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1. 发明申请

WO2006039685A2 METHODS FOR SYNTHESIS OF CHIRAL INTERMEDIATES OF CAROTENOIDS, CAROTENOID ANALOGS, AND CAROTENOID DERIVATIVES 审中-公开
标题翻译：合成CAROTENOIDS，CAROTENOID ANALOGS和CAROTENOID DERIVATIVES的CHIRAL中间体的方法
公开(公告)号：WO2006039685A2
公开(公告)日：2006-04-13
申请号：PCT/US2005/035599
申请日：2005-10-03
申请人： HAWAII BIOTECH, INC. , LOCKWOOD, Samuel, F. , TANG, Peng, Cho , NADOLSKI, Geoff , FANG, Zhiqiang , DU, Yishu , GEISS, William , WILLIAMS, Richard , BURDICK, William , YANG, Min
发明人： LOCKWOOD, Samuel, F. , TANG, Peng, Cho , NADOLSKI, Geoff , FANG, Zhiqiang , DU, Yishu , GEISS, William , WILLIAMS, Richard , BURDICK, William , YANG, Min
IPC分类号： C07C29/145 , C07C33/14 , C07C401/00
CPC分类号： C07C403/24 , C07B2200/07 , C07B2200/09 , C07C29/143 , C07C45/298 , C07C45/511 , C07C45/61 , C07C45/64 , C07C45/673 , C07C45/70 , C07C45/71 , C07C47/21 , C07C49/713 , C07C49/753 , C07C403/08 , C07C2601/16 , C07D319/06 , C07F7/188 , C07F7/1892 , C07F9/113 , C07F9/5442 , C12P23/00 , C07C49/603 , C07C33/02 , C07C35/08 , C07C35/21
摘要： A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids.
摘要翻译：用于合成用于合成类胡萝卜素和类胡萝卜素类似物的中间体和/或类胡萝卜素衍生物的方法。在一些实施方案中，本发明包括用于合成可用于合成光学活性类胡萝卜素的光学活性中间体的方法。

2. 发明申请

WO2006119125A2 METHODS FOR SYNTHESIS OF CAROTENOIDS, INCLUDING ANALOGS, DERIVATIVES, AND SYNTHETIC AND BIOLOGICAL INTERMEDIATES 审中-公开
标题翻译：用于合成碳酸的方法，包括模拟物，衍生物，合成和生物中间体
公开(公告)号：WO2006119125A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016487
申请日：2006-05-01
申请人： HAWAII BIOTECH, INC. , LOCKWOOD, Samuel, F. , NADOLSKI, Geoff , BURDICK, David , TANG, Peng Cho , JACKSON, Henry, L. , FANG, Zhiqiang , DU, Yishu , YANG, Min , GEISS, William , WILLIAMS, Richard
发明人： LOCKWOOD, Samuel, F. , NADOLSKI, Geoff , BURDICK, David , TANG, Peng Cho , JACKSON, Henry, L. , FANG, Zhiqiang , DU, Yishu , YANG, Min , GEISS, William , WILLIAMS, Richard
IPC分类号： C07F9/113 , C07C69/40
CPC分类号： C07C29/147 , C07C11/21 , C07C33/02 , C07C45/298 , C07C47/21 , C07C49/743 , C07C67/08 , C07C67/30 , C07C67/343 , C07C67/39 , C07C69/40 , C07C69/602 , C07C403/24 , C07C2601/16 , C07F9/113 , C07F9/65515 , C07C69/73 , C07C35/21
摘要： A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
摘要翻译：用于合成用于合成类胡萝卜素合成中间体，类胡萝卜素类似物和/或类胡萝卜素衍生物的中间体的方法。类胡萝卜素类似物，衍生物或中间体可以施用于受试者以抑制和/或改善涉及产生活性氧，活性氮物质，自由基和/或非自由基的任何疾病。在一些实施方案中，本发明可以包括合成包括类胡萝卜素类似物或衍生物的化合物的方法。类胡萝卜素类似物或衍生物可包括无环端基。在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。取代基可以增强类胡萝卜素类似物或衍生物的溶解度，使得类胡萝卜素类似物或衍生物至少部分地溶解在水中。

