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1. 发明申请

WO2008145563A3 PROCESS FOR PREPARING TRIAZOLONES 审中-公开
标题翻译：制备三唑的方法
公开(公告)号：WO2008145563A3
公开(公告)日：2009-04-09
申请号：PCT/EP2008056166
申请日：2008-05-20
申请人： HOFFMANN LA ROCHE , ARZENO HUMBERTO BARTOLOME , LEE GARY M , MARTIN MICHAEL , SARMA KESHAB , ZHU JIANG
发明人： ARZENO HUMBERTO BARTOLOME , LEE GARY M , MARTIN MICHAEL , SARMA KESHAB , ZHU JIANG
IPC分类号： C07D249/10 , C07C205/11
CPC分类号： C07D249/12 , C07C17/18 , C07C45/004 , C07C253/14 , C07C253/30 , C07C25/18 , C07C47/55 , C07C255/54 , C07C255/56
摘要： The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles (2) which are useful intermediates in a new process for the preparation of triazolones (20).
摘要翻译：本方法提供了制备烷基硫烷基取代的三唑（2）的改进方法，其在制备三唑酮（20）的新方法中是有用的中间体。

2. 发明申请

WO2014108806A8 A NOVEL PROCESS FOR THE PREPARATION OF N-(4-NITRO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER AND N-(4-AMINO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER 审中-公开
标题翻译：制备N-（4-硝基-2-磺酰基 - 苯基） - 马来酸甲酯和N-（4-氨基-2-磺酰基 - 苯基） - 马来酸甲酯的新方法
公开(公告)号：WO2014108806A8
公开(公告)日：2015-04-30
申请号：PCT/IB2014000538
申请日：2014-01-13
申请人： HOFFMANN LA ROCHE
发明人： ZHU JIANG
IPC分类号： C07C311/46 , C07C303/38 , C07C303/40 , C07C311/39
CPC分类号： C07C303/40 , C07C303/38 , C07C311/46 , C07C311/39
摘要： The present invention provides a novel method for preparing compounds N-(4-nitro-2- sulfamoyl-phenyl)-malonamic acid methyl ester and N-(4-amino-2-sulfamoyl-phenyl)- malonamic acid methyl ester, which are novel intermediates for preparing a key intermediate N- (4-methanesulfonylamino-2-sulfamoyl-phenyl)-malonamic acid methyl ester, for the preparation of N-(3 - {( 1 R,2S,7R,8S)-3 -[(4-fluorophenyl)methyl] -6-hydroxy-4-oxo-3 -azatricyclo [6.2.1.02'7]undec-5-en-5-yl}-l,l-dioxo-l,4-dihydro-lX6,2,4-benzothiadiazin-7- yl)methanesulfonamide, also known commercially as Setrobuvir, a compound useful in treating hepatitis C.
摘要翻译：本发明提供了制备N-（4-硝基-2-氨磺酰基 - 苯基） - 丙酰胺酸甲酯和N-（4-氨基-2-氨磺酰基 - 苯基） - 丙酰胺酸甲酯的新方法，它们是制备N-（3 - {（1R，2S，7R，8S）-3- [4-（4-甲磺酰氨基-2-氨磺酰基 - 苯基） - 丙酰胺酸甲酯的新型中间体，（4-氟苯基）甲基] -6-羟基-4-氧代-3-叠氮基[6.2.1.02'7]十一碳-5-烯-5-基} -1,1-二氧代-1,4-二氢-6- ，2,4-苯并噻二嗪-7-基）甲磺酰胺，也称为Setrobuvir，一种可用于治疗丙型肝炎的化合物。

