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1. 发明申请

WO2005003296A3 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2005003296A3
公开(公告)日：2005-04-21
申请号：PCT/US2004001369
申请日：2004-01-20
申请人： HUMAN GENOME SCIENCES INC , HASELTINE WILLIAM A , ROSEN CRAIG A
发明人： HASELTINE WILLIAM A , ROSEN CRAIG A
IPC分类号： A61K38/00 , A61K38/38 , A61K47/48 , C07H21/04 , C07K14/765 , C12N20060101 , C12P21/02 , C12P21/04
CPC分类号： A61K38/38 , A61K47/643 , C07K14/765 , C07K2319/31
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disordrs or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括清蛋白融合蛋白。编码本发明的清蛋白融合蛋白的核酸分子也包括在本发明中，含有这些核酸的载体，用这些核酸载体转化的宿主细胞以及制备本发明的清蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。此外，本发明涵盖包含清蛋白融合蛋白的药物组合物以及使用本发明的清蛋白融合蛋白治疗，预防或改善疾病，失调或病症的方法。

2. 发明申请

WO0177137A9 ALBUMIN FUSION PROTEINS 审中-公开
公开(公告)号：WO0177137A9
公开(公告)日：2002-05-02
申请号：PCT/US0111988
申请日：2001-04-12
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , HASELTINE WILLIAM A
发明人： ROSEN CRAIG A , HASELTINE WILLIAM A
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/43 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P3/14 , A61P5/00 , A61P5/10 , A61P5/14 , A61P5/40 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/18 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P17/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P33/06 , A61P33/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P39/02 , A61P41/00 , A61P43/00 , C07K14/47 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/585 , C07K14/60 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/705 , C07K14/715 , C07K14/745 , C07K14/75 , C07K14/76 , C07K14/765 , C07K14/81 , C07K16/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N9/14 , C12N9/74 , C12N9/99 , C12N15/62 , C07H21/04
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

3. 发明申请

WO0179443A3 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO0179443A3
公开(公告)日：2002-02-21
申请号：PCT/US0111924
申请日：2001-04-12
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , HASELTINE WILLIAM A
发明人： ROSEN CRAIG A , HASELTINE WILLIAM A
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/43 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P3/14 , A61P5/00 , A61P5/10 , A61P5/14 , A61P5/40 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/18 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P17/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P33/06 , A61P33/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P39/02 , A61P41/00 , A61P43/00 , C07K14/47 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/585 , C07K14/60 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/705 , C07K14/715 , C07K14/745 , C07K14/75 , C07K14/76 , C07K14/765 , C07K14/81 , C07K16/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N9/14 , C12N9/74 , C12N9/99 , C12N15/62 , C07K1/00 , A01N37/18
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acid vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

4. 发明申请

WO2005077042A3 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2005077042A3
公开(公告)日：2006-11-30
申请号：PCT/US2005004041
申请日：2005-02-09
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , HASELTINE WILLIAM A , MOORE PAUL A , BOCK JASON B , BELL ADAM , SHI YANGGU , LAFLEUR DAVID
发明人： ROSEN CRAIG A , HASELTINE WILLIAM A , MOORE PAUL A , BOCK JASON B , BELL ADAM , SHI YANGGU , LAFLEUR DAVID
IPC分类号： A61K38/38 , C07K14/76 , C07K14/765 , C12N15/62
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

5. 发明申请

WO0179480A9 ALBUMIN FUSION PROTEINS 审中-公开
公开(公告)号：WO0179480A9
公开(公告)日：2003-09-18
申请号：PCT/US0111991
申请日：2001-04-12
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , HASELTINE WILLIAM A
发明人： ROSEN CRAIG A , HASELTINE WILLIAM A
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/43 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P3/14 , A61P5/00 , A61P5/10 , A61P5/14 , A61P5/40 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/18 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P17/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P33/06 , A61P33/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P39/02 , A61P41/00 , A61P43/00 , C07K14/47 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/585 , C07K14/60 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/705 , C07K14/715 , C07K14/745 , C07K14/75 , C07K14/76 , C07K14/765 , C07K14/81 , C07K16/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N9/14 , C12N9/74 , C12N9/99 , C12N15/62 , C12N15/00
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

