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1. 发明申请

WO0171345A9 OPTICALLY AND FLUIDICALLY ENHANCED IN VITRO DIAGNOSTIC TEST CHAMBER 审中-公开
标题翻译：在体外诊断测试室中光学和流体增强
公开(公告)号：WO0171345A9
公开(公告)日：2002-12-19
申请号：PCT/US0109100
申请日：2001-03-20
申请人： HITACHI CHEMICAL DIAGNOSTICS I , INNERST DIANNA , KASSINOS ADONIS , WOOLEY C BENJAMIN , WILMARTH BRETT , SELL WILLIAM J , ZYCHLINSKY EMI , MARINO DONALD , YAMADA SANDY , RYAN RENEE , DING KAREN , ZATZKE MICHAEL
发明人： INNERST DIANNA , KASSINOS ADONIS , WOOLEY C BENJAMIN , WILMARTH BRETT , SELL WILLIAM J , ZYCHLINSKY EMI , MARINO DONALD , YAMADA SANDY , RYAN RENEE , DING KAREN , ZATZKE MICHAEL
IPC分类号： G01N33/53 , B01L3/00 , G01N21/03 , G01N21/25 , G01N21/76 , G01N37/00 , G01N23/06
CPC分类号： B01L3/5025 , B01L2300/087 , B01L2400/0406 , G01N21/0303 , G01N21/253 , G01N21/76 , G01N2021/6482 , Y10T436/11
摘要： An enclosed chamber is used in a system for screening of a liquid specimen through binding assays. The enclosed chamber includes an inlet, an outlet, and a plurality of discrete reactant containing wells communicated by a common reagent flow path between the inlet and the outlet. A transparent member or coverslip defines on an inside thereof the plurality of wells. Each well has a bottom for receiving an allergen/antigen/reactant, which emits light upon reacting. The coverslip can optionally define at least one lens at each well. A bottom encloses the plurality of wells and defines between the inlet and the outlet a common reagent flow path between the inlet and the outlet. This bottom defines for each of the plurality of wells a flow-diverting member. An opaque partition is disclosed for surrounding the individual lenses and generally isolating the light path from each well.
摘要翻译：在通过结合测定筛选液体样品的系统中使用封闭室。封闭的腔室包括入口，出口和多个离散的反应物容纳孔，其通过入口和出口之间的公共试剂流动路径连通。透明构件或盖玻片在其内部限定多个孔。每个孔都有一个底部，用于接收变应原/抗原/反应物，反应时会发光。盖玻片可以可选地在每个孔处限定至少一个透镜。底部包围多个孔并且在入口和出口之间限定入口和出口之间的公共试剂流动路径。该底部为多个井中的每一个限定了一个流动分流构件。公开了一种不透明的分隔体，用于围绕各个透镜并且通常将光路与每个孔隔离。

2. 发明申请

WO0171345A8 OPTICALLY AND FLUIDICALLY ENHANCED IN VITRO DIAGNOSTIC TEST CHAMBER 审中-公开
标题翻译：在体外诊断测试室中光学和流体增强
公开(公告)号：WO0171345A8
公开(公告)日：2001-12-06
申请号：PCT/US0109100
申请日：2001-03-20
申请人： HITACHI CHEMICAL DIAGNOSTICS I , INNERST DIANNA , KASSINOS ADONIS , WOOLEY C BENJAMIN , WILMARTH BRETT , SELL WILLIAM J , ZYCHLINSKY EMI , MARINO DONALD , YAMADA SANDY , RYAN RENEE , DING KAREN , ZATZKE MICHAEL
发明人： INNERST DIANNA , KASSINOS ADONIS , WOOLEY C BENJAMIN , WILMARTH BRETT , SELL WILLIAM J , ZYCHLINSKY EMI , MARINO DONALD , YAMADA SANDY , RYAN RENEE , DING KAREN , ZATZKE MICHAEL
IPC分类号： G01N33/53 , B01L3/00 , G01N21/03 , G01N21/25 , G01N21/76 , G01N37/00 , G01N23/06
CPC分类号： B01L3/5025 , B01L2300/087 , B01L2400/0406 , G01N21/0303 , G01N21/253 , G01N21/76 , G01N2021/6482 , Y10T436/11
摘要： An enclosed chamber is used in a system for screening of a liquid specimen through binding assays. The enclosed chamber includes an inlet, an outlet, and a plurality of discrete reactant containing wells communicated by a common reagent flow path between the inlet and the outlet. A transparent member or coverslip defines on an inside thereof the plurality of wells. Each well has a bottom for receiving an allergen/antigen/reactant, which emits light upon reacting. The coverslip can optionally define at least one lens at each well. A bottom encloses the plurality of wells and defines between the inlet and the outlet a common reagent flow path between the inlet and the outlet. This bottom defines for each of the plurality of wells a flow-diverting member. An opaque partition is disclosed for surrounding the individual lenses and generally isolating the light path from each well.
摘要翻译：在通过结合测定筛选液体样品的系统中使用封闭室。封闭的腔室包括入口，出口和多个离散的反应物容纳孔，其通过入口和出口之间的公共试剂流动路径连通。透明构件或盖玻片在其内部限定多个孔。每个孔都有一个底部，用于接收变应原/抗原/反应物，反应时会发光。盖玻片可以可选地在每个孔处限定至少一个透镜。底部包围多个孔并且在入口和出口之间限定入口和出口之间的公共试剂流动路径。该底部为多个井中的每一个限定了一个流动分流构件。公开了一种不透明分隔件，用于围绕各个透镜，并且通常将光路与每个孔隔离。