3. 发明申请

WO2014108806A2 A NOVEL PROCESS FOR THE PREPARATION OF N-(4-NITRO-2-SULFAMOLY-PHENYL)-MALONAMIC ACID METHYL ESTER AND N-(4-AMINO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER 审中-公开
标题翻译：制备N-（4-硝基-2-磺酰基苯基） - 马来酰氨基甲基酯和N-（4-氨基-2-氨基磺酰基苯基） - 马来酰氨基甲基酯的新工艺
公开(公告)号：WO2014108806A2
公开(公告)日：2014-07-17
申请号：PCT/IB2014000538
申请日：2014-01-13
申请人： HOFFMANN LA ROCHE
发明人： ZHU JIANG
IPC分类号： C07C311/46
CPC分类号： C07C303/40 , C07C303/38 , C07C311/46 , C07C311/39
摘要： The present invention provides a novel method for preparing compounds N-(4-nitro-2- sulfamoyl-phenyl)-malonamic acid methyl ester and N-(4-amino-2-sulfamoyl-phenyl)- malonamic acid methyl ester, which are novel intermediates for preparing a key intermediate N- (4-methanesulfonylamino-2-sulfamoyl-phenyl)-malonamic acid methyl ester, for the preparation of N-(3 - {( 1 R,2S,7R,8S)-3 -[(4-fluorophenyl)methyl] -6-hydroxy-4-oxo-3 -azatricyclo [6.2.1.02'7]undec-5-en-5-yl}-l,l-dioxo-l,4-dihydro-lX6,2,4-benzothiadiazin-7- yl)methanesulfonamide, also known commercially as Setrobuvir, a compound useful in treating hepatitis C.
摘要翻译：本发明提供了制备N-（4-硝基-2-氨磺酰基 - 苯基） - 丙酰胺酸甲酯和N-（4-氨基-2-氨磺酰基 - 苯基） - 丙酰胺酸甲酯的新型方法，它们是用于制备N-（3 - {（1R，2S，7R，8S）-3 - [（4-甲基磺酰基氨基-2-氨磺酰基 - 苯基） - 丙酰胺酸甲酯）（4-氟苯基）甲基] -6-羟基-4-氧代-3-氮杂三环[6.2.1.0 2,7]十一-5-烯-5-基} -1,1-二氧代-1,4-二氢-1λ6 ，2,4-苯并噻二嗪-7-基）甲磺酰胺，商业上也称为Setrobuvir，一种可用于治疗丙型肝炎的化合物。

4. 发明申请

WO2007095069A3 NF-YA ACTIVATES MULTIPLE HEMATOPOIETIC STEM CELL (HSC) REGULATORY GENES AND PROMOTES HSC SELF-RENEWAL 审中-公开
标题翻译： NF-YA激活多重HEMATOPOIETIC干细胞（HSC）调节基因和促进HSC自我更新
公开(公告)号：WO2007095069A3
公开(公告)日：2008-03-27
申请号：PCT/US2007003434
申请日：2007-02-08
申请人： UNIV PENNSYLVANIA , EMERSON STEPHEN G , ZHU JIANG , DOMASHENKO ALEVTINA
发明人： EMERSON STEPHEN G , ZHU JIANG , DOMASHENKO ALEVTINA
IPC分类号： C12N15/85 , C12N5/0789
CPC分类号： C07K14/4702 , C12N5/0647
摘要： Provide are methods for enhancing hematopoietic stem cell (HSC) self-renewal and/or proliferation resulting from increasing the intracellular concentration of NF-Ya in the cell, as well as, the resulting enhanced HSC resulting from the use of the provided methods, therapeutic use of such enhanced HSC and kits relating thereto.
摘要翻译：提供的是增加造血干细胞（HSC）自我更新和/或增殖的方法，其是由于增加细胞中NF-Ya的细胞内浓度，以及由使用所提供的方法得到的增强的HSC，治疗使用与之相关的增强型HSC和套件。

5. 发明申请

WO2011038290A8 NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE 审中-公开
标题翻译：将抗体中和到HIV-1及其使用
公开(公告)号：WO2011038290A8
公开(公告)日：2011-04-28
申请号：PCT/US2010050295
申请日：2010-09-24
申请人： US HEALTH , MASCOLA JOHN R , WYATT RICHARD , WU XUELING , LI YUXING , HOGERKORP CARL-MAGNUS , ROEDERER MARIO , YANG ZHI-YONG , NABEL GARY , KWONG PETER , ZHO TONGQING , CONNORS MARK , OFEK GILAD , SHAPIRO LAWRENCE , ZHU JIANG
发明人： MASCOLA JOHN R , WYATT RICHARD , WU XUELING , LI YUXING , HOGERKORP CARL-MAGNUS , ROEDERER MARIO , YANG ZHI-YONG , NABEL GARY , KWONG PETER , ZHO TONGQING , CONNORS MARK , OFEK GILAD , SHAPIRO LAWRENCE , ZHU JIANG
IPC分类号： C07K16/10
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-I gpl20. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-I gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译：公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。还公开了特异性结合HIV-1 gp41的单克隆中和抗体。还公开了这些抗体的鉴定，以及这些抗体的用途。还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。