6. 发明申请

WO0179442A3 ALBUMIN FUSION PROTEINS 审中-公开
公开(公告)号：WO0179442A3
公开(公告)日：2002-06-06
申请号：PCT/US0111850
申请日：2001-04-12
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , HASELTINE WILLIAM A
发明人： ROSEN CRAIG A , HASELTINE WILLIAM A
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/43 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P3/14 , A61P5/00 , A61P5/10 , A61P5/14 , A61P5/40 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/18 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P17/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P33/06 , A61P33/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P39/02 , A61P41/00 , A61P43/00 , C07K14/47 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/585 , C07K14/60 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/705 , C07K14/715 , C07K14/745 , C07K14/75 , C07K14/76 , C07K14/765 , C07K14/81 , C07K16/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N9/14 , C12N9/74 , C12N9/99 , C12N15/62 , C12N1/18
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

7. 发明申请

WO0179444A3 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO0179444A3
公开(公告)日：2002-05-23
申请号：PCT/US0112013
申请日：2001-04-12
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , HASELTINE WILLIAM A
发明人： ROSEN CRAIG A , HASELTINE WILLIAM A
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/43 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P3/14 , A61P5/00 , A61P5/10 , A61P5/14 , A61P5/40 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/18 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P17/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P33/06 , A61P33/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P39/02 , A61P41/00 , A61P43/00 , C07K14/47 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/585 , C07K14/60 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/705 , C07K14/715 , C07K14/745 , C07K14/75 , C07K14/76 , C07K14/765 , C07K14/81 , C07K16/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N9/14 , C12N9/74 , C12N9/99 , C12N15/62 , A61K39/00 , C07K1/00
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

8. 发明申请

WO2007146038A3 ALBUMIN FUSION PROTEINS 审中-公开
公开(公告)号：WO2007146038A3
公开(公告)日：2008-10-09
申请号：PCT/US2007013383
申请日：2007-06-07
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BELL ADAM , LAFLEUR DAVID W , WOODS DOUGLAS B , FENG PING , SMITH RODGER G
发明人： ROSEN CRAIG A , BELL ADAM , LAFLEUR DAVID W , WOODS DOUGLAS B , FENG PING , SMITH RODGER G
IPC分类号： A61K38/26 , C07K14/605 , C07K14/76
CPC分类号： C12N9/96 , A61K38/00 , C07K14/765 , C07K2319/00 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

9. 发明申请

WO2004042000A3 157 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 157人类分泌蛋白
公开(公告)号：WO2004042000A3
公开(公告)日：2005-10-06
申请号：PCT/US0315439
申请日：2003-05-16
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , RUBEN STEVEN M , OLSEN HENRIK , BAKER KEVIN P , FISCELLA MICHELE , WEI PING , BIRSE CHARLES E , KOMATSOULIS GEORGE , CHOI GIL H , MOORE PAUL A , GUPTA RAM , SHI YANGGU
发明人： ROSEN CRAIG A , RUBEN STEVEN M , OLSEN HENRIK , BAKER KEVIN P , FISCELLA MICHELE , WEI PING , BIRSE CHARLES E , KOMATSOULIS GEORGE , CHOI GIL H , MOORE PAUL A , GUPTA RAM , SHI YANGGU
IPC分类号： C07K14/47 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

10. 发明申请

WO2004003144A3 ANTIBODIES THAT SPECIFICALLY BIND TO REG IV 审中-公开
标题翻译： IV特异性结合的抗体
公开(公告)号：WO2004003144A3
公开(公告)日：2004-06-10
申请号：PCT/US0319908
申请日：2003-06-26
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A
发明人： ROSEN CRAIG A
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that specifically bind to Reg IV. Such antibodies have uses, for example, in the prevention and treatment of gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes. The invention also relates to nucleic acid molecules encoding anti-Reg IV antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to Reg IV.
摘要翻译：本发明涉及特异性结合Reg IV的抗体和相关分子。这些抗体例如用于预防和治疗胃肠道癌症，炎症性肠病和糖尿病。本发明还涉及编码抗Reg III抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是胃肠道癌症，炎症性肠病和糖尿病的方法和组合物，所述方法和组合物包含给予动物，优选人类有效量的一种或更多的与Reg IV特异性结合的抗体或其片段或变体或相关分子。

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