3. 发明申请

WO2007140185A2 METHODS FOR NON-INVASIVE ANALYTE MEASUREMENT 审中-公开
标题翻译：非入侵分析测量方法
公开(公告)号：WO2007140185A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069454
申请日：2007-05-22
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL , DAHLEN JEFFREY R , SELL WILLIAM J
发明人： BURD JOHN F , WILLIAMS PAUL , DAHLEN JEFFREY R , SELL WILLIAM J
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/7239
摘要： A method of non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject includes exposing at least a portion of a tissue of the subject to electromagnetic radiation; obtaining a measurement of electromagnetic radiation from the tissue; and determining the presence, absence, or concentration of one or more analytes by determining a radiation signature of the electromagnetic radiation; correlating the radiation signature of the electromagnetic radiation with at least one of concentration, presence, and absence of one or more analytes by utilizing a mathematic transformation such as a transformation based on a 1st or higher derivative of the measurement to determine the presence, absence, or concentration of one or more analytes in the subject.
摘要翻译：非侵入性测量受试者组织中一种或多种分析物的存在，不存在或浓度的方法包括将受试者的组织的至少一部分暴露于电磁辐射; 获得来自组织的电磁辐射的测量; 以及通过确定所述电磁辐射的辐射特征来确定一种或多种分析物的存在，不存在或浓度; 通过利用诸如基于测量的第一或更高导数的变换的数学变换来将电磁辐射的辐射特征与浓度，存在和不存在一种或多种分析物的至少一种相关联，以确定存在，不存在，或浓度在受试者中的一种或多种分析物。

4. 发明申请

WO2008014131A2 APPARATUS AND METHOD OF USE FOR NON-INVASIVE ANALYTE MEASUREMENT DEVICE 审中-公开
标题翻译：用于无创分析测量装置的装置和方法
公开(公告)号：WO2008014131A2
公开(公告)日：2008-01-31
申请号：PCT/US2007073463
申请日：2007-07-13
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL , SELL WILLIAM J
发明人： BURD JOHN F , WILLIAMS PAUL , SELL WILLIAM J
IPC分类号： A61B5/00 , G06F17/00 , G06Q99/00
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/6887
摘要： An apparatus and method of use for enabling a NAM device are provided. The NAM device is configured to authenticate its use each time a measurement is requested. The operation of the NAM device is governed by a refillable media card that tracks a predetermined number of authorized uses. The NAM device confirms that remaining authorized uses are available on the refillable media card. In addition to tracking the number of authorized uses of the NAM device, the media card may also store the results of the measurements for tracking by a tracking server. When the number of authorized uses on the media card is depleted, the media card may be refilled by completing a refill transaction over a wired or wireless communication network. Alternatively, the media card may be refilled at a kiosk station or a new media card may be obtained for use with the NAM device.
摘要翻译：提供了用于启用NAM设备的设备和方法。 NAM设备配置为在每次请求测量时验证其使用。 NAM设备的操作由跟踪预定数量的授权使用的可再填充媒体卡管理。 NAM设备确认剩余的授权使用可用于可填充媒体卡。除了追踪NAM设备的授权使用数量之外，媒体卡还可以存储测量结果以供跟踪服务器进行跟踪。当媒体卡上授权使用的数量被耗尽时，媒体卡可通过在有线或无线通信网络上完成再填充事务来重新填充。或者，媒体卡可以在自助终端站重新填充，或者可以获得新的媒体卡用于与NAM设备一起使用。

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