3. 发明申请

WO2007147163A2 METHODS FOR SYNTHESIS OF CAROTENOIDS, INCLUDING ANALOGS, DERIVATIVES, AND SYNTHETIC AND BIOLOGICAL INTERMEDIATES 审中-公开
标题翻译：用于合成碳酸的方法，包括模拟物，衍生物，合成和生物中间体
公开(公告)号：WO2007147163A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/071482
申请日：2007-06-18
申请人： CARDAX PHARMACEUTICALS, INC. , LOCKWOOD, Samuel, F , TANG, Peng Cho , NADOLSKI, Geoff , JACKSON, Henry L. , FANG, Zhiqiang , DU, Yishu , YANG, Min , GEISS, William , WILLIAMS, Richard , BURDICK, David , BRAUN, Christi L.
发明人： LOCKWOOD, Samuel, F , TANG, Peng Cho , NADOLSKI, Geoff , JACKSON, Henry L. , FANG, Zhiqiang , DU, Yishu , YANG, Min , GEISS, William , WILLIAMS, Richard , BURDICK, David , BRAUN, Christi L.
CPC分类号： C07F9/113 , C07C33/02 , C07C45/298 , C07C47/21 , C07C67/343 , C07C69/40 , C07C229/12 , C07C229/26 , C07C271/22 , C07D207/16 , C07D295/205 , C07C69/602
摘要： A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
摘要翻译：用于合成用于合成类胡萝卜素合成中间体，类胡萝卜素类似物和/或类胡萝卜素衍生物的中间体的方法。类胡萝卜素类似物，衍生物或中间体可以施用于受试者以抑制和/或改善涉及产生活性氧，活性氮物质，自由基和/或非自由基的任何疾病。在一些实施方案中，本发明可以包括合成包括类胡萝卜素类似物或衍生物的化合物的方法。类胡萝卜素类似物或衍生物可包括无环端基。在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。取代基可以增强类胡萝卜素类似物或衍生物的溶解度，使得类胡萝卜素类似物或衍生物至少部分地溶解在水中。

4. 发明申请

WO2006102576A1 WATER-DISPERSIBLE CAROTENOIDS, INCLUDING ANALOGS AND DERIVATIVES 审中-公开
标题翻译：含水不溶性毛细血管细胞，包括模拟物和衍生物
公开(公告)号：WO2006102576A1
公开(公告)日：2006-09-28
申请号：PCT/US2006/010726
申请日：2006-03-23
申请人： HAWAII BIOTECH, INC. , LOCKWOOD, Samuel, F , NADOLSKI, Geoff
发明人： LOCKWOOD, Samuel, F , NADOLSKI, Geoff
IPC分类号： C07C403/24 , C07F9/117 , C07F9/655 , A61K31/225 , A61K31/665 , A61K31/6615 , A61P27/02
CPC分类号： C07D295/205 , A61K31/07 , A61K31/12 , A61K31/225 , A61K31/6615 , A61K31/665 , C07C403/24 , C07D307/62 , C07F9/117 , C07F9/65515
摘要： A chemical composition; comprising one or more carotenoid analogs or derivatives having a structure (I), (II) and (III) where each R 3 is independently hydrogen or methyl, and where each R 1 and R 2 are independently wherein each R 5 is independently hydrogen, -OH, or -OR 6 , wherein at least one R 5 group is -OR 6 ; wherein each R 6 is independently: alkyl; aryl; -alkyl-N(R 7 ) 2 ; -aryl-N(R 7 ) 2 ; -alkyl-N + (R 7 ) 3 ; -aryl-N + (R 7 ) 3 ; -alkyl-CO 2 R 7 ; -aryl-CO 2 R 7 ; -alkyl-CO 2 ; -aryl-CO 2 ; -CO 2 R 8 ; -P(O)(OR 8 ) 2 ; -S(O)(OR 8 ) 2 ; an amino acid; a peptide, a carbohydrate; -C(O)- (CH 2 ) 0 -CO 2 R 9 ; a nucleoside residue, or a co-antioxidant; wherein R 7 is hydrogen, alkyl, or aryl; wherein R 8 is hydrogen, alkyl, aryl, benzyl or a co-antioxidant; wherein R 9 is hydrogen; alkyl; aryl; -P(0)(OR 8 ) 2 ; -S(0)(OR 8 ) 2 ; an amino acid; a peptide, a carbohydrate; a nucleoside, or a co-antioxidant; and wherein n is 1 to 9. The compounds are useful for the inhibition and amelioration of diseases resulting in change and/or loss of vision.
摘要翻译：化学成分; 包含一种或多种具有结构（I），（II）和（III）的类胡萝卜素类似物或衍生物，其中每个R 3独立地为氢或甲基，并且其中每个R 1〜 >和R 2独立地是其中每个R 5独立地是氢，-OH或-OR 6，其中至少一个R 0 > 5 组为-OR 6; 其中每个R 6独立地为：烷基; 芳基; - 烷基-N（R ^{7 ）_{2 ; 芳基 - N（R ^{7 ）_{2 ; - 烷基-N +（R 7）3 - ; 芳基-N ^{+ （R ^{7 ）_{3 ; - 烷基CO _{2 - [R ^{7 ; - 芳基 - CO _{2 - [R ^{7 ; - 烷基CO _{2 ; - 芳基 - CO _{2 ; -CO _{2 - [R ^{8 ; -P（O）（OR ^{8 ）_{2 ; -S（O）（OR ^{8 ）_{2 ; 氨基酸; 肽，碳水化合物; -C（O） - （CH 2 CH 2）2 -CO 2 R 9; 核苷残基或共抗氧化剂; 其中R 7为氢，烷基或芳基; 其中R 8为氢，烷基，芳基，苄基或共抗氧化剂; 其中R 9是氢; 烷基; 芳基; -P（O）（OR ^{8 ）_{2 ; -S（O）（OR ^{8 ）_{2 ; 氨基酸; 肽，碳水化合物; 核苷或共抗氧化剂; 并且其中n为1至9.所述化合物可用于抑制和改善导致变化和/或视力丧失的疾病。}}}}}}}}}}}}}}}}}}}}}}}

