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1. 发明申请

WO2011038290A3 NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE 审中-公开
标题翻译：中和抗HIV-1抗体及其用途
公开(公告)号：WO2011038290A3
公开(公告)日：2011-07-14
申请号：PCT/US2010050295
申请日：2010-09-24
申请人： US HEALTH , MASCOLA JOHN R , WYATT RICHARD , WU XUELING , LI YUXING , HOGERKORP CARL-MAGNUS , ROEDERER MARIO , YANG ZHI-YONG , NABEL GARY , KWONG PETER , ZHO TONGQING , CONNORS MARK , OFEK GILAD , SHAPIRO LAWRENCE , ZHU JIANG
发明人： MASCOLA JOHN R , WYATT RICHARD , WU XUELING , LI YUXING , HOGERKORP CARL-MAGNUS , ROEDERER MARIO , YANG ZHI-YONG , NABEL GARY , KWONG PETER , ZHO TONGQING , CONNORS MARK , OFEK GILAD , SHAPIRO LAWRENCE , ZHU JIANG
IPC分类号： C07K16/10
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-I gpl20. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-I gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译：公开了单克隆中和抗体，其特异性结合HIV-1 gp120的CD4结合位点。还公开了特异性结合HIV-1 gp41的单克隆中和抗体。还公开了这些抗体的鉴定以及这些抗体的用途。还提供了使用表位支架探针增强任何抗体的结合和中和活性的方法。

2. 发明申请

WO2011038290A8 NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE 审中-公开
标题翻译：将抗体中和到HIV-1及其使用
公开(公告)号：WO2011038290A8
公开(公告)日：2011-04-28
申请号：PCT/US2010050295
申请日：2010-09-24
申请人： US HEALTH , MASCOLA JOHN R , WYATT RICHARD , WU XUELING , LI YUXING , HOGERKORP CARL-MAGNUS , ROEDERER MARIO , YANG ZHI-YONG , NABEL GARY , KWONG PETER , ZHO TONGQING , CONNORS MARK , OFEK GILAD , SHAPIRO LAWRENCE , ZHU JIANG
发明人： MASCOLA JOHN R , WYATT RICHARD , WU XUELING , LI YUXING , HOGERKORP CARL-MAGNUS , ROEDERER MARIO , YANG ZHI-YONG , NABEL GARY , KWONG PETER , ZHO TONGQING , CONNORS MARK , OFEK GILAD , SHAPIRO LAWRENCE , ZHU JIANG
IPC分类号： C07K16/10
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-I gpl20. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-I gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译：公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。还公开了特异性结合HIV-1 gp41的单克隆中和抗体。还公开了这些抗体的鉴定，以及这些抗体的用途。还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。

3. 发明申请

WO2009151496A4 INDUCTION OF PROLIFERATION, EFFECTOR MOLECULE EXPRESSION, AND CYTOLYTIC CAPACITY OF HIV-SPECIFIC CD8+ T CELLS 审中-公开
公开(公告)号：WO2009151496A4
公开(公告)日：2010-05-14
申请号：PCT/US2009001859
申请日：2009-03-25
申请人： US GOV HEALTH & HUMAN SERV , CONNORS MARK , MIGUELES STEPHEN A
发明人： CONNORS MARK , MIGUELES STEPHEN A
IPC分类号： A61K31/235 , A61K31/555 , A61K33/06 , A61P31/18 , A61P37/00
CPC分类号： A61K31/235 , A61K31/555 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N2500/14 , C12N2501/999 , A61K2300/00
摘要： Provided is a method of activating an immune cell of a subject with Human Immunodeficiency Virus (HIV), comprising contacting the immune cell with a phorbol ester and a calcium ionophore. Also provided is a composition comprising immune cells of a subject diagnosed with HIV, wherein the immune cells are activated by contact with a phorbol ester and a calcium ionophore. Methods of using the disclosed compositions are also disclosed.

