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1. 发明申请

WO2012028525A2 METHOD FOR PRODUCING A LIPID PARTICLE, THE LIPID PARTICLE ITSELF AND ITS USE 审中-公开
标题翻译：生产脂肪颗粒的方法，脂质颗粒及其用途
公开(公告)号：WO2012028525A2
公开(公告)日：2012-03-08
申请号：PCT/EP2011064601
申请日：2011-08-25
申请人： HOFFMANN LA ROCHE , BADER MARTIN , BAEHNER MONIKA , JOCHNER ANTON , KETTENBERGER HUBERT , MOHL SILKE
发明人： BADER MARTIN , BAEHNER MONIKA , JOCHNER ANTON , KETTENBERGER HUBERT , MOHL SILKE
IPC分类号： A61K9/127 , A61K38/47 , C07K14/775 , C12N15/62
CPC分类号： A61K9/1275 , A61K9/1277 , A61K38/1709
摘要： Herein is reported a method for producing a lipid particle comprising the following steps i) providing a first solution comprising denatured apolipoprotein, ii) adding the first solution to a second solution comprising at least two lipids and a detergent but no apolipoprotein, and iii) removing the detergent from the solution obtained in step ii) and thereby producing a lipid particle.
摘要翻译：本文报道了一种生产脂质颗粒的方法，包括以下步骤：i）提供包含变性载脂蛋白的第一溶液，ii）将第一溶液加入到包含至少两种脂质和洗涤剂但不含载脂蛋白的第二溶液中，和iii）除去来自步骤ii）中获得的溶液的洗涤剂，从而产生脂质颗粒。

2. 发明申请

WO2012028524A3 METHOD FOR PRODUCING A TETRANECTIN-APOLIPOPROTEIN A-I LIPID PARTICLE, THE LIPID PARTICLE ITSELF AND ITS USE 审中-公开
标题翻译：生产四乙酰丙酸纤维素A-I脂肪颗粒的方法，脂质颗粒及其用途
公开(公告)号：WO2012028524A3
公开(公告)日：2012-11-15
申请号：PCT/EP2011064600
申请日：2011-08-25
申请人： HOFFMANN LA ROCHE , BADER MARTIN , BAEHNER MONIKA , GROSSMANN ADELBERT , MOHL SILKE
发明人： BADER MARTIN , BAEHNER MONIKA , GROSSMANN ADELBERT , MOHL SILKE
IPC分类号： A61K9/127 , A61K38/47 , A61K47/48 , C07K14/775 , C12N15/62
CPC分类号： A61K9/1275 , A61K38/1709 , A61K38/28
摘要： Herein is reported a method for producing a lipid particle comprising the following steps i) providing a first solution comprising denatured apolipoprotein, ii) adding the first solution to a second solution comprising at least two lipids and a detergent but no apolipoprotein, and iii) removing the detergent from the solution obtained in step ii) and thereby producing a lipid particle.
摘要翻译：本文报道了一种生产脂质颗粒的方法，包括以下步骤：i）提供包含变性载脂蛋白的第一溶液，ii）将第一溶液加入到包含至少两种脂质和洗涤剂但不含载脂蛋白的第二溶液中，和iii）除去来自步骤ii）中获得的溶液的洗涤剂，从而产生脂质颗粒。

3. 发明申请

WO2012028526A2 TETRANECTIN-APOLIPOPROTEIN A-I, LIPID PARTICLES CONTAINING IT AND ITS USE 审中-公开
标题翻译：四氯乙烯 - 阿波罗平蛋白A-I，含有它的脂质及其使用
公开(公告)号：WO2012028526A2
公开(公告)日：2012-03-08
申请号：PCT/EP2011064602
申请日：2011-08-25
申请人： HOFFMANN LA ROCHE , BADER MARTIN , BAEHNER MONIKA , FINGERLE JUERGEN , KOHNERT ULRICH , MARY JEAN-LUC , MOHL SILKE
发明人： BADER MARTIN , BAEHNER MONIKA , FINGERLE JUERGEN , KOHNERT ULRICH , MARY JEAN-LUC , MOHL SILKE
IPC分类号： A61K9/127 , A61K9/00 , A61K38/47 , C07K14/775 , C12N15/62
CPC分类号： C07K14/775 , A61K9/127 , A61K38/1709 , A61K47/186 , A61K47/44 , C07K2319/73
摘要： Herein is reported a lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70 % sequence identity with the selected sequence.
摘要翻译：本文报道了包含载脂蛋白，磷脂酰胆碱和脂质如磷脂，脂肪酸或类固醇脂质的脂质颗粒。在一个实施方案中，脂质颗粒仅包含一种载脂蛋白。在一个实施方案中，脂质颗粒由一种载脂蛋白，磷脂，脂质和洗涤剂组成。在一个实施方案中，脂质是第二磷脂酰胆碱，其中第一磷脂酰胆碱和第二磷脂酰胆碱在一个或两个脂肪酸残基或被酯化成磷脂酰胆碱的甘油骨架的脂肪酸残基衍生物不同。在一个实施方案中，载脂蛋白选自具有选自SEQ ID NO：01,02,66和67的氨基酸序列的载脂蛋白，或其是与所选序列具有至少70％序列同一性的变体。