6. 发明申请

WO2005012171A3 SIDEWALL FUNCTIONALIZATION OF CARBON NANOTUBES WITH ORGANOSILANES FOR POLYMER COMPOSITES 审中-公开
标题翻译：碳纳米管与有机硅烷在聚合物复合材料中的侧壁功能化
公开(公告)号：WO2005012171A3
公开(公告)日：2005-07-14
申请号：PCT/US2004024338
申请日：2004-07-28
申请人： UNIV RICE WILLIAM M , BARRERA ENRIQUE V , ZHU JIANG , ZHANG LEI , KHABASHESKU VALERY N , KIM JONG DAE , MARGRAVE MARY LOU LF
发明人： BARRERA ENRIQUE V , ZHU JIANG , ZHANG LEI , KHABASHESKU VALERY N , KIM JONG DAE , MARGRAVE JOHN L DI
IPC分类号： C01B31/02 , C09C1/56 , C08K3/04 , C08K7/02 , C08K7/14 , C08K7/24 , C08K9/06 , C09C1/44 , C09C3/12
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/174 , C01B2202/02 , C01B2202/04 , C01B2202/06 , C01P2002/82 , C01P2004/03 , C01P2004/04 , C01P2004/13 , C01P2004/133 , C01P2004/64 , C09C1/48 , C09C1/56 , C09C1/565 , Y10T442/2926 , Y10T442/2951 , Y10T442/2992 , Y10T442/3138
摘要： The present invention is directed to methods of functionalizing carbon nanotubes (CNTs), particularly single-wall carbon nanotubes (SWNTs), with organosilane species, wherein such functionalization enables fabrication of advanced polymer composites. The present invention is also directed toward the functionalized CNTs, advanced CNT-polymer composites made with such functionalized CNTs, and methods of making such advanced CNT-polymer composites.
摘要翻译：本发明涉及使用有机硅烷种类官能化碳纳米管（CNT），特别是单壁碳纳米管（SWNT）的方法，其中这种官能化使得能够制造先进的聚合物复合材料。本发明还涉及官能化CNT，用这种官能化CNT制备的先进CNT-聚合物复合材料以及制备这种先进CNT-聚合物复合材料的方法。

7. 发明申请

WO2011144056A3 METHOD AND DEVICE FOR MONITORING BASE STATION POWER CONSUMPTION 审中-公开
标题翻译：监测基站消耗电力的方法和装置
公开(公告)号：WO2011144056A3
公开(公告)日：2012-04-26
申请号：PCT/CN2011074390
申请日：2011-05-20
申请人： HUAWEI TECH CO LTD , LI JINFENG , ZHU JIANG , ZHANG QIANYING
发明人： LI JINFENG , ZHU JIANG , ZHANG QIANYING
IPC分类号： H04W52/00
CPC分类号： H04W52/0206 , Y02D70/00
摘要： Embodiments of the present invention relate to a method and device for monitoring base station power consumption, in which the method for monitoring base station power consumption comprises: determining an amount of power consumption units in a first power consumption group and obtaining power consumption values of the power consumption units, wherein the power consumption units are the power consumption units whose power consumption is stable; determining an amount of power consumption units in a second power consumption group and obtaining power consumption values of the power consumption units, or monitoring a first relevant parameter of the power consumption units and obtaining, according to power consumption variation rule, corresponding power consumption values, wherein the power consumption units are the power consumption units whose power consumption variation is regular; determining an amount of power consumption units in a third power consumption group and obtaining power consumption values of the power consumption units, or monitoring a second relevant parameter of the power consumption units in the third power consumption group and obtaining power consumption values after calculation, wherein the power consumption units are the power consumption units whose power consumption variation is irregular; and obtaining a power consumption value of a base station according to amounts and power consumption values of total power consumption units. The monitoring accuracy of base station power consumption is improved by dividing the power consumption units of a base station into power consumption groups.
摘要翻译：本发明的实施例涉及一种用于监视基站功耗的方法和装置，其中用于监视基站功耗的方法包括：确定第一功耗组中的功耗单元的数量，并获得第功耗单元，其中功耗单元是其功耗稳定的功耗单元; 确定第二功耗组中的功耗单元的数量并获得功耗单元的功耗值，或者监视功耗单元的第一相关参数，并根据功耗变化规则获得相应的功耗值，其特征在于，所述功耗单元是功耗变化规律的功耗单元; 确定第三功耗组中的功耗单元的数量并获得功耗单元的功耗值，或者监视第三功耗组中的功耗单元的第二相关参数，并获得计算后的功耗值，其中功耗单位是功耗变化不规则的功耗单位; 并且根据总功耗单位的量和功耗值获得基站的功耗值。通过将基站的功耗单位分为功耗组，提高基站功耗的监控精度。