4. 发明申请

WO2004027034A3 METHODS FOR ASSESSING THE ABILITY OF HIV PATIENTS TO RESTRICT HIV REPLICATION 审中-公开
标题翻译：评估艾滋病毒患者限制艾滋病毒复制能力的方法
公开(公告)号：WO2004027034A3
公开(公告)日：2005-06-02
申请号：PCT/US0329549
申请日：2003-09-22
申请人： US GOV HEALTH & HUMAN SERV , CONNORS MARK , MIGUELES STEPHEN A
发明人： CONNORS MARK , MIGUELES STEPHEN A
IPC分类号： C07K14/16 , G01N33/569 , C12Q1/00
CPC分类号： C07K14/005 , C12N2710/24143 , C12N2740/16222 , G01N33/56972 , G01N2333/16
摘要： There are provided methods for evaluating the effectiveness of HIV therapies and vaccines and methods for assessing the ability of HIV patients to restrict virus replication. Upon restimulation of CD8 T cells or peripheral blood mononuclear cells from a patient, proliferation of the CD8 T cells, the expression of perforin in these cells, and the cell cycle stage of these cells may be measured and used as in vitro markers for monitoring the patient's ability to restrict HIV replication and the effectiveness of the therapies and vaccines applied. Significant proliferation of CD8 T cell, the presence of perforin in these cells, and the ability of these cells to progress beyond the G1 stage signify the patient's ability to restrict HIV replication and a favorable effect of the therapies or vaccines. These methods may be advantageously applied in conjunction with other measurements of HIV specific immune response such as HLA tetramers.
摘要翻译：提供了评估艾滋病毒治疗和疫苗有效性的方法以及评估艾滋病毒患者限制病毒复制能力的方法。在对来自患者的CD8 + T细胞或外周血单核细胞进行再刺激后，可测量CD8 + T细胞的增殖，这些细胞中穿孔素的表达和这些细胞的细胞周期，并将其用作用于监测患者限制HIV复制能力的体外标志物以及所应用的治疗和疫苗的有效性。 CD8 + T细胞的显着增殖，这些细胞中穿孔素的存在以及这些细胞超出G1期的能力意味着患者限制HIV复制的能力和治疗或疫苗的有利效果。这些方法可以有利地与HIV特异性免疫应答的其他测量结合使用，例如HLA四聚体。

5. 发明申请

WO2009151496A3 INDUCTION OF PROLIFERATION, EFFECTOR MOLECULE EXPRESSION, AND CYTOLYTIC CAPACITY OF HIV-SPECIFIC CD8+ T CELLS 审中-公开
标题翻译：感染HIV特异性CD8 + T细胞的增殖，影响分子表达和CYTOLYY能力
公开(公告)号：WO2009151496A3
公开(公告)日：2010-03-25
申请号：PCT/US2009001859
申请日：2009-03-25
申请人： US GOV HEALTH & HUMAN SERV , CONNORS MARK , MIGUELES STEPHEN A
发明人： CONNORS MARK , MIGUELES STEPHEN A
IPC分类号： A61K31/235 , A61K31/555 , A61K33/06 , A61P31/18 , A61P37/00
CPC分类号： A61K31/235 , A61K31/555 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N2500/14 , C12N2501/999 , A61K2300/00
摘要： Provided is a method of activating an immune cell of a subject with Human Immunodeficiency Virus (HIV), comprising contacting the immune cell with a phorbol ester and a calcium ionophore. Also provided is a composition comprising immune cells of a subject diagnosed with HIV, wherein the immune cells are activated by contact with a phorbol ester and a calcium ionophore. Methods of using the disclosed compositions are also disclosed.
摘要翻译：提供了用人免疫缺陷病毒（HIV）激活受试者的免疫细胞的方法，包括使免疫细胞与佛波酯和钙离子载体接触。还提供了包含被诊断为HIV的受试者的免疫细胞的组合物，其中所述免疫细胞通过与佛波酯和钙离子载体接触来活化。还公开了使用所公开的组合物的方法。

