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1. 发明申请

WO2018122204A1 NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF 审中-公开
公开(公告)号：WO2018122204A1
公开(公告)日：2018-07-05
申请号：PCT/EP2017084538
申请日：2017-12-22
申请人： HOFFMANN LA ROCHE , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS INC
发明人： GERG MICHAEL , HILLRINGHAUS LARS , HIRZEL KLAUS , HOJER CAROLINE DOROTHEA , JOSEL HANS-PETER , SEIDEL CHRISTOPH , SCHRAEML MICHAEL , VON PROFF LEOPOLD
IPC分类号： C07K16/00 , C07K16/40 , G01N33/53
CPC分类号： C07K16/00 , C07K16/40 , C07K2317/34 , C07K2317/92 , G01N33/53
摘要： The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

2. 发明申请

WO2004087950A3 IMPROVED SYSTEM FOR MULTI COLOR REAL TIME PCR 审中-公开
标题翻译：改进的多色实时PCR系统
公开(公告)号：WO2004087950A3
公开(公告)日：2004-11-25
申请号：PCT/EP2004003457
申请日：2004-04-01
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , SAGNER GREGOR , BECHLER INGRID , BOLTE JOACHIM , HEINDL DIETER , JOSEL HANS-PETER , GUTEKUNST MARTIN , SEIBL RUDOLF , MUELLER CHRISTOPH
发明人： SAGNER GREGOR , BECHLER INGRID , BOLTE JOACHIM , HEINDL DIETER , JOSEL HANS-PETER , GUTEKUNST MARTIN , SEIBL RUDOLF , MUELLER CHRISTOPH
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , G01N2021/6421 , C12Q2565/101 , C12Q2561/113 , C12Q2537/143
摘要： The invention is directed to a system for performing multi-color real time PCT, comprising a flexible real time PCT instrument and a specific composition or reaction mixture for performing multiplex PCR: In particular, the present invention is directed to a composition or reaction mixtuer which comprises at least 3, preferably 4-5 and most preferably exactly 4 pairs of FRET hybridization probes. Each pair of said hybridization probes consists of a FRET donor probe carrying a FRET donor moiety and a FRET acceptor probe carrying a FRET acceptor moiety having an emission maximum between 550 and 710 nm.
摘要翻译：本发明涉及一种用于执行多色实时PCT的系统，其包括灵活的实时PCT仪器和用于进行多重PCR的特定组合物或反应混合物：具体地，本发明涉及组合物或反应混合物，其中包含至少3个，优选4-5个，最优选恰好4对FRET杂交探针。每对所述杂交探针由携带FRET供体部分的FRET供体探针和携带具有550-710nm发射最大值的FRET受体部分的FRET受体探针组成。

3. 发明申请

WO0227315A3 COMPOUNDS WITH A BRANCHED LINKER 审中-公开
标题翻译：具有分支链接器的化合物
公开(公告)号：WO0227315A3
公开(公告)日：2002-07-11
申请号：PCT/EP0111118
申请日：2001-09-26
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , ANDRES HERBERT , JOSEL HANS-PETER , HOESS EVA , HERRMANN RUPERT , ELTZ HERBERT VON DER
发明人： ANDRES HERBERT , JOSEL HANS-PETER , HOESS EVA , HERRMANN RUPERT , VON DER ELTZ HERBERT
IPC分类号： G01N33/543 , C07F15/00 , C07K1/107 , C07K5/02 , C07K7/02 , C07K14/00 , C07K14/16 , C07K19/00 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/547 , G01N33/58 , G01N33/68 , C07K14/18
CPC分类号： G01N33/6845 , C07K1/1075 , C07K1/1077 , C07K14/001 , G01N33/5306 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/68
摘要： The present invention concerns new compounds comprising a branched linker and their use for producing conjugates for applications in diagnostic or therapeutic methods.
摘要翻译：本发明涉及包含支链接头的新化合物及其用于制备用于诊断或治疗方法的缀合物的用途。

4. 发明申请

WO2014019709A3 NEW IRIDIUM-BASED COMPLEXES FOR ECL 审中-公开
公开(公告)号：WO2014019709A3
公开(公告)日：2014-04-03
申请号：PCT/EP2013002323
申请日：2013-08-02
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , UNIV MUENSTER WILHELMS , ROCHE DIAGNOSTICS OPERATIONS
发明人： BERGMANN FRANK , CYSEWSKI ROBERT , DE COLA LUISA , DZIADEK SEBASTIAN , FERNANDEZ HERNANDEZ JESUS MIGUEL , JOSEL HANS-PETER , SEIDEL CHRISTOPH
IPC分类号： C09K11/06 , C07F15/00
CPC分类号： C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1007 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
摘要： The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.