5. 发明申请

WO2005102356A1 CAROTENOID ANALOGS OR DERIVATIVES FOR THE INHIBITION AND AMELIORATION OF INFLAMMATION 审中-公开
标题翻译：用于抑制和改善炎症的毛细血管细胞模拟物或衍生物
公开(公告)号：WO2005102356A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/012811
申请日：2005-04-14
申请人： HAWAII BIOTECH, INC. , LOCKWOOD, Samuel, F. , O'MALLEY, Sean , JACKSON, Henry , NADOLSKI, Geoff
发明人： LOCKWOOD, Samuel, F. , O'MALLEY, Sean , JACKSON, Henry , NADOLSKI, Geoff
IPC分类号： A61K31/6615
CPC分类号： A61K31/015 , A61K31/12 , A61K31/225 , A61K31/341 , A61K31/66 , A61K31/6615
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases in a human subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative. In some embodiments, the administration of analogs or derivatives of carotenoids may inhibit and/or ameliorate the occurrence of diseases in subjects. In some embodiments, analogs or derivatives of carotenoids may be water-soluble and/or water dispersible. Maladies that may be treated with analogs or derivatives of carotenoids embodied herein may include diseases that provoke or trigger an inflammatory response. In an embodiment, asthma may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of eicosanoids. In an embodiment, atherosclerosis may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering the analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of 5-LO-catalyzed eicosanoid metabolites. In an embodiment, 5-LO-catalyzed eicosanoid metabolites that may be controlled or affected by administering analogs or derivatives of carotenoids to a subject may include proinflammatory effector molecules (e.g., leukotrienes).
摘要翻译：一种抑制和/或改善人类受试者中疾病发生的方法，其中受试者单独或与另一种类胡萝卜素类似物或衍生物组合施用类胡萝卜素类似物或衍生物。在一些实施方案中，类胡萝卜素类似物或衍生物的施用可以抑制和/或改善受试者中疾病的发生。在一些实施方案中，类胡萝卜素的类似物或衍生物可以是水溶性的和/或水分散的。可用本文体现的类胡萝卜素类似物或衍生物治疗的疟疾可能包括引发或触发炎性反应的疾病。在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗哮喘。在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响类花生酸的生物利用度。在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗动脉粥样硬化。在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响5-LO催化的类花生酸酯代谢物的生物利用度。在一个实施方案中，可以通过向受试者施用类胡萝卜素的类似物或衍生物来控制或影响的5-LO-催化的类花生酸代谢物可以包括促炎效应分子（例如白三烯）。

