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1. 发明申请

WO2007054279A8 CYCLIC-DINUCLEOTIDES AND ITS CONJUGATES AS ADJUVANTS AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS 审中-公开
公开(公告)号：WO2007054279A8
公开(公告)日：2007-07-12
申请号：PCT/EP2006010693
申请日：2006-11-08
申请人： HELMHOLTZ INFEKTIONSFORSCHUNG , EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A
发明人： EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A
IPC分类号： A61K39/00 , A61K31/7084 , A61K39/39 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P37/00
CPC分类号： A61K39/39 , A61K31/7076 , A61K31/7084 , A61K2039/55511
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

2. 发明申请

WO2008028667A3 USE OF GLYCOLIPIDS AS ADJUVANTS 审中-公开
标题翻译：作为ADJUVANTS的甘油酯的使用
公开(公告)号：WO2008028667A3
公开(公告)日：2008-07-03
申请号：PCT/EP2007007794
申请日：2007-09-06
申请人： HELMHOLTZ INFEKTIONSFORSCHUNG , EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A , MILKEREIT GOETZ
发明人： EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A , MILKEREIT GOETZ
IPC分类号： A61K39/39 , A61K47/26 , A61P37/04 , C07H15/04 , C07H15/08
CPC分类号： A61K39/39 , A61K2039/55511
摘要： The present invention relates to adjuvants of the glycolipid type and their uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new uses of compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours and allergies. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants.
摘要翻译：本发明涉及糖脂类型的佐剂及其在药物组合物中的用途，如疫苗中。特别地，本发明提供了用作治疗感染性疾病，炎性疾病，自身免疫性疾病，肿瘤和过敏症中的预防和/或治疗性疫苗的辅助剂的新用途。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。

3. 发明申请

WO2007059931A8 NEW ADJUVANTS ON THE BASIS OF BISACYLOXYPROPYLCYSTEINE CONJUGATES AND DERIVATIVES AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：基于双二羟甲基丙氧基偶联物及衍生物的新型辅料及其在药物组合物中的应用
公开(公告)号：WO2007059931A8
公开(公告)日：2007-07-19
申请号：PCT/EP2006011182
申请日：2006-11-22
申请人： HELMHOLTZ INFEKTIONSFORSCHUNG , EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A
发明人： EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A
IPC分类号： A61K47/48
CPC分类号： A61K47/60
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new conjugates of the bisacyloxycysteine type useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗中的用途。具体而言，本发明提供了可用作治疗感染性疾病，炎症性疾病，自身免疫性疾病，肿瘤，变态反应以及用于控制以下疾病的预防和/或治疗性疫苗接种的双酰氧基半胱氨酸类型的新偶联物：佐剂和/或免疫调节剂人类或动物种群的生育力。该化合物不仅作为全身用药特别有用，而且优选作为粘膜佐剂。另外，本发明涉及其用作药物组合物中的活性成分的用途。

4. 发明申请

WO2007054279A2 CYCLIC-DINUCLEOTIDES AND ITS CONJUGATES AS ADJUVANTS AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：周期性胆固醇及其作为调节剂及其在药物组合物中的用途
公开(公告)号：WO2007054279A2
公开(公告)日：2007-05-18
申请号：PCT/EP2006010693
申请日：2006-11-08
申请人： HELMHOLTZ INFEKTIONSFORSCHUNG , EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A
发明人： EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A
CPC分类号： A61K39/39 , A61K31/7076 , A61K31/7084 , A61K2039/55511
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗。特别地，本发明提供了新的化合物，其可用作用于治疗感染性疾病，炎性疾病，自身免疫性疾病，肿瘤，过敏症以及用于控制人的生育能力的预防和/或治疗性疫苗的佐剂和/或免疫调节剂动物种群。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。此外，本发明涉及其作为药物组合物中的活性成分的用途。

5. 发明申请

WO2007054283A2 PQS AND ITS CONJUGATES AS ADJUVANTS AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： PQS及其作为补充剂及其在药物组合物中的应用
公开(公告)号：WO2007054283A2
公开(公告)日：2007-05-18
申请号：PCT/EP2006010699
申请日：2006-11-08
申请人： HELMHOLTZ INFEKTIONSFORSCHUNG , EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A
发明人： EBENSEN THOMAS , MORR MICHAEL , GUZMAN CARLOS A
CPC分类号： A61K39/39 , A61K31/7076 , A61K31/7084 , A61K2039/55511
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗。特别地，本发明提供了新的化合物，其可用作用于治疗感染性疾病，炎性疾病，自身免疫性疾病，肿瘤，过敏症以及用于控制人的生育能力的预防和/或治疗性疫苗的佐剂和/或免疫调节剂动物种群。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。此外，本发明涉及其作为药物组合物中的活性成分的用途。

6. 发明申请

WO2006024502A2 REGIOSELECTIVE OXIDATION METHOD 审中-公开
标题翻译：过程将选择氧化REGIO
公开(公告)号：WO2006024502A2
公开(公告)日：2006-03-09
申请号：PCT/EP2005009348
申请日：2005-08-30
申请人： BIOTECHNOLOG FORSCHUNG GMBH , MORR MICHAEL , SASSE FLORENZ , HINKELMANN BETTINA , NIMTZ MANFRED , WRAY VICTOR
发明人： MORR MICHAEL , SASSE FLORENZ , HINKELMANN BETTINA , NIMTZ MANFRED , WRAY VICTOR
IPC分类号： C12P7/04 , C12P7/26 , C12P41/00
CPC分类号： C12P7/18 , C12P7/04 , C12P7/26
摘要： The invention relates to a method for regioselective oxidation of a compound having a multiple methyl hydrocarbon chain branched by an enzyme system.
摘要翻译：本发明涉及一种通过酶系统与多个甲基支链烃链的化合物的区域选择性氧化的方法。

7. 发明申请

WO2004009125A3 BISACYLOXYPROPYLCYSTEINE CONJUGATES AND THE USE THEREOF 审中-公开
标题翻译：双异丙氧基丙酮共轭物及其用途
公开(公告)号：WO2004009125A3
公开(公告)日：2004-05-27
申请号：PCT/EP0307892
申请日：2003-07-18
申请人： BIOTECHNOLOG FORSCHUNG GMBH , MUEHLRADT PETER , MORR MICHAEL
发明人： MUEHLRADT PETER , MORR MICHAEL
IPC分类号： A61K47/48
CPC分类号： A61K47/60
摘要： The invention relates to novel lipopeptide conjugates, in which a cysteine that is double-substituted by a fatty acid is bonded by means of the carboxyl group to a highly soluble, physiologically compatible and non-immunogenic, polymeric conjugate group. The novel conjugates exhibit an excellent macrophage stimulant action and do not require additional solutizing. They can be used in a wide range of applications, in particular for stimulating macrophages, for stimulating antibody synthesis, for combating infection, as an immunostimulant, in particular in relation to tumours, for preventing and treating septicaemic shock, for wound healing and as an adjuvant for vaccines.
摘要翻译：存在其中的双脂肪酸取代的羧基基团的半胱氨酸来提出的新的脂肽缀合物一个易溶于水的和生理上耐受的和非免疫原性聚合物缀合物基团结合。新的结合物显示非常好的巨噬细胞刺激作用，并且不需要额外的溶解。它们本身对许多用途，特别是用于刺激巨噬细胞，刺激抗体的合成，用于抗感染防御，用于刺激免疫，特别是抗肿瘤，对于脓毒性休克的预防和治疗，用于伤口愈合，并作为疫苗的佐剂。

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