5. 发明申请

WO2013113822A3 OZONE SCAVENGERS FOR NUCLEIC ACID HYBRIDIZATION EXPERIMENTS 审中-公开
标题翻译：臭氧清除剂用于核酸杂交实验
公开(公告)号：WO2013113822A3
公开(公告)日：2013-10-10
申请号：PCT/EP2013051915
申请日：2013-01-31
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , BERGMANN FRANK , HEINDL DIETER , JOSEL HANS-PETER , LUCKEY JOHN
发明人： BERGMANN FRANK , HEINDL DIETER , JOSEL HANS-PETER , LUCKEY JOHN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6813 , C12Q2527/125 , C12Q2563/107
摘要： The present invention relates to a method, a buffer and a kit for scavenging reactive oxygen species in nucleic acid hybridization experiments.
摘要翻译：本发明涉及用于在核酸杂交实验中清除活性氧的方法，缓冲液和试剂盒。

6. 发明申请

WO02099097A8 NOVEL COMPOUNDS FOR CHEMILUMINESCENSE PROCEDURES 审中-公开
标题翻译：新型化合物治疗慢性淋巴细胞白血病
公开(公告)号：WO02099097A8
公开(公告)日：2003-03-06
申请号：PCT/EP0205855
申请日：2002-05-28
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , HEINDL DIETER , HERRMANN RUPERT , JOSEL HANS-PETER , HUBER ERASMUS , KLAUSE URSULA
发明人： HEINDL DIETER , HERRMANN RUPERT , JOSEL HANS-PETER , HUBER ERASMUS , KLAUSE URSULA
IPC分类号： G01N21/76 , A61K39/00 , A61K48/00 , C07D219/06 , C07D277/66 , C07D401/12 , C07D413/06 , C07D417/04 , C07D417/14 , C07K16/18 , C09B15/00 , C09B57/00 , C12N5/10 , C12N9/18 , C12N15/62 , C12Q1/28 , C12Q1/66 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/533 , G01N33/58
CPC分类号： C07D401/12 , C07D219/06 , C07D417/04 , C07D417/14 , C12Q1/28 , G01N33/533 , G01N33/582 , Y10S435/968 , Y10S436/80 , Y10S436/904
摘要： The present invention relates to a chemical compound comprising a light emitting moiety precursor (eg. acridine, luciferine) and a precursor of a leaving group (eg. oxazine, anilide), bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converted into the leaving group. The invention also relates to compounds additionally comprising a coupling group to the use of such compounds for labeling of biomolecules and more generally to the use of such compounds in chemiluminescence detection procedures.
摘要翻译：本发明涉及包含发光部分前体（例如吖啶，荧光素）和离去基团（例如恶嗪，酰苯胺）的前体的化合物，其通过酰胺或酯键彼此结合并表征因为氧化后的离去基团前体被转化成离去基团。本发明还涉及另外包含使用这种化合物的偶联基团用于标记生物分子的化合物，更一般地，在化学发光检测程序中使用这些化合物。

7. 发明申请

WO2014019707A2 NEW IRIDIUM-BASED COMPLEXES FOR ECL 审中-公开
标题翻译：用于ECL的新的铱基配合物
公开(公告)号：WO2014019707A2
公开(公告)日：2014-02-06
申请号：PCT/EP2013002321
申请日：2013-08-02
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , UNIV MUENSTER WILHELMS , ROCHE DIAGNOSTICS OPERATIONS
发明人： BERGMANN FRANK , CYSEWSKI ROBERT , DE COLA LUISA , DZIADEK SEBASTIAN , FERNANDEZ HERNANDEZ JESUS MIGUEL , JOSEL HANS-PETER , SEIDEL CHRISTOPH
IPC分类号： C07F15/00 , C09K11/06
CPC分类号： C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
摘要： The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
摘要翻译：本发明涉及新颖的基于铱的Ir（III）发光复合物，包含这些复合物作为标记的缀合物及其应用，例如，在基于电化学发光的分析物检测中。