6. 发明申请

WO2006105214A3 REDUCTION IN COMPLEMENT ACTIVATION AND INFLAMMATION DURING TISSUE INJURY BY CAROTENOIDS, CAROTENOID ANALOGS, OR DERIVATIVES THEREOF 审中-公开
公开(公告)号：WO2006105214A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/011496
申请日：2006-03-29
申请人： HAWAII BIOTECH, INC. , NADOLSKI, Geoff , LOCKWOOD, Samuel, F.
发明人： NADOLSKI, Geoff , LOCKWOOD, Samuel, F.
IPC分类号： A61K31/225 , A61K31/341 , A61K31/665 , A61P9/10 , A61P29/00
摘要： Administering water-soluble or dispersible synthetic analogs or derivatives of astaxanthin, lutein, zeaxanthin, or lycophyll and/or other carotenoids to a subject may reduce some of the adverse effects of inflammation in a body organ or tissue. The analogs or derivatives may be incorporated into pharmaceutical, over-the-counter, or nutraceutical preparations. Administration of the analogs or derivatives described herein may reduce deposition of inflammatory mediators such as C-reactive protein, complement system proteins or the membrane attack complex (MAC) in tissues. Reduced deposition of these molecules in tissues may reduce cell damage and/or lysis in the tissues.

7. 发明申请

WO2006099015A2 CAROTENOIDS, CAROTENOID ANALOGS, OR CAROTENOID DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：类胡萝卜素，类胡萝卜素类似物或类胡萝卜素衍生物用于治疗增殖性疾病
公开(公告)号：WO2006099015A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/008363
申请日：2006-03-09
申请人： HAWAII BIOTECH, INC. , LOCKWOOD, Samuel, F , NADOLSKI, Geoff , FREY, Dean, Allen , MCLAWS, Mark , BURDICK, David
发明人： LOCKWOOD, Samuel, F , NADOLSKI, Geoff , FREY, Dean, Allen , MCLAWS, Mark , BURDICK, David
IPC分类号： A61K31/7024 , A61K31/6615 , A61K31/215 , A61K31/01 , A61P35/00
CPC分类号： A61K31/01 , A61K31/12 , A61K31/13 , A61K31/185 , A61K31/192 , A61K31/195 , A61K31/215 , A61K31/6615 , A61K31/7024 , A61K38/16
摘要： A method and system used for treating proliferative disorders using carotenoids, carotenoid analogs, and/or carotenoid derivatives. The method and system may be used for chemoprevention and/or chemotherapy. The method and system may induce apoptosis in target cells, tissues, and/or organs. The analog, derivative, or intermediate may be administered to a cell, a group of cells, a tissue, an organ or a subject, such that at least a portion of the undesirable consequences of the proliferative disorder are thereby reduced.
摘要翻译：使用类胡萝卜素，类胡萝卜素类似物和/或类胡萝卜素衍生物治疗增殖性疾病的方法和系统。该方法和系统可用于化学预防和/或化疗。该方法和系统可以诱导靶细胞，组织和/或器官的凋亡。类似物，衍生物或中间体可以施用于细胞，一组细胞，组织，器官或受试者，从而减少增殖性疾病的不良后果的至少一部分。

8. 发明申请

WO2007090095A3 SYNTHESIS OF CAROTENOID ANALOGS OR DERIVATIVES WITH IMPROVED ANTIOXIDANT CHARACTERISTICS 审中-公开
公开(公告)号：WO2007090095A3
公开(公告)日：2007-08-09
申请号：PCT/US2007/061241
申请日：2007-01-29
申请人： CARDAX PHARMACEUTICALS, INC. , LOCKWOOD, Samuel, F , NADOLSKI, Geoff , FOSS, Bente J.
发明人： LOCKWOOD, Samuel, F , NADOLSKI, Geoff , FOSS, Bente J.
IPC分类号： C07C39/21 , C07C39/23 , C07C43/205 , A61K31/05 , A61K31/085 , A61P35/00 , A61P9/06 , A61P9/04
摘要： A method is described for synthesizing and adminisitering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.