4. 发明申请

WO2007038619A3 PROTEINACEOUS PHARMACEUTICALS AND USES THEREOF 审中-公开
标题翻译：蛋白质药物及其用途
公开(公告)号：WO2007038619A3
公开(公告)日：2009-04-30
申请号：PCT/US2006037713
申请日：2006-09-27
申请人： AMUNIX INC , STEMMER WILLEM P C , SCHELLENBERGER VOLKER , BADER MARTIN , SCHOLLE MICHAEL
发明人： STEMMER WILLEM P C , SCHELLENBERGER VOLKER , BADER MARTIN , SCHOLLE MICHAEL
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： G01N33/6845 , C07K14/001 , C07K14/415 , C12N15/1044
摘要： The present invention provides cysteine-containing scaffolds and/or proteins, expression vectors, host cell and display systems harboring and/or expressing such cysteine-containing products. The present invention also provides methods of designing libraries of such products, methods of screening such libraries to yield entities exhibiting binding specificities towards a taraget molecule. Further provided by the invention are pharmaceutical compositions comprising the cysteine-containing products of the present invention.
摘要翻译：本发明提供含半胱氨酸的支架和/或蛋白质，表达载体，宿主细胞和含有和/或表达这种含半胱氨酸的产品的显示系统。本发明还提供了设计此类产品的文库的方法，筛选此类文库以产生显示针对taraget分子的结合特异性的实体的方法。本发明进一步提供的是包含本发明的含半胱氨酸的产品的药物组合物。

5. 发明申请

WO2010108202A8 BOTTLE OPENER 审中-公开
标题翻译：开瓶器
公开(公告)号：WO2010108202A8
公开(公告)日：2011-10-13
申请号：PCT/AT2010000078
申请日：2010-03-15
申请人： NEUBERGER ALFRED FRANZ , BADER MARTIN
发明人： BADER MARTIN
IPC分类号： B67B7/18
CPC分类号： B67B7/18
摘要： Bottle opener for opening a bottle closed with a screw cap, in particular a wine bottle, wherein the bottle opener comprises an annular contact element (1) having an inside surface (2) for resting against the screw cap, wherein the inside surface (2) delimits a receiving cavity (3) for receiving the screw cap, and the inside surface (2) is delimited by two, preferably circular, edges (4, 4') of the contact element (1) and the diameter (5) of the receiving cavity (3) delimited by the inside surface (2) decreases at least regionally, starting from at least one of the edges (4) in the direction toward the other edge (4''), and a left-handed internal thread (6) is formed on the inside surface.
摘要翻译：开瓶器用于打开具有螺帽瓶，特别是葡萄酒瓶，其具有（1）具有内表面（2），用于接合所述螺纹盖，其中，所述内表面（2）限定的容纳腔（3），用于接收螺旋盖的环形接触元件瓶子密封和所述内表面（2）的两个，优选圆形边缘（4,4“）的接触元件（1）是有限的，直径（5）的内表面（2）的限定接纳腔（3），从所述边缘中的至少一个开始形成（4）至少在朝向其他边缘（4“）的方向上和在左手内螺纹（6）的内表面部分地减小。

6. 发明申请

WO2010108202A2 BOTTLE OPENER 审中-公开
标题翻译：开瓶器
公开(公告)号：WO2010108202A2
公开(公告)日：2010-09-30
申请号：PCT/AT2010000078
申请日：2010-03-15
申请人： BADER MARTIN
发明人： BADER MARTIN
IPC分类号： B67B7/18
CPC分类号： B67B7/18
摘要： Bottle opener for opening a bottle closed with a screw cap, in particular a wine bottle, wherein the bottle opener comprises an annular contact element (1) having an inside surface (2) for resting against the screw cap, wherein the inside surface (2) delimits a receiving cavity (3) for receiving the screw cap, and the inside surface (2) is delimited by two, preferably circular, edges (4, 4') of the contact element (1) and the diameter (5) of the receiving cavity (3) delimited by the inside surface (2) decreases at least regionally, starting from at least one of the edges (4) in the direction toward the other edge (4''), and a left-handed internal thread (6) is formed on the inside surface.
摘要翻译：开瓶器用于打开具有螺帽瓶，特别是葡萄酒瓶，其具有（1）具有内表面（2），用于接合所述螺纹盖，其中，所述内表面（2）限定的容纳腔（3），用于接收螺旋盖的环形接触元件瓶子密封和所述内表面（2）的两个，优选圆形边缘（4,4“）的接触元件（1）是有限的，直径（5）的内表面（2）的限定接纳腔（3），从所述边缘中的至少一个开始形成（4）至少在朝向其他边缘（4“）的方向上和在左手内螺纹（6）的内表面部分地减小。

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