6. 发明申请

WO2009151496A2 INDUCTION OF PROLIFERATION, EFFECTOR MOLECULE EXPRESSION, AND CYTOLYTIC CAPACITY OF HIV-SPECIFIC CD8+ T CELLS 审中-公开
标题翻译：艾滋病毒特异性CD8 + T细胞的增殖，影响分子表达和CYTOLYIC能力的诱导
公开(公告)号：WO2009151496A2
公开(公告)日：2009-12-17
申请号：PCT/US2009001859
申请日：2009-03-25
申请人： US GOV HEALTH & HUMAN SERV , CONNORS MARK , MIGUELES STEPHEN A
发明人： CONNORS MARK , MIGUELES STEPHEN A
IPC分类号： A61K31/235 , A61K31/555 , A61K33/06 , A61P31/18 , A61P37/00
CPC分类号： A61K31/235 , A61K31/555 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N2500/14 , C12N2501/999 , A61K2300/00
摘要： Provided is a method of activating an immune cell of a subject with Human Immunodeficiency Virus (HIV), comprising contacting the immune cell with a phorbol ester and a calcium ionophore. Also provided is a composition comprising immune cells of a subject diagnosed with HIV, wherein the immune cells are activated by contact with a phorbol ester and a calcium ionophore. Methods of using the disclosed compositions are also disclosed.
摘要翻译：提供了一种用人免疫缺陷病毒（HIV）激活受试者的免疫细胞的方法，包括使免疫细胞与佛波酯和钙离子载体接触。还提供了包含被诊断为HIV的受试者的免疫细胞的组合物，其中所述免疫细胞通过与佛波酯和钙离子载体接触来活化。还公开了使用所公开的组合物的方法。

7. 发明申请

WO2013070776A8 NEUTRALIZING GP41 ANTIBODIES AND THEIR USE 审中-公开
标题翻译：中和GP41抗体及其使用
公开(公告)号：WO2013070776A8
公开(公告)日：2014-06-12
申请号：PCT/US2012063958
申请日：2012-11-07
申请人： US HEALTH
发明人： CONNORS MARK , HUANG JINGHE , LAUB LEO B , KWONG PETER , NABEL GARY , MASCOLA JOHN R , ZHANG BAOSHAN , RUDICELL REBECCA S , GEORGIEV IVELIN , YANG YONGPING , ZHU JIANG , OFEK GILAD
IPC分类号： C07K16/10 , A61K39/42 , A61P31/18 , C12N15/13
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K16/00 , C07K16/1045 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , G01N33/56972 , G01N33/56983 , G01N33/56988 , G01N2333/161
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
摘要翻译：公开了特异性结合HIV-1 gp41膜近端外部区域（MPER）的单克隆中和抗体。还公开了包括所公开的特异性结合gp41的抗体，编码这些抗体的核酸，包括核酸的表达载体和表达核酸的分离的宿主细胞的组合物。本文公开的抗体和组合物可用于检测生物样品中HIV-1的存在，或检测受试者中的HIV-1感染或AIDS的诊断。此外，所公开的抗体的广泛中和宽度使其成为治疗HIV感染的受试者的理想选择。因此，公开了治疗和/或预防HIV感染的方法。

8. 发明申请

WO2016154003A8 NEUTRALIZING ANTIBODIES TO GP120 AND THEIR USE 审中-公开
标题翻译：中和抗GP120抗体及其用途
公开(公告)号：WO2016154003A8
公开(公告)日：2016-10-27
申请号：PCT/US2016023145
申请日：2016-03-18
申请人： US HEALTH
发明人： CONNORS MARK , HUANG JINGHE , KANG BYONG HA , MASCOLA JOHN , ISHIDA ELISE , ZHOU TONGQING , KWONG PETER , ZHENG ANQI
IPC分类号： C07K16/10 , A61P31/18
CPC分类号： C07K16/1063 , A61K2039/505 , A61K2039/545 , C07K2317/76
摘要： Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
摘要翻译：公开了与gp120特异性结合并中和HIV-1的抗体和抗原结合片段。还提供了编码这些抗体的核酸，载体和宿主细胞。公开了使用这些抗体检测HIV-1的方法。另外，公开了使用这些抗体，抗原结合片段，核酸和载体预防和/或治疗HIV-1感染。

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