9. 发明申请

WO2007027834A1 CAROTENOID ANALOGS OR DERIVATIVES FOR THE INHIBITION AND AMELIORATION OF INFLAMMATION 审中-公开
标题翻译：用于抑制和改善炎症的毛细血管细胞模拟物或衍生物
公开(公告)号：WO2007027834A1
公开(公告)日：2007-03-08
申请号：PCT/US2006/033948
申请日：2006-08-29
申请人： CARDAX PHARMACEUTICALS INC. , LOCKWOOD, Samuel, Fournier , O'MALLEY, Sean , JACKSON, Henry , NADOLSKI, Geoff
发明人： LOCKWOOD, Samuel, Fournier , O'MALLEY, Sean , JACKSON, Henry , NADOLSKI, Geoff
IPC分类号： A61K31/661 , A61K31/6615 , A61K31/225 , A61P35/00 , A61P11/06 , A61P29/00
CPC分类号： A61K31/015 , A61K31/12 , A61K31/225 , A61K31/66 , A61K31/661 , A61K31/6615
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases in a human subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative. In some embodiments, the administration of analogs or derivatives of carotenoids may inhibit and/or ameliorate the occurrence of diseases in subjects. In some embodiments, analogs or derivatives of carotenoids may be water-soluble and/or water dispersible. Maladies that may be treated with analogs or derivatives of carotenoids embodied herein may include diseases that provoke or trigger an inflammatory response. In an embodiment, asthma may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of eicosanoids. In an embodiment, atherosclerosis may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering the analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of 5-LO-catalyzed eicosanoid metabolites. In an embodiment, 5-LO-catalyzed eicosanoid metabolites that may be controlled or affected by administering analogs or derivatives of carotenoids to a subject may include proinflammatory effector molecules (e.g., leukotrienes).
摘要翻译：一种抑制和/或改善人类受试者中疾病发生的方法，其中受试者单独或与另一种类胡萝卜素类似物或衍生物组合施用类胡萝卜素类似物或衍生物。在一些实施方案中，类胡萝卜素类似物或衍生物的施用可以抑制和/或改善受试者中疾病的发生。在一些实施方案中，类胡萝卜素的类似物或衍生物可以是水溶性的和/或水分散的。可用本文体现的类胡萝卜素类似物或衍生物治疗的疟疾可能包括引发或触发炎性反应的疾病。在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗哮喘。在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响类花生酸的生物利用度。在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗动脉粥样硬化。在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响5-LO催化的类花生酸酯代谢物的生物利用度。在一个实施方案中，可以通过向受试者施用类胡萝卜素的类似物或衍生物来控制或影响的5-LO-催化的类花生酸代谢物可以包括促炎效应分子（例如白三烯）。

10. 发明申请

WO2004011423A2 STRUCTURAL CAROTENOID ANALOGS FOR THE INHIBITION AND AMELIORATION OF DISEASE 审中-公开
标题翻译：结构类胡萝卜素类药物对疾病的抑制和改善作用
公开(公告)号：WO2004011423A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023706
申请日：2003-07-29
申请人： HAWAII BIOTECH, INC.
发明人： LOCKWOOD, Samuel, Fournier , O'MALLEY, Sean , WATUMULL, David, G. , HIX, Laura, M. , JACKSON, Henry , NADOLSKI, Geoff
IPC分类号： C07C403/24
CPC分类号： C07C403/24 , C07D207/16 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of liver disease. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cancer. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cardiac arrhythmia and/or sudden cardiac death. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.
摘要翻译：一种用于抑制和/或改善受试者中与活性氧类，活性氮类，自由基和/或非自由基相关的疾病的发生的方法，由此向受试者施用类胡萝卜素结构类似物，单独或与另一种类胡萝卜素类似物或辅助抗氧化剂配制剂组合。施用类似物或类似物组合以使得受试者经历与活性氧物质，活性氮物质，自由基和/或非自由基有关的疾病的风险可因此降低。类似物或类似物组合可以施用于受试者以用于抑制和/或改善缺血 - 再灌注损伤。类似物或类似物组合可以施用于受试者以抑制和/或改善肝脏疾病。类似物或类似物组合可以被施用于受试者以抑制和/或改善癌症。类似物或类似物组合可以施用于受试者以用于抑制和/或改善心律失常和/或心脏猝死。类似物或类似物组合可以施用于受试者以抑制和/或改善涉及产生活性氧物质，活性氮物质，自由基和/或非自由基的任何疾病。在一个实施方案中，水溶性和/或水分散性虾青素类似物是特别有效的。本发明进一步包括单独或组合包含结构类胡萝卜素类似物的药物组合物。

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