8. 发明申请

WO0227317A3 CONJUGATES OF DEFINED STOICHIOMETRY 审中-公开
标题翻译：定义STOICHIOMETRY的结合
公开(公告)号：WO0227317A3
公开(公告)日：2003-09-12
申请号：PCT/EP0111101
申请日：2001-09-26
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , HOESS EVA , ANDRES HERBERT , DONIE FREDERIC , VOGEL RUDOLF , JOSEL HANS-PETER , HERRMANN RUPERT , ELTZ HERBERT VON DER
发明人： HOESS EVA , ANDRES HERBERT , DONIE FREDERIC , VOGEL RUDOLF , JOSEL HANS-PETER , HERRMANN RUPERT , VON DER ELTZ HERBERT
IPC分类号： A61K47/48 , C07K1/107 , G01N30/88 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/566 , G01N33/68
CPC分类号： C07K1/1077 , A61K47/643 , A61K47/6889 , G01N33/5306 , G01N33/531 , G01N33/68 , G01N33/6845 , Y10S435/961 , Y10S435/962
摘要： The invention relates to a process for the production of a biomolecule-linker conjugate of uniform stochiometry. It especially relates to a conjugate consisting of a biomolecule of a molecular weight between 5 kD and 500 kD and a hydrophilic linker molecule said linker having a molecular weight between 1 and 15 kD and between 4 and 60 charged residues, characterized in that said conjugate comprises at least one biomelecule-linker product of uniform stoichiometry in a pre-selected amount.
摘要翻译：本发明涉及一种制备均匀化学计量学的生物分子 - 接头共轭物的方法。其特别涉及由分子量在5kD至500kD之间的生物分子和亲水性接头分子所组成的共轭物，所述接头分子量为1至15kD，4至60个带电荷的残基，其特征在于所述共轭物包含至少一种具有预选量的均匀化学计量的生物分子 - 接头产物。

9. 发明申请

WO0102017A3 ERYTHROPOIETIN CONJUGATES WITH POLYETHYLENGLYCOL 审中-公开
标题翻译：聚乙烯吡咯烷酮与聚乙烯醇共聚
公开(公告)号：WO0102017A3
公开(公告)日：2001-08-09
申请号：PCT/EP0006009
申请日：2000-06-28
申请人： HOFFMANN LA ROCHE
发明人： BURG JOSEF , HILGER BERND , JOSEL HANS-PETER
IPC分类号： A61K38/00 , A61K38/22 , A61K47/48 , A61P7/06 , A61P13/12 , A61P31/18 , A61P35/00 , C07K14/505
CPC分类号： C07K14/505 , A61K38/00 , A61K47/60
摘要： Erythropoietin glycoprotein conjugates are disclosed, said conjugates comprise an erythropoietin glycoprotein having at least one free amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have the primary structure of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or by the rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to form one to three lower-alkoxy poly(ethylene glycol) groups, each poly(ethylene glycol) group being covalently linked to the glycoprotein via a linker of the formula -C(O)-X-S-Y- with the C(O) of the linker forming an amide bond with one of said amino groups, wherein X and Y are as defined in the description and claims, the average molecular weight of each poly(ethylene glycol) moiety is from about 20 kilodaltons to about 40 kilodaltons, and the molecular weight of the conjugate is from about 51 kilodaltons to about 175 kilodaltons.
摘要翻译：所述缀合物包含具有至少一个游离氨基并且具有引起骨髓细胞的体内生物学活性以增加网织红细胞和红细胞的产生的促红细胞生成素糖蛋白，并选自由人类红细胞生成素及其类似物组成的组，其具有通过加入1至6个糖基化位点或通过重排至少一个糖基化位点而修饰的促红细胞生成素的一级结构; 所述糖蛋白共价连接以形成一至三个低级烷氧基聚（乙二醇）基团，每个聚（乙二醇）基团通过式-C（O）的连接体与糖蛋白共价连接）-XSY-，其中所述连接体的C（O）与所述氨基之一形成酰胺键，其中X和Y如说明书和权利要求中所定义，每个聚（乙二醇）部分的平均分子量为约20千道尔顿至约40千道尔顿，共轭物的分子量为约51千道尔顿至约175千道尔顿。

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