8. 发明申请

WO2011103304A3 NANO-COATINGS FOR ARTICLES 审中-公开
标题翻译：用于制品的纳米涂层
公开(公告)号：WO2011103304A3
公开(公告)日：2011-11-24
申请号：PCT/US2011025265
申请日：2011-02-17
申请人： BAKER HUGHES INC , CHAKRABORTY SOMA , ZHU JIANG , AGRAWAL GAURAV
发明人： CHAKRABORTY SOMA , ZHU JIANG , AGRAWAL GAURAV
IPC分类号： B32B27/06 , B32B7/12 , B32B27/04
CPC分类号： B05D7/52 , B05D1/005 , B05D1/02 , B05D1/18 , B05D1/185 , B05D1/36 , B05D3/002 , B05D3/044 , B05D3/0446 , B05D3/062 , B05D3/063 , B05D3/101 , B05D5/08 , B05D7/04 , B05D2505/50 , B82Y30/00 , C08J7/045 , C08J2323/16 , C08J2433/02 , C08J2479/02 , C09D1/00 , C09D5/38 , C09D7/1216 , C09D7/1291 , C09D7/61 , C09D7/70 , Y10S977/902 , Y10T428/31504 , Y10T428/31507 , Y10T428/31511 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31678 , Y10T428/31721 , Y10T428/31786 , Y10T428/31931 , Y10T428/31935 , Y10T428/31938 , Y10T428/31942
摘要： A composite includes a substrate, a binder layer disposed on a surface of the substrate; and a nanofiller layer comprising nanographene and disposed on a surface of the binder layer opposite the substrate. In addition, a nano-coating layer for coating a substrate includes multiple alternating layers of the binder layer and the nanofiller layer. Articles coated with the nano-coating layer prepared from alternating layers of nanofiller layer and binder layer have improved barrier properties, and may be used in down-hole applications.
摘要翻译：复合物包括基底，设置在基底表面上的粘合剂层; 以及纳米填料层，其包含纳米石墨烯并且设置在与基底相对的粘合剂层的表面上。另外，用于涂覆基底的纳米涂层包括粘合剂层和纳米填料层的多个交替层。用纳米填料层和粘合剂层的交替层制备的涂有纳米涂层的制品具有改进的阻隔性能，并且可以用于井下应用。

9. 发明申请

WO2011038290A3 NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE 审中-公开
标题翻译：中和抗HIV-1抗体及其用途
公开(公告)号：WO2011038290A3
公开(公告)日：2011-07-14
申请号：PCT/US2010050295
申请日：2010-09-24
申请人： US HEALTH , MASCOLA JOHN R , WYATT RICHARD , WU XUELING , LI YUXING , HOGERKORP CARL-MAGNUS , ROEDERER MARIO , YANG ZHI-YONG , NABEL GARY , KWONG PETER , ZHO TONGQING , CONNORS MARK , OFEK GILAD , SHAPIRO LAWRENCE , ZHU JIANG
发明人： MASCOLA JOHN R , WYATT RICHARD , WU XUELING , LI YUXING , HOGERKORP CARL-MAGNUS , ROEDERER MARIO , YANG ZHI-YONG , NABEL GARY , KWONG PETER , ZHO TONGQING , CONNORS MARK , OFEK GILAD , SHAPIRO LAWRENCE , ZHU JIANG
IPC分类号： C07K16/10
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-I gpl20. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-I gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译：公开了单克隆中和抗体，其特异性结合HIV-1 gp120的CD4结合位点。还公开了特异性结合HIV-1 gp41的单克隆中和抗体。还公开了这些抗体的鉴定以及这些抗体的用途。还提供了使用表位支架探针增强任何抗体的结合和中和活性的方法。

10. 发明申请

WO0244128A3 SALICYLATE ANALOGS AS INTERLEUKIN-4 ANTAGONISTS 审中-公开
标题翻译：脂质体模拟物作为白细胞介素-4拮抗剂
公开(公告)号：WO0244128A3
公开(公告)日：2003-03-13
申请号：PCT/US0144643
申请日：2001-11-27
申请人： SUNESIS PHARMACEUTICALS INC , BARR KENNETH J , CUNNINGHAM BRIAN C , FLANAGAN WILLIAM MICHAEL , LU WANLI , RAIMUNDO BRIAN C , WAAL NATHAN D , WILKINSON JENNIFER , ZHU JIANG , YANG WENJIN
发明人： BARR KENNETH J , CUNNINGHAM BRIAN C , FLANAGAN WILLIAM MICHAEL , LU WANLI , RAIMUNDO BRIAN C , WAAL NATHAN D , WILKINSON JENNIFER , ZHU JIANG , YANG WENJIN
IPC分类号： A61P19/00 , A61P29/00 , A61P37/00 , C07C65/105 , C07C65/19 , C07C233/87 , C07C235/42 , C07C235/48 , A61K31/166 , A61K31/192
CPC分类号： C07C235/48 , C07C65/105 , C07C65/19 , C07C233/87 , C07C235/42
摘要： Salicycate analogs of formula, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are interleukin-4 antagonists, and are useful for the treatment of asthma and allergies.
摘要翻译：式的脂环类似物，其制备方法，含有它们的药物组合物及其使用方法。化合物是白细胞介素-4拮抗剂，可用于治疗哮喘和过敏。

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