至少一个离散塞。第一流体可以是液体，第二流体是气体。提供减小区域通道段以帮助计量一个或多个离散流体塞。在另一方面，通过用流体填充微流体室，密封入口通道，然后提取流体来计量微流体体积。

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