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1. 发明申请

WO2003014314A2 13 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 13人类分泌蛋白
公开(公告)号：WO2003014314A2
公开(公告)日：2003-02-20
申请号：PCT/US2002/025107
申请日：2002-08-08
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping , DUAN, Roxanne, D. , SHI, Yanggu
发明人： ROSEN, Craig, A. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping , DUAN, Roxanne, D. , SHI, Yanggu
IPC分类号： C12N
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

2. 发明申请

WO2004042000A2 157 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 157人类分泌蛋白
公开(公告)号：WO2004042000A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/015439
申请日：2003-05-16
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , RUBEN, Steven, M. , OLSEN, Henrik , BAKER, Kevin, P. , FISCELLA, Michele , WEI, Ping , BIRSE, Charles, E. , KOMATSOULIS, George , CHOI, Gil, H. , MOORE, Paul, A. , GUPTA, Ram , SHI, Yanggu
发明人： ROSEN, Craig, A. , RUBEN, Steven, M. , OLSEN, Henrik , BAKER, Kevin, P. , FISCELLA, Michele , WEI, Ping , BIRSE, Charles, E. , KOMATSOULIS, George , CHOI, Gil, H. , MOORE, Paul, A. , GUPTA, Ram , SHI, Yanggu
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

3. 发明申请

WO2002068628A1 70 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 70人类分泌蛋白
公开(公告)号：WO2002068628A1
公开(公告)日：2002-09-06
申请号：PCT/US2002/005301
申请日：2002-02-21
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , KOMATSOULIS, George , BAKER, Kevin, P. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping , DUAN, D., Roxanne , SHI, Yanggu , GUPTA, Ram
发明人： ROSEN, Craig, A. , KOMATSOULIS, George , BAKER, Kevin, P. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping , DUAN, D., Roxanne , SHI, Yanggu , GUPTA, Ram
IPC分类号： C12N15/00
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

4. 发明申请

WO2003080797A2 6 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 6人类分泌蛋白
公开(公告)号：WO2003080797A2
公开(公告)日：2003-10-02
申请号：PCT/US2003/004818
申请日：2003-02-20
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , RUBEN, Steven, M. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping
发明人： ROSEN, Craig, A. , RUBEN, Steven, M. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新型人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

5. 发明申请

WO2003080797A3 6 HUMAN SECRETED PROTEINS 审中-公开
公开(公告)号：WO2003080797A3
公开(公告)日：2003-10-02
申请号：PCT/US2003/004818
申请日：2003-02-20
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , RUBEN, Steven, M. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping
发明人： ROSEN, Craig, A. , RUBEN, Steven, M. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping
IPC分类号： C07H21/02 , C07K14/00 , C12N15/63 , C12N15/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

6. 发明申请

WO2009058322A1 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2009058322A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/012306
申请日：2008-10-30
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , BELL, Adam , MOORE, Paul, A. , SHI, Yanggu , LAFLEUR, David , BOCK, Jason, B. , LAIRD, Michael, W. , HASELTINE, William, A. , WOODS, Douglas, B. , SUBRAMANIAN, Mani
发明人： ROSEN, Craig, A. , BELL, Adam , MOORE, Paul, A. , SHI, Yanggu , LAFLEUR, David , BOCK, Jason, B. , LAIRD, Michael, W. , HASELTINE, William, A. , WOODS, Douglas, B. , SUBRAMANIAN, Mani
IPC分类号： A61K38/00 , C07K17/00
CPC分类号： C07K14/58 , C07K14/765 , C07K2319/01
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

7. 发明申请

WO2005077042A2 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2005077042A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/004041
申请日：2005-02-09
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , HASELTINE, William, A. , MOORE, Paul, A. , BOCK, Jason, B. , BELL, Adam , SHI, Yanggu , LAFLEUR, David
发明人： ROSEN, Craig, A. , HASELTINE, William, A. , MOORE, Paul, A. , BOCK, Jason, B. , BELL, Adam , SHI, Yanggu , LAFLEUR, David
IPC分类号： C07K14/765 , C12N15/62
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

8. 发明申请

WO2002026931A3 71 HUMAN SECRETED PROTEINS 审中-公开
公开(公告)号：WO2002026931A3
公开(公告)日：2002-04-04
申请号：PCT/US2001/029871
申请日：2001-09-24
申请人： HUMAN GENOME SCIENCES, INC. , RUBEN, Steven, M. , KOMATSOULIS, George , DUAN, D., Roxanne , ROSEN, Craig, A. , MOORE, Paul, A. , SHI, Yanggu , LAFLEUR, David, W. , OLSEN, Henrik , BREWER, Laurie, A. , FLORENCE, Kimberly, A. , YOUNG, Paul, E. , SOPPET, Daniel, R. , ENDRESS, Gregory, A. , MUCENSKI, Michael , EBNER, Reinhard
发明人： RUBEN, Steven, M. , KOMATSOULIS, George , DUAN, D., Roxanne , ROSEN, Craig, A. , MOORE, Paul, A. , SHI, Yanggu , LAFLEUR, David, W. , OLSEN, Henrik , BREWER, Laurie, A. , FLORENCE, Kimberly, A. , YOUNG, Paul, E. , SOPPET, Daniel, R. , ENDRESS, Gregory, A. , MUCENSKI, Michael , EBNER, Reinhard
IPC分类号： C07H21/04
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

9. 发明申请

WO2002068588A2 CYTOKINE RECEPTOR COMMON GAMMA CHAIN LIKE 审中-公开
标题翻译：细胞因子受体常见的GAMMA链样
公开(公告)号：WO2002068588A2
公开(公告)日：2002-09-06
申请号：PCT/US2002/004878
申请日：2002-02-20
申请人： HUMAN GENOME SCIENCES, INC. , RUBEN, Steven, M. , ROSEN, Craig, A. , MOORE, Paul, A.
发明人： RUBEN, Steven, M. , ROSEN, Craig, A. , MOORE, Paul, A.
IPC分类号： C12N
CPC分类号： C07K14/715
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or "CRCGCL." This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating, diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.
摘要翻译：本发明涉及编码细胞因子受体家族成员的多肽的新型人类基因。更具体地说，本发明涉及编码命名为细胞因子受体共同γ链样的新型人类多肽或“CRCGCL”的多核苷酸。本发明还涉及CRCGCL多肽，以及载体，宿主细胞，针对CRCGCL多肽的抗体，以及用于生产它们的重组方法。还提供了用于检测与免疫系统相关的病症的诊断方法，以及用于治疗，诊断，检测和/或预防这些病症的治疗方法。本发明还涉及鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。

10. 发明申请

WO2004003144A2 ANTIBODIES THAT SPECIFICALLY BIND TO REG IV 审中-公开
标题翻译：特定于REG IV的抗体
公开(公告)号：WO2004003144A2
公开(公告)日：2004-01-08
申请号：PCT/US2003/019908
申请日：2003-06-26
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A.
发明人： ROSEN, Craig, A.
IPC分类号： C12N
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that specifically bind to Reg IV. Such antibodies have uses, for example, in the prevention and treatment of gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes. The invention also relates to nucleic acid molecules encoding anti-Reg IV antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to Reg IV.
摘要翻译：本发明涉及特异性结合Reg IV的抗体和相关分子。这样的抗体具有例如用于预防和治疗胃肠道癌症，炎症性肠病和糖尿病的用途。本发明还涉及编码抗Reg IV抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是胃肠道癌症，炎症性肠病和糖尿病的方法和组合物，包括向动物，优选人类施用有效量的一种或更多的与Reg IV特异性结合的抗体或其片段或变体，或